Lack of thrombospondin-2 reduces fibrosis and increases vascularity around cardiac cell grafts

Cardiovascular Pathology

Volumn 22, Issue 1, 2013, Pages 91-95

  Reinecke, Hans ^a   Robey, Thomas E ^b   Mignone, John L ^a   Muskheli, Veronica ^a   Bornstein, Paul ^c   Murry, Charles E ^a,b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b University of Washington   (United States)

^c UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

Angiogenesis; Cardiac repair; Cell transplantation; Fibrosis; Scar; Thrombospondin

Indexed keywords

THROMBOSPONDIN 2;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL TRANSPLANTATION; CONTROLLED STUDY; ENDOTHELIUM CELL; GRAFT SURVIVAL; HEART GRAFT; HEART MUSCLE CELL; HEART MUSCLE FIBROSIS; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; VASCULARIZATION; WILD TYPE;

ANIMALS; CELL PROLIFERATION; CELL SURVIVAL; CELLS, CULTURED; COLLAGEN TYPE I; ENDOTHELIAL CELLS; FIBROSIS; MICE; MICE, 129 STRAIN; MICE, KNOCKOUT; MYOCARDIUM; MYOCYTES, CARDIAC; NEOVASCULARIZATION, PHYSIOLOGIC; RNA, MESSENGER; THROMBOSPONDINS; TIME FACTORS;

EID: 84870863315     PISSN: 10548807     EISSN: 18791336     Source Type: Journal    
DOI: 10.1016/j.carpath.2012.03.005     Document Type: Article

References (23)

