Tertiary dentinogenesis with calcium hydroxide: A review of proposed mechanisms

International Endodontic Journal

Volumn 46, Issue 1, 2013, Pages 3-19

  Sangwan, P ^a   Sangwan, A ^a   Duhan, J ^a   Rohilla, A ^a  

^a PT B D SHARMA UNIVERSITY OF HEALTH SCIENCES   (India)

Author keywords

Calcium hydroxide; Dentinogenesis; Mechanism; Odontoblast

Indexed keywords

BIOMEDICAL AND DENTAL MATERIALS; CALCIUM HYDROXIDE; SCLEROPROTEIN;

ARTICLE; CYTOLOGY; DRUG EFFECT; GROWTH, DEVELOPMENT AND AGING; HUMAN; ODONTOBLAST; PHYSIOLOGY; TOOTH PULP; TOOTH PULP DISEASE;

CALCIUM HYDROXIDE; DENTAL PULP; DENTIN, SECONDARY; EXTRACELLULAR MATRIX PROTEINS; HUMANS; ODONTOBLASTS; PULP CAPPING AND PULPECTOMY AGENTS;

EID: 84870779682     PISSN: 01432885     EISSN: 13652591     Source Type: Journal    
DOI: 10.1111/j.1365-2591.2012.02101.x     Document Type: Article

References (133)

