메뉴 건너뛰기




Volumn 21, Issue 126, 2012, Pages 321-327

Pathways in pulmonary arterial hypertension: The future is here

Author keywords

Endothelin; Nitric oxide; Prostacyclin; Pulmonary arterial hypertension; Survival

Indexed keywords

AMBRISENTAN; BERAPROST; BOSENTAN; CYCLOSPORIN; ENDOTHELIN; ENDOTHELIN 1; ENDOTHELIN A RECEPTOR; ENDOTHELIN B RECEPTOR; ENDOTHELIN RECEPTOR ANTAGONIST; IMATINIB; KETOCONAZOLE; MACITENTAN; NITRATE; NITRIC OXIDE; PHOSPHODIESTERASE V; PLACEBO; PLATELET DERIVED GROWTH FACTOR; PROSTACYCLIN; PROSTAGLANDIN RECEPTOR; PROSTANOID; RIOCIGUAT; SELEXIPAG; SILDENAFIL; TADALAFIL; TERGURIDE; THROMBOXANE A2; TREPROSTINIL; WARFARIN;

EID: 84870755485     PISSN: 09059180     EISSN: 16000617     Source Type: Journal    
DOI: 10.1183/09059180.00004812     Document Type: Review
Times cited : (108)

References (60)
  • 1
    • 77956396934 scopus 로고    scopus 로고
    • Pulmonary arterial hypertension: From the kingdom of the near-dead to multiple clinical trial metaanalyses
    • Galie' N, Palazzini M, Manes A. Pulmonary arterial hypertension: from the kingdom of the near-dead to multiple clinical trial metaanalyses. Eur Heart J 2010; 31: 2080-2086.
    • (2010) Eur Heart J , vol.31 , pp. 2080-2086
    • Galie', N.1    Palazzini, M.2    Manes, A.3
  • 2
    • 4644290657 scopus 로고    scopus 로고
    • Treatment of pulmonary arterial hypertension
    • Humbert M, Sitbon O, Simonneau G. Treatment of pulmonary arterial hypertension. N Engl J Med 2004; 351: 1425-1436.
    • (2004) N Engl J Med , vol.351 , pp. 1425-1436
    • Humbert, M.1    Sitbon, O.2    Simonneau, G.3
  • 3
    • 34547857041 scopus 로고    scopus 로고
    • Endothelin: Setting the scene in PAH
    • Dupuis J. Endothelin: setting the scene in PAH. Eur Respir Rev 2007; 16: 3-7.
    • (2007) Eur Respir Rev , vol.16 , pp. 3-7
    • Dupuis, J.1
  • 4
    • 0001295079 scopus 로고    scopus 로고
    • The new clinical trials on pharmacologic treatment in pulmonary arterial hypertension
    • Galie' N, Manes A, Branzi A, et al. The new clinical trials on pharmacologic treatment in pulmonary arterial hypertension. Eur J Clin Investig 1996; 26: A48.
    • (1996) Eur J Clin Investig , vol.26
    • Galie', N.1    Manes, A.2    Branzi, A.3
  • 5
    • 0027324745 scopus 로고
    • Expression of endothelin-1 in the lungs of patients with pulmonary hypertension
    • Giaid A, Yanagisawa M, Langleben D, et al. Expression of endothelin-1 in the lungs of patients with pulmonary hypertension. N Engl J Med 1993; 328: 1732-1739.
    • (1993) N Engl J Med , vol.328 , pp. 1732-1739
    • Giaid, A.1    Yanagisawa, M.2    Langleben, D.3
  • 6
    • 0346492721 scopus 로고    scopus 로고
    • The endothelin system in pulmonary arterial hypertension
    • Galié N, Manes A, Branzi A. The endothelin system in pulmonary arterial hypertension. Cardiovasc Res 2004; 61: 227-237.
