Effects of a Novel Pharmacologic Inhibitor of Myeloperoxidase in a Mouse Atherosclerosis Model

PLoS ONE

Volumn 7, Issue 12, 2012, Pages

  Liu, Cuiqing ^a,b   Desikan, Rajagopal ^c   Ying, Zhekang ^b   Gushchina, Liubov ^b   Kampfrath, Thomas ^b   Deiuliis, Jeffrey ^b   Wang, Aixia ^b   Xu, Xiaohua ^b   Zhong, Jixin ^b   Rao, Xiaoquan ^b   Sun, Qinghua ^b   Maiseyeu, Andrei ^b   Parthasarathy, Sampath ^b   Rajagopalan, Sanjay ^b  

^a HANGZHOU NORMAL UNIVERSITY   (China)

^b OHIO STATE UNIVERSITY   (United States)

^c InVasc Therapeutics   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 NITROTYROSINE; ACETYLCHOLINE; CD11B ANTIGEN; ENZYME INHIBITOR; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 6; INV 315; LYSINE; MYELOPEROXIDASE; MYELOPEROXIDASE INHIBITOR; PLACEBO; SUPEROXIDE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIATHEROSCLEROSIS ACTIVITY; AORTA; ARTICLE; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; BLOOD PRESSURE; BODY WEIGHT; CARDIOVASCULAR FUNCTION; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG EFFICACY; DRUG MEGADOSE; ENZYME ACTIVITY; ENZYME INHIBITION; EX VIVO STUDY; FEASIBILITY STUDY; GENE EXPRESSION; INFLAMMATION; INOS GENE; LEUKOCYTE ADHERENCE; LIPID DIET; LOW DRUG DOSE; MALE; MONOCYTE; MOUSE; NONHUMAN; OXIDATIVE STRESS; TREATMENT DURATION; TREATMENT RESPONSE;

ANIMALS; AORTA; APOLIPOPROTEINS E; ATHEROSCLEROSIS; BLOOD PRESSURE; DISEASE MODELS, ANIMAL; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; INFLAMMATION; INTERLEUKIN-6; MALE; MICE; MICE, KNOCKOUT; OXIDATIVE STRESS; PEROXIDASE; PLAQUE, ATHEROSCLEROTIC;

MUS;

EID: 84870887288     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0050767     Document Type: Article

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