Endothelial differentiation of SHED requires MEK1/ERK signaling

Journal of Dental Research

Volumn 92, Issue 1, 2013, Pages 51-57

  Bento, L W ^a,b   Zhang, Z ^a   Imai, A ^a   Nor F ^a   Dong, Z ^a   Shi, S ^c   Araujo, F B ^b   Nor J E ^a,d,e  

^a UNIVERSITY OF MICHIGAN SCHOOL OF DENTISTRY   (United States)

^b FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^d UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^e University of Michigan   (United States)

Author keywords

angiogenesis; blood vessels; dental pulp stem cells; endodontics; stemness; tissue engineering

Indexed keywords

1,3 BUTADIENE DERIVATIVE; 1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; CD31 ANTIGEN; ENZYME INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE; NITRILE; ONCOPROTEIN; STAT3 PROTEIN; STAT3 PROTEIN, HUMAN; TISSUE SCAFFOLD; VASCULOTROPIN A; VASCULOTROPIN RECEPTOR 2; VEGFA PROTEIN, HUMAN;

ANIMAL; ARTICLE; BLOOD VESSEL; CELL DIFFERENTIATION; COMPARATIVE STUDY; CULTURE MEDIUM; CULTURE TECHNIQUE; CYTOLOGY; DECIDUOUS TOOTH; DRUG ANTAGONISM; DRUG EFFECT; ENDOTHELIUM CELL; ENZYME ACTIVATION; GENE SILENCING; GENETICS; HUMAN; IMMUNOLOGY; MOUSE; MOUSE MUTANT; PHOSPHORYLATION; PHYSIOLOGY; SIGNAL TRANSDUCTION; STEM CELL; TOOTH PULP;

ANIMALS; ANTIGENS, CD31; BLOOD VESSELS; BUTADIENES; CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; CULTURE MEDIA; DENTAL PULP; ENDOTHELIAL CELLS; ENZYME ACTIVATION; ENZYME INHIBITORS; GENE SILENCING; HUMANS; MAP KINASE KINASE 1; MAP KINASE KINASE KINASES; MAP KINASE SIGNALING SYSTEM; MICE; MICE, KNOCKOUT; MICE, SCID; NITRILES; ONCOGENE PROTEIN V-AKT; PHOSPHORYLATION; STAT3 TRANSCRIPTION FACTOR; STEM CELLS; TISSUE SCAFFOLDS; TOOTH, DECIDUOUS; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 84870872389     PISSN: 00220345     EISSN: 15440591     Source Type: Journal    
DOI: 10.1177/0022034512466263     Document Type: Article

References (23)

1. Albelda SM, Muller WA, Buck CA, Newman PJ. Molecular and cellular properties of PECAM-1 (endoCAM/CD31): a novel vascular cell-cell adhesion molecule. J Cell Biol. 1991 ; 114: 1059-1068
2. Behr B, Tang C, Germann G, Longaker MT, Quarto N. Locally applied vascular endothelial growth factor A increases the osteogenic healing capacity of human adipose-derived stem cells by promoting osteogenic and endothelial differentiation. Stem Cells. 2011 ; 29: 286-296
3. Cao Y. Positive and negative modulation of angiogenesis by VEGFR1 ligands. Sci Signal. 2009 ; 2 (59). re1
4. Cao Y, Sun Z, Liao L, Meng Y, Han Q, Zhao RC. Human adipose tissue-derived stem cells differentiate into endothelial cells in vitro and improve postnatal neovascularization in vivo. Biochem Biophys Res Commun. 2005 ; 332: 370-379
5. Casagrande L, Demarco FF, Zhang Z, Araujo FB, Shi S, Nör JE. Dentin-derived BMP-2 and odontoblast differentiation. J Dent Res. 2010 ; 89: 603-608
6. Casagrande L, Cordeiro MM, Nör SA, Nör JE. Dental pulp stem cells in regenerative dentistry. Odontology. 2011 ; 99: 1-7
7. Cordeiro MM, Dong Z, Kaneko T, Zhang Z, Miyazawa M, Shi S, et al. Dental pulp tissue engineering with stem cells from exfoliated deciduous teeth. J Endod. 2008 ; 34: 962-969
8. d'Aquino R, Graziano A, Sampaolesi M, Laino G, Pirozzi G, De Rosa A, et al. Human postnatal dental pulp cells co-differentiate into osteoblasts and endotheliocytes: a pivotal synergy leading to adult bone tissue formation. Cell Death Differ. 2007 ; 14: 1162-1171
9. Fan F, Wey JS, McCarty MF, Belcheva A, Liu W, Bauer TW, et al. Expression and function of vascular endothelial growth factor receptor-1 on human colorectal cancer cells. Oncogene. 2005 ; 24: 2647-2653
10. Hoeben A, Landuyt B, Highley MS, Wildiers H, Van Oosterom AT, De Bruijn EA. Vascular endothelial growth factor and angiogenesis. Pharmacol Rev. 2004 ; 56: 549-580
11. Iohara K, Zheng L, Wake H, Ito M, Nabekura J, Wakita H, et al. A novel stem cell source for vasculogenesis in ischemia: subfraction of side population cells from dental pulp. Stem Cells. 2008 ; 26: 2408-2418
12. Kearney JB, Kappas NC, Ellerstrom C, DiPaola FW, Bautch VL. The VEGF receptor flt-1 (VEGFR-1) is a positive modulator of vascular sprout formation and branching morphogenesis. Blood. 2004 ; 103: 4527-4535
13. Matsuda T, Nakamura T, Nakao K, Arai T, Katsuki M, Heike T, et al. STAT3 activation is sufficient to maintain an undifferentiated state of mouse embryonic stem cells. EMBO J. 1999 ; 18: 4261-4269
14. Miura M, Gronthos S, Zhao M, Lu B, Fisher LW, Robey PG, et al. SHED: stem cells from human exfoliated deciduous teeth. Proc Natl Acad Sci USA. 2003 ; 100: 5807-5812
15. Quirici N, Soligo D, Caneva L, Servida F, Bossolasco P, Deliliers GL. Differentiation and expansion of endothelial cells from human bone marrow CD133(+) cells. Br J Haematol. 2001 ; 115: 186-194
16. Roberts-Clark DJ, Smith AJ. Angiogenic growth factors in human dentine matrix. Arch Oral Biol. 2000 ; 45: 1013-1016
17. Roy H, Bhardwaj S, Yla-Herttuala S. Biology of vascular endothelial growth factors. FEBS Lett. 2006 ; 580: 2879-2887
18. Sakai VT, Zhang Z, Dong Z, Neiva KG, Machado MA, Shi S, et al. SHED differentiate into functional odontoblasts and endothelium. J Dent Res. 2010 ; 89: 791-796
19. Tran-Hung L, Laurent P, Camps J, About I. Quantification of angiogenic growth factors released by human dental cells after injury. Arch Oral Biol. 2008 ; 53: 9-13
20. Xu J, Liu X, Jiang Y, Chu L, Hao H, Liua Z, et al. MAPK/ERK signalling mediates VEGF-induced bone marrow stem cell differentiation into endothelial cell. J Cell Mol Med. 2008 ; 12: 2395-2406
21. Yamaguchi TP, Dumont DJ, Conlon RA, Breitman ML, Rossant J. flk-1, an flt-related receptor tyrosine kinase is an early marker for endothelial cell precursors. Development. 1993 ; 118: 489-498
22. Zhang P, Moudgill N, Hager E, Tarola N, Dimatteo C, McIlhenny S, et al. Endothelial differentiation of adipose-derived stem cells from elderly patients with cardiovascular disease. Stem Cells Dev. 2011 ; 20: 977-988
23. Zhang Z, Neiva KG, Lingen MW, Ellis LM, Nör JE. VEGF-dependent tumor angiogenesis requires inverse and reciprocal regulation of VEGFR1 and VEGFR2. Cell Death Differ. 2010 ; 17: 499-512