MRI Evidence: Acute Mountain Sickness Is Not Associated with Cerebral Edema Formation during Simulated High Altitude

PLoS ONE

Volumn 7, Issue 11, 2012, Pages

  Mairer, Klemens ^a   Göbel, Markus ^a   Defrancesco, Michaela ^b   Wille, Maria ^a   Messner, Hubert ^c   Loizides, Alexander ^c   Schocke, Michael ^c   Burtscher, Martin ^a  

^a UNIVERSITY OF INNSBRUCK   (Austria)

^b UNIVERSITY HOSPITAL INNSBRUCK   (Austria)

^c INNSBRUCK MEDICAL UNIVERSITY   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ALTITUDE DISEASE; ARTICLE; BRAIN EDEMA; BRAIN REGION; BRAIN SIZE; CEREBELLUM; CLINICAL ARTICLE; CONTROLLED STUDY; CROSSOVER PROCEDURE; DISEASE ASSOCIATION; FRONTAL LOBE; GRAY MATTER; HEADACHE; HUMAN; LIMBIC CORTEX; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; OCCIPITAL LOBE; PARIETAL LOBE; PREVALENCE; RANDOMIZED CONTROLLED TRIAL; SIMULATION; TEMPORAL LOBE; VOXEL BASED MORPHOMETRY; WHITE MATTER;

ACCLIMATIZATION; ACUTE DISEASE; ADULT; ALTITUDE; ALTITUDE SICKNESS; ANOXIA; BRAIN EDEMA; CEREBRUM; CROSS-OVER STUDIES; EXERCISE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE;

EID: 84870618346     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0050334     Document Type: Article

References (44)

