The ghosts of departed quantities: Approaches to dealing with observations below the limit of quantitation

Statistics in Medicine

Volumn 31, Issue 30, 2012, Pages 4280-4295

  Senn, Stephen ^a,b   Holford, Nick ^c   Hockey, Hans ^d  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b LUXEMBOURG INSTITUTE OF HEALTH   (Luxembourg)

^c UNIVERSITY OF AUCKLAND   (New Zealand)

^d Biometrics Matters Limited   (New Zealand)

Author keywords

Censored sample; Maximum likelihood; Pattern mixture model; PKPD modelling; Truncated sample

Indexed keywords

VORICONAZOLE;

ARTICLE; DRUG BLOOD LEVEL; DRUG EFFICACY; HUMAN; LIMIT OF QUANTITATION; MAXIMUM LIKELIHOOD METHOD; SIMULATION; STATISTICAL ANALYSIS; STATISTICAL DISTRIBUTION; STATISTICAL MODEL;

ANTIFUNGAL AGENTS; BIAS (EPIDEMIOLOGY); CLINICAL TRIALS, PHASE II AS TOPIC; CLINICAL TRIALS, PHASE III AS TOPIC; DATA INTERPRETATION, STATISTICAL; HUMANS; LIKELIHOOD FUNCTIONS; MODELS, THEORETICAL; NORMAL DISTRIBUTION; PHARMACOKINETICS; PYRIMIDINES; REPRODUCIBILITY OF RESULTS; RESEARCH DESIGN; TRIAZOLES;

EID: 84870870773     PISSN: 02776715     EISSN: 10970258     Source Type: Journal    
DOI: 10.1002/sim.5515     Document Type: Article

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