Dual nano-electrospray for probing solution interactions and fast reactions of complex biomolecules

European Journal of Mass Spectrometry

Volumn 18, Issue 5, 2012, Pages 439-446

  Mark, Lewis P ^a   Gill, Matthew C ^b   Mahut, Marek ^c   Derrick, Peter J ^a,d  

^a UNIVERSITY OF WARWICK   (United Kingdom)

^b Shimadzu Research Laboratory   (United Kingdom)

^c UNIVERSITY OF VIENNA   (Austria)

^d MASSEY UNIVERSITY   (New Zealand)

Author keywords

Dual channel; Electrospray ionization; Mass spectrometry

Indexed keywords

AMINO ACIDS; MASS SPECTROMETRY;

DUAL CHANNEL; EXCHANGE REACTION; FAST REACTION; FOURIER TRANSFORM ION CYCLOTRON RESONANCE; NANO-ELECTROSPRAY EMITTER; NON-COVALENT ADDUCTS; SEPARATED CHANNELS; SOLUTION INTERACTIONS;

ELECTROSPRAY IONIZATION;

DEUTERIUM; N(ALPHA), N (EPSILON) DIACETYL LYSYL ALANYL ALANINE; N(ALPHA), N-(EPSILON)-DIACETYL-LYSYL-ALANYL-ALANINE; OLIGOPEPTIDE; VANCOMYCIN;

ARTICLE; CHEMISTRY; ELECTROSPRAY MASS SPECTROMETRY; EQUIPMENT DESIGN; INFRARED SPECTROSCOPY; INSTRUMENTATION; METHODOLOGY; NANOTECHNOLOGY; SOLUTION AND SOLUBILITY;

DEUTERIUM; EQUIPMENT DESIGN; NANOTECHNOLOGY; OLIGOPEPTIDES; SOLUTIONS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; VANCOMYCIN;

EID: 84870893204     PISSN: None     EISSN: 17516838     Source Type: Journal    
DOI: 10.1255/ejms.1198     Document Type: Article

References (57)

