Oral T4-like phage cocktail application to healthy adult volunteers from Bangladesh

Virology

Volumn 434, Issue 2, 2012, Pages 222-232

  Sarker, Shafiqul Alam ^a   McCallin, Shawna ^b   Barretto, Caroline ^b   Berger, Bernard ^b   Pittet, Anne Cécile ^b   Sultana, Shamima ^a   Krause, Lutz ^b,c   Huq, Sayeda ^a   Bibiloni, Rodrigo ^b,d   Bruttin, Anne ^b   Reuteler, Gloria ^b   Brüssow, Harald ^b  

^a INTERNATIONAL CENTRE FOR DIARRHOEAL DISEASE RESEARCH   (Bangladesh)

^b NESTLÉ RESEARCH CENTER   (Switzerland)

^c QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^d RUAKURA RESEARCH CENTRE   (New Zealand)

Author keywords

Bacteriophages; Bioavailability; Escherichia coli; Fecal microbiota; Human phage therapy; Safety

Indexed keywords

BACTERIOPHAGE DNA; PLACEBO; RNA 16S;

ABSENCE OF SIDE EFFECTS; ADULT; ARTICLE; BANGLADESH; BLOOD EXAMINATION; CLINICAL EXAMINATION; COLIPHAGE; CONTROLLED STUDY; ESCHERICHIA COLI; FECES MICROFLORA; GENETIC DATABASE; GENETIC SCREENING; GENETIC VARIABILITY; HORIZONTAL GENE TRANSFER; HUMAN; HUMAN EXPERIMENT; KIDNEY FUNCTION TEST; LABORATORY TEST; LIVER FUNCTION TEST; NORMAL HUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SELF REPORT; SEQUENCE ANALYSIS; SIDE EFFECT; VIRUS LOAD; VOLUNTEER;

ADMINISTRATION, ORAL; ADULT; BANGLADESH; BIOLOGICAL AGENTS; BIOLOGICAL THERAPY; FECES; FEMALE; HUMAN EXPERIMENTATION; HUMANS; MALE; PLACEBOS; T-PHAGES; YOUNG ADULT;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI;

EID: 84870658147     PISSN: 00426822     EISSN: 10960341     Source Type: Journal    
DOI: 10.1016/j.virol.2012.09.002     Document Type: Article

References (41)

