MiR-106a overexpression and pRB downregulation in sporadic colorectal cancer

Experimental and Molecular Pathology

Volumn 94, Issue 1, 2013, Pages 148-154

  Catela Ivkovic, T ^a   Aralica, G ^b,c   Cacev, T ^a   Loncar, B ^b   Kapitanovic, S ^a  

^a RUDER BO KOVI INSTITUTE   (Croatia)

^b University of Zagreb School of Medicine   (Croatia)

^c UNIVERSITY OF ZAGREB   (Croatia)

Author keywords

MiR 106a expression; PRb; Rb1

Indexed keywords

MICRORNA; MICRORNA 106A; RETINOBLASTOMA PROTEIN; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; ADULT; ARTICLE; CANCER GROWTH; CANCER STAGING; CANCER SURVIVAL; COLON CARCINOGENESIS; COLORECTAL CANCER; CONTROLLED STUDY; DNA METHYLATION; DOWN REGULATION; FEMALE; GENE LOCUS; GENE OVEREXPRESSION; GENE SILENCING; HETEROZYGOSITY; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; MALIGNANT TRANSFORMATION; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; TUMOR GENE; TUMOR SUPPRESSOR GENE; TUMOR VOLUME;

3' UNTRANSLATED REGIONS; ADULT; AGED; AGED, 80 AND OVER; CELL CYCLE; COLORECTAL NEOPLASMS; DNA METHYLATION; DOWN-REGULATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; MICRORNAS; MIDDLE AGED; PROMOTER REGIONS, GENETIC; RETINOBLASTOMA PROTEIN; RNA, MESSENGER; TUMOR MARKERS, BIOLOGICAL; YOUNG ADULT;

EID: 84870868566     PISSN: 00144800     EISSN: 10960945     Source Type: Journal    
DOI: 10.1016/j.yexmp.2012.11.002     Document Type: Article

References (57)

