Effect of acetazolamide and autocpap therapy on breathing disturbances among patients with obstructive sleep apnea syndrome who travel to altitude: A randomized controlled trial

JAMA

Volumn 308, Issue 22, 2012, Pages 2390-2398

  Latshang, Tsogyal D ^a,b   Nussbaumer Ochsner, Yvonne ^a,b   Henn, Rahel M ^a,b   Ulrich, Silvia ^a,b   Lo Cascio, Christian M ^a,b   Ledergerber, Bruno ^a   Kohler, Malcolm ^a,b   Bloch, Konrad E ^a,b  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^b UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ACETAZOLAMIDE; PLACEBO;

ADULT; ADVERSE OUTCOME; AGED; ALTITUDE; APNEA HYPOPNEA INDEX; ARTICLE; COMPARATIVE EFFECTIVENESS; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG EFFICACY; DRUG SAFETY; EVENING DOSAGE; EXERCISE; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MORNING DOSAGE; OUTCOME ASSESSMENT; OXYGEN SATURATION; PARESTHESIA; POSITIVE END EXPIRATORY PRESSURE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RESPIRATION CONTROL; SLEEP DISORDERED BREATHING; SWITZERLAND; TASTE DISORDER; TRAVEL; UNIVERSITY HOSPITAL;

EID: 84870865191     PISSN: 00987484     EISSN: 15383598     Source Type: Journal    
DOI: 10.1001/jama.2012.94847     Document Type: Article

References (34)