    • (2004) Cardiovasc Res , vol.61 , pp. 227-237
    • Galié, N.1    Manes, A.2    Branzi, A.3
  • 7
    • 78649864855 scopus 로고    scopus 로고
    • At the heart of tissue: Endothelin system and end-organ damage
    • Iglarz M, Clozel M. At the heart of tissue: endothelin system and end-organ damage. Clin Sci (Lond) 2010; 119: 453-463.
    • (2010) Clin Sci (Lond) , vol.119 , pp. 453-463
    • Iglarz, M.1    Clozel, M.2
  • 8
    • 40649084619 scopus 로고    scopus 로고
    • Endothelin receptor antagonists in pulmonary arterial hypertension
    • Dupuis J, Hoeper MM. Endothelin receptor antagonists in pulmonary arterial hypertension. Eur J Respir 2008; 31: 407-415.
    • (2008) Eur J Respir , vol.31 , pp. 407-415
    • Dupuis, J.1    Hoeper, M.M.2
  • 9
    • 0028890875 scopus 로고
    • Role of endogenous endothelin in normal hemodynamic status of anesthetized dogs
    • Teerlink JR, Carteaux JP, Sprecher U, et al. Role of endogenous endothelin in normal hemodynamic status of anesthetized dogs. Am J Physiol 1995; 268: H432-H440.
    • (1995) Am J Physiol , vol.268
    • Teerlink, J.R.1    Carteaux, J.P.2    Sprecher, U.3
  • 10
    • 0027983753 scopus 로고
    • Contribution of endogenous generation of endothelin-1 to basal vascular tone
    • Haynes WG, Webb DJ. Contribution of endogenous generation of endothelin-1 to basal vascular tone. Lancet 1994; 344: 852-854.
    • (1994) Lancet , vol.344 , pp. 852-854
    • Haynes, W.G.1    Webb, D.J.2
  • 11
    • 0026698004 scopus 로고
    • Polar secretion of endothelin-1 by cultured endothelial cells
    • Wagner OF, Christ G, Wojta J, et al. Polar secretion of endothelin-1 by cultured endothelial cells. J Biol Chem 1992; 267: 16066-16068.
    • (1992) J Biol Chem , vol.267 , pp. 16066-16068
    • Wagner, O.F.1    Christ, G.2    Wojta, J.3
  • 12
    • 0036468709 scopus 로고    scopus 로고
    • ET(A) and ET(B) receptors modulate the proliferation of human pulmonary artery smooth muscle cells
    • Davie N, Haleen SJ, Upton PD, et al. ET(A) and ET(B) receptors modulate the proliferation of human pulmonary artery smooth muscle cells. Am J Respir Crit Care Med 2002; 165: 398-405.
    • (2002) Am J Respir Crit Care Med , vol.165 , pp. 398-405
    • Davie, N.1    Haleen, S.J.2    Upton, P.D.3
  • 13
    • 85047675323 scopus 로고
    • Why are circulating concentrations of endothelin-1 so low
    • Frelin C, Guedin D. Why are circulating concentrations of endothelin-1 so low? Cardiovasc Res 1994; 28: 1613-1622.
    • (1994) Cardiovasc Res , vol.28 , pp. 1613-1622
    • Frelin, C.1    Guedin, D.2
  • 14
    • 0030473271 scopus 로고    scopus 로고
    • Interaction of endothelin-1 with cloned bovine ETA receptors: Biochemical parameters and functional consequences
    • Desmarets J, Gresser O, Guedin D, et al. Interaction of endothelin-1 with cloned bovine ETA receptors: biochemical parameters and functional consequences. Biochemistry 1996; 35: 14868-14875.
    • (1996) Biochemistry , vol.35 , pp. 14868-14875
    • Desmarets, J.1    Gresser, O.2    Guedin, D.3
  • 15
    • 57349133022 scopus 로고    scopus 로고
    • Pharmacology of macitentan, an orally active tissue-targeting dual endothelin receptor antagonist
    • Iglarz M, Binkert C, Morrison K, et al. Pharmacology of macitentan, an orally active tissue-targeting dual endothelin receptor antagonist. J Pharmacol Exp Ther 2008; 327: 736-745.