1. Ali A.A., Marcus J.N., Harvey J.P., Roll R., Hodgson C.P., Wildrick D.M., Chakraborty A., Boman B.M. RB1 protein in normal and malignant human colorectal tissue and colon cancer cell lines. The FASEB Journal 1993, 7(10):931-937.
2. Arhel N.J., Packham G., Townsend P.A., Collard T.J., H-Zadeh A.M., Sharp A., Cutress R.I., Malik K., Hague A., Paraskeva C., Williams A.C. The retinoblastoma protein interacts with Bag-1 in human colonic adenoma and carcinoma derived cell lines. International Journal of Cancer 2003, 106(3):364-371.
3. Blanquicett C., Johnson M.R., Heslin M., Diasio R.B. Housekeeping gene variability in normal and carcinomatous colorectal and liver tissues: applications in pharmacogenomic gene expression studies. Analytical Biochemistry 2002, 303(2):209-214.
4. Burkhart D.L., Sage J. Cellular mechanisms of tumor suppression by the retinoblastoma gene. Nature Reviews. Cancer 2008, 8(9):71-82.
5. Cance W.G., Brennan M.F., Dudas M.E., Huang C.-M., Cordon-Cardo C. Altered expression of the retinoblastoma gene product in human sarcomas. The New England Journal of Medicine 1990, 323:1457-1462.
6. Cassinotti E., Melson J., Liggett T., Melnikov A., Yi Q., Replogle C., Mobarhan S., Boni L., Segato S., Levenson V. DNA methylation patterns in blood of patients with colorectal cancer and adenomatous colorectal polyps. International Journal of Cancer 2012, 131(5):1153-1157.
7. Cetani F., Pardi E., Viacava P., Pollina G.D., Fanelli G., Picone A., Borsari S., Gazzerro E., Miccoli P., Berti P., Pinchera A., Marcocci C. A reappraisal of the Rb1 gene abnormalities in the diagnosis of parathyroid cancer. Clinical Endocrinology 2004, 60(1):99-106.
8. Clemo N.K., Arhel N.J., Barnes J.D., Baker J., Moorghen M., Packham G.K., Paraskeva C., Williams A.C. The role of the retinoblastoma protein (Rb) in the nuclear localization of BAG-1: implications for colorectal tumor cell survival. Biochemical Society Transactions 2005, 33:676-678.
9. Dannenberg J.H., te Riele H.P. The retinoblastoma gene family in cell cycle regulation and suppression of tumorigenesis. Results and Problems in Cell Differentiation 2006, 42:183-225.
10. Deans G.T., Parks T.G., Rowlands B.J., Spence R.A. Prognostic factors in colorectal cancer. The British Journal of Surgery 1992, 79:608-613.
11. DiCiommo D., Gallie B.L., Bremner R. Retinoblastoma: the disease, gene and protein provide critical leads to understand cancer. Seminars in Cancer Biology 2000, 10(4):255-269.
12. Dong S.M., Lee E.J., Jeon E.S., Park C.K., Kim K.M. Progressive methylation during the serrated neoplasia pathway of the colorectum. Modern Pathology 2005, 18(2):170-178.
13. Eads C.A., Lord R.V., Wickramasinghe K., Long T.I., Kurumboor S.K., Bernstein L., Peters J.H., DeMeester S.R., DeMeester T.R., Skinner K.A., Laird P.W. Epigenetic patterns in the progression of esophageal adenocarcinoma. Cancer Research 2001, 61(8):3410-3418.
14. Fearon E.R., Vogelstein B. A genetic model for colorectal tumorigenesis. Cell 1990, 61(5):759-767.
15. Friend S.H., Bernards R., Rogelj S., Weinberg R.A., Rapaport J.M., Albert D.M., Dryja T.P. A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma. Nature 1986, 323(6089):643-646.
16. Ghosh S., Ghosh A., Maiti G.P., Mukherjee N., Dutta S., Roy A., Roychoudhury S., Panda C.K. LIMD1 is more frequently altered than RB1 in head and neck squamous cell carcinoma: clinical and prognostic implications. Molecular Cancer 2010, 9:58.
17. Gope R., Gope M.L. Abundance and state of phosphorylation of the retinoblastoma susceptibility gene product in human colon cancer. Molecular and Cellular Biochemistry 1992, 110(2):123-133.
18. Gope R., Christensen M.A., Thorson A., Lynch H.T., Smyrk T., Hodgson C., Wildrick D.M., Gope M.L., Boman B.M. Increased expression of the retinoblastoma gene in human colorectal carcinomas relative to normal colonic mucosa. Journal of the National Cancer Institute 1990, 82(4):310-314.
19. Greger V., Debus N., Lohmann D., Höpping W., Passarge E., Horsthemke B. Frequency and parental origin of hypermethylated RB1 alleles in retinoblastoma. Human Genetics 1994, 94(5):491-496.