1. Ward MP, Milledge JS, West JB (2000) High Altitude Medicine and Physiology, 3rd ed. London: Arnold.
2. Bailey DM, Bärtsch P, Knauth M, Baumgartner RW, (2009a) Emerging concepts in acute mountain sickness and high-altitude cerebral edema: from the molecular to the morphological. Cell Mol Life Sci 66: 3583-3594.
3. Kallenberg K, Bailey DM, Christ S, Mohr A, Roukens R, et al. (2007) Magnetic resonance imaging evidence of cytotoxic cerebral edema in acute mountain sickness. J Cereb Blood Flow Metab 27: 1064-1071.
4. Lassen NA, (1992) Increase of cerebral blood flow at high altitude: its possible relation to AMS. Int J Sports Med 13: 47-48.
5. Roach RC, Hackett PH, (2001) Frontiers of hypoxia research: acute mountain sickness. J Exp Biol 204: 3161-3170.
6. Schoonman GG, Sándor PS, Nirkko AC, Lange T, Jaermann T, et al. (2008) Hypoxia-induced acute mountain sickness is associated with intracellular cerebral edema: a 3 T magnetic resonance imaging study. J Cereb Blood Flow Metab 28: 198-206.
7. Roach RC, Maes D, Sandoval D, Robergs RA, Icenogle M, et al. (2000) Exercise exacerbates acute mountain sickness at simulated high altitude. J Appl Physiol 88: 581-585.
8. Burtscher M, Likar R, Nachbauer W, Philadelphy M, Pühringer R, et al. (2001) Effects of aspirin during exercise on the incidence of high-altitude headache: a randomized, double-blind placebo-controlled trial. Headache 41: 542-545.
9. Mairer K, Wille M, Bucher T, Burtscher M, (2009) Prevalence of acute mountain sickness in the Eastern Alps. High Alt Med Biol 10: 239-245.
10. Mairer K, Wille M, Burtscher M, (2010) Prevalence of and risk factors for acute mountain sickness in the Eastern and Western Alps. High Alt Med Biol 11: 343-348.
11. Schneider M, Bernasch D, Weymann J, Holle R, Bärtsch P, (2002) Acute mountain sickness: influence of susceptibility, preexposure and ascent rate. Med Sci Sports Exerc 34: 1886-1891.
12. Roach RC, Bärtsch P, Oelz O, Hackett PH (1993) The Lake Louise acute mountain sickness scoring system. In: Sutton JR, Houston CS, Coates G, editors. Hypoxia and Molecular Medicine. Burlington: Queen City Printers. pp. 272-274.
13. Maggiorini M, Müller A, Hofstetter D, Bärtsch P, Oelz O, (1998) Assessment of acute mountain sickness by different score protocols in the Swiss Alps. Aviat Space Environ Med 69: 1186-1192.
14. Ashburner J, Friston KJ, (2005) Unified segmentation. Neuroimage 11: 805-821.
15. Ashburner J, (2007) A fast diffeomorphic image registration algorithm. Neuroimage 38: 95-113.
16. Roach RC, Loeppky JA, Icenogle MV, (1996) Acute mountain sickness: increased severity during simulated altitude compared with normobaric hypoxia. J Appl Physiol 81: 1908-1910.
17. Ito J, Marmarou A, Barzó P, Fatouros P, Corwin F, (1996) Characterization of edema by diffusion-weighted imaging in experimental traumatic brain injury. J Neurosurg 84: 97-103.
18. Patel N, White S, Dhanjal NS, Oatridge A, Taylor-Robinson SD, (2004) Changes in brain size in hepatic encephalopathy: a coregistered MRI study. Metab Brain Dis 19: 431-445.
19. Sorensen SC, Lassen NA, Severinghaus JW, Coudert J, Zamora MP, (1974) Cerebral glucose metabolism and cerebral blood flow in high-altitude residents. J Appl Physiol 37: 305-310.
20. Jensen JB, Wright AD, Lassen NA, Harvey TC, Winterborn MH, et al. (1990) Cerebral blood flow in acute mountain sickness. J Appl Physiol 69: 430-433.
21. Baumgartner RW, Bärtsch P, Maggiorini M, Waber U, Oelz O, (1994) Enhanced cerebral blood flow in acute mountain sickness. Aviat Space Environ Med 65: 726-729.
22. Moller K, Paulson OB, Hornbein TF, Colier WNJM, Paulson AS, et al. (2002) Unchanged cerebral blood flow and oxidative metabolism after acclimatization to high altitude. J Cereb Blood Flow Metab 22: 118-126.
23. Levine BD, Zhang R, Roach RC (1999) Dynamic cerebral autoregulation at high altitude. In: Hypoxia: Roach RC, Wagner PD, Hackett PH, editors. Into the next millennium. New York: Plenum/Kluwer Academic Publishing. pp. 319-322.
24. Subudhi AW, Panerai RB, Roach RC, (2009) Acute hypoxia impairs dynamic cerebral autoregulation: results from two independent techniques. J Appl Physiol 107: 1165-1171.
25. Subudhi AW, Panerai RB, Roach RC, (2010) Effects of hypobaric hypoxia on cerebral autoregulation. Stroke 41: 641-646.
26. Subudhi AW, Dimmen AC, Julian CG, Wilson MJ, Panerai RB, et al. (2011) Effects of acetazolamide and dexamethasone on cerebral hemodynamics in hypoxia. J Appl Physiol 110: 1219-1225.
27. Mayhan WG, Heistad D, (1986) Role of veins and cerebral venous pressure in disruption of the blood-brain barrier. Circ Res 59: 216-220.
28. Bailey DM, Evans KA, James PE, McEneny J, Young IS, et al. (2009b) Altered free radical metabolism in acute mountain sickness: implications for dynamic cerebral autoregulation and blood-brain barrier function. J Physiol 587: 73-85.
29. Bailey DM, Taudorf S, Berg RMG, Lundby C, McEneny, et al. (2009c) Increased cerebral output of free radicals during hypoxia: implications for acute mountain sickness? Am J Physiol Regul Integr Comp Physiol 297: R1283-R1292.
30. Kaur C, Ling EA, (2008) Blood brain barrier in hypoxic-ischemic conditions. Curr Neurovasc Res 5: 71-81.
31. Kaur C, Sivakumar V, Zhang Y, Ling EA, (2006) Hypoxia-induced astrocytic reaction and increased vascular permeability in the rat cerebellum. Glia 54: 826-839.
32. Schoch HJ, Fischer S, Marti HH, (2002) Hypoxia-induced vascular endothelial growth factor expression causes vascular leakage in the brain. Brain 125: 2549-2557.
33. Mayhan WG, (1999) VEGF increases permeability of the blood-brain barrier via a nitric oxide synthase/cGMP-dependent pathway. Am J Physiol 276: C1148-1153.
34. Julian CG, Subudhi AW, Wilson MJ, Dimmen AC, Pecha T, et al. (2011) Acute mountain sickness, inflammation, and permeability: new insights from a blood biomarker study. J Appl Physiol 111: 392-399.
35. Subudhi AW, Lorenz MC, Fulco CS, Roach RC, (2007) Cerebrovascular responses to incremental exercise during hypobaric hypoxia: effect of oxygenation on maximal performance. Am J Physiol Heart Circ Physiol 294: 164-171.
36. Vogiatzis I, Louvaris Z, Habazettl H, Athanasopoulos D, Andrianopoulos V, et al. (2011) Frontal cerebral cortex blood flow, oxygen delivery and oxygenation during normoxic and hypoxic exercise in athletes. J Physiol 15: 4027-4039.
37. Brugniaux J, Hodges ANH, Hanly PJ, Poulin MJ, (2007) Cerebrovascular responses to altitude. Resp Physiol Neurobiol 158: 212-223.
38. Gupta AK, Menon DK, Czosnyka M, Smielewski P, Jones JG, (1997) Thresholds for hypoxic cerebral vasodilation in volunteers. Anesth Analg 85: 817-820.
39. Saito S, Nishihara F, Iakazawa T, Kanai M, Aso C, et al. (1999) Exercise-induced cerebral deoxygenation among untrained trekkers at moderate altitudes. Arch Environ Health 54: 271-276.
40. Jiang BH, Semenza GL, Bauer C, Marti HH, (1996) Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension. Am J Physiol 271: 1172-1180.
41. Powell RR, (1982) Technique for differentiating cortical hemisphere activity following exercise. Percept Mot Skills 54: 932-923.
42. Guadagno JV, Jones PS, Fryer TD, Barret O, Aigbirhio FI, et al. (2006) Local relationships between restricted water diffusion and oxygen consumption in the ischemic human brain. Stroke 37: 1741-1748.
43. Burtscher M, Likar R, Nachbauer W, Schaffert W, Philadelphy M, (1995) Ibuprofen versus sumatriptan for high-altitude headache. BMJ 346: 254-255.
44. Burtscher M, (2009) High-altitude cerebral effects: risks and mechanisms - authors' reply. Lancet Neurol 8: 604-605.