    • (2008) J Pharmacol Exp Ther , vol.327 , pp. 736-745
    • Iglarz, M.1    Binkert, C.2    Morrison, K.3
  • 16
    • 84870740909 scopus 로고    scopus 로고
    • Optimization of tissue targeting properties of macitentan, a new dual endothelin receptor antagonist, improves its efficacy in a rat model of pulmonary fibrosis associated with pulmonary arterial hypertension
    • Iglarz M, Landskroner K, Rey M, et al. Optimization of tissue targeting properties of macitentan, a new dual endothelin receptor antagonist, improves its efficacy in a rat model of pulmonary fibrosis associated with pulmonary arterial hypertension. Am J Respir Crit Care Med 2011; 183: A6445.
    • (2011) Am J Respir Crit Care Med , vol.183
    • Iglarz, M.1    Landskroner, K.2    Rey, M.3
  • 17
    • 77956242973 scopus 로고    scopus 로고
    • Macitentan, a tissue-targeting endothelin receptor antagonist for the potential oral treatment of pulmonary arterial hypertension and idiopathic pulmonary fibrosis
    • Raja SG. Macitentan, a tissue-targeting endothelin receptor antagonist for the potential oral treatment of pulmonary arterial hypertension and idiopathic pulmonary fibrosis. Curr Opin Investig Drugs 2010; 11: 1066-1073.
    • (2010) Curr Opin Investig Drugs , vol.11 , pp. 1066-1073
    • Raja, S.G.1
  • 18
    • 0035036050 scopus 로고    scopus 로고
    • The endothelin antagonist bosentan inhibits the canalicular bile salt export pump: A potential mechanism for hepatic adverse reactions
    • Fattinger K, Funk C, Pantze M, et al. The endothelin antagonist bosentan inhibits the canalicular bile salt export pump: a potential mechanism for hepatic adverse reactions. Clin Pharmacol Ther 2001; 69: 223-231.
    • (2001) Clin Pharmacol Ther , vol.69 , pp. 223-231
    • Fattinger, K.1    Funk, C.2    Pantze, M.3
  • 19
    • 84865136582 scopus 로고    scopus 로고
    • Efficacy and safety of macitentan in idiopathic pulmonary fibrosis: Results of a prospective, randomized, double-blind, placebo-controlled trial
    • Raghu G, Million-Rousseau R, Morganti A, et al. Efficacy and safety of macitentan in idiopathic pulmonary fibrosis: results of a prospective, randomized, double-blind, placebo-controlled trial. Am J Respir Crit Care Med 2012; 185: A3631.
    • (2012) Am J Respir Crit Care Med , vol.185
    • Raghu, G.1    Million-Rousseau, R.2    Morganti, A.3
  • 20
    • 84857627857 scopus 로고    scopus 로고
    • Effect of cyclosporine and rifampin on the pharmacokinetics of macitentan, a tissuetargeting dual endothelin receptor antagonist
    • Bruderer S, Aänismaa P, Homery MC, et al. Effect of cyclosporine and rifampin on the pharmacokinetics of macitentan, a tissuetargeting dual endothelin receptor antagonist. AAPS J 2011; 14: 68-78.
    • (2011) AAPS J , vol.14 , pp. 68-78
    • Bruderer, S.1    Aänismaa, P.2    Homery, M.C.3
  • 21
    • 84857627601 scopus 로고    scopus 로고
    • Investigation of the effect of ketoconazole on the pharmacokinetics of macitentan in healthy male subjects
    • Sidharta PN, Atsmon J, Dingemanse J. Investigation of the effect of ketoconazole on the pharmacokinetics of macitentan in healthy male subjects. Br J Clin Pharmacol 2010; 70: 730-731.