20. Guy M., Moorghen M., Bond J.A., Collard T.J., Paraskeva C., Williams A.C. Transcriptional down-regulation of the retinoblastoma protein is associated with differentiation and apoptosis in human colorectal epithelial cells. British Journal of Cancer 2001, 84(4):520-528.
21. Hanahan D., Weinberg R.A. The hallmarks of cancer. Cell 2000, 100(1):57-70.
22. Indovina P., Marcelli E., Casini N., Rizzo V., Giordano A. Emerging roles of RB family: new defense mechanisms against tumor progression. Journal of Cellular Physiology 2013, 228(3):525-535.
23. Jemal A., Bray F., Center M.M., Ferlay J., Ward E., Forman D. Global cancer statistics. CA: a Cancer Journal for Clinicians 2011, 61(2):69-90.
24. Jiang Y., Wu Y., Greenlee A.R., Wu J., Han Z., Li X., Zhao Y. miR-106a-mediated malignant transformation of cells induced by anti-benzo(a)pyrene-trans-7,8-diol-9,10-epoxide. Toxicological Sciences 2011, 119(1):50-60.
25. Kishi M., Nakamura M., Nishimine M., Ikuta M., Kirita T., Konishi N. Genetic and epigenetic alteration profiles for multiple genes in salivary gland carcinomas. Oral Oncology 2005, 41(2):161-169.
26. Kristensen L.S., Hansen L.L. PCR-based methods for detecting single-locus DNA methylation biomarkers in cancer diagnostics, prognostics, and response to treatment. Clinical Chemistry 2009, 55(8):1471-1483.
27. Kucherlapati M.H., Yang K., Fan K., Kuraguchi M., Sonkin D., Rosulek A., Lipkin M., Bronson R.T., Aronow B.J., Kucherlapati R. Loss of Rb1 in the gastrointestinal tract of Apc1638N mice promotes tumors of the cecum and proximal colon. Proceedings of the National Academy of Sciences of the United States of America 2008, 105(40):15493-15498.
28. Lai P.S., Cheah P.Y., Kadam P., Chua C.L., Lie D.K., Li H.H., Eu K.W., Seow-Choen F., Lee A.S. Overexpression of RB1 transcript is significantly correlated with 13q14 allelic imbalance in colorectal carcinomas. International Journal of Cancer 2006, 119(5):1061-1066.
29. Lea I.A., Jackson M.A., Li X., Bailey S., Peddada S.D., Dunnick J.K. Genetic pathways and mutation profiles of human cancers: site- and exposure-specific patterns. Carcinogenesis 2007, 28(9):1851-1858.
30. Lee W.H., Bookstein R., Hong F., Young L.J., Shew J.Y., Lee E.Y. Human retinoblastoma susceptibility gene: cloning, identification, and sequence. Science 1987, 235(4794):1394-1399.
31. Link A., Balaguer F., Shen Y., Nagasaka T., Lozano J.J., Boland C.R., Goel A. Fecal MicroRNAs as novel biomarkers for colon cancer screening. Cancer Epidemiology, Biomarkers & Prevention 2010, 19(7):1766-1774.
32. Ma Y., Zhang P., Yang J., Liu Z., Yang Z., Qin H. Candidate MicroRNA biomarkers in human colorectal cancer: systematic review profiling studies and experimental validation. International Journal of Cancer 2012, 130(9):2077-2087.
33. Malekzadeh K., Sobti R.C., Nikbakht M., Shekari M., Hosseini S.A., Tamandani D.K., Singh S.K. Methylation patterns of Rb1 and Casp-8 promoters and their impact on their expression in bladder cancer. Cancer Investigation 2009, 27(1):70-80.
34. Manning A.L., Dyson N.J. pRB, a tumor suppressor with a stabilizing presence. Trends in Cell Biology 2011, 21(8):433-441.
35. Manning A.L., Dyson N.J. RB: mitotic implications of a tumour suppressor. Nature Reviews. Cancer 2012, 12(3):220-226.
36. Mathivanan J., Rohini K., Gope M.L., Anandh B., Gope R. Altered structure and deregulated expression of the tumor suppressor gene retinoblastoma (RB1) in human brain tumors. Molecular and Cellular Biochemistry 2007, 302(1-2):67-77.
37. Meling G.I., Lothe R.A., Børresen A.L., Hauge S., Graue C., Clausen O.P., Rognum T.O. Genetic alterations within the retinoblastoma locus in colorectal carcinomas. Relation to DNA ploidy pattern studied by flow cytometric analysis. British Journal of Cancer 1991, 64(3):475-480.
38. Moghaddam S.J., Haghighi E.N., Samiee S., Shahid N., Keramati A.R., Dadgar S., Zali M.R. Immunohistochemical analysis of p53, cyclinD1, RB1, c-fos and N-ras gene expression in hepatocellular carcinoma in Iran. World Journal of Gastroenterology 2007, 13(4):588-593.
39. Park H.J., Yu E., Shim Y.H. DNA methyltransferase expression and DNA hypermethylation in human hepatocellular carcinoma. Cancer Letters 2006, 233(2):271-278.