1. Young T, Palta M, Dempsey J, Skatrud J, Weber S, Badr S. The occurrence of sleep-disordered breathing among middle-aged adults. N Engl J Med. 1993;328(17):1230-1235.
2. Terán-Santos J, Jiménez-Gómez A, Cordero-Guevara J; Cooperative Group Burgos-Santander. The association between sleep apnea and the risk of traffic accidents. N Engl J Med. 1999;340(11):847-851.
3. Marin JM, Carrizo SJ, Vicente E, Agusti AG. Long-term cardiovascular outcomes in men with obstructive sleep apnoea-hypopnoea with or without treatment with continuous positive airway pressure: an observational study. Lancet. 2005;365(9464):1046-1053.
4. Kohler M, Stradling JR. Mechanisms of vascular damage in obstructive sleep apnea. Nat Rev Cardiol. 2010;7(12):677-685.
5. Basner RC. Continuous positive airway pressure for obstructive sleep apnea. N Engl J Med. 2007;356(17):1751-1758.
6. Nussbaumer-Ochsner Y, Schuepfer N, Ulrich S, Bloch KE. Exacerbation of sleep apnoea by frequent central events in patients with the obstructive sleep apnoea syndrome at altitude: a randomised trial. Thorax. 2010;65(5):429-435.
7. Nussbaumer-Ochsner Y, Latshang TD, Ulrich S, Kohler M, Thurnheer R, Bloch KE. Patients with obstructive sleep apnea syndrome benefit from acetazolamide during an altitude sojourn: a randomized, placebo-controlled, double-blind trial. Chest. 2012;141(1):131-138.
8. Basnyat B, Gertsch JH, Johnson EW, Castro-Marin F, Inoue Y, Yeh C. Efficacy of low-dose acetazolamide (125 mg BID) for the prophylaxis of acute mountain sickness: a prospective, double-blind, randomized, placebo-controlled trial. High Alt Med Biol. 2003;4(1):45-52.
9. Fischer R, Lang SM, Leitl M, Thiere M, Steiner U, Huber RM. Theophylline and acetazolamide reduce sleep-disordered breathing at high altitude. Eur Respir J. 2004;23(1):47-52.
10. Latshang TD, Bloch KE. How to treat patients with obstructive sleep apnea syndrome during an altitude sojourn. High Alt Med Biol. 2011;12(4):303-307.
11. Kohler M, Stoewhas AC, Ayers L, et al. Effects of continuous positive airway pressure therapy withdrawal in patients with obstructive sleep apnea: a randomized controlled trial. Am J Respir Crit Care Med. 2011;184(10):1192-1199.
12. Bloch KE, Schoch OD, Zhang JN, Russi EW. German version of the Epworth Sleepiness Scale. Respiration. 1999;66(5):440-447.
13. Bloch KE. Polysomnography: a systematic review. Technol Health Care. 1997;5(4):285-305.
14. Bloch KE, Li Y, Sackner MA, Russi EW. Breathing pattern during sleep disruptive snoring. Eur Respir J. 1997;10(3):576-586.
15. Senn O, Clarenbach CF, Kaplan V, Maggiorini M, Bloch KE. Monitoring carbon dioxide tension and arterial oxygen saturation by a single earlobe sensor in patients with critical illness or sleep apnea. Chest. 2005;128(3):1291-1296.
16. Kaida K, Takahashi M, Akerstedt T, et al. Validation of the Karolinska sleepiness scale against performance and EEG variables. Clin Neurophysiol. 2006;117(7):1574-1581.
17. Sampson JB, Cymerman A, Burse RL, Maher JT, Rock PB. Procedures for the measurement of acute mountain sickness. Aviat Space Environ Med. 1983;54(12 pt 1):1063-1073.
18. Roach RC, Bartsch P, Hackett PH, Oelz O; The Lake Louise Consensus Committee. The Lake Louise acute mountain sickness scoring system. In: Sutton JR, Coates G, Huston CS, eds. Hypoxia and Molecular Medicine: Proceedings of the Eighth International Hypoxia Symposium. Burlington, VT: Queen City Printers; 1993:272-274.
19. Dinges DF, Pack F, Williams K, et al. Cumulative sleepiness, mood disturbance, and psychomotor vigilance performance decrements during a week of sleep restricted to 4-5 hours per night. Sleep. 1997;20(4):267-277.
20. Juniper M, Hack MA, George CF, Davies RJ, Stradling JR. Steering simulation performance in patients with obstructive sleep apnoea and matched control subjects. Eur Respir J. 2000;15(3):590-595.
21. Miller MR, Hankinson J, Brusasco V, et al; ATS/ERS Task Force. Standardisation of spirometry. Eur Respir J. 2005;26(2):319-338.
22. Macintyre N, Crapo RO, Viegi G, et al. Standardisation of the single-breath determination of carbon monoxide uptake in the lung. Eur Respir J. 2005;26(4):720-735.
23. ATS Committee on Proficiency Standards for Clinical Pulmonary Function Laboratories. ATS statement: guidelines for the six-minute walk test. Am J Respir Crit Care Med. 2002;166(1):111-117.
24. Kazis LE, Anderson JJ, Meenan RF. Effect sizes for interpreting changes in health status. Med Care. 1989;27(3)(suppl):S178-S189.
25. Burgess KR, Cooper J, Rice A, Wong K, Kinsman T, Hahn A. Effect of simulated altitude during sleep on moderate-severity OSA. Respirology. 2006;11(1):62-69.
26. Bradley TD, Logan AG, Kimoff RJ, et al; CANPAP Investigators. Continuous positive airway pressure for central sleep apnea and heart failure. N Engl J Med. 2005;353(19):2025-2033.
27. Morgenthaler TI, Kagramanov V, Hanak V, Decker PA. Complex sleep apnea syndrome: is it a unique clinical syndrome? Sleep. 2006;29(9):1203-1209.
28. Senn O, Brack T, Matthews F, Russi EW, Bloch KE. Randomized short-term trial of two autoCPAP devices versus fixed continuous positive airway pressure for the treatment of sleep apnea. Am J Respir Crit Care Med. 2003;168(12):1506-1511.
29. Smith I, Lasserson TJ. Pressure modification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea. Cochrane Database Syst Rev. 2009;(4):CD003531.
30. Ulrich S, Nussbaumer-Ochsner Y, Vasic I, et al. Brain tissue oxygenation during sleep in patients with the obstructive sleep apnea syndrome during an altitude sojourn. Eur Respir J. 2010;36:980s.
31. Senn O, Clarenbach CF, Fischler M, et al. Do changes in lung function predict high-altitude pulmonary edema at an early stage? Med Sci Sports Exerc. 2006;38(9):1565-1570.
32. Cremona G, Asnaghi R, Baderna P, et al. Pulmonary extravascular fluid accumulation in recreational climbers: a prospective study. Lancet. 2002;359(9303):303-309.
33. Yumino D, Redolfi S, Ruttanaumpawan P, et al. Nocturnal rostral fluid shift: a unifying concept for the pathogenesis of obstructive and central sleep apnea in men with heart failure. Circulation. 2010;121(14):1598-1605.
34. Patz DS, Swihart B, White DP. CPAP pressure requirements for obstructive sleep apnea patients at varying altitudes. Sleep. 2010;33(5):715-718.