1. Accorinte ML, Loguercio AD, Reis A et al. (2008) Response of human dental pulp capped with MTA and calcium hydroxide powder. Operative Dentistry 33, 488-95.
2. Adams GB, Chabner KT, Alley IR et al. (2006) Stem cell engraftment at the endosteal niche is specified by the calcium-sensing receptor. Nature 439, 599-603.
3. Aeinehchi M, Eslami B, Ghanbariha M, Saffar AS (2003) Mineral trioxide aggregate (MTA) and calcium hydroxide as pulp-capping agents in human teeth: a preliminary report. International Endodontic Journal 36, 225-31.
4. Alliot-Licht B, Hurtrel D, Gregoire M (2001) Characterization of smooth muscle actin positive cells in mineralized human dental pulp cultures. Archives of Oral Biology 46, 221-8.
5. Athanassiadis B, Abbott PV, Walsh LJ (2007) The use of calcium hydroxide, antibiotics and biocides as antimicrobial medicaments in endodontics. Australian Dental Journal 52, S64-82.
6. Baik JE, Jang KS, Kang SS et al. (2011) Calcium hydroxide inactivates lipoteichoic acid from Enterococcus faecalis through deacylation of the lipid moiety. Journal of Endodontics 37, 191-6.
7. Barcellos-Hoff MH (1996) Latency and activation in the control of TGF-beta. Journal of Mammary Gland Biology and Neoplasia 1, 353-63.
8. Barthel CR, Levin LG, Reisner HM, Trope M (1997) TNF-alpha release in monocytes after exposure to calcium hydroxide treated Escherichia coli LPS. International Endodontic Journal 30, 155-9.
9. Bystrom A, Claesson R, Sundqvist G (1985) The antibacterial effect of camphorated paramonochlorophenol, camphorated phenol and calcium hydroxide in the treatment of infected root canals. Endodontics & Dental Traumatology 1, 170-5.
10. Carlile MJ, Sturrock MG, Chisholm DM, Ogden GR, Schor AM (2000) The presence of pericytes and transitional cells in the vasculature of the human dental pulp: an ultrastructural study. The Histochemical journal 32, 239-45.
11. Chun SY, Lee HJ, Choi YA et al. (2011) Analysis of the soluble human tooth proteome and its ability to induce dentin/tooth regeneration. Tissue Engineering part A 17, 181-91.
12. Cochran DL (2008) Inflammation and bone loss in periodontal disease. Journal of Periodontology 79, 1569-76.
13. Cox CF, Bergenholtz G, Heys DR, Syed SA, Fitzgerald M, Heys RJ (1985) Pulp capping of dental pulp mechanically exposed to oral microflora: a 1-2 year observation of wound healing in the monkey. Journal of Oral Pathology 14, 156-68.
14. Cox CF, Hafez AA, Akimoto N, Otsuki M, Mills JC (1999) Biological basis for clinical success: pulp protection and the tooth restoration interface. Practical Periodontics and Aesthetic Dentistry 11, 819-26.
15. Cvek M, Granath L, Cleaton-Jones P, Austin J (1987) Hard tissue barrier formation in pulpotomized monkey teeth capped with cyanoacrylate or calcium hydroxide for 10 and 60 minutes. Journal of Dental Research 66, 1166-74.
16. Da Silva RA, Leonardo MR, da Silva LA, de Castro LM, Rosa AL, de Oliveira PT (2008) Effects of the association between a calcium hydroxide paste and 0.4% chlorhexidine on the development of the osteogenic phenotype in vitro. Journal of Endodontics 34, 1485-9.
17. Dammaschke T, Leidinger J, Schäfer E (2010a) Long-term evaluation of direct pulp capping-treatment outcomes over an average period of 6.1 years. Clinical Oral Investigations 14, 559-67.
18. Dammaschke T, Stratmann U, Wolff P, Sagheri D, Schäfer E (2010b) Direct pulp capping with mineral trioxide aggregate: an immunohistologic comparison with calcium hydroxide in rodents. Journal of Endodontics 36, 814-9.
19. Dammaschke T, Wolff P, Sagheri D, Stratmann U, Schäfer E (2010c) Mineral trioxide aggregate for direct pulp capping: a histologic comparison with calcium hydroxide in rat molars. Quintessence International 41, e20-30.
20. Dobie K, Smith G, Sloan AJ, Smith AJ (2002) Effects of alginate hydrogels and TGF-beta 1 on human dental pulp repair in vitro. Connective Tissue Research 43, 387-90.
21. Durand SH, Flacher V, Roméas A et al. (2006) Lipoteichoic acid increases TLR and functional chemokine expression while reducing dentin formation in in vitro differentiated human odontoblasts. The Journal of Immunology 176, 2880-7.
