A neural stimulator frontend with high-voltage compliance and programmable pulse shape for epiretinal implants

IEEE Journal of Solid-State Circuits

Volumn 47, Issue 1, 2012, Pages 244-256

  Noorsal, Emilia ^a   Sooksood, Kriangkrai ^a   Xu, Hongcheng ^a   Hornig, Ralf ^b   Becker, Joachim ^a   Ortmanns, Maurits ^a  

^a UNIVERSITY OF ULM   (Germany)

^b IMI Intell Med Implants GmbH   (Germany)

Author keywords

Active charge balancing; charge balancing; compliance monitor; current driver; epiretinal implant; flexible stimulator; functional electrical stimulation (FES); high voltage (HV); HVCMOS; implantable biomedical devices; level shifter; neural stimulator; offset regulation charge balancing; programmable stimulation patterns; visual prosthesis

Indexed keywords

ACTIVE CHARGE BALANCING; CHARGE BALANCING; COMPLIANCE MONITOR; CURRENT DRIVERS; FLEXIBLE STIMULATOR; FUNCTIONAL ELECTRICAL STIMULATION; HIGH VOLTAGE; HVCMOS; IMPLANTABLE BIOMEDICAL DEVICES; LEVEL SHIFTER; NEURAL STIMULATOR; PROGRAMMABLE STIMULATION; VISUAL PROSTHESIS;

FUNCTIONAL ELECTRIC STIMULATION; MICROPROCESSOR CHIPS;

NEURAL PROSTHESES;

EID: 84870813021     PISSN: 00189200     EISSN: None     Source Type: Journal    
DOI: 10.1109/JSSC.2011.2164667     Document Type: Article

References (38)

