Cardiomyocytes from late embryos and neonates do optimal work and striate best on substrates with tissue-level elasticity: Metrics and mathematics

Biomechanics and Modeling in Mechanobiology

Volumn 11, Issue 8, 2012, Pages 1219-1225

  Majkut, Stephanie F ^a   Discher, Dennis E ^b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Cardiomyocyte; Mechanosensitivity; Myofibrillogenesis; Striation; Substrate stiffness

Indexed keywords

FUNCTIONS; STIFFNESS; TISSUE;

CARDIOMYOCYTES; CELL/B.E; CULTURE SUBSTRATE; MECHANOSENSITIVITY; MYOFIBRILLOGENESIS; PRODUCTION WORK; STRIATION; SUBSTRATE STIFFNESS; TISSUE LEVELS; WORK OUTPUT;

SUBSTRATES;

ANIMAL; ARTICLE; BIOLOGICAL MODEL; CELL CULTURE; COMPUTER SIMULATION; CYTOLOGY; HEART CONTRACTION; HEART MUSCLE CELL; HEART MUSCLE CONDUCTION SYSTEM; HUMAN; PHYSIOLOGY; PRENATAL DEVELOPMENT; YOUNG MODULUS;

ANIMALS; CELLS, CULTURED; COMPUTER SIMULATION; ELASTIC MODULUS; HEART CONDUCTION SYSTEM; HUMANS; MODELS, CARDIOVASCULAR; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC;

EID: 84870850060     PISSN: 16177959     EISSN: 16177940     Source Type: Journal    
DOI: 10.1007/s10237-012-0413-8     Document Type: Review

References (26)

1. Bajaj P, Tang X, Saif TA, Bashir R (2010) Stiffness of the substrate influences the phenotype of embryonic chicken cardiac myocytes. J Biomed Mater Res Part A 95(4):1261-1269
2. Bers DM (2001) Excitation-contraction coupling and cardiac contractile force, 2nd ed. Kluwer, Dordrecht
3. Bhana B, Iyer RK, Chen WLK, Zhao R, Sider KL, Likhitpanichkul M, Simmons CA, Radisic M (2009) Influence of substrate stiffness on the phenotype of heart cells. Biotechnol Bioeng 105(6):2151-2162
4. Cadete VJJ, Sawicka J, Polewicz D, Doroszko A, Wozniak M, Sawicki G (2010) Effects of the Rho kinase inhibitor Y-27632 on the proteome of hearts with ischemia-reperfusion injury. Proteomics 10(24):4377-4385
5. Engler AJ, Carag-Krieger C, Johnson CP, Raab M, Tang H, Spelcher DW, Sanger JW, Sanger JM, Discher DE (2008) Embryonic cardiomyocytes beat best on a matrix with heartlike elasticity: scar-like rigidity inhibits beating. J Cell Sci 121:3794-3802
6. Fila BA, Bayly PV, Taber LA (2010) Mechanical stress as a regulator of cytoskeletal contractility and nuclear shape in embryo epithelia. Ann Biomed Eng 39(1):443-454
7. Friedrich BM, Safran SA (2012) How cells feel their substrate: spontaneous symmetry breaking of active surface stresses. Soft Matter 8:3223-3230
8. Friedrich BM, Buxboim A, Discher DE, Safran SA (2011) Striated acto-myosin fibers can reorganize and register in response to elastic interactions with the matrix. Biophys J 100:2706-2715
9. Gregorio CC, Antin PB (2000) To the heart of myofibril assembly. Trends Cell Biol 10(9):355-362 (Pubitemid 30612461)
10. Jacot JG, McCulloch AD, Omens JH (2008) Substrate stiffness affects the functional maturation of neonatal rat ventricular myocytes. Biophys J 95:3479-3487
11. Jacot JG, Kita-Matsuo H, Wei KA, Chen HSV, Omens JH, Mercola M, McCulloch AD (2010) Cardiac myocyte force development during differentiation and maturation. Ann N Y Acad Sci 1188:121-127
12. Johnson CP, Tang H, Carag C, Speicher DW, Discher DE (2007) Forced unfolding of proteins within cells. Science 317(5838):663-666 (Pubitemid 47229965)
13. Krieg M, Arboleda-Estudillo Y, Puech PH, Kafer J, Graner F, Muller DJ, Heisenberg CP (2008) Tensile forces govern germ-layer organization in zebrafish. Nat Cell Biol 10:429-436
14. Lahmers S, Wu Y, Call DR, Labeit S, Granzier H (2004) Developmental control of titin isoform expression and passive stiffness in fetal and neonatal myocardium. Circ Res 94:505-513 (Pubitemid 38326286)
15. Liu J, Sun N, Bruce MA, Wu JC, Butte MJ (2012) Atomic force mechanobiology of pluripotent stem cell-derived cardiomyocytes. PLoS One 7(5):e37559
16. McCain ML, Parker KK (2011) Mechanotransduction: the role of mechanical stress, myocyte shape, and cytoskeletal architecture on cardiac function. Eur J Physiol 462:89-104
17. McKenna NM, Johnson CS, Wang Y (1986) Formation and alignment of Z lines in living chickmyotubes microinjected with rhodaminelabeled alpha-actinin. J Cell Biol 103(6):2163-2171 (Pubitemid 17216644)
18. Rodriguez AH, Han SJ, Regnier M, Sniadecki NJ (2011) Substrate stiffness increases twitch power of neonatal cardiomyocytes in correlation with changes in myofibril structure and intracellular calcium. Biophys J 101:2455-2464
19. Sachinidis A, Fleischmann BK, Kolossov E, Wartenberg M, Sauer H, Hescheler J (2003) Cardiac specific differentiation of mouse embryonic stem cells. Cardiovasc Res 58:278-291 (Pubitemid 36570387)
20. Sanger JW, Kang S, Siebrands CC, Freeman N, Du A, Wang J, Stout AL, Sanger JM (2005) How to build a myofibril. J Muscle Res Cell Motil 26:343-354
21. Sanger JW, Wang J, Fan Y, White J, Sanger JM (2010) Assembly and dynamics of myofibrils. J Biomed Biotechnol. doi:10.1155/2010/858606
22. Segers VFM, Lee RT (2008) Stem-cell therapy for cardiac disease. Nature 451:937-942 (Pubitemid 351301749)
23. von Dassow M, Davidson LA (2009) Natural variation in embryo mechanics: gastrulation in Xenopus laevis is highly robust to variation in tissue stiffness. Dev Dyn 238(1):2-18
24. Young JL, Engler AJ (2011) Hydrogels with time-dependent material properties enhance cardiomyocyte differentiation in vitro. Biomaterials 32(4):1002-1009
25. Zamir EA, Srinivasan V, Perucchio R, Taber LA (2003) Mechanical asymmetry in the embryonic chick heart during looping. Ann Biomech Eng 31:1327-1336
26. Zwi L, Caspi O, Arbel G, Huber I, Gepstein A, Park IH, Gepstein L (2009) Cardiomyocyte differentiation of human induced pluripotent stem cells. Circulation 120:1513-1523