1. K. Tang, A.V. Tolmachev, E. Nikolaev, R. Zhang, M.E. Belov, H.R. Udseth and R.D. Smith, "Independent control of ion transmission in a jet disrupter dual-channel ion funnel electrospray ionization MS interface", Anal. Chem. 74, 5431 (2002). doi: 10.1021/ac0202583
2. M.E. Belov, G.A. Anderson, M.A. Wingerd, H.R. Udseth, K. Tang, D.C. Prior, K.R. Swanson, M.A. Buschbach, E.F. Strittmatter, R.J. Moore and R.D. Smith, "An automated high performance capillary liquid chromatography- Fourier transform ion cyclotron resonance mass spectrometer for high-throughput proteomics", J. Am. Soc. Mass Spectrom. 15, 212 (2004). doi: 10.1016/j.jasms.2003.09.008
3. R.T. Kelly, A.V. Tolmachev, J.S. Page, K. Tang and R.D. Smith, "The ion funnel: theory, implementations, and applications", Mass Spectrom. Rev. 29, 294 (2010). doi: 10.1002/mas.20232
4. S.A. Shaffer, A. Tolmachev, D.C. Prior, G.A. Anderson, H.R. Udseth and R.D. Smith, "Characterization of an improved electrodynamic ion funnel interface for electrospray ionization mass spectrometry", Anal. Chem. 71, 2957 (1999). doi: 10.1021/ac990346w
5. P.J. Derrick, A.W. Colburn and A. Giannakopulos, "An ion focussing and conveying device and a method of focussing and conveying ions", UK Patents 2373630, 2408384 and 2408385, Priority date 23-11-2000.
6. A.W. Colburn, A.E. Giannakopulos and P.J. Derrick, "The ion conveyor. An ion focussing and conveying device", Eur. J. Mass Spectrom. 10, 149 (2004). doi: 10.1255/ejms.630
7. J.W. Flora, A.P. Null and D.C. Muddiman, "Dual-micro-ESI source for precise mass determination on a quadrupole time-of-flight mass spectrometer for genomic and proteomic applications", Anal. Bioanal. Chem. 373, 538 (2002). doi: 10.1007/s00216-002-1357-0
8. W.J. Erb and K.G. Owens, "Development of a dual-spray electrospray deposition system for matrix-assisted laser desorption/ionization time-of-flight mass spectrometry", Rapid Commun. Mass Spectrom. 22, 1168 (2008). doi: 10.1002/rcm.3492
9. S. Dandavino, C. Ataman, H. Shea, C. Ryan and J. Stark, "Microfabrication of capillary electrospray emitters and ToF characterization of the emitted beam," in Proceedings of The 32nd International Electric Propulsion Conference, Wiesbaden, Germany, September 11-15, (2011).
10. G. Bonvin, J-L. Veuthey, S. Rudaz and J. Schappler, "Evaluation of a sheathless nanospray interface based on a porous tip sprayer for CE-ESI-MS coupling", Electrophoresis 33, 552 (2012). doi: 10.1002/elps.201100461
11. T. Sikanen, S. Franssila, T.J. Kauppila, R. Kostiainen, T. Kotiaho and R.A. Ketola, "Microchip technology in mass spectrometry", Mass Spectrom. Rev. 29, 351 (2010). doi: 10.1002/mas.20238
12. C. Chen and J.H. Hahn, "Dual-channel method for interference-free in-channel amperometric detection in microchip capillary electrophoresis", Anal. Chem. 79, 7182 (2007). doi: 10.1021/ac070721h
13. L. Yang, S. Zhu, W. Hang, L. Wu and X. Yan, "Development of an ultrasensitive dual-channel flow cytometer for the individual analysis of nanosized particles and biomolecules", Anal. Chem. 81, 2555 (2009). doi: 10.1021/ac802464a
14. C. Lee and J. Shiea, "Gas chromatography connected to multiple channel electrospray ionization mass spectrometry for the detection of volatile organic compounds", Anal. Chem. 70, 2757 (1998). doi: 10.1021/ac971325+
15. D-Y. Chang, C-C. Lee and J. Shiea, "Detecting large biomolecules from high-salt solutions by fused-droplet electrospray ionization mass spectrometry", Anal. Chem. 74, 2465 (2002). doi: 10.1021/ac010788j
16. J. Shiea, D. Chang, C. Lin and S. Jiang, "Generating multiply charged protein ions by ultrasonic nebulization/multiple channel-electrospray ionization mass spectrometry", Anal. Chem. 73, 4983 (2001). doi: 10.1021/ac0101609
17. I. Shieh, C. Lee and J. Shiea, "Eliminating the interferences from TRIS buffer and SDS in protein analysis by fused-droplet electrospray ionization mass spectrometry", J. Protein Res. 4, 606 (2005). doi: 10.1021/pr049765m
18. H. Chen, A. Venter and R.G. Cooks, "Extractive electrospray ionization for direct analysis of undiluted urine, milk and other complex mixtures without sample preparation", Chem. Commun. 2042 (2006). doi: 10.1039/b602614a
