TGF-β3 induces ectopic mineralization in fetal mouse dental pulp during tooth germ development

Development Growth and Differentiation

Volumn 47, Issue 3, 2005, Pages 141-152

  Huojia, Muhetaer ^a   Muraoka, Noriko ^a   Yoshizaki, Keigo ^a   Fukumoto, Satoshi ^a   Nakashima, Misako ^a   Akamine, Akifumi ^a   Nonaka, Kazuaki ^a   Ohishi, Masamichi ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

Ectopic mineralization; Pulp cells; TGF 3

Indexed keywords

COLLAGEN TYPE 1; MESSENGER RNA; OSTEOCALCIN; PHOSPHOPROTEIN; PROTEIN; SIALOPHOSPHOPROTEIN; SIALOPROTEIN; TRANSFORMING GROWTH FACTOR BETA3; UNCLASSIFIED DRUG; ALIZARIN RED S; ANTHRAQUINONE DERIVATIVE; MICROSPHERE; PRIMER DNA; SIALOGLYCOPROTEIN; TGFB3 PROTEIN, MOUSE; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CALVARIA; CELL DIFFERENTIATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENTIN; DOSE RESPONSE; EXTRACELLULAR MATRIX; FETUS; IN VIVO STUDY; MINERALIZATION; MOUSE; NONHUMAN; ODONTOBLAST; OSTEOBLAST; PROTEIN EXPRESSION; PROTEIN FAMILY; STEM CELL; TOOTH DEVELOPMENT; TOOTH FLORA; TOOTH PULP; ANIMAL; COMPARATIVE STUDY; DRUG EFFECT; GENE EXPRESSION REGULATION; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; METABOLISM; MOLAR TOOTH; PRENATAL DEVELOPMENT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALIA;

ANIMALS; ANTHRAQUINONES; COLLAGEN TYPE I; DENTAL PULP; DNA PRIMERS; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION, DEVELOPMENTAL; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MICE; MICROSPHERES; MOLAR; OSTEOCALCIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIALOGLYCOPROTEINS; TOOTH CALCIFICATION; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA3;

EID: 18744389182     PISSN: 00121592     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1440-169x.2005.00790.x     Document Type: Article

References (39)