    • (2010) Br J Clin Pharmacol , vol.70 , pp. 730-731
    • Sidharta, P.N.1    Atsmon, J.2    Dingemanse, J.3
  • 22
    • 80054771944 scopus 로고    scopus 로고
    • Macitentan: Entry-into-humans study with a new endothelin receptor antagonist
    • Sidharta PN, van Giersbergen PL, Halabi A, et al. Macitentan: entry-into-humans study with a new endothelin receptor antagonist. Eur J Clin Pharmacol 2011; 67: 977-984.
    • (2011) Eur J Clin Pharmacol , vol.67 , pp. 977-984
    • Sidharta, P.N.1    van Giersbergen, P.L.2    Halabi, A.3
  • 23
    • 33748998458 scopus 로고    scopus 로고
    • Pulmonary arterial hypertension
    • McLaughlin VV, McGoon MD. Pulmonary arterial hypertension. Circulation 2006; 114: 1417-1431.
    • (2006) Circulation , vol.114 , pp. 1417-1431
    • McLaughlin, V.V.1    McGoon, M.D.2
  • 24
    • 0023505509 scopus 로고
    • Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide
    • Ignarro LJ, Buga GM, Wood KS, et al. Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc Natl Acad Sci USA 1987; 84: 9265-9269.
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 9265-9269
    • Ignarro, L.J.1    Buga, G.M.2    Wood, K.S.3
  • 25
    • 0000707453 scopus 로고
    • Nitric oxide activates guanylate cyclase and increases guanosine 3':5'-cyclic monophosphate levels in various tissue preparations
    • Arnold WP, Mittal CK, Katsuki S, et al. Nitric oxide activates guanylate cyclase and increases guanosine 3':5'-cyclic monophosphate levels in various tissue preparations. Proc Natl Acad Sci USA 1977; 74: 3203-3207.
    • (1977) Proc Natl Acad Sci USA , vol.74 , pp. 3203-3207
    • Arnold, W.P.1    Mittal, C.K.2    Katsuki, S.3
  • 26
    • 0030559686 scopus 로고    scopus 로고
    • Rebound pulmonary hypertension after inhalation of nitric oxide
    • Atz AM, Adatia I, Wessel DL. Rebound pulmonary hypertension after inhalation of nitric oxide. Ann Thorac Surg 1996; 62: 1759-1764.
    • (1996) Ann Thorac Surg , vol.62 , pp. 1759-1764
    • Atz, A.M.1    Adatia, I.2    Wessel, D.L.3
  • 27
    • 33746584053 scopus 로고    scopus 로고
    • Sildenafil: From angina to erectile dysfunction to pulmonary hypertension and beyond
    • Ghofrani HA, Osterloh IH, Grimminger F. Sildenafil: from angina to erectile dysfunction to pulmonary hypertension and beyond. Nat Rev Drug Discov 2006; 5: 689-702.
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 689-702
    • Ghofrani, H.A.1    Osterloh, I.H.2    Grimminger, F.3
  • 28
    • 0037006966 scopus 로고    scopus 로고
    • Combination therapy with oral sildenafil and inhaled iloprost for severe pulmonary hypertension
    • Ghofrani HA, Wiedemann R, Rose F, et al. Combination therapy with oral sildenafil and inhaled iloprost for severe pulmonary hypertension. Ann Intern Med 2002; 136: 515-522.
    • (2002) Ann Intern Med , vol.136 , pp. 515-522
    • Ghofrani, H.A.1    Wiedemann, R.2    Rose, F.3
  • 29
    • 26444534291 scopus 로고    scopus 로고
    • Sildenafil Use in Pulmonary Arterial Hypertension (SUPER) study group. Sildenafil citrate therapy for pulmonary arterial hypertension
    • Galie' N, Ghofrani HA, Torbicki A, et al. Sildenafil Use in Pulmonary Arterial Hypertension (SUPER) study group. Sildenafil citrate therapy for pulmonary arterial hypertension. N Engl J Med 2005; 353: 2148-2157.
    • (2005) N Engl J Med , vol.353 , pp. 2148-2157
    • Galie', N.1    Ghofrani, H.A.2    Torbicki, A.3
  • 30
    • 67649523052 scopus 로고    scopus 로고
    • Tadalafil therapy for pulmonary arterial hypertension
    • Galie' N, Brundage BH, Ghofrani HA, et al. Tadalafil therapy for pulmonary arterial hypertension. Circulation 2009; 119: 2894-2903.
    • (2009) Circulation , vol.119 , pp. 2894-2903
    • Galie', N.1    Brundage, B.H.2    Ghofrani, H.A.3
  • 31
    • 0141482069 scopus 로고    scopus 로고
    • Immediate and long-term hemodynamic and clinical effects of sildenafil in patients with pulmonary arterial hypertension receiving vasodilator therapy
    • Bhatia S, Frantz RP, Severson CJ, et al. Immediate and long-term hemodynamic and clinical effects of sildenafil in patients with pulmonary arterial hypertension receiving vasodilator therapy. Mayo Clin Proc 2003; 78: 1207-1213.
    • (2003) Mayo Clin Proc , vol.78 , pp. 1207-1213
    • Bhatia, S.1    Frantz, R.P.2    Severson, C.J.3
  • 32
    • 63849256355 scopus 로고    scopus 로고
    • First acute haemodynamic study of soluble guanylate cyclase stimulator riociguat in pulmonary hypertension
    • Grimminger F, Weimann G, Frey R, et al. First acute haemodynamic study of soluble guanylate cyclase stimulator riociguat in pulmonary hypertension. Eur Respir J 2009; 33: 785-792.
    • (2009) Eur Respir J , vol.33 , pp. 785-792
    • Grimminger, F.1    Weimann, G.2    Frey, R.3
  • 33
    • 77956664858 scopus 로고    scopus 로고
    • Riociguat for chronic thromboembolic pulmonary hypertension and pulmonary arterial hypertension: A phase II study
    • Ghofrani HA, Hoeper MM, Halank M, et al. Riociguat for chronic thromboembolic pulmonary hypertension and pulmonary arterial hypertension: a phase II study. Eur Respir J 2010; 36: 792-799.
    • (2010) Eur Respir J , vol.36 , pp. 792-799
    • Ghofrani, H.A.1    Hoeper, M.M.2    Halank, M.3
  • 34
    • 73749086478 scopus 로고    scopus 로고
    • A review of prostaglandin analogs in the management of patients with pulmonary arterial hypertension
    • Mubarak KK. A review of prostaglandin analogs in the management of patients with pulmonary arterial hypertension. Respir Med 2010; 104: 9-21.
    • (2010) Respir Med , vol.104 , pp. 9-21
    • Mubarak, K.K.1
  • 35
    • 0026628265 scopus 로고
    • An imbalance between the excretion of thromboxane and prostacyclin metabolites in pulmonary hypertension
    • Christman BW, McPherson CD, Newman JH, et al. An imbalance between the excretion of thromboxane and prostacyclin metabolites in pulmonary hypertension. N Engl J Med 1992; 327: 70-75.
    • (1992) N Engl J Med , vol.327 , pp. 70-75
    • Christman, B.W.1    McPherson, C.D.2    Newman, J.H.3
  • 36
    • 0033032949 scopus 로고    scopus 로고
    • Prostacyclin synthase expression is decreased in lungs from patients with severe pulmonary hypertension
    • Tuder RM, Cool CD, Geraci MW, et al. Prostacyclin synthase expression is decreased in lungs from patients with severe pulmonary hypertension. Am J Respir Crit Care Med 1999; 159: 1925-1932.
