Automated core-penumbra quantification in neonatal ischemic brain injury

Journal of Cerebral Blood Flow and Metabolism

Volumn 32, Issue 12, 2012, Pages 2161-2170

  Ghosh, Nirmalya ^a   Yuan, Xiangpeng ^a   Turenius, Christine I ^a   Tone, Beatriz ^a   Ambadipudi, Kamalakar ^b   Snyder, Evan Y ^c   Obenaus, Andre ^a,d   Ashwal, Stephen ^a  

^a LOMA LINDA UNIVERSITY   (United States)

^b LOMA LINDA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c BURNHAM INSTITUTE   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

animal models; brain ischemia; cerebrovascular disease; diffusion weighted MRI; focal ischemia; global ischemia; MRI; neonatal ischemia; pediatric stroke; perfusion weighted MRI

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; BRAIN REGION; BRAIN SIZE; BRAIN TISSUE; CLINICAL ARTICLE; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC APPROACH ROUTE; DIAGNOSTIC TEST ACCURACY STUDY; DIFFUSION COEFFICIENT; DIFFUSION PERFUSION MISMATCH; DIFFUSION WEIGHTED IMAGING; HIERARCHICAL REGION SPLITTING; HUMAN; HYPOXIC ISCHEMIC ENCEPHALOPATHY; IMMUNOHISTOCHEMISTRY; NEWBORN; NEWBORN DISEASE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT;

ANIMALS; ANIMALS, NEWBORN; BRAIN; BRAIN INJURIES; BRAIN ISCHEMIA; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; INFANT, NEWBORN; INFANT, NEWBORN, DISEASES; MAGNETIC RESONANCE ANGIOGRAPHY; MALE; RATS;

EID: 84870604752     PISSN: 0271678X     EISSN: 15597016     Source Type: Journal    
DOI: 10.1038/jcbfm.2012.121     Document Type: Article

References (40)

1. Kirton A, deVeber G. Advances in perinatal ischemