The effects of angiotensin receptor blockers vs. calcium channel blockers on the acute exercise-induced inflammatory and thrombotic response

Hypertension Research

Volumn 35, Issue 12, 2012, Pages 1193-1200

  Liakos, Charalampos I ^a   Vyssoulis, Gregory P ^a   Michaelides, Andreas P ^a   Chatzistamatiou, Evangelos I ^b   Theodosiades, George ^b   Toutouza, Marina G ^b   Markou, Maria I ^c   Synetos, Andreas G ^a   Kallikazaros, Ioannis E ^b   Stefanadis, Christodoulos I ^a  

^a UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^b HIPPOKRATION HOSPITAL   (Greece)

^c 417 VA Hospital (NIMTS)   (Greece)

Author keywords

antihypertensive treatment; exercise testing; inflammatory response; physical activity; thrombotic response

Indexed keywords

C REACTIVE PROTEIN; DILTIAZEM; FIBRINOGEN; HIGH SENSITIVITY C REACTIVE PROTEIN; HYDROCHLOROTHIAZIDE; INTERLEUKIN 6; IRBESARTAN; PLASMINOGEN ACTIVATOR INHIBITOR 1; SERUM AMYLOID A; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VON WILLEBRAND FACTOR;

ACUTE PHASE RESPONSE; ADD ON THERAPY; ADULT; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DRUG DOSE TITRATION; FEMALE; HUMAN; HYPERTENSION; INFLAMMATION; LEUKOCYTE; MAJOR CLINICAL STUDY; MALE; PHYSICAL STRESS; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; THROMBOSIS; TREADMILL EXERCISE;

ADULT; AGED; ANGIOTENSIN RECEPTOR ANTAGONISTS; CALCIUM CHANNEL BLOCKERS; CARDIOVASCULAR DISEASES; EXERCISE; EXERCISE TEST; FEMALE; HUMANS; INFLAMMATION; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; RISK ASSESSMENT; THROMBOSIS;

EID: 84870772582     PISSN: 09169636     EISSN: 13484214     Source Type: Journal    
DOI: 10.1038/hr.2012.134     Document Type: Article

References (35)