1. Baba, O., Qin, C., Brunn, J. C. et al. 2004. Detection of dentin sialoprotein in rat periodontium. Eur. J. Oral Sci. 112, 163-170.
2. Beniash, E., Traub, W., Veis, A. & Weiner, S. 2000. A transmission electron microscope study using vitrified ice sections of predentin: structural changes in the dentin collagenous matrix prior to mineralization. J. Struct. Biol. 132, 212-225.
3. Bleicher, F., Couble, M. L., Farges, J. C., Couble, P. & Magloire, H. 1999. Sequential expression of matrix protein in developing rat teeth. Matrix Biol. 18, 133-143.
4. Cassidy, N., Fahey, M., Prime, S. S. & Smith, A. J. 1997. Comparative analysis of transforming growth factor-beta isoforms 1-3 in human and rabbit dentine matrices. Arch. Oral Biol. 42, 219-223.
5. Fukumoto, E., Sakai, H., Fukumoto, S., Yagi, T., Takagi, O. & Kato, Y. 2003. Cadherin-related neuronal receptors in incisor development. J. Dent Res. 82, 17-22.
6. Gronthos, S., Mankani, M., Brahim, J., Robey, P. G. & Shi, S. 2000. Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo. Proc. Natl Acad. Sci. USA 97, 13625-13630.
7. Hao, J. J., Zou, B. S., Narayanan, K. & George, A. 2004. Differential expression patterns of the dentin matrix proteins during mineralized tissue formation. Bone. 34, 921-932.
8. He, W. X., Niu, Z. Y., Zhao, S. L., Jin, W. L., Gao, J. & Smith, A. J. 2004. TGF-beta activated Smad signalling leads to a Smad3-mediated down-regulation of DSPP in an odontoblast cell line. Arch. Oral Biol. 49, 911-918.
9. Hegert, C., Kramer, J., Hargus, G. et al. 2002. Differentiation plasticity of chondrocytes derived from mouse embryonic stem cells. J. Cell Sci. 115 (23), 4617-4628.
10. Hu, C. C., Zhang, C., Qian, Q. & Tatum, N. B. 1998. Reparative dentin formation in rat molars after direct pulp capping with growth factors. J. Endod. 24, 744-751.
11. Iohara, K., Nakashima, M., Ito, M., Ishikawa, M., Nakasima, A. & Akamine, A. 2004. Dentin regeneration by dental pulp stem cell therapy with recombinant human bone morphogenetic protein 2. J. Dent Res. 83, 590-595.
12. Kohama, K., Nonaka, K., Hosokawa, R., Shum, L. & Ohishi, M. 2002. TGF-beta-3 promotes scarless repair of cleft lip in mouse fetuses. J. Dent Res. 81, 688-694.
13. Mackay, A. M., Beck, S. C., Murphy, J. M., Barry, F. P., Chichester, C. O. & Pittenger, M. F. 1998. Chondrogenic differentiation of cultured human mesenchymal stem cells from marrow. Tissue Eng. 4, 415-428.
14. Massague, J. 1998. TGF-beta signal transduction. Annu. Rev. Biochem. 67, 753-791.
15. Mina, M. & Braut, A. 2004. New insight into progenitor/stem cells in dental pulp using Col1a1-GFP transgenes. Cells Tissues Organs 176, 120-133.
16. Nakashima, M., Mizunuma, K., Murakami, T. & Akamine, A. 2002. Induction of dental pulp stem cell differentiation into odontoblasts by electroporation-mediated gene delivery of growth/differentiation factor 11 (Gdf11). Gene Ther. 9, 814-818.
17. Nakashima, M., Nagasawa, H., Yamada, Y. & Reddi, A. H. 1994. Regulatory role of transforming growth factor-beta, bone morphogenetic protein-2, and protein-4 on gene expression of extracellular matrix proteins and differentiation of dental pulp cells. Dev. Biol. 162, 18-28.
18. Nakashima, M., Toyono, T., Murakami, T. & Akamine, A. 1998. Transforming growth factor-beta superfamily members expressed in rat incisor pulp. Arch. Oral Biol. 43, 745-751.
19. Narayanan, K., Srinivas, R., Ramachandran, A., Hao, J. & Quinn. & George, A. 2001. Differentiation of embryonic mesenchymal cells to odontoblast-like cells by overexpression of dentin matrix protein 1. Proc. Natl Acad. Sci. USA 98, 4516-4521.
20. Nonaka, K., Shum, L., Takahashi, I. et al. 1999. Convergence of the BMP and EGF signaling pathways on Smad1 in the regulation of chondrogenesis. Int. J. Dev Biol. 43, 795-807.
21. Ritchie, H. H., Berry, J. E., Somerman, M. J. et al. 1997. Dentin sialoprotein (DSP) transcripts: developmentally-sustained expression in odontoblasts and transient expression in preameloblasts. Eur. J. Oral Sci. 105, 405-413.
22. Roberts, A. B. & Sporn, M. B. 1993. Physiological actions and clinical applications of transforming growth factor-beta (TGF-beta). Growth Factors 8, 1-9.
23. Roelen, B. A. & Dijke, P. 2003. Controlling mesenchymal stem cell differentiation by TGFBeta family members. J. Orthop Sci. 8, 740-748. Review.
24. Shiba, H., Fujita, T., Doi, N. et al. 1998. Differential effects of various growth factors and cytokines on the syntheses of DNA, type I collagen, laminin, fibronectin, osteonectin/secreted protein, acidic and rich in cysteine (SPARC), and alkaline phosphatase by human pulp cells in culture. J. Cell Physiol. 174, 194-205.
25. Shirakawa, M., Shiba, H., Nakanishi, K. et al. 1994. Transforming growth factor-beta-1 reduces alkaline phosphatase mRNA and activity and stimulates cell proliferation in cultures of human pulp cells. J. Dent Res. 73, 1509-1514.
26. Slavkin, H., Nuckolls, G. & Shum, L. 2000. Craniofacial development and patterning. Meth. Mol. Biol. 136, 45-54.
27. Sloan, A. J., Couble, M. L., Bleicher, F., Magloire, H., Smith, A. J. & Farges, J. C. 2001. Expression of TGF-beta receptors I and II in the human dental pulp by in situ hybridization. Adv. Dent Res. 15, 63-67.
28. Sloan, A. J., Perry, H., Mathews, J. B. & Smith, A. J. 2000. Transforming growth factor-beta isoform expression in mature human healthy and carious molar teeth. Histochem. J. 32, 247-252.
29. Sloan, A. J. & Smith, A. J. 1999. Stimulation of the dentine-pulp complex of rat incisor teeth by transforming growth factor-beta isoforms 1-3 in vitro. Arch. Oral Biol. 44, 149-156.
30. Smith, A. J. 2002. Pulpal responses to caries and dental repair. Caries Res. 36, 223-232.
31. Sreenath, T., Thyagarajan, T., Hall, B. et al. 2003. Dentin sialophosphoprotein knockout mouse teeth display widened predentin zone and develop defective dentin mineralization similar to human dentinogenesis imperfecta type III. J. Biol. Chem. 278, 24874-24880.
32. Thyagarajan, T., Sreenath, T., Cho, A., Wright, J. T. & Kulkarni, A. B. 2001. Reduced expression of dentin sialophosphoprotein is associated with dysplastic dentin in mice overexpressing transforming growth factor-beta 1 in teeth. J. Biol. Chem. 276, 11016-11020.
33. Toyono, T., Nakashima, M., Kuhara, S. & Akamine, A. 1997a. Temporal changes in expression of transforming growth factor-beta superfamily members and their receptors during bovine preodontoblast differentiation in vitro. Arch. Oral Biol. 42, 481-488.
34. Toyono, T., Nakashima, M., Kuhara, S. & Akamine, A. 1997b. Expression of TGF-beta superfamily receptors in dental pulp. J. Dent Res. 76, 1555-1560.
35. Tziafas, D., Smith, A. J. & Lesot, H. 2000. Designing new treatment strategies in vital pulp therapy. J. Dent. 28, 77-92.
36. Unterbrink, A., O'Sullivan, M., Chen, S. & MacDougall, M. 2002. TGF beta-1 downregulates DMP-1 and DSPP in odontoblasts. Connect Tissue Res. 43, 354-358.
37. Vaahtokari, A., Vainio, S. & Thesleff, I. 1991. Associations between transforming growth factor beta 1 RNA expression and epithelial-mesenchymal interactions during tooth morphogenesis. Development 113, 985-994.
38. Yamamura, T. 1985. Differentiation of pulpal cells and inductive influences of various matrices with reference to pulpal wound healing. J. Dent Res. 64, 530-540.
39. Yuasa, K., Fukumoto, S., Kamasaki, Y. et al. 2004. Laminin is essential for odontoblast differentiation regulating dentin sialoprotein expression. J. Biol. Chem. 279, 10286-10292.