NdgR, a common transcriptional activator for methionine and leucine biosynthesis in Streptomyces coelicolor

Journal of Bacteriology

Volumn 194, Issue 24, 2012, Pages 6837-6846

  Kim, Songhee H ^a   Lee, Bo Rahm ^a   Kim, Ji Nu ^a   Kim, Byung Gee ^a  

^a Seoul National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); BACTERIAL PROTEIN; CYSTEINE; LEUCINE; METHIONINE; METHIONINE SYNTHASE; NDGR PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL CELL; BINDING AFFINITY; CELL LYSATE; CONTROLLED STUDY; GEL MOBILITY SHIFT ASSAY; GENE INACTIVATION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN METABOLISM; PROTEIN SYNTHESIS; STREPTOMYCES COELICOLOR; TRANSCRIPTION INITIATION;

5,10-METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); 5-METHYLTETRAHYDROFOLATE-HOMOCYSTEINE S-METHYLTRANSFERASE; CYSTEINE; GENE EXPRESSION REGULATION, BACTERIAL; GENES, BACTERIAL; ISOMERASES; LEUCINE; METHIONINE; STREPTOMYCES COELICOLOR; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSCRIPTIONAL ACTIVATION;

ACTINOBACTERIA (CLASS); STREPTOMYCES; STREPTOMYCES COELICOLOR;

EID: 84870687706     PISSN: 00219193     EISSN: 10985530     Source Type: Journal    
DOI: 10.1128/JB.00695-12     Document Type: Article

References (33)