1. W. M. Grill and J. T. Mortimer, "Stimulus waveforms for selective neural stimulation," IEEE Eng. Med. Biol. Mag., vol. 14, no. 4, pp. 375-385, 1995.
2. D. R. Merrill, M. Bikson, and J. G. Jefferys, "Electrical stimulation of excitable tissue: Design of efficacious and safe protocols," J. Neurosci. Methods, vol. 141, no. 2, pp. 171-198, Feb. 2005.
3. L. Wong, S. Hossain, A. Ta, J. Edvinsson, D. Rivas, and H. Nääs, "A very low-power CMOS mixed-signal IC for implantable pacemaker applications," IEEE J. Solid-State Circuits, vol. 39, no. 12, pp. 2446-2456, Dec. 2004.
4. F.-G. Zeng, S. Rebscher, W. Harrison, X. Sun, and H. Feng, "Cochlear implants: System design, integration, and evaluation," IEEE Rev. Biomed. Eng., vol. 1, pp. 115-142, 2008.
5. K. Arabi and M. A. Sawan, "Electronic design of a multichannel programmable implant for neuromuscular electrical stimulation," IEEE Trans. Rehabil. Eng., vol. 7, no. 2, pp. 204-214, Jun. 1999.
6. S. Boyer, M. Sawan, M. Abdel-Gawad, S. Robin, and M. M. Elhilali, "Implantable selective stimulator to improve bladder voiding: Design and chronic experiments in dogs," IEEE Trans. Rehabil. Eng., vol. 8, no. 4, pp. 464-470, Dec. 2000.
7. P. Nadeau and M. Sawan, "A flexible high voltage biphasic current-controlled stimulator," in Proc. 2006 IEEE Biomed. Circuits Syst. Conf., Nov. 29-Dec. 1 2006, pp. 206-209.
8. A. Kuncel, S. Cooper, B. Wolgamuth, and W. Grill, "Amplitude-and frequency-dependent changes in neuronal regularity parallel changes in tremor with thalamic deep brain stimulation," IEEE Trans. Neural Syst. Rehabil. Eng., vol. 15, no. 2, pp. 190-197, Jun. 2007.
9. J. Coulombe,M. Sawan, and J. F. Gervais, "A highly flexible system for microstimulation of the visual cortex: Design and implementation," IEEE Trans. Biomed. Circuits Syst., vol. 1, no. 4, pp. 258-269, Dec. 2007.
10. B. K. Thurgood, D. J. Warren, N. M. Ledbetter, G. A. Clark, and R. R. Harrison, "A wireless integrated circuit for 100-channel charge-balanced neural stimulation," IEEE Trans. Biomed. Circuits Syst., vol. 3, no. 6, pp. 405-414, Dec. 2009.
11. W. Liu and M. Humayun, "Retinal prosthesis," in 2004 IEEE ISSCC Dig. Tech. Papers, 2004, pp. 218-219.
12. M. Sivaprakasam, W. Liu, G. Wang, J. D. Weiland, and M. S. Humayun, "Architecture tradeoffs in high-density microstimulators for retinal prosthesis," IEEE Trans. Circuits Syst. I, Reg. Papers, vol. 52, no. 12, pp. 2629-2641, Dec. 2005.
13. Y. Wong, N. Dommel, P. Preston, L. Hallum, T. Lehmann, N. Lovell, and G. Suaning, "Retinal neurostimulator for a multifocal vision prosthesis," IEEE Trans. Neural Syst. Rehabil. Eng., vol. 15, no. 3, pp. 425-434, Sep. 2007.
14. M. Ortmanns, A. Rocke,M. Gehrke, and H. J. A. T. H. J. Tiedtke, "A 232-channel epiretinal stimulator ASIC," IEEE J. Solid-State Circuits, vol. 42, no. 12, pp. 2946-2959, Dec. 2007.
15. K. Chen, Z. Yang, L. Hoang, J. Weiland, M. Humayun, and W. Liu, "An integrated 256-channel epiretinal prosthesis," IEEE J. Solid-State Circuits, vol. 45, no. 9, pp. 1946-1956, Sep. 2010.
16. H.-G. Graf, C. Harendt, T. Engelhardt, C. Scherjon, K. Warkentin, H. Richter, and J. Burghartz, "High dynamic range CMOS imager technologies for biomedical applications," IEEE J. Solid-State Circuits, vol. 44, no. 1, pp. 281-289, Jan. 2009.
17. A. Rothermel, L. Liu, N. Pour-Aryan, M. Fischer, J.Wuenschmann, S. Kibbel, and A. Harscher, "A CMOS chip with active pixel array and specific test features for subretinal implantation," IEEE J. Solid-State Circuits, vol. 44, no. 1, pp. 290-300, Jan. 2009.
18. D. Shire, S. Kelly, J. Chen, P. Doyle, M. Gingerich, S. Cogan, W. Drohan, O. Mendoza, L. Theogarajan, J. Wyatt, and J. Rizzo, "Development and implantation of a minimally invasive wireless subretinal neurostimulator," IEEE Trans. Biomed. Eng., vol. 56, no. 10, pp. 2502-2511, Oct. 2009.
19. E. Zrenner, "Will retinal implants restore vision?," Science, vol. 295, no. 5557, pp. 1022-1025, Feb. 2002.