    • (1999) Am J Respir Crit Care Med , vol.159 , pp. 1925-1932
    • Tuder, R.M.1    Cool, C.D.2    Geraci, M.W.3
  • 37
    • 0033971515 scopus 로고    scopus 로고
    • The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs
    • Abramovitz M, Adam M, Boie Y, et al. The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta 2000; 1483: 285-293.
    • (2000) Biochim Biophys Acta , vol.1483 , pp. 285-293
    • Abramovitz, M.1    Adam, M.2    Boie, Y.3
  • 38
    • 34548101404 scopus 로고    scopus 로고
    • 2-[4-[(5,6-diphenylpyrazin-2-yl)(isopropyl)amino]butoxy]-N-(methylsulfonyl)acetamide (NS-304), an orally available and long-acting prostacyclin receptor agonist prodrug
    • Kuwano K, Hashino A, Asaki T, et al. 2-[4-[(5,6-diphenylpyrazin-2-yl)(isopropyl)amino]butoxy]-N-(methylsulfonyl)acetamide (NS-304), an orally available and long-acting prostacyclin receptor agonist prodrug. J Pharmacol Exp Ther 2007; 322: 1181-1188.
    • (2007) J Pharmacol Exp Ther , vol.322 , pp. 1181-1188
    • Kuwano, K.1    Hashino, A.2    Asaki, T.3
  • 39
    • 84865706347 scopus 로고    scopus 로고
    • Use of parenteral prostanoids at time of death in patients with pulmonary arterial hypertension in REVEAL
    • Farber HW, Miller DP, Beery FS, et al. Use of parenteral prostanoids at time of death in patients with pulmonary arterial hypertension in REVEAL. Chest 2011; 140: 903A.
    • (2011) Chest , vol.140
    • Farber, H.W.1    Miller, D.P.2    Beery, F.S.3
  • 40
    • 84863937744 scopus 로고    scopus 로고
    • FREEDOM-M: Efficacy and safety of oral treprostinil diethanolamine as monotherapy in patients with pulmonary arterial hypertension
    • Rubin LJ, Parikh K, Pulido T, et al. FREEDOM-M: efficacy and safety of oral treprostinil diethanolamine as monotherapy in patients with pulmonary arterial hypertension. Chest 2011; 140: 1044A.
    • (2011) Chest , vol.140
    • Rubin, L.J.1    Parikh, K.2    Pulido, T.3
  • 43
    • 0036183638 scopus 로고    scopus 로고
    • Beraprost: A review of its pharmacology and therapeutic efficacy in the treatment of peripheral arterial disease and pulmonary arterial hypertension
    • Melian EB, Goa KL. Beraprost: a review of its pharmacology and therapeutic efficacy in the treatment of peripheral arterial disease and pulmonary arterial hypertension. Drugs 2002; 62: 107-133.
    • (2002) Drugs , vol.62 , pp. 107-133
    • Melian, E.B.1    Goa, K.L.2
  • 44
    • 58849159146 scopus 로고    scopus 로고
    • The search for an oral prostanoid to treat pulmonary arterial hypertension continues
    • Rich J, Hoeper MM. The search for an oral prostanoid to treat pulmonary arterial hypertension continues. Are we getting any closer? Int J Clin Pract Suppl 2009; 161: 17-18.
    • (2009) Are we getting any closer? Int J Clin Pract Suppl , vol.161 , pp. 17-18
    • Rich, J.1    Hoeper, M.M.2
  • 45
    • 36949037998 scopus 로고    scopus 로고
    • Pilot study of short-term effects of a novel long-acting oral beraprost in patients with pulmonary arterial hypertension
    • Ikeda D, Tsujino I, Sakaue S, et al. Pilot study of short-term effects of a novel long-acting oral beraprost in patients with pulmonary arterial hypertension. Circ J 2007; 71: 1829-1831.