1. Arbiol C., Comeau A.M., Kutateladze M., Adamia R., Krisch H.M. Mobile regulatory cassettes mediate modular shuffling in T4-type phage genomes. Genome Biol. Evol. 2010, 2:140-152.
2. Brüssow H. Control of bacterial diarrhea with phages: coverage and safety issues of bacteriophage therapy. Bacteriophages in the Control of Food- and Waterborne Pathogens 2010, 273-295. ASM Press, Washington DC. P.M. Sarbour, M.W. Griffiths (Eds.).
3. Brüssow H., Canchaya C., Hardt W.D. Phages and the evolution of bacterial pathogens: from genomic rearrangements to lysogenic conversion. Microbiol. Mol. Biol. Rev. 2004, 68:560-602.
4. Brüssow H., Sidoti J., Link H., Hoang Y.K., Barclay D., Dirren H., Freire W.B. Age-specific prevalence of antibody to enterotoxigenic Escherichia coli in Ecuadorian and German children. J. Infect. Dis. 1990, 162:974-977.
5. Bruttin A., Brüssow H. Human volunteers receiving Escherichia coli phage T4 orally: a safety test of phage therapy. Antimicrob. Agents Chemother. 2005, 49:2874-2878.
6. Canchaya C., Proux C., Fournous G., Bruttin A., Brüssow H. Prophage genomics. Microbiol. Mol. Biol. Rev. 2003, 67:238-276.
7. Casjens S.R., Thuman-Commike P.A. Evolution of mosaically related tailed bacteriophage genomes seen through the lens of phage P22 virion assembly. Virology 2011, 411:393-415.
8. Chibani-Chennoufi S., Sidoti J., Bruttin A., Kutter E., Sarker S., Brüssow H. In vitro and in vivo bacteriolytic activities of Escherichia coli phages: implications for phage therapy. Antimirob. Agents Chemother. 2004, 48:2558-2569.
9. Chibani-Chennoufi S., Sidoti J., Bruttin A., Dillmann M.L., Kutter E., Qadri F., Sarker S., Brüssow H. Isolation of Escherichia coli bacteriophages from the stool of pediatric diarrhea patients in Bangladesh. J. Bacteriol. 2004, 186:8287-8294.
10. Claus S.P., Ellero S.L., Berger B., Krause L., Bruttin A., Molina J., Paris A., Want E.J., Nicholson J.K. Colonization-induced host-gut microbial metabolic interaction. mBio 2011, 2:e00271-10.
11. Comeau A.M., Arbiol C., Krisch H.M. Gene network visualization and quantitative synteny analysis of more than 300 marine T4-like phage scaffolds from the GOS metagenome. Mol. Biol. Evol. 2010, 27:1935-1944.
12. Comeau A.M., Bertrand C., Letarov A., Tétart F., Krisch H.M. Modular architecture of the T4 phage superfamily: a conserved core genome and a plastic periphery. Virology 2007, 362:384-396.
13. Denou E., Bruttin A., Barretto C., Ngom-Bru C., Brüssow H., Zuber S. T4 phages against Escherichia coli diarrhea: potentials and problems. Virology 2009, 388:21-23.
14. Firmesse O., Mogenet A., Bresson J.L., Corthier G., Furet J.P. Lactobacillus rhamnosus R11 consumed in a food supplement survived human digestive transit without modifying microbiota equilibrium as assessed by real-time polymerase chain reaction. J. Mol. Microbiol. Biotechnol. 2008, 14:90-99.
15. Frank J.A., Reich C.I., Sharma S., Weisbaum J.S., Wilson B.A., Olsen G.J. Critical evaluation of two primers commonly used for amplification of bacterial 16S rRNA genes. Appl. Environ. Microbiol. 2008, 74:2461-2470.
16. Hamady M., Walker J.J., Harris J.K., Gold N.J., Knight R. Error-correcting barcoded primers for pyrosequencing hundreds of samples in multiplex. Nat. Methods 2008, 5:235-237.
17. Jamalludeen N., Johnson R.P., Shewen P.E., Gyles C.L. Evaluation of bacteriophages for prevention and treatment of diarrhea due to experimental enterotoxigenic Escherichia coli O149 infection of pigs. Vet. Microbiol. 2009, 136:135-141.
18. Jaquet M., Rochat I., Moulin J., Cavin C., Bibiloni R. Impact of coffee consumption on the gut microbiota: a human volunteer study. Int. J. Food Microbiol. 2009, 130:117-121.
19. Kaliniene L., Klausa V., Zajančkauskaite A., Nivinskas R., Truncaite L. Genome of low-temperature T4-related bacteriophage vB_EcoM-VR7. Arch. Virol. 2011, 156:1913-1916.