22. Eda S (1961) Histochemical analysis on the mechanism of dentin formation in dog′s pulp. The Bulletin of Tokyo Dental College 2, 59-88.
23. Estrela C, Pécora JD, Souza-Neto MD, Estrela CR, Bammann LL (1999) Effect of vehicle on antimicrobial properties of calcium hydroxide pastes. Brazilian Dental Journal 10, 63-72.
24. Faraco IM Jr, Holland R (2001) Response of the pulp of dogs to capping with mineral trioxide aggregate or a calcium hydroxide cement. Dental Traumatology 17, 163-6.
25. Farges JC, Joffre A, Magloire H (1993) Response of odontoblastic and pulpal cells to carious lesions. Comptes Rendus Des Séances De La Société De Biologie Et De Ses Filiales 187, 582-95.
26. Feng J, Mantesso A, De Bari C, Nishiyama A, Sharpe PT (2011) Dual origin of mesenchymal stem cells contributing to organ growth and repair. Proceedings of the National Academy of Sciences of the United States of America 108, 6503-8.
27. Fernandes AM, Silva GA, Lopes N Jr, Napimoga MH, Benatti BB, Alves JB (2008) Direct capping of human pulps with a dentin bonding system and calcium hydroxide: an immunohistochemical analysis. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics 105, 385-90.
28. Fitzgerald M (1979) Cellular mechanics of dentinal bridge repair using 3H-thymidine. Journal of Dental Research 58, 2198-206.
29. Fitzgerald M, Chiego DJ Jr, Heys DR (1990) Autoradiographic analysis of odontoblast replacement following pulp exposure in primate teeth. Archives of Oral Biology 35, 707-15.
30. Fridland M, Rosado R (2003) Mineral Trioxide Aggregate (MTA) solubility and porosity with different water-to-powder ratios. Journal of Endodontics 29, 814-7.
31. Gabay C, Lamacchia C, Palmer G (2010) IL-1 pathways in inflammation and human diseases. Nature Reviews Rheumatology 6, 232-41.
32. Glass RL, Zander HA (1949) Pulp healing. Journal of Dental Research 28, 97-107.
33. Goldberg M, Smith AJ (2004) Cells and extracellular matrices of dentin and pulp: a biological basis for repair and tissue engineering. Critical Reviews in Oral Biology and Medicine 15, 13-27.
34. Goldberg M, Six N, Decup F et al. (2001) Application of bioactive molecules in pulp-capping situations. Advances in Dental Research 15, 91-5.
35. Goldberg M, Farges JC, Lacerda-Pinheiro S et al. (2008) Inflammatory and immunological aspects of dental pulp repair. Pharmacological Research 58, 137-47.
36. Graham L, Cooper PR, Cassidy N, Nor JE, Sloan AJ, Smith AJ (2006) The effect of calcium hydroxide on solubilisation of bio-active dentine matrix components. Biomaterials 27, 2865-73.
37. Hasselgren G, Tronstad L (1977) Enzyme activity in the pulp following preparation of cavities and insertion of medicaments in cavities in monkey teeth. Acta Odontologica Scandinavica 35, 289-95.
38. Heithersay GS (1975) Calcium hydroxide in the treatment of pulpless teeth with associated pathology. Journal of the British Endodontic Society 8, 74-93.
39. Hermann B (1928) Ein weiterer Beitrag zur Frage der Pulpenbehandlung. Zahnärztliche Rundschau 37, 1327-76.
40. Heymann R, About I, Lendahl U, Franquin JC, Obrink B, Mitsiadis TA (2002) E- and N-cadherin distribution in developing and functional human teeth under normal and pathological conditions. The American Journal of Pathology 160, 2123-33.
41. Heys DR, Cox CF, Heys RJ, Avery JK (1981) Histological considerations of direct pulp capping agents. Journal of Dental Research 60, 1371-9.
42. Heys DR, Fitzgerald M, Heys RJ, Chiego DJ Jr. (1990) Healing of primate dental pulps capped with Teflon. Oral Surgery, Oral Medicine, and Oral Pathology 69, 227-37.
43. Hirschfeld Z, Bab I, Tamari I, Sela J (1982) Primary mineralization of dentin in rats after pulp capping with calcium-hydroxide. Journal of Oral Pathology 11, 426-33.
44. Höhl E (1896) Beitrag zur Histologie der Pulpa und des Dentins. Archiv für Anatomie und Physiologie 32, 31-54.
45. Holland R, Pinheiro CE, de Mello W, Nery MJ, de Souza V (1982) Histochemical analysis of dogs′ dental pulp after capping with calcium, barium, and strontium hydroxides. Journal of Endodontics 8, 444-7.
46. Hørsted-Bindslev P, Løvschall H (2002) Treatment outcome of vital pulp treatment. Endodontic Topics 2, 24-34.
47. Huojia M, Muraoka N, Yoshizaki K et al. (2005) TGF-beta3 induces ectopic mineralization in fetal mouse dental pulp during tooth germ development. Development, Growth & Differentiation 47, 141-52.
48. Ishikawa Y, Ida-Yonemochi H, Suzuki H et al. (2010) Mapping of BrdU label-retaining dental pulp cells in growing teeth and their regenerative capacity after injuries. Histochemistry and Cell Biology 134, 227-41.
49. Jaunberzins A, Gutmann JL, Witherspoon DE, Harper RP (2000) TGF-beta 1 alone and in combination with calcium hydroxide is synergistic to TGF-beta 1 production by osteoblasts in vitro. International Endodontic Journal 33, 421-6.
50. Ji YM, Jeon SH, Park JY, Chung JH, Choung YH, Choung PH (2010) Dental stem cell therapy with calcium hydroxide in dental pulp capping. Tissue Engineering Part A 16, 1823-33.
51. Kaida H, Hamachi T, Anan H, Maeda K (2008) Wound healing process of injured pulp tissues with emdogain gel. Journal of Endodontics 34, 26-30.
52. Kakehashi S, Stanley HR, Fitzgerald RJ (1965) The effects of surgical exposures of dental pulps in germ-free and conventional laboratory rats. Oral Surgery, Oral Medicine, and Oral Pathology 20, 340-9.
53. Kakehashi S, Stanley HR, Fitzgerald R (1969) The exposed germ-free pulp: effects of topical corticosteroid medication and restoration. Oral Surgery, Oral Medicine, and Oral Pathology 27, 60-7.
54. Kettunen P, Laurikkala J, Itäranta P, Vainio S, Itoh N, Thesleff I (2000) Associations of FGF-3 and FGF-10 with signaling networks regulating tooth morphogenesis. Developmental Dynamics 219, 322-32.
55. Khan AA, Sun X, Hargreaves KM (2008) Effect of calcium hydroxide on proinflammatory cytokines and neuropeptides. Journal of Endodontics 34, 1360-3.
56. Kim YS, Min KS, Jeong DH, Jang JH, Kim HW, Kim EC (2010) Effects of fibroblast growth factor-2 on the expression and regulation of chemokines in human dental pulp cells. Journal of Endodontics 36, 1824-30.
57. Kitasako Y, Shibata S, Arakawa M, Cox CF, Tagami J (2000) A light and transmission microscopic study of mechanically exposed monkey pulps: dynamics of fiber elements during early dentin bridge formation. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics 89, 224-30.
58. Klont B, ten Cate JM (1990) Release of organic matrix components from bovine incisor roots during in vitro lesion formation. Journal of Dental Research 69, 896-900.
59. Kulesz-Martin MF, Fabian D, Bertram JS (1984) Differential calcium requirements for growth of mouse skin epithelial and fibroblast cells. Cell and Tissue Kinetics 17, 523-33.
60. Lansdown AB (2002) Calcium: a potential central regulator in wound healing in the skin. Wound Repair and Regeneration 10, 271-85.
61. Laurent P, Camps J, About I (2012) Biodentine(TM) induces TGF-β1 release from human pulp cells and early dental pulp mineralization. International Endodontic Journal 45, 439-48.
62. Leites AB, Baldissera EZ, Silva AF et al. (2011) Histologic response and tenascin and fibronectin expression after pulp capping in pig primary teeth with mineral trioxide aggregate or calcium hydroxide. Operative Dentistry 36, 448-56.
63. Lesot H, Osman M, Ruch JV (1981) Immunofluorescent localization of collagens, fibronectin, and laminin during terminal differentiation of odontoblasts. Developmental Biology 82, 371-81.
64. Lesot H, Karcher-Djuricic V, Kubler MD, Ruch JV (1988) Membrane-cytoskeleton interactions; inhibition of odontoblast differentiation by a monoclonal antibody against a membrane protein. Differentiation 37, 62-72.
65. Lesot H, Beguekirn C, Kubler MD et al. (1993) Experimental induction of odontoblast differentiation and stimulation during reparative processes. Cells & Materials 3, 201-17.
66. Lin ZM, Qin W, Zhang NH, Xiao L, Ling JQ (2007) Adenovirus-mediated recombinant human bone morphogenetic protein-7 expression promotes differentiation of human dental pulp cells. Journal of Endodontics 33, 930-5.
67. Løvschall H, Tummers M, Thesleff I, Füchtbauer EM, Poulsen K (2005) Activation of the Notch signaling pathway in response to pulp capping of rat molars. European Journal of Oral Sciences 113, 312-7.
68. Lu Y, Liu T, Li H, Pi G (2008) Histological evaluation of direct pulp capping with a self-etching adhesive and calcium hydroxide on human pulp tissue. International Endodontic Journal 41, 643-50.
69. Lyons RM, Keski-Oja J, Moses HL (1988) Proteolytic activation of latent transforming growth factor-beta from fibroblast-conditioned medium. The Journal of Cell Biology 106, 1659-65.
70. Mathias RS, Mathews CH, Machule C, Gao D, Li W, Denbesten PK (2001) Identification of the calcium-sensing receptor in the developing tooth organ. Journal of Bone and Mineral Research 16, 2238-44.
71. Melin M, Joffre-Romeas A, Farges JC, Couble ML, Magloire H, Bleicher F (2000) Effects of TGF beta1 on dental pulp cells in cultured human tooth slices. Journal of Dental Research 79, 1689-96.
72. Mente J, Geletneky B, Ohle M et al. (2010) Mineral trioxide aggregate or calcium hydroxide direct pulp capping: an analysis of the clinical treatment outcome. Journal of Endodontics 36, 806-13.
73. Mitsiadis TA, Rahiotis C (2004) Parallels between tooth development and repair: conserved molecular mechanisms following carious and dental injury. Journal of Dental Research 83, 896-902.
74. Mizuno M, Banzai Y (2008) Calcium ion release from calcium hydroxide stimulated fibronectin gene expression in dental pulp cells and the differentiation of dental pulp cells to mineralized tissue forming cells by fibronectin. International Endodontic Journal 41, 933-8.
75. Mjor IA (1985) Dentin-predentin complex and its permeability: physiologic overview. Journal of Dental Research 64, 621-7, special issue.
76. Mjor IA, Dahl E, Cox CF (1991) Healing of pulp exposures: an ultrastructural study. Journal of Oral Pathology and Medicine 20, 496-501.
77. Mooradian DL, Lucas RC, Weatherbee J, Furcht LT (1989) Transforming growth factor-βl binds to immobilized fibronectin. Journal of Cellular Biochemistry 41, 189-200.
78. Murray PE, García-Godoy F (2006) The incidence of pulp healing defects with direct capping materials. American Journal of Dentistry 19, 171-7.
79. Nakagawa K, Yoshida T, Asai Y (1989) Ultrastructure of initial calcification on exposed human pulp applied with autogenous dentin fragments. The Bulletin of Tokyo Dental College 30, 137-43.
80. Nakashima M (1994a) Induction of dentin formation on canine amputated pulp by recombinant human bone morphogenetic proteins (BMP)-2 and -4. Journal of Dental Research 73, 1515-22.
81. Nakashima M (1994b) Induction of dentine in amputated pulp of dogs by recombinant human bone morphogenetic proteins-2 and -4 with collagen matrix. Archives of Oral Biology 39, 1085-9.
82. Nakashima M (2005) Bone morphogenetic proteins in dentin regeneration for potential use in endodontic therapy. Cytokine & Growth Factor Reviews 16, 369-76.
83. Nie X, Tian W, Zhang Y et al. (2006) Induction of transforming growth factor-beta 1 on dentine pulp cells in different culture patterns. Cell Biology International 30, 295-300.
84. Nomiyama K, Kitamura C, Tsujisawa T et al. (2007) Effects of lipopolysaccharide on newly established rat dental pulp-derived cell line with odontoblastic properties. Journal of Endodontics 33, 1187-91.
85. Okabe T, Sakamoto M, Takeuchi H, Matsushima K (2006) Effects of pH on mineralization ability of human dental pulp cells. Journal of Endodontics 32, 198-201.
86. Okiji T, Yoshiba K (2009) Reparative dentinogenesis induced by Mineral Trioxide Aggregate: a review from the biological and physicochemical points of view. International Journal of Dentistry 2009 (Article ID 464280), pp. 12.
87. Onishi T, Kinoshita S, Shintani S, Sobue S, Ooshima T (1999) Stimulation of proliferation and differentiation of dog dental pulp cells in serum-free culture medium by insulin-like growth factor. Archives of Oral Biology 44, 361-71.
88. Pitt Ford TR, Torabinejad M, Abedi HR, Bakland LK, Kariyawasam SP (1996) Using mineral trioxide aggregate as a pulp-capping material. Journal of American Dental Association 127, 1491-4.
89. Piva E, Tarquínio SB, Demarco FF, Silva AF, de Araújo VC (2006) Immunohistochemical expression of fibronectin and tenascin after direct pulp capping with calcium hydroxide. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics 102, e66-71.
