Hypoxia inhibits the differentiation of mesenchymal stem cells into osteoblasts by activation of Notch signaling

Experimental and Molecular Pathology

Volumn 94, Issue 1, 2013, Pages 33-39

  Xu, Ningru ^a,b   Liu, Hui ^c   Qu, Feng ^b   Fan, Jun ^b   Mao, Kezheng ^a   Yin, Yi ^a   Liu, Jianheng ^a   Geng, Zhenying ^b   Wang, Yan ^a  

^a CHINESE PLA GENERAL HOSPITAL   (China)

^b NANKAI UNIVERSITY   (China)

^c The 175th Hospital of PLA   (China)

Author keywords

Hypoxia; Mesenchymal stem cell; Notch signaling; Osteoblast

Indexed keywords

ALKALINE PHOSPHATASE; FIBRONECTIN; NOTCH RECEPTOR; NOTCH1 RECEPTOR; OSTEOCALCIN; OSTEOPONTIN; SHORT HAIRPIN RNA; TRANSCRIPTION FACTOR RUNX2;

ANIMAL CELL; ARTICLE; BONE DEVELOPMENT; CELL DIFFERENTIATION; CELL ISOLATION; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; HYPOXIA; MALE; MESENCHYMAL STEM CELL; NONHUMAN; OSTEOBLAST; OXYGEN TENSION; PROTEIN BINDING; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; UPREGULATION;

ANIMALS; CELL DIFFERENTIATION; CELL HYPOXIA; CELLS, CULTURED; CORE BINDING FACTOR ALPHA 1 SUBUNIT; MALE; MESENCHYMAL STROMAL CELLS; OSTEOBLASTS; OSTEOGENESIS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, NOTCH1; RNA INTERFERENCE; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC; TRANSCRIPTIONAL ACTIVATION;

EID: 84870885699     PISSN: 00144800     EISSN: 10960945     Source Type: Journal    
DOI: 10.1016/j.yexmp.2012.08.003     Document Type: Article

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