Synthesis of chamaecypanone C analogues from in situ-generated cyclopentadienones and their biological evaluation

Journal of the American Chemical Society

Volumn 134, Issue 48, 2012, Pages 19782-19787

  Dong, Suwei ^a,d   Qin, Tian ^a   Hamel, Ernest ^b   Beutler, John A ^c   Porco, John A ^a  

^a Boston University   (United States)

^b FREDERICK NATIONAL LABORATORY FOR CANCER RESEARCH   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

^d MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL EVALUATION; CYCLOPENTADIENONES; CYTOTOXIC AGENTS; DIELS-ALDER CYCLOADDITIONS; MICROTUBULES; PARENT STRUCTURE; RHODIUM-CATALYZED;

CYCLOADDITION; RHODIUM;

IN SITU PROCESSING;

2,4 DIARYLCYCLOPENTADIENONE DERIVATIVE; 3,5 DIARYLCYCLOPENTENONE DERIVATVE; CHAMAECYPANONE C DERIVATIVE; CYCLOHEXANONE; CYTOTOXIC AGENT; NATURAL PRODUCT; RHODIUM; UNCLASSIFIED DRUG;

ARTICLE; CYTOTOXICITY; DEHYDROGENATION; DIELS ALDER REACTION; DRUG STRUCTURE; IC 50; MICROTUBULE;

BICYCLO COMPOUNDS; CATALYSIS; CYCLOPENTANES; MICROTUBULES; MOLECULAR STRUCTURE; RHODIUM; TUBULIN MODULATORS;

EID: 84870660894     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja3084708     Document Type: Article

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