19. W.S. Law, H.W. Chen, J.H. Ding, S.P. Yang, L. Zhu, G. Gomez, K. Chingin, Y.L. Ren and R. Zenobi, "Rapid characterization of complex viscous liquids at the molecular level", Angew. Chem. Int. Ed. 48, 8277 (2009). doi: 10.1002/anie.200902360
20. I.X. Peng, R.R. Ogorzalek Loo, E. Margalith, M.W. Little and J.A. Loo, "Electrospray-assisted laser desorption ionization mass spectrometry (ELDI-MS) with an infrared laser for characterising peptides and proteins", Analyst 135, 769 (2010). doi: 10.1039/b923303b
21. J.S. Sampson, A.M. Hawkridge and D.C. Muddiman, "Generation and detection of multiply-charged peptides and proteins by matrix-assisted laser desorption electrospray ionization (MALDESI) Fourier transform ion cyclotron resonance mass spectrometry", J. Am. Soc. Mass Spectrom. 17, 1712 (2006). doi: 10.1016/j.jasms.2006.08.003
22. L. Meier, C. Berchtold, S. Schmid and R. Zenobi, "Extractive electrospray ionization mass spectrometry-enhanced sensitivity using an ion funnel", Anal. Chem. 84, 2076 (2012). doi: 10.1021/ac203022x
23. G.M.H. Meesters, P.H.W. Vercoulen, J.C.M. Marijnissen and B. Scarlett, "Generation of micron-sized droplets from the Taylor cone", J. Aerosol Sci. 23, 37 (1992). doi: 10.1016/0021-8502(92)90316-N
24. J. Fernandez de la Mora, "The fluid dynamics of Taylor cones", Annu. Rev. Fluid Mechanics 39, 217 (2007). doi: 10.1146/annurev.fluid.39.050905. 110159
25. G.I. Taylor, "Disintegration of water drops in an electric field", Proc. Roy. Soc. A280, 383 (1964).
26. L.A. Leuthold, F. Reymond, J.S. Rossier, E. Varesis and G. Hopfgartner, "Multi-track single- and dual-channel plastic microchips for electrospray mass spectrometry", Eur. J. Mass Spectrom. 16, 47 (2010). doi: 10.1255/ejms.1043
27. J.S. Rossier, C. Vollet, A. Carnal, G. Lagger, V. Grobry, H.H. Girault, P. Michel and F. Reymond, "Plasma etched polymer microelectrochemical systems", Lab. Chip 2, 145 (2002). doi: 10.1039/b204063h
28. J.B. Fenn, M. Mann, C.K. Meng, S.F. Wong and C.M. Whitehouse, "Electrospray ionization for mass spectrometry of large biomolecules", Science 246, 64 (1989). doi: 10.1126/science.2675315
29. F. Sobott and C.V. Robinson, "Protein complexes gain momentum", Curr. Opin. Struct. Biol. 12, 729 (2002). doi: 10.1016/S0959-440X(02)00400-1
30. T.J. Hill, D. Lafitte, J.I. Wallace, H.J. Cooper, P.O. Tsvetkov and P.J. Derrick, "Calmodulin-peptide interactions: Apocalmodulin binding to the myosin light chain kinase target-site" Biochemistry 39, 7284 (2000). doi: 10.1021/bi000139m
31. M. Sharon and C.V. Robinson, "The role of mass spectrometry in structure elucidation of dynamic protein complexes", Annu. Rev. Biochem. 76, 167 (2007). doi: 10.1146/annurev.biochem.76.061005.090816
32. O.V. Moroz, W. Burkitt, H. Wittkowski, W. He, A. Ianoul, V. Novitskaya, J. Xie, O. Polyakova, I.K. Lednev, A. Shekhtman, P.J. Derrick, P. Bjoerk, D. Foell and I.B. Bronstein, "Both Ca2+ and Zn2+ are essential for S100A12 protein-oligomerization and function", BMC Biochem. 10, 1471 (2009). doi: 10.1186/1471-2091-10-11
33. H. Hernández and C.V. Robinson, "Determining the stoichiometry and interactions of macromolecular assemblies from mass spectrometry", Nature Protocols 2, 715 (2007). doi: 10.1038/nprot.2007.73
34. K. Lorenzen, A. Vannini, P. Cramer and A.J.R. Heck, "Structural biology of RNA polymerase III: mass spectrometry elucidates subcomplex architecture", Structure 15, 1237 (2007). doi: 10.1016/j.str.2007.07.016
35. M. Dole, L.L. Mack, R.L. Hines, R.C. Mobley, L.D. Ferguson and M.B. Alice, "Molecular beams of macroions ", J. Chem. Phys. 49, 2240 (1968). doi: 10.1063/1.1670391
36. G. Schmelzeisen-Reseker, L. Bütfering and F.W. Röllgen, "Desolvation of ions and molecules in thermospray mass spectrometry", Int. J. Mass Spectrom. Ion Proc. 90, 139 (1989). doi: 10.1016/0168-1176(89) 85004-9
37. P. Kebarle and L. Tang, "From ions in solution to ions in the gas phase", Anal. Chem. 65, 972A (1993).
38. B.A. Thomson and J.V. Iribarne, "Field induced ion evaporation from liquid surfaces at atmospheric pressure", J. Chem. Phys. 71, 4451 (1979). doi: 10.1063/1.438198
