The LEGSKO Mouse: A Mouse Model of Age-Related Nuclear Cataract Based on Genetic Suppression of Lens Glutathione Synthesis

PLoS ONE

Volumn 7, Issue 11, 2012, Pages

  Fan, Xingjun ^a   Liu, Xiaoqin ^a   Hao, Shuyu ^a   Wang, Benlian ^b   Robinson, Michael L ^c   Monnier, Vincent M ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CASE WESTERN RESERVE UNIVERSITY   (United States)

^c MIAMI UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

METHIONINE; REACTIVE OXYGEN METABOLITE; SULFOXIDE;

AMINO ACID METABOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EXPERIMENTAL MODEL; GENOTYPE; GLUTATHIONE METABOLISM; KNOCKOUT MOUSE; LENS GLUTATHIONE SYNTHESIS KNOCKOUT MOUSE; METABOLIC INHIBITION; MOUSE; NONHUMAN; OXIDATIVE STRESS; PHENOTYPE; SENILE CATARACT;

AGING; ANIMALS; CATARACT; DISEASE MODELS, ANIMAL; DNA; GENE DELETION; GENOTYPE; GLUTAMATE-CYSTEINE LIGASE; GLUTATHIONE; GLYCOSYLATION; HUMANS; LENS NUCLEUS, CRYSTALLINE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PHENOTYPE; REACTIVE OXYGEN SPECIES; SUPPRESSION, GENETIC;

MUS; MUS MUSCULUS;

EID: 84870662236     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0050832     Document Type: Article

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