20. J. D. Weiland and M. S. Humayun, "Visual prosthesis," Proc. IEEE, vol. 96, no. 7, pp. 1076-1084, Jul. 2008.
21. J. Mouine, K. A. Ammar, and Z. Chtourou, "A completely programmable and very flexible implantable pain controller," in Proc. 22nd Annu. Int. Conf. IEEE EMBS, 2000, vol. 2, pp. 1104-1107.
22. T. M. Bruns, N. Bhadra, and K. J. Gustafson, "Variable patterned pudendal nerve stimuli improves reflex bladder activation," IEEE Trans. Neural Syst. Rehabil. Eng., vol. 16, no. 2, pp. 140-148, Apr. 2008.
23. P. Walter and K. Heimann, "Evoked cortical potentials after electrical stimulation of the inner retina in rabbits," Graefe's Arch. Clin. Exp. Ophthalmol., vol. 238, pp. 315-318, 2000.
24. O. Macherey, A. van Wieringen, R. Carlyon, J. Deeks, and J. Wouters, "Asymmetric pulses in cochlear implants: Effects of pulse shape, polarity, and rate," J. Assoc. Res. Otolaryngol., vol. 7, no. 3, pp. 253-266, 2006.
25. M. Sahin and Y. Tie, "Non-rectangular waveforms for neural stimulation with practical electrodes," J. Neural Eng., vol. 4, no. 3, pp. 227-233, Sep. 2007.
26. M. E. Halpern and J. Fallon, "Current waveforms for neural stimulation-charge delivery with reduced maximum electrode voltage," IEEE Trans. Biomed. Eng., vol. 57, no. 9, pp. 2304-2312, Sep. 2010.
27. M. S. Humayun, J. D. Weiland, G. Y. Fujii, R. Greenberg, R. Williamson, J. Little, B. Mech, V. Cimmarusti, G. V. Boemel, G. Dagnelie, and E. de Juan, Jr., "Visual perception in a blind subject with a chronic microelectronic retinal prothesis," Vision Res., vol. 43, no. 24, pp. 2573-2581, 2003.
28. M. Mahadevappa, J. D. Weiland, D. Yanai, I. Fine, R. J. Greenberg, and M. S. Humayun, "Perceptual thresholds and electrode impedance in three retial prosthesis subjects," IEEE Trans. Neural Syst. Rehabil. Eng., vol. 13, no. 2, pp. 201-206, Jun. 2005.
29. M. Ghovanloo and K. Najafi, "A compact large voltage-compliance high output-impedance programmable current source for implantable microstimulators," IEEE Trans. Biomed. Eng., vol. 52, no. 1, pp. 97-105, Jan. 2005.
30. M. Sivaprakasam, W. Liu, J. D. Weiland, and H. M. S., "Power efficient multiple voltage stimulation for implantable retinal prothesis," in Proc. 3rd Int. IEEE EMBS Special Topic Conf. Microtechnologies in Medicine and Biology, May 12-15, 2005, pp. 104-107.
31. M. Ghovanloo and K. Najafi, "A modular 32-site wireless neural stimulation microsystem," IEEE J. Solid-State Circuits, vol. 39, no. 12, pp. 2457-2466, Dec. 2004.
32. K. Sooksood, T. Stieglitz, and M. Ortmanns, "An active approach for charge balancing in functional electrical stimulation," IEEE Trans. Biomed. Circuits Syst., vol. 4, no. 3, pp. 162-170, Jun. 2010.
33. M. Sivaprakasam, W. Liu, M. Humayun, and J. Weiland, "A variable range bi-phasic current stimulus driver circuitry for an implantable retinal prosthetic device," IEEE J. Solid-State Circuits, vol. 40, no. 3, pp. 763-771, Mar. 2005.
34. S. Lange, H. Xu, C. Lang, H. Pless, J. Becker, H.-J. Tiedtke, E. Hennig, and M. Ortmanns, "An ac-powered optical receiver consuming 270 Wfor transcutaneous 2Mb/s data transfer," in 2011 IEEE ISSCC Dig. Tech. Papers, 2011, pp. 304-305.
35. E. Noorsal and M. Ortmanns, "An architecture for a universal neural stimulator with almost arbitrary current waveform," in Proc. 32nd Annu. Int. Conf. IEEE EMBS, Aug. 31-Sept. 4 2010, pp. 2931-2934.
36. K. Sooksood, E. Noorsal, J. Becker, and M. Ortmanns, "A neural stimulator front-end with arbitrary pulse shape, HV compliance and adaptive supply requiring 0.05 mm in 0.35 m HVCMOS," in 2011 IEEE ISSCC Dig. Tech. Papers, 2011, pp. 306-307.
37. B. Choi, "Enhancement of current driving capability in data driver ICs for plasma display panels," IEEE Trans. Consum. Electron., vol. 55, no. 3, pp. 992-997, Aug. 2009.
38. M. Azin, D. Guggenmos, S. Barbay, R. Nudo, and P. Mohseni, "A battery-powered activity-dependent intracortical microstimulation ic for brain-machine-brain interface," IEEE J. Solid-State Circuits, vol. 46, no. 4, pp. 731-745, Apr. 2011.