1. M.G. Klug, Soonpaa MH, Koh GY, and Field LJ Genetically selected cardiomyocytes from differentiating embyronic stem cells form stable intracardiac grafts J Clin Invest 98 1 1996 216 224 (Pubitemid 26243839)
2. Ghostine S, Carrion C, Souza LC, Richard P, Bruneval P, and Vilquin JT Long-term efficacy of myoblast transplantation on regional structure and function after myocardial infarction Circulation 106 12 Suppl 1 2002 I131 I136
3. Stevens KR, Rolle MW, Minami E, Ueno S, Nourse MB, and Virag JI Chemical dimerization of fibroblast growth factor receptor-1 induces myoblast proliferation, increases intracardiac graft size, and reduces ventricular dilation in infarcted hearts Hum Gene Ther 18 5 2007 401 412 (Pubitemid 46850132)
4. Reinecke H, Zhang M, Bartosek T, and Murry CE Survival, integration, and differentiation of cardiomyocyte grafts: a study in normal and injured rat hearts Circulation 100 2 1999 193 202 (Pubitemid 29330019)
5. Laflamme MA, Chen KY, Naumova AV, Muskheli V, Fugate JA, and Dupras SK Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance function of infarcted rat hearts Nat Biotechnol 25 9 2007 1015 1024 (Pubitemid 47517637)
6. Brower GL, Gardner JD, Forman MF, Murray DB, Voloshenyuk T, and Levick SP The relationship between myocardial extracellular matrix remodeling and ventricular function Eur J Cardiothorac Surg 30 4 2006 604 610 (Pubitemid 44332949)
7. Kyriakides TR, Leach KJ, Hoffman AS, Ratner BD, and Bornstein P Mice that lack the angiogenesis inhibitor, thrombospondin 2, mount an altered foreign body reaction characterized by increased vascularity Proc Natl Acad Sci U S A 96 8 1999 4449 4454 (Pubitemid 29190356)
8. Kyriakides TR, Tam JW, and Bornstein P Accelerated wound healing in mice with a disruption of the thrombospondin 2 gene J Invest Dermatol 113 5 1999 782 787
9. Bornstein P, Armstrong LC, Hankenson KD, Kyriakides TR, and Yang Z Thrombospondin 2, a matricellular protein with diverse functions Matrix Biol 19 7 2000 557 568
10. Agah A, Kyriakides TR, Letrondo N, Bjorkblom B, and Bornstein P Thrombospondin 2 levels are increased in aged mice: consequences for cutaneous wound healing and angiogenesis Matrix Biol 22 7 2004 539 547 (Pubitemid 38283777)
11. Kyriakides TR, Zhu YH, Smith LT, Bain SD, Yang Z, and Lin MT Mice that lack thrombospondin 2 display connective tissue abnormalities that are associated with disordered collagen fibrillogenesis, an increased vascular density, and a bleeding diathesis J Cell Biol 140 2 1998 419 430 (Pubitemid 28078405)
12. Bornstein P, Agah A, and Kyriakides TR The role of thrombospondins 1 and 2 in the regulation of cell-matrix interactions, collagen fibril formation, and the response to injury Int J Biochem Cell Biol 36 6 2004 1115 1125 (Pubitemid 38501563)
13. Kyriakides TR, Hartzel T, Huynh G, and Bornstein P Regulation of angiogenesis and matrix remodeling by localized, matrix-mediated antisense gene delivery Mol Ther 3 6 2001 842 849 (Pubitemid 32611293)
14. Schroen B, Heymans S, Sharma U, Blankesteijn WM, Pokharel S, and Cleutjens JP Thrombospondin-2 is essential for myocardial matrix integrity: increased expression identifies failure-prone cardiac hypertrophy Circ Res 95 5 2004 515 522 (Pubitemid 39180932)
15. Cleutjens JP, Blankesteijn WM, Daemen MJ, and Smits JF The infarcted myocardium: simply dead tissue, or a lively target for therapeutic interventions Cardiovasc Res 44 2 1999 232 241 (Pubitemid 29474084)
16. Rysa J, Leskinen H, Ilves M, and Ruskoaho H Distinct upregulation of extracellular matrix genes in transition from hypertrophy to hypertensive heart failure Hypertension 45 5 2005 927 933 (Pubitemid 40628939)
17. Sezaki S, Hirohata S, Iwabu A, Nakamura K, Toeda K, and Miyoshi T Thrombospondin-1 is induced in rat myocardial infarction and its induction is accelerated by ischemia/reperfusion Exp Biol Med (Maywood) 230 9 2005 621 630 (Pubitemid 41506857)
18. Virag JI, and Murry CE Myofibroblast and endothelial cell proliferation during murine myocardial infarct repair Am J Pathol 163 6 2003 2433 2440 (Pubitemid 37466484)
19. Robey TE, and Murry CE Absence of regeneration in the MRL/MpJ mouse heart following infarction or cryoinjury Cardiovasc Pathol 17 1 2008 6 13 (Pubitemid 350298446)
20. Kyriakides TR, Zhu YH, Yang Z, and Bornstein P The distribution of the matricellular protein thrombospondin 2 in tissues of embryonic and adult mice J Histochem Cytochem 46 9 1998 1007 1015 (Pubitemid 28402481)
21. Agah A, Kyriakides TR, and Bornstein P Proteolysis of cell-surface tissue transglutaminase by matrix metalloproteinase-2 contributes to the adhesive defect and matrix abnormalities in thrombospondin-2-null fibroblasts and mice Am J Pathol 167 1 2005 81 88 (Pubitemid 40884772)
22. Armstrong LC, Bjorkblom B, Hankenson KD, Siadak AW, Stiles CE, and Bornstein P Thrombospondin 2 inhibits microvascular endothelial cell proliferation by a caspase-independent mechanism Mol Biol Cell 13 6 2002 1893 1905 (Pubitemid 34651480)
23. Oganesian A, Armstrong LC, Migliorini MM, Strickland DK, and Bornstein P Thrombospondins use the VLDL receptor and a nonapoptotic pathway to inhibit cell division in microvascular endothelial cells Mol Biol Cell 19 2 2008 563 571 (Pubitemid 351272145)