90. Prosser HJ, Groffman DM, Wilson AD (1982) The effect of composition on the erosion properties of calcium hydroxide cements. Journal of Dental Research 61, 1431-5.
91. Qudeimat MA, Barrieshi-Nusair KM, Owais AI (2007) Calcium hydroxide vs mineral trioxide aggregates for partial pulpotomy of permanent molars with deep caries. European Archives of Paediatric Dentistry 8, 99-104.
92. Rashid F, Shiba H, Mizuno N et al. (2003) The effect of extracellular calcium ion on gene expression of bone-related proteins in human pulp cells. Journal of Endodontics 29, 104-7.
93. Reyes-Carmona JF, Santos AR, Figueiredo CP, Felippe MS, Felippe WT, Cordeiro MM (2011) In vivo host interactions with mineral trioxide aggregate and calcium hydroxide: inflammatory molecular signaling assessment. Journal of Endodontics 37, 1225-35.
94. Ruch JV (1985) Odontoblast differentiation and the formation of odontoblast layer. Journal of Dental Research 64, 489-98.
95. Safavi KE, Nichols FC (1993) Effect of calcium hydroxide on bacterial lipopolysaccharide. Journal of Endodontics 19, 76-8.
96. Saluk-Juszczak J, Wachowicz B (2005) The proinflammatory activity of lipopolysaccharide. Postepy Biochemii 51, 280-7.
97. Schröder U (1978) A 2-year follow-up of primary molars, pulpotomized with a gentle technique and capped with calcium hydroxide. Scandinavian Journal of Dental Research 86, 273-8.
98. Schröder U (1985) Effects of calcium hydroxide-containing pulp-capping agents on pulp cell migration, proliferation, and differentiation. Journal of Dental Research 64 Spec No, 541-8.
99. Schröder U, Granath LE (1971) Early reaction of intact human teeth to calcium hydroxide following experimental pulpotomy and its significance to the hard tissue barrier. Odontologisk Revy 22, 379-96.
100. Segura JJ, Llamas R, Rubio-Manzanares AJ, Jimenez-Planas A, Guerrero JM, Calvo JR (1997) Calcium hydroxide inhibits substrate adherence capacity of macrophages. Journal of Endodontics 23, 444-7.
101. Sela J, Tamari I, Hirschfeld Z, Bab I (1981) Transmission electron microscopy of reparative dentin in rat molar pulps. Primary mineralization via extracellular matrix vesicles. Acta Anatomica 109, 247-51.
102. Senzaki H (1980) A histological study of reparative dentinogenesis in the rat incisor after colchicine administration. Archives of Oral Biology 25, 737-43.
103. Seux D, Couble ML, Hartmann DJ, Gauthier JP, Magloire H (1991) Odontoblast-like cytodifferentiation of human dental pulp cells in vitro in the presence of a calcium hydroxide-containing cement. Archives of Oral Biology 36, 117-28.
104. Shayegan A, Petein M, Vanden Abbeele A (2009) The use of beta-tricalcium phosphate, white MTA, white Portland cement and calcium hydroxide for direct pulp capping of primary pig teeth. Dental Traumatology 25, 413-9.
105. Siqueira JF Jr, Lopes HP (1999) Mechanisms of antimicrobial activity of calcium hydroxide: a critical review. International Endodontic Journal 32, 361-9.
106. Six N, Lasfargues JJ, Goldberg M (2002) Differential repair responses in the coronal and radicular areas of the exposed rat molar pulp induced by recombinant human bone morphogenetic protein 7 (osteogenic protein 1). Archives of Oral Biology 47, 177-87.
107. Smith AJ, Smith G (1998) Solubilisation of TGFβ1 by dentine conditioning agents. Journal of Dental Research 77, 1034 abstr.
108. Smith AJ, Tobias RS, Cassidy N et al. (1994) Odontoblast stimulation in ferrets by dentine matrix components. Archives of Oral Biology 39, 13-22.
109. Smith AJ, Tobias RS, Murray PE (2001) Transdentinal stimulation of reactionary dentinogenesis in ferrets by dentine matrix components. Journal of Dentistry 29, 341-6.
110. Stanley HR, Lundy T (1972) Dycal therapy for pulp exposures. Oral Surgery, Oral Medicine, and Oral Pathology 34, 818-27.
111. Suzuki S, Sreenath T, Haruyama N et al. (2009) Dentin sialoprotein and dentin phosphoprotein have distinct roles in dentin mineralization. Matrix Biology 28, 221-9.
112. Swift EJ, Trope M, Ritter AV (2003) Vital pulp therapy for the mature tooth - can it work? Endodontic Topics 5, 49-56.