1. Thompson PD, Franklin BA, Balady GJ, Blair SN, Corrado D, Estes III NA, Fulton JE,Gordon NF, Haskell WL, Link MS, Maron BJ, Mittleman MA, Pelliccia A, Wenger NK,Willich SN, Costa F. Exercise and acute cardiovascular events: placing the risks intoperspective. A scientific statement from the American Heart Association Council onNutrition, Physical Activity, and Metabolism and the Council on Clinical Cardiology incollaboration with the American College of Sports Medicine. Circulation 2007; 115:2358-2368.
2. Sesso HD, Wang L, Buring JE, Ridker PM, Gaziano JM. Comparison of interleukin-6and C-reactive protein for the risk of developing hypertension in women. Hypertension2007; 49: 304-310.
3. Bautista LE, Vera LM, Arenas IA, Gamarra G. Independent association betweeninflammatory markers (C-reactive protein, interleukin-6, and TNF-alpha) and essentialhypertension. J Hum Hypertens 2005; 19: 149-154.
4. Lip GY, Beevers DG. Abnormalities of rheology and coagulation in hypertension. J HumHypertens 1994; 8: 693-702.
5. Koenig W, Khuseyinova N. Biomarkers of atherosclerotic plaque instability and rupture.Arterioscler Thromb Vasc Biol 2007; 27: 15-26.
6. Suzuki M, Saito M, Nagai T. Systemic versus coronary levels of inflammation in acutecoronary syndromes. Angiology 2006; 57: 459-463.
7. Catena C, Novello M, Lapenna R, Baroselli S, Colussi G, Nadalini E, Favret G, CavarapeA, Soardo G, Sechi LA. New risk factors for atherosclerosis in hypertension: focus onthe prothrombotic state and lipoprotein(a). J Hypertens 2005; 23: 1617-1632.
8. Pai JK, Pischon T, Ma J, Manson JE, Hankinson SE, Joshipura K, Curhan GC, Rifai N,Cannuscio CC, Stampfer MJ, Rimm EB. Inflammatory markers and the risk of coronaryheart disease in men and women. N Engl J Med 2004; 351: 2599-2610.
9. Johnson BD, Kip KE, Marroquin OC, Ridker PM, Kelsey SF, Shaw LJ, Pepine CJ, SharafB, Bairey Merz CN, Sopko G, Olson MB, Reis SE. Serum amyloid A as a predictor ofcoronary artery disease and cardiovascular outcome in women: the National Heart,Lung, and Blood Institute-Sponsored Women's Ischemia Syndrome Evaluation (WISE).Circulation 2004; 109: 726-732.
10. Danesh J, Collins R, Appleby P, Peto R. Association of fibrinogen, C-reactive protein,albumin, or leukocyte count with coronary heart disease: meta-analyses of prospectivestudies. JAMA 1998; 279: 1477-1482.
11. Juhan-Vague I, Alessi MC. Plasminogen activator inhibitor 1 and atherothrombosis.Thromb Haemost 1993; 70: 138-143.
12. Kasapis C, Thompson PD. The effects of physical activity on serum C-reactive proteinand inflammatory markers: a systematic review. J Am Coll Cardiol 2005; 45:1563-1569.
13. Cox AJ, Pyne DB, Gleeson M, Callister R. Relationship between C-reactive proteinconcentration and cytokine responses to exercise in healthy and illness-prone runners.Eur J Appl Physiol 2009; 107: 611-614.
14. Suzuki K, Nakaji S, Yamada M, Totsuka M, Sato K, Sugawara K. Systemic inflammatoryresponse to exhaustive exercise. Cytokine kinetics. Exerc Immunol Rev 2002; 8: 6-48.
15. Ostrowski K, Schjerling P, Pedersen BK. Physical activity and plasma interleukin-6 inhumans:effect of intensity of exercise. Eur J Appl Physiol 2000; 83: 512-515.
16. Ostrowski K, Hermann C, Bangash A, Schjerling P, Nielsen JN, Pedersen BK. A traumalikeelevation of plasma cytokines in humans in response to treadmill running. J Physiol1998; 513: 889-894.
17. Mendham AE, Donges CE, Liberts EA, Duffield R. Effects of mode and intensity on theacute exercise-induced IL-6 and CRP responses in a sedentary, overweight population.Eur J Appl Physiol 2011; 111: 1035-1045.
18. Tartibian B, Azadpoor N, Abbasi A. Effects of two different type of treadmill running onhuman blood leukocyte populations and inflammatory indices in young untrained men.J Sports Med Phys Fitness 2009; 49: 214-223.
19. Plaisance EP, Taylor JK, Alhassan S, Abebe A, Mestek ML, Grandjean PW. Cardiovascularfitness and vascular inflammatory markers after acute aerobic exercise.Int J Sport Nutr Exerc Metab 2007; 17: 152-162.
20. Andreozzi GM, Martini R, Cordova R, D'Eri A, Salmistraro G, Mussap M, Plebani M.Circulating levels of cytokines (IL-6 and IL-1beta) in patients with intermittentclaudication, at rest, after maximal exercise treadmill test and during restorephase. Could they be progression markers of the disease? Int Angiol 2007; 26:245-252.
