Interactive Association of Five Candidate Polymorphisms in Apelin/APJ Pathway with Coronary Artery Disease among Chinese Hypertensive Patients

PLoS ONE

Volumn 7, Issue 12, 2012, Pages

  Jin, Wei ^a   Su, Xiuxiu ^a   Xu, Min ^a   Liu, Yan ^a   Shi, Jingyi ^a   Lu, Lin ^a   Niu, Wenquan ^a,b  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b Shanghai Institute of Hypertension   (China)

Author keywords

[No Author keywords available]

Indexed keywords

APELIN; APELIN RECEPTOR; CHOLESTEROL; GENOMIC DNA; LOW DENSITY LIPOPROTEIN CHOLESTEROL; UREA; URIC ACID;

ADULT; AGED; ANGIOCARDIOGRAPHY; APELIN GENE; APJ GENE; ARTICLE; BODY MASS; CHINESE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CORONARY ARTERY DISEASE; DNA POLYMORPHISM; FEMALE; GENDER; GENE; GENE LOCUS; GENE OVEREXPRESSION; GENE SEQUENCE; GENETIC ANALYSIS; GENETIC RISK; GENOTYPE; HAPLOTYPE; HOSPITAL BASED CASE CONTROL STUDY; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; MOLECULAR GENETICS; POLYMERASE CHAIN REACTION; SYSTOLIC BLOOD PRESSURE; UREA NITROGEN BLOOD LEVEL; URIC ACID BLOOD LEVEL;

ASIAN CONTINENTAL ANCESTRY GROUP; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; CHINA; CORONARY ARTERY DISEASE; EPISTASIS, GENETIC; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION STUDIES; GENETIC LOCI; GENETIC PREDISPOSITION TO DISEASE; GENOME, HUMAN; HAPLOTYPES; HUMANS; HYPERTENSION; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MIDDLE AGED; MULTIFACTOR DIMENSIONALITY REDUCTION; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION;

EID: 84870722130     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0051123     Document Type: Article

References (29)

