Theophylline and acetazolamide reduce sleep-disordered breathing at high altitude

European Respiratory Journal

Volumn 23, Issue 1, 2004, Pages 47-52

  Fischer, Rainald ^a   Lang, S M ^b   Leitl, M ^a   Thiere, M ^a   Steiner, U ^a   Huber, R M ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b Klinik Bad Reichenhall   (Germany)

Author keywords

Acetazolamide; High altitude; Sleep disordered breathing; Theophylline

Indexed keywords

ACETAZOLAMIDE; OXYHEMOGLOBIN; PLACEBO; THEOPHYLLINE;

ALTITUDE DISEASE; ARTERIAL GAS; ARTERIAL OXYGEN TENSION; ARTICLE; CHEYNE STOKES BREATHING; CLINICAL ARTICLE; CLINICAL FEATURE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG EFFICACY; HEART PALPITATION; HEMOGLOBIN DETERMINATION; HUMAN; MALE; MEDICAL ASSESSMENT; MEDICAL RESEARCH; NOCTURIA; PARESTHESIA; PATHOPHYSIOLOGY; POLYSOMNOGRAPHY; PRIORITY JOURNAL; PULSE RATE; RANDOMIZED CONTROLLED TRIAL; SLEEP APNEA SYNDROME; SLOW DRUG RELEASE; TABLET; TASTE DISORDER; THEOPHYLLINE BLOOD LEVEL;

ACETAZOLAMIDE; ADMINISTRATION, ORAL; ALTITUDE; ALTITUDE SICKNESS; APNEA; AUTACOIDS; BLOOD GAS ANALYSIS; DOUBLE-BLIND METHOD; HUMANS; MALE; OXYHEMOGLOBINS; POLYSOMNOGRAPHY; PULSE; SLEEP APNEA SYNDROMES; THEOPHYLLINE;

EID: 0346505542     PISSN: 09031936     EISSN: None     Source Type: Journal    
DOI: 10.1183/09031936.03.00113102     Document Type: Article

References (24)

1. Anholm JD, Powles AC, Downey R III, et al. Operation Everest II: arterial oxygen saturation and sleep at extreme simulated altitude. Am Rev Respir Dis 1992; 145: 817-826.
2. Salvaggio A, Insalaco G, Marrone O, et al. Effects of high-altitude periodic breathing on sleep and arterial oxyhaemoglobin saturation. Eur Respir J 1998; 12: 408-413.
3. Zielinski J, Koziej M, Mankowski M, et al. The quality of sleep and periodic breathing in healthy subjects at an altitude of 3,200 m. High Alt Med Biol 2000; 1: 331-336.
4. Khoo MC, Anholm JD, Ko SW, et al. Dynamics of periodic breathing and arousal during sleep at extreme altitude. Respir Physiol 1996; 103: 33-43.
5. Weil JV, Kryger MH, Scoggin CH. Sleep and breathing at high altitude. In: Guilleminault C, Dement W, eds. Sleep Apnea Syndromes Proceedings. New York, Liss, 2002; pp. 119-136.
6. Hackett PH, Roach RC, Harrison GL, Schoene RB, Mills WJ Jr. Respiratory stimulants and sleep periodic breathing at high altitude. Almitrine versus acetazolamide. Am Rev Respir Dis 1987; 135: 896-898.
7. Fischer R, Lang SM, Steiner U, et al. Theophylline improves acute mountain sickness. Eur Respir J 2000; 15: 123-127.
8. 2 in preterm infants. Pediatr Pulmonol 1994; 17: 291-295.
9. Javaheri S, Parker TJ, Wexler L, Liming JD, Lindower P, Roselle GA. Effect of theophylline on sleep-disordered breathing in heart failure. N Engl J Med 1996; 335: 562-567.
10. Rechtschaffen A, Kales A. A manual of standardized terminology, techniques and scoring system for sleep stages of human subjects. Washington, US Government Printing Office, 1968.
11. American Sleep Disorders Association. EEG arousals: scoring rules and examples: a preliminary report from the Sleep Disorders Atlas Task Force of the American Sleep Disorders Association. Sleep 1992; 15: 173-184.
12. Series F, Marc I. Nasal pressure recording in the diagnosis of sleep apnoea hypopnoea syndrome. Thorax 1999; 54: 506-510.
13. American Academy of Sleep Medicine Task Force. Sleep-related breathing disorders in adults: recommendations for syndrome definition and measurement techniques in clinical research. The Report of an American Academy of Sleep Medicine Task Force. Sleep 1999; 22: 667-689.
14. White DP, Zwillich CW, Pickett CK, Douglas NJ, Findley LJ, Weil JV. Central sleep apnea. Improvement with acetazolamide therapy. Arch Intern Med 1982; 142: 1816-1819.
15. Khoo MC, Kronauer RE, Strohl KP, Slutsky AS. Factors inducing periodic breathing in humans: a general model. J Appl Physiol 1982; 53: 644-659.
16. Javaheri S, Guerra L. Lung function, hypoxic and hypercapnic ventilatory responses, and respiratory muscle strength in normal subjects taking oral theophylline. Thorax 1990; 45: 743-747.
17. Darnall RA Jr. Aminophylline reduces hypoxic ventilatory depression: possible role of adenosine. Pediatr Res 1985; 19: 706-710.
18. Javaheri S, Teppema LJ, Evers JA. Effects of aminophylline on hypoxemia-induced ventilatory depression in the cat. J Appl Physiol 1988; 64: 1837-1843.
19. Khoo MC, Gottschalk A, Pack AI. Sleep-induced periodic breathing and apnea: a theoretical study. J Appl Physiol 1991; 70: 2014-2024.
20. Xie A, Skatrud JB, Dempsey JA. Effect of hypoxia on the hypopnoeic and apnoeic threshold for CO(2) in sleeping humans. J Physiol 2001; 535: 269-278.
21. Eichenberger U, Weiss E, Riemann D, Oelz O, Bartsch P. Nocturnal periodic breathing and the development of acute high altitude illness. Am J Respir Crit Care Med 1996; 154: 1748-1754.
22. Goldenberg F, Richalet JP, Onnen I, Antezana AM. Sleep apneas and high altitude newcomers. Int J Sports Med 1992; 13: Suppl. 1; S34-S36.
23. Reite M, Jackson D, Cahoon RL, Weil JV. Sleep physiology at high altitude. Electroencephalogr Clin Neurophysiol 1975; 38: 463-471.
24. Marchand E, Decramer M. Respiratory muscle function and drive in chronic obstructive pulmonary disease. Clin Chest Med 2000; 21: 679-692.