20. Liu B., Pop M. ARDB-Antibiotic Resistance Genes Database. Nucleic Acids Res. 2009, 37:D443-D447.
21. Merabishvili M., Pirnay J.P., Verbeken G., Chanishvili N., Tediashvili M., et al. Quality-controlled small-scale production of a well-defined bacteriophage cocktail for use in human clinical trials. PLoS One 2009, 4:e4944.
22. Merril C.R., Scholl D., Adhya S. The prospect for bacteriophage therapy in Western medicine. Nat. Rev. Drug Discov. 2003, 2:489-497.
23. Miller E.S., Kutter E., Mosig G., Arisaka F., Kunisawa T., Rüger W. Bacteriophage T4 genome. Microbiol. Mol. Biol. Rev. 2003, 67:86-156.
24. Payne R.J., Jansen V.A. Pharmacokinetic principles of bacteriophage therapy. Clin. Pharmacokinet. 2003, 42:315-325.
25. Rappaport H., Russel M., Susman M. Some acridine-resistant mutations of bacteriophage T4D. Genetics 1974, 78:579-592.
26. Rhoads D.D., Wolcott R.D., Kuskowski M.A., Wolcott B.M., Ward L.S., Sulakvelidze A. Bacteriophage therapy of venous leg ulcers in humans: results of a phase I safety trial. J. Wound Care 2009, 18:237-243.
27. Roberts M.D., Martin N.L., Kropinski A.M. The genome and proteome of coliphage T1. Virology 2004, 318:245-266.
28. Rotman E., Amado L., Kuzminov A. Unauthorized horizontal spread in the laboratory environment: the tactics of Lula, a temperate lambdoid bacteriophage of Escherichia coli. PLoS One 2010, 5:e11106.
29. Sulakvelidze A., Alavidze Z., Morris J.G. Bacteriophage therapy. Antimicrob. Agents Chemother. 2001, 45:649-659.
30. Sulakvelidze A., Kutter E. Bacteriophage therapy in humans. Bacteriophages-Biology and Applications 2005, 381-436. CRC Press, Boca Raton. E. Kutter, A. Sulakvelidze (Eds.).
31. Summers W.C. Bacteriophage therapy. Annu. Rev. Microbiol. 2001, 55:437-451.
32. Tannock G.W., Munro K., Bibiloni R., Simon M.A., Hargreaves P., et al. Impact of consumption of oligosaccharide-containing biscuits on the fecal microbiota of humans. Appl. Environ. Microbiol. 2004, 70:2129-2136.
33. Tétart F., Desplats C., Krisch H.M. Genome plasticity in the distal tail fiber locus of the T-even bacteriophage: recombination between conserved motifs swaps adhesin specificity. J. Mol. Biol. 1998, 282:543-556.
34. Tétart F., Desplats C., Kutateladze M., Monod C., Ackermann H.W., Krisch H.M. Phylogeny of the major head and tail genes of wide-ranging T4-type bacteriophages. J. Bacteriol. 2001, 183:358-366.
35. Thompson J.D., Higgins D.G., Gibson T.J. CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res. 1994, 22:4673-4680.
36. Vanhoutte T., Huys G.E., de Brandt G., Swings J. Temporal stability analysis of the microbiota in human feces by denaturing gradient gel electrophoresis using universal and group-specific 16S rRNA gene primers. FEMS Microbiol. Ecol. 2004, 48:437-446.
37. Wang F.J., Ripley L.S. The spectrum of acridine resistant mutants of bacteriophage T4 reveals cryptic effects of the tsL141 DNA polymerase allele on spontaneous mutagenesis. Genetics 1998, 148:1655-1665.
38. Weiss M., Denou E., Bruttin A., Serra-Moreno R., Dillmann M.L., Brüssow H. In vivo replication of T4 and T7 bacteriophages in germ-free mice colonized with Escherichia coli. Virology 2009, 393:16-23.
39. Wright A., Hawkins C.H., Anggard E.E., Harper D.R. A controlled clinical trial of a therapeutical bacteriophage preparation in chronic otitis due to antibiotic-resistant Pseudomonas aeruginosa; a preliminary report of efficacy. Clin. Otolaryngol. 2009, 34:349-357.
40. Yang J., Chen L., Sun L., Yu J., Jin Q. VFDB 2008 release: an enhanced web-based resource for comparative pathogenomics. Nucleic Acids Res. 2008, 36:D539-D542.
41. Zuber S., Ngom-Bru C., Barretto C., Bruttin A., Brüssow H., Denou E. Genome analysis of phage JS98 defines a fourth major subgroup of T4-like phages in Escherichia coli. J. Bacteriol. 2007, 189:8206-8214.