40. Plisiecka-Hałasa J., Dansonka-Mieszkowska A., Kraszewska E., Dańska-Bidzińska A., Kupryjańczyk J. Loss of heterozygosity, microsatellite instability and TP53 gene status in ovarian carcinomas. Anticancer Research 2008, 28:989-996.
41. Poller D.N., Baxter K.J., Shepherd N.A. p53 and Rb1 protein expression: are they prognostically useful in colorectal cancer?. British Journal of Cancer 1997, 75(1):87-93.
42. Sakai T., Toguchida J., Ohtani N., Yandell D.W., Rapaport J.M., Dryja T.P. Allele-specific hypermethylation of the retinoblastoma tumor-suppressor gene. American Journal of Human Genetics 1991, 48(5):880-888.
43. Schetter A.J., Leung S.Y., Sohn J.J., Zanetti K.A., Bowman E.D., Yanaihara N., Yuen S.T., Chan T.L., Kwong D.L., Au G.K., Liu C.G., Calin G.A., Croce C.M., Harris C.C. MicroRNA expression profiles associated with prognosis and therapeutic outcome in colon adenocarcinoma. Journal of the American Medical Association 2008, 299(4):425-436.
44. Spaventi R., Pečur L., Pavelić K., Pavelić Z.P., Spaventi Š., Stambrook P.J. Human Tumor Bank in Croatia: a possible model for a small bank as a part of future European tumor bank network. European Journal of Cancer 1994, 30A:419.
45. Tamura K., Zhang X., Murakami Y., Hirohashi S., Xu H.J., Hu S.X., Benedict W.F., Sekiya T. Deletion of three distinct regions on chromosome 13q in human non-small-cell lung cancer. International Journal of Cancer 1997, 74(1):45-49.
46. Tsuji N., Kamagata C., Furuya M., Kobayashi D., Yagihashi A., Morita T., Horita S., Watanabe N. Selection of an internal control gene for quantitation of mRNA in colonic tissues. Anticancer Research 2002, 22(6C):4173-4178.
47. Turnubull R.B., Kyle K., Watson F.R., Spratt J. Cancer of the rectum: the influence of the no-tuch isolation technique on survival rates. Annals of Surgery 1967, 166:420-427.
48. Viatour P., Sage J. Newly identified aspects of tumor suppression by RB. Disease Models & Mechanisms 2011, 4(5):581-585.
49. Volinia S., Calin G.A., Liu C.G., Ambs S., Cimmino A., Petrocca F., Visone R., Iorio M., Roldo C., Ferracin M., Prueitt R.L., Yanaihara N., Lanza G., Scarpa A., Vecchione A., Negrini M., Harris C.C., Croce C.M. A microRNA expression signature of human solid tumors defines cancer gene targets. Proceedings of the National Academy of Sciences of the United States of America 2006, 103(7):2257-2261.
50. Voortman J., Lee J.H., Killian J.K., Suuriniemi M., Wang Y., Lucchi M., Smith W.I., Meltzer P., Wang Y., Giaccone G. Array comparative genomic hybridization-based characterization of genetic alterations in pulmonary neuroendocrine tumors. Proceedings of the National Academy of Sciences of the United States of America 2010, 107(29):13040-13045.
51. Xiao B., Guo J., Miao Y., Jiang Z., Huan R., Zhang Y., Zhong J. Detection of miR-106a in gastric carcinoma and its clinical significance. Clinica Chimica Acta 2009, 400:97-102.
52. Xing E.P., Yang G.Y., Wang L.D., Shi S.T., Yang C.S. Loss of heterozygosity of the Rb gene correlates with pRb protein expression and associates with p53 alteration in human esophageal cancer. Clinical Cancer Research 1999, 5(5):1231-1240.
53. Xu H.-J., Hu S.-X., Cagle P.T., Moore G.E., Benedict W.F. Absence of retinoblastoma protein expression in primary nonsmall cell lung carcinomas. Cancer Research 1991, 51:2735-2739.
54. Yamamoto H., Soh J.W., Monden T., Klein M.G., Zhang L.M., Shirin H., Arber N., Tomita N., Schieren I., Stein C.A., Weinstein I.B. Paradoxical increase in retinoblastoma protein in colorectal carcinomas may protect cells from apoptosis. Clinical Cancer Research 1999, 5(7):1805-1815.
55. Yu J., Ni M., Xu J., Zhang H., Gao B., Gu J., Chen J., Zhang L., Wu M., Zhen S., Zhu J. Methylation profiling of twenty promoter-CpG islands of genes which may contribute to hepatocellular carcinogenesis. BMC Cancer 2002, 2:29.
56. Zhao Y.F., Zhang Y.G., Tian X.X., Du J., Zheng J. Aberrant methylation of multiple genes in gastric carcinomas. International Journal of Surgical Pathology 2007, 15(3):242-251.
57. Zou J., Luo H., Zeng Q., Dong Z., Wu D., Liu L. Protein kinase CK2α is overexpressed in colorectal cancer and modulates cell proliferation and invasion via regulating EMT-related genes. Journal of Translational Medicine 2011, 9:97.