113. Tada H, Nemoto E, Kanaya S, Hamaji N, Sato H, Shimauchi H (2010) Elevated extracellular calcium increases expression of bone morphogenetic protein-2 gene via a calcium channel and ERK pathway in human dental pulp cells. Biochemical & Biophysical Research Communications 394, 1093-7.
114. Thesleff I, Vaahtokari A (1992) The role of growth factors in determination and differentiation of the odontoblastic cell lineage. Proceedings of the Finnish Dental Society 8, 357-68.
115. Thesleff I, Vaahtokari A, Kettunen P, Aberg T (1995) Epithelial-mesenchymal signaling during tooth development. Connective Tissue Research 32, 9-15.
116. Thyagarajan T, Sreenath T, Cho A, Wright JT, Kulkarni AB (2001) Reduced expression of dentin sialophosphoprotein is associated with dysplastic dentin in mice overexpressing transforming growth factor-beta 1 in teeth. The Journal of Biological Chemistry 276, 11016-20.
117. Tomson PL, Grover LM, Lumley PJ, Sloan AJ, Smith AJ, Cooper PR (2007) Dissolution of bio-active dentine matrix components by mineral trioxide aggregate. Journal of Dentistry 35, 636-42.
118. Torneck CD, Moe H, Howley TP (1983) The effect of calcium hydroxide on porcine pulp fibroblasts in vitro. Journal of Endodontics 9, 131-6.
119. Tsuji T, Takei K, Inoue T, Shimono M, Yamamura T (1987) An experimental study on wound healing of surgically exposed dental pulps in germ-free rats. The Bulletin of Tokyo Dental College 28, 35-8.
120. Tziafas D (1995) Basic mechanisms of cytodifferentiation and dentinogenesis during dental pulp repair. The International Journal of Developmental Biology 39, 281-90.
121. Tziafas D (2010) Dentinogenic potential of the dental pulp: facts and hypotheses. Endodontic Topics 17, 42-64.
122. Tziafas D, Economides N (1999) Formation of crystals on the surface of calcium hydroxide-containing materials in vitro. Journal of Endodontics 25, 539-42.
123. Tziafas D, Kolokuris I, Alvanou A, Kaidoglou K (1992) Short-term dentinogenic response of dog dental pulp tissue after its induction by demineralized or native dentine, or predentine. Archives of Oral Biology 37, 119-28.
124. Tziafas D, Alvanou A, Panagiotakopoulos N et al. (1995a) Induction of odontoblast-like cell differentiation in dog dental pulps after in vivo implantation of dentine matrix components. Archives of Oral Biology 40, 883-93.
125. Tziafas D, Panagiotakopoulos N, Komnenou A (1995b) Immunolocalization of fibronectin during the early response of dog dental pulp to demineralized dentine or calcium hydroxide-containing cement. Archives of Oral Biology 40, 23-31.
126. Wang JD, Hume WR (1988) Diffusion of hydrogen ion and hydroxyl ion from various sources through dentine. International Endodontic Journal 21, 17-26.
127. Wang P, Hao J, Shi J (2000) Actions of bovine plasma fibronectin on cultured human dental pulp cells. Chinese Journal of Dental Research 3, 55-62.
128. Willershausen B, Willershausen I, Ross A, Velikonja S, Kasaj A, Blettner M (2011) Retrospective study on direct pulp capping with calcium hydroxide. Quintessence International 42, 165-71.
129. Yamaguchi T, Chattopadhyay N, Kifor O, Butters RR Jr, Sugimoto T, Brown EM (1998) Mouse osteoblastic cell line (MC3T3-E1) expresses extracellular calcium (Ca2 + o)-sensing receptor and its agonists stimulate chemotaxis and proliferation of MC3T3-E1 cells. Journal of Bone and Mineral Research 13, 1530-8.
130. Yoshiba N, Yoshiba K, Iwaku M, Nakamura H, Ozawa H (1994) A confocal laser scanning microscopic study of the immunofluorescent localization of fibronectin in the odontoblast layer of human teeth. Archives of Oral Biology 39, 395-400.
131. Yoshiba K, Yoshiba N, Nakamura H, Iwaku M, Ozawa H (1996) Immunolocalization of fibronectin during reparative dentinogenesis in human teeth after pulp capping with calcium hydroxide. Journal of Dental Research 75, 1590-7.
132. Zayzafoon M (2006) Calcium/calmodulin signaling controls osteoblast growth and differentiation. Journal of Cellular Biochemistry 97, 56-70.
133. Zhang R, Cooper PR, Smith G, Nör JE, Smith AJ (2011) Angiogenic activity of dentin matrix components. Journal of Endodontics 37, 26-30.