39. S.C. Davis, V. Natoli, G.M. Neumann and P.J. Derrick, "A model of ion evaporation tested through field desorption experiments on glucose mixed with alkali metal salts", Int. J. Mass Spectrom. Ion Proc. 78, 17 (1987). doi: 10.1016/0168-1176(87)87039-8
40. M. Gill, "A dual-channelled nano-electrospray source for mass spectrometry", M. Chem. Project Report, Department of Chemistry, University of Warwick, (2005).
41. C.G. Zampronio, A.E. Giannakopulos, M. Zeller, E. Bitziou, J.V. Macpherson and P.J. Derrick, "Production and properties of nanoelectrospray emitters used in Fourier transform ion cyclotron resonance mass spectrometry: implications for determination of association constants for noncovalent complexes", Anal. Chem. 76, 5172 (2004). doi: 10.1021/ac049569z
42. M. Wilm and M. Mann, "Analytical properties of the nanoelectrospray ion source", Anal. Chem. 68, 1 (1996). doi: 10.1021/ac9509519
43. A. Schmidt, M. Karas and T.J. Dülcks, "Effect of different solution flow rates on analyte ion signals in nano-ESI MS, or: when does ESI turn into nano-ESI?", J. Am. Soc. Mass Spectrom. 14, 492 (2003). doi: 10.1016/S1044-0305(03)00128-4
44. T. Rob and D.J. Wilson, "A versatile microfluidic chip for millisecond time-scale kinetic studies by electrospray mass spectrometry", J. Am. Soc. Mass Spectrum. 1, 124 (2009). doi: 10.1016/j.jasms.2008.09.005
45. D.J. Wilson and L.A. Konerman, "Analytical properties of the nanoelectrospray ion source", Anal. Chem. 75, 6408 (2003). doi: 10.1021/ac0346757
46. A.J.R. Heck, T.D. Jorgensen, M. O'Sullivan, M. von Raumer and P.J. Derrick, "Gas-phase noncovalent interactions between vancomycin-group antibiotics and bacterial cell-wall precursor peptides probed by hydrogen/deuterium exchange", J. Am. Soc. Mass Spectrom. 9, 1255 (1998). doi: 10.1016/S1044-0305(98)00110-X
47. E.F. Gale, E. Cundliffe, P. Reynolds, M.H. Richmond and M.J. Waring, The Molecular Basis of Antibiotic Action 2nd Edn. Wiley-Interscience, New York, USA (1981).
48. R. Kannan, C.M. Harris, T.M. Harris, J.P. Waltho, N.J. Skelton and D.H. Williams, "Function of the amino sugar and N-terminal amino acid of the antibiotic vancomycin in its complexation with cell wall peptides", J. Am. Chem. Soc. 110, 2946 (1988). doi: 10.1021/ja00217a042
49. M.L. Cohen, "Epidemiology of drug resistance: implications for a post-antimicrobial ear", Science 257, 1050 (1992). doi: 10.1126/science.257.5073.1050
50. M. Nieto and H.R. Perkins, "Physicochemical properties of vancomycin and iodovancomycin and their complexes with diacetyl-L-lysyl-D-alanyl-D- alanine", Biochem. J. 123, 773 (1971). doi: 10.1021/ja00189a017
51. J.P. Waltho and D.H. Williams, "Aspects of molecular recognition: solvent exclusion and dimerization of the antibiotic ristocetin when bound to a model bacterial cell-wall precursor", J. Am. Chem. Soc. 111, 2475 (1989). doi: 10.1021/ja00189a017
52. G. Batta, F. Sztaricskai, K.E. Kover, C. Ruedel and T.F. Berdnikova, "An NMR study of eremomycin and its derivatives. Full 1H and 13C assignment, motional behavior, dimerization and complexation with Ac-D-Ala-D-Ala", J. Antibiotics 44, 1208 (1991). doi: 10.7164/antibiotics. 44.1208
53. J.P. Mackay, U. Gerhard, D.A. Beauregard, D.H. Williams, M.S. Westwell and M.S. Searle, "Glycopeptide antibiotic activity and the possible role of dimerization: a model for biological signaling", J. Am. Chem. Soc. 116, 4581 (1994). doi: 10.1021/ja00090a006
54. L. Mark, "Carbon nanotubes and other highly curved surfaces for field emission and field-pronated ionisation", PhD Thesis, University of Warwick (2009).
55. J.V. Macpherson and P.R. Unwin, "Radial flow microring electrode: development and characterization", Anal. Chem. 70, 2914 (1998). doi: 10.1021/ac9801667
56. M. Palmblad, K. Hakansson, P. Hakansson, X. Feng, H.J. Cooper, A.E. Gianakopulos, P.S. Green and P.J. Derrick, "A 9.4 T Fourier transform ion cyclotron resonance mass spectrometer: description and performance", Eur. J. Mass Spectrum. 6, 267 (2000). doi: 10.1255/ejms.348
57. A.G. Marshall, C.L. Hendrickson and G.S. Jackson, "Fourier transform ion cyclotron resonance mass spectrometry: A primer", Mass Spectrom. Rev. 17, 1 (1998). doi: 10.1002/(SICI)1098-2787(1998)17:1<1::AID-MAS1<3.0.CO;2- K