1. Hardy J, Singleton A, (2009) Genomewide association studies and human disease. N Engl J Med 360: 1759-1768.
2. Eleftherohorinou H, Wright V, Hoggart C, Hartikainen AL, Jarvelin MR, et al. (2009) Pathway analysis of GWAS provides new insights into genetic susceptibility to 3 inflammatory diseases. PLoS One 4: e8068.
3. Chen MM, Ashley EA, Deng DX, Tsalenko A, Deng A, et al. (2003) Novel role for the potent endogenous inotrope apelin in human cardiac dysfunction. Circulation 108: 1432-1439.
4. Pitkin SL, Maguire JJ, Kuc RE, Davenport AP, (2010) Modulation of the apelin/APJ system in heart failure and atherosclerosis in man. Br J Pharmacol 160: 1785-1795.
5. O'Dowd BF, Heiber M, Chan A, Heng HH, Tsui LC, et al. (1993) A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11. Gene 136: 355-360.
6. Tatemoto K, Hosoya M, Habata Y, Fujii R, Kakegawa T, et al. (1998) Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor. Biochem Biophys Res Commun 251: 471-476.
7. Kuba K, Zhang L, Imai Y, Arab S, Chen M, et al. (2007) Impaired heart contractility in Apelin gene-deficient mice associated with aging and pressure overload. Circ Res 101: e32-42.
8. Japp AG, Cruden NL, Amer DA, Li VK, Goudie EB, et al. (2008) Vascular effects of apelin in vivo in man. J Am Coll Cardiol 52: 908-913.
9. McCarthy MI, Abecasis GR, Cardon LR, Goldstein DB, Little J, et al. (2008) Genome-wide association studies for complex traits: consensus, uncertainty and challenges. Nat Rev Genet 9: 356-369.
10. Li WW, Niu WQ, Zhang Y, Wu S, Gao PJ, et al. (2009) Family-based analysis of apelin and AGTRL1 gene polymorphisms with hypertension in Han Chinese. J Hypertens 27: 1194-1201.
11. Niu W, Wu S, Zhang Y, Li W, Ji K, et al. (2010) Validation of genetic association in apelin-AGTRL1 system with hypertension in a larger Han Chinese population. J Hypertens 28: 1854-1861.
12. Khot UN, Khot MB, Bajzer CT, Sapp SK, Ohman EM, et al. (2003) Prevalence of conventional risk factors in patients with coronary heart disease. JAMA 290: 898-904.
13. Wilson PW, (1994) Established risk factors and coronary artery disease: the Framingham Study. Am J Hypertens 7: 7S-12S.
14. Hata J, Matsuda K, Ninomiya T, Yonemoto K, Matsushita T, et al. (2007) Functional SNP in an Sp1-binding site of AGTRL1 gene is associated with susceptibility to brain infarction. Hum Mol Genet 16: 630-639.
15. Khanna M, Park P, Zirvi M, Cao W, Picon A, et al. (1999) Multiplex PCR/LDR for detection of K-ras mutations in primary colon tumors. Oncogene 18: 27-38.
16. Pattin KA, White BC, Barney N, Gui J, Nelson HH, et al. (2009) A computationally efficient hypothesis testing method for epistasis analysis using multifactor dimensionality reduction. Genet Epidemiol 33: 87-94.
17. Hahn LW, Ritchie MD, Moore JH, (2003) Multifactor dimensionality reduction software for detecting gene-gene and gene-environment interactions. Bioinformatics 19: 376-382.
18. Gao LR, Zhang NK, Bai J, Ding QA, Wang ZG, et al. (2010) The apelin-APJ pathway exists in cardiomyogenic cells derived from mesenchymal stem cells in vitro and in vivo. Cell Transplant 19: 949-958.
19. Foldes G, Horkay F, Szokodi I, Vuolteenaho O, Ilves M, et al. (2003) Circulating and cardiac levels of apelin, the novel ligand of the orphan receptor APJ, in patients with heart failure. Biochem Biophys Res Commun 308: 480-485.
20. Katugampola SD, Maguire JJ, Matthewson SR, Davenport AP, (2001) [(125)I]-(Pyr(1))Apelin-13 is a novel radioligand for localizing the APJ orphan receptor in human and rat tissues with evidence for a vasoconstrictor role in man. Br J Pharmacol 132: 1255-1260.
21. Padmanabhan S, Melander O, Hastie C, Menni C, Delles C, et al. (2008) Hypertension and genome-wide association studies: combining high fidelity phenotyping and hypercontrols. J Hypertens 26: 1275-1281.
22. Falcone C, Bozzini S, Schirinzi S, Buzzi MP, Boiocchi C, et al. (2012) APJ polymorphisms in coronary artery disease patients with and without. Mol Med Report 5: 321-325.
23. Hinohara K, Nakajima T, Sasaoka T, Sawabe M, Lee BS, et al. (2009) Validation of the association between AGTRL1 polymorphism and coronary artery disease in the Japanese and Korean populations. J Hum Genet 54: 554-556.
24. Schork NJ, Murray SS, Frazer KA, Topol EJ, (2009) Common vs. rare allele hypotheses for complex diseases. Curr Opin Genet Dev 19: 212-219.
25. Kalea AZ, Batlle D, (2010) Apelin and ACE2 in cardiovascular disease. Curr Opin Investig Drugs 11: 273-282.
26. Barton M, Meyer MR, (2009) Postmenopausal hypertension: mechanisms and therapy. Hypertension 54: 11-18.
27. Niu W, Qi Y, Hou S, Zhai X, Zhou W, et al. (2009) Haplotype-based association of the renin-angiotensin-aldosterone system genes polymorphisms with essential hypertension among Han Chinese: the Fangshan study. J Hypertens 27: 1384-1391.
28. Cardon LR, Bell JI, (2001) Association study designs for complex diseases. Nat Rev Genet 2: 91-99.
29. Zintzaras E, Raman G, Kitsios G, Lau J, (2008) Angiotensin-converting enzyme insertion/deletion gene polymorphic variant as a marker of coronary artery disease: a meta-analysis. Arch Intern Med 168: 1077-1089.