    • (2007) Circ J , vol.71 , pp. 1829-1831
    • Ikeda, D.1    Tsujino, I.2    Sakaue, S.3
  • 46
    • 84866604676 scopus 로고    scopus 로고
    • Long-term follow-up in PAH patients dosed with beraprost sodium modified release (BPSMR) tablets, an oral twice daily prostacyclin analogue
    • Oudiz RJ, Benza RL, Delcroix M, et al. Long-term follow-up in PAH patients dosed with beraprost sodium modified release (BPSMR) tablets, an oral twice daily prostacyclin analogue. Am J Respir Crit Care Med 2011; 183: A5905.
    • (2011) Am J Respir Crit Care Med , vol.183
    • Oudiz, R.J.1    Benza, R.L.2    Delcroix, M.3
  • 47
    • 84912119520 scopus 로고    scopus 로고
    • Clinical pharmacology and safety of beraprost sodium modified release (BPS-MR), an oral twice daily prostacyclin analogue-a phase II study
    • Armstrong DJ, Benza RL, Delcroix M, et al. Clinical pharmacology and safety of beraprost sodium modified release (BPS-MR), an oral twice daily prostacyclin analogue-a phase II study. Am J Respir Crit Care Med 2010; 181: A3360.
    • (2010) Am J Respir Crit Care Med , vol.181
    • Armstrong, D.J.1    Benza, R.L.2    Delcroix, M.3
  • 48
    • 77957237185 scopus 로고    scopus 로고
    • Selexipag: A selective prostacyclin receptor agonist that does not affect rat gastric function
    • Morrison K, Ernst R, Hess P, et al. Selexipag: a selective prostacyclin receptor agonist that does not affect rat gastric function. J Pharmacol Exp Ther 2010; 335: 249-255.
    • (2010) J Pharmacol Exp Ther , vol.335 , pp. 249-255
    • Morrison, K.1    Ernst, R.2    Hess, P.3
  • 49
    • 84863528040 scopus 로고    scopus 로고
    • Selexipag, an oral, selective IP receptor agonist for the treatment of pulmonary arterial hypertension
    • Simonneau G, Torbicki A, Hoeper MM, et al. Selexipag, an oral, selective IP receptor agonist for the treatment of pulmonary arterial hypertension. Eur Respir J 2012; 40: 874-880.
    • (2012) Eur Respir J , vol.40 , pp. 874-880
    • Simonneau, G.1    Torbicki, A.2    Hoeper, M.M.3
  • 50
    • 84555190301 scopus 로고    scopus 로고
    • Imatinib mesylate for the treatment of pulmonary arterial hypertension
    • Freyhaus H, Dumitrescu D, Berghausen E, et al. Imatinib mesylate for the treatment of pulmonary arterial hypertension. Expert Opin Investig Drugs 2012; 21: 119-134.
    • (2012) Expert Opin Investig Drugs , vol.21 , pp. 119-134
    • Freyhaus, H.1    Dumitrescu, D.2    Berghausen, E.3
  • 51
    • 26444552166 scopus 로고    scopus 로고
    • PDGF signaling in pulmonary arterial hypertension
    • Barst RJ. PDGF signaling in pulmonary arterial hypertension. J Clin Invest 2005; 115: 2691-2694.
    • (2005) J Clin Invest , vol.115 , pp. 2691-2694
    • Barst, R.J.1
  • 52
    • 26444540768 scopus 로고    scopus 로고
    • Reversal of experimental pulmonary hypertension by PDGF inhibition
    • Schermuly RT, Dony E, Ghofrani HA, et al. Reversal of experimental pulmonary hypertension by PDGF inhibition. J Clin Invest 2005; 115: 2811-2821.
    • (2005) J Clin Invest , vol.115 , pp. 2811-2821
    • Schermuly, R.T.1    Dony, E.2    Ghofrani, H.A.3
  • 53
    • 77649162823 scopus 로고    scopus 로고
    • Why doesn't imatinib cure chronic myeloid leukemia
    • Redner RL. Why doesn't imatinib cure chronic myeloid leukemia? Oncologist 2010; 15: 182-186.
    • (2010) Oncologist , vol.15 , pp. 182-186
    • Redner, R.L.1
  • 54
    • 25444484658 scopus 로고    scopus 로고
    • Imatinib for the treatment of pulmonary arterial hypertension
    • Ghofrani HA, Seeger W, Grimminger F. Imatinib for the treatment of pulmonary arterial hypertension. N Engl J Med 2005; 353: 1412-1413.
    • (2005) N Engl J Med , vol.353 , pp. 1412-1413
    • Ghofrani, H.A.1    Seeger, W.2    Grimminger, F.3
  • 55
    • 33746745449 scopus 로고    scopus 로고
    • Imatinib mesylate in the treatment of refractory idiopathic pulmonary arterial hypertension
    • Patterson KC, Weissmann A, Ahmadi T, et al. Imatinib mesylate in the treatment of refractory idiopathic pulmonary arterial hypertension. Ann Intern Med 2006; 145: 152-153.
    • (2006) Ann Intern Med , vol.145 , pp. 152-153
    • Patterson, K.C.1    Weissmann, A.2    Ahmadi, T.3
  • 56
    • 33747041655 scopus 로고    scopus 로고
    • Long term imatinib treatment in pulmonary arterial hypertension
    • Souza R, Sitbon O, Parent F, et al. Long term imatinib treatment in pulmonary arterial hypertension. Thorax 2006; 61: 736.
    • (2006) Thorax , vol.61 , pp. 736
    • Souza, R.1    Sitbon, O.2    Parent, F.3
  • 57
    • 77956709644 scopus 로고    scopus 로고
    • Imatinib in pulmonary arterial hypertension patients with inadequate response to established therapy
    • Ghofrani HA, Morrell NW, Hoeper MM, et al. Imatinib in pulmonary arterial hypertension patients with inadequate response to established therapy. Am J Respir Crit Care Med 2010; 182: 1171-1177.
    • (2010) Am J Respir Crit Care Med , vol.182 , pp. 1171-1177
    • Ghofrani, H.A.1    Morrell, N.W.2    Hoeper, M.M.3
  • 58
    • 84858809665 scopus 로고    scopus 로고
    • Imatinib improves exercise capacity and hemodynamics at 24 weeks as add-on therapy in symptomatic pulmonary arterial hypertension patients: The IMPRES Study
    • Hoeper MM, Barst R, Bourge R, et al. Imatinib improves exercise capacity and hemodynamics at 24 weeks as add-on therapy in symptomatic pulmonary arterial hypertension patients: the IMPRES Study. Chest 2011; 140: 1045A.
    • (2011) Chest , vol.140
    • Hoeper, M.M.1    Barst, R.2    Bourge, R.3
  • 59
    • 84860346274 scopus 로고    scopus 로고
    • Pulmonary arterial hypertension in patients treated by dasatinib
    • Montani D, Bergot E, Günther S, et al. Pulmonary arterial hypertension in patients treated by dasatinib. Circulation 2012; 125: 2128-2137.
    • (2012) Circulation , vol.125 , pp. 2128-2137
    • Montani, D.1    Bergot, E.2    Günther, S.3
  • 60
    • 84870738242 scopus 로고    scopus 로고
    • Proof-ofconcept study to investigate the efficacy, hemodynamics and tolerability of terguride vs. placebo in subjects with pulmonary arterial hypertension: Results of a double blind, randomised, prospective phase IIa study
    • Ghofrani HA, Al-Hiti H, Vonk-Noordegraaf A, et al. Proof-ofconcept study to investigate the efficacy, hemodynamics and tolerability of terguride vs. placebo in subjects with pulmonary arterial hypertension: results of a double blind, randomised, prospective phase IIa study. Am J Respir Crit Care Med 2012; 185: A2496.
    • (2012) Am J Respir Crit Care Med , vol.185
    • Ghofrani, H.A.1    Al-Hiti, H.2    Vonk-Noordegraaf, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.