1. Bentley SD, et al. 2002. Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2). Nature 417:141-147.
2. Blanco J, Coque JJ, Martin JF. 1998. The folate branch of the methionine biosynthesis pathway in Streptomyces lividans: disruption of the 5,10-methylenetetrahydrofolate reductase gene leads to methionine auxotrophy. J. Bacteriol. 180:1586-1591.
3. Brune I, et al. 2007. The IclR-type transcriptional repressor LtbR regulates the expression of leucine and tryptophan biosynthesis genes in the amino acid produce Corynebacterium glutamicum. J. Bacteriol. 189:2720-2733.
4. Champness EC. 2000. Prokaryotic development. ASM Press, Washington, DC.
5. Daza A, Martin JF, Dominguez A, Gil JA. 1989. Sporulation of several species of Streptomyces in submerged cultures after nutritional downshift. J. Gen. Microbiol. 135:2483-2491.
6. De Rossi E, Leva R, Gusberti L, Manachini PL, Riccardi G. 1995. Cloning, sequencing and expression of the ilvBNC gene cluster from Streptomyces avermitilis. Gene 166:127-132.
7. Gehring AM, Wang ST, Kearns DB, Storer NY, Losick R. 2004. Novel genes that influence development in Streptomyces coelicolor. J. Bacteriol. 186:3570-3577.
8. Glazebrook MA, Doull JL, Stuttard C, Vining LC. 1990. Sporulation of Streptomyces venezuelae in submerged cultures. J. Gen. Microbiol. 136: 581-588.
9. Gust B, Challis GL, Fowler K, Kieser T, Chater KF. 2003. PCR-targeted Streptomyces gene replacement identifies a protein domain needed for biosynthesis of the sesquiterpene soil odor geosmin. Proc. Natl. Acad. Sci. U. S. A. 100:1541-1546.
10. Hirano S, Tanaka K, Ohnishi Y, Horinouchi S. 2008. Conditionally positive effect of the TetR-family transcriptiona regulator AtrA on streptomycin production by Streptomyces griseus. Microbiology 154:905-914.
11. Hopwood DA. 1967. Genetic analysis and genome structure in Streptomyces coelicolor. Bacteriol. Rev. 31:373-403.
12. R regulon of Streptomyces coelicolor A32 reveals a key role in protein quality control during disulphide stress. Microbiology 156:1661-1672.
13. Kieser T, Bibb M, Buttner MJ, Chater K, Hopwood D. 2000. Practical Streptomyces Genetics. Crowes, Norwich, England.
14. Kirby KS, Fox-Carter E, Guest M. 1967. Isolation of deoxyribonucleic acid and ribosomal ribonucleic acid from bacteria. Biochem. J. 104:258-262.
15. B governs osmotic and oxidative response as well as differentiation via a network of sigma factors in Streptomyces coelicolor. Mol. Microbiol. 57:1252-1264.
16. -ΔΔCT method. Methods 25: 402-408.
17. Malm S, et al. 2009. The roles of the nitrate reductase NarGHJI, the nitrite reductase NirBD and the response regulator GlnR in nitrate assimilation of Mycobacterium tuberculosis. Microbiology 155:1332-1339.
18. Massey LK, Sokatch JR, Conrad RS. 1976. Branched-chain amino acid catabolism in bacteria. Bacteriol. Rev. 40:42-54.
19. Mitchell W. 2011. Natural products from synthetic biology. Curr. Opin. Chem. Biol. 15:505-515.
20. Newton GL, et al. 1996. Distribution of thiols in microorganisms: mycothiol is a major thiol in most actinomycetes. J. Bacteriol. 178:1990-1995.
21. Park SS, et al. 2009. Mass spectrometric screening of transcriptional regulators involved in antibiotic biosynthesis in Streptomyces coelicolor A3(2). J. Ind. Microbiol. Biotechnol. 36:1073-1083.
22. Perez-Redondo R, et al. 2012. ArgR of Streptomyces coelicolor is a versatile regulator. PLoS One 7:e32697. doi:10.1371/journal.pone.0032697.
23. Pullan ST, Chandra G, Bibb MJ, Merrick M. 2011. Genome-wide analysis of the role of GlnR in Streptomyces venezuelae provides new insights into global nitrogen regulation in actinomycetes. BMC Genomics 12:175. doi:10.1186/1471-2164-12-175.
24. Rigali S, et al. 2006. The sugar phosphotransferase system of Streptomyces coelicolor is regulated by the GntR-family regulator DasR and links Nacetylglucosamine metabolism to the control of development. Mol. Microbiol. 61:1237-1251.
25. Rodriguez-Garcia A, Ludovice M, Martin JF, Liras P. 1997. Arginine boxes and the argR gene in Streptomyces clavuligerus: evidence for a clear regulation of the arginine pathway. Mol. Microbiol. 25:219-228.
26. Santamarta I, et al. 2007. Connecting primary and secondary metabolism: AreB, an IclR-like protein, binds the ARE(ccaR) sequence of S. clavuligerus and modulates leucine biosynthesis and cephamycin C and clavulanic acid production. Mol. Microbiol. 66:511-524.
27. Stirrett K, Denoya C, Westpheling J. 2009. Branched-chain amino acid catabolism provides precursors for the Type II polyketide antibiotic, actinorhodin, via pathways that are nutrient dependent. J. Ind. Microbiol. Biotechnol. 36:129-137.
28. Strauch E, Takano E, Baylis HA, Bibb MJ. 1991. The stringent response in Streptomyces coelicolor A3(2). Mol. Microbiol. 5:289-298.
29. Tang L, Zhang YX, Hutchinson CR. 1994. Amino acid catabolism and antibiotic synthesis: valine is a source of precursors for macrolide biosynthesis in Streptomyces ambofaciens and Streptomyces fradiae. J. Bacteriol. 176:6107-6119.
30. Vohradsky J, Thompson CJ. 2006. Systems level analysis of protein synthesis patterns associated with bacterial growth and metabolic transitions. Proteomics 6:785-793.
31. Yang YH, et al. 2009. NdgR, an IclR-like regulator involved in aminoacid-dependent growth, quorum sensing, and antibiotic production in Streptomyces coelicolor. Appl. Microbiol. Biotechnol. 82:501-511.
32. Yang YH, et al. 2012. Characterization of a new ScbR-like gammabutyrolactone binding regulator (SlbR) in Streptomyces coelicolor. Appl. Microbiol. Biotechnol. 96:113-121.
33. Zhang J, et al. 2012. PEAKS DB: De Novo sequencing assisted database search for sensitive and accurate peptide identification. Mol. Cell. Proteomics 11:M111.010587.