21. DeSouza CA, Dengel DR, Rogers MA, Cox K, Macko RF. Fibrinolytic responses to acutephysical activity in older hypertensive men. J Appl Physiol 1997; 82: 1765-1770.
22. Merchant N, Rahman ST, Ferdinand KC, Haque T, Umpierrez GE, Khan BV. Effects ofnebivolol in obese African Americans with hypertension (NOAAH): markers ofinflammation and obesity in response to exercise-induced stress. J Hum Hypertens2011; 25: 196-202.
23. Martinez-Martin FJ, Macias-Batista A, Comi-Diaz C, Rodriguez-Rosas H, Soriano-Perera P, Pedrianes-Martin P. Effects of manidipine and its combination with an ACEinhibitor on insulin sensitivity and metabolic, inflammatory and prothrombotic markersin hypertensive patients with metabolic syndrome: the MARCADOR study. Clin DrugInvestig 2011; 31: 201-212.
24. Martinez-Martin FJ, Rodriguez-Rosas H, Peiro-Martinez I, Soriano-Perera P, Pedrianes-Martin P, Comi-Diaz C. Olmesartan/amlodipine vs olmesartan/hydrochlorothiazide inhypertensive patients with metabolic syndrome: the OLAS study. J Hum Hypertens2011; 25: 346-353.
25. Vaccari CS, Rahman ST, Khan QA, Cheema FA, Khan BV. Effects of angiotensinconvertingenzyme inhibitor therapy on levels of inflammatory markers in response toexercise-induced stress: studies in the metabolic syndrome. J Cardiometab Syndr2008; 3: 12-17.
26. Fliser D, Buchholz K, Haller H. EUropean Trial on Olmesartan and Pravastatin inInflammation and Atherosclerosis (EUTOPIA) Investigators. Antiinflammatory effects ofangiotensin II subtype 1 receptor blockade in hypertensive patients with microinflammation.Circulation 2004; 110: 1103-1107.
27. Gibbons RJ, Balady GJ, Bricker JT, Chaitman BR, Fletcher GF, Froelicher VF, Mark DB,McCallister BD, Mooss AN, O'Reilly MG, Winters Jr WL. ACC/AHA 2002 guidelineupdate for exercise testing: a report of the American College of Cardiology/AmericanHeart Association Task Force on Practice Guidelines (Committee on Exercise Testing).Available at ACC Web-site: www.acc.org/clinical/ guidelines/exercise/dirIndex.htm.
28. Mancia G, DeBacker G, Dominiczak A, Cifkova R, Fagard R, Germano G, Grassi G,Heagerty AM, Kjeldsen SE, Laurent S, Narkiewicz K, Ruilope L, Rynkiewicz A,Schmieder RE, Boudier HA, Zanchetti A. 2007 ESH-ESC guidelines for the managementof arterial hypertension: the task force for the management of arterial hypertensionof the European Society of Hypertension and of the European Society ofCardiology. Blood Press 2007; 16: 135-232.
29. D'Agostino RB, Vasan RS, Pencina MJ, Wolf PA, Cobain M, Massaro JM, Kannel WB.General cardiovascular risk profile for use in primary care: the Framingham HeartStudy. Circulation 2008; 117: 743-753.
30. Conroy RM, Pyörälä K, Fitzgerald A, Sans S, Menotti A, DeBacker G, DeBacquer D,Ducimetière P, Jousilahti P, Keil U, Njølstad I, Oganov RG, Thomsen T, Tunstall-PedoeH, Tverdal A, Wedel H, Whincup P, Wilhelmsen L, Graham IM. Estimation of ten-yearrisk of fatal cardiovascular disease in Europe: the SCORE project. Eur Heart J 2003;24: 987-1003.
31. Craig CL, Marshall AL, Sjöström M, Bauman AE, Booth ML, Ainsworth BE, Pratt M,Ekelund U, Yngve A, Sallis JF, Oja P. International physical activity questionnaire:12-Country reliability and validity. Med Sci Sports Exerc 2003; 35: 1381-1395.
32. Kavouras SA, Panagiotakos DB, Pitsavos C, Chrysohoou C, Anastasiou CA, Lentzas Y,Stefanadis C. Physical activity, obesity status, and glycemic control: the ATTICA study.Med Sci Sports Exerc 2007; 39: 606-611.
33. Pitsavos C, Chrysohoou C, Panagiotakos DB, Skoumas J, Zeimbekis A, Kokkinos P,Stefanadis C, Toutouzas PK. Association of leisure-time physical activity on inflammationmarkers (C-reactive protein, white cell blood count, serum amyloid A, andfibrinogen) in healthy subjects (from the ATTICA study). Am J Cardiol 2003; 91:368-370.
34. Pescatello LS, Franklin BA, Fagard R, Farquhar WB, Kelley GA, Ray CA. AmericanCollege of Sports Medicine position stand. Exercise and hypertension. Med Sci SportsExerc 2004; 36: 533-553.
35. Brull DJ, Serrano N, Zito F, Jones L, Montgomery HE, Rumley A, Sharma P, Lowe GD,World MJ, Humphries SE, Hingorani AD. Human CRP gene polymorphism influencesCRP levels: implications for the prediction and pathogenesis of coronary heart disease.Arterioscler Thromb Vasc Biol 2003; 23: 2063-2069.