Impact of low percentage of data below the quantification limit on parameter estimates of pharmacokinetic models

Journal of Pharmacokinetics and Pharmacodynamics

Volumn 38, Issue 4, 2011, Pages 423-432

  Xu, Xu Steven ^a   Dunne, Adrian ^b,c   Kimko, Holly ^a   Nandy, Partha ^a   Vermeulen, An ^b  

^a JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

^b JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

^c UNIVERSITY COLLEGE DUBLIN   (Ireland)

Author keywords

BQL; Parameter estimate; Pharmacokinetics

Indexed keywords

DRUG;

ANALYTICAL ERROR; ARTICLE; COMPARTMENT MODEL; CONTROLLED STUDY; DATA ANALYSIS; DRUG CONCENTRATION; INTERMETHOD COMPARISON; LIMIT OF QUANTITATION; PHARMACOKINETIC MODEL; PHARMACOKINETICS; PRIORITY JOURNAL; SIMULATION; STATISTICAL MODEL;

COMPUTER SIMULATION; DATA INTERPRETATION, STATISTICAL; LIMIT OF DETECTION; MODELS, BIOLOGICAL; PHARMACOKINETICS;

EID: 80052606147     PISSN: 1567567X     EISSN: 15738744     Source Type: Journal    
DOI: 10.1007/s10928-011-9201-9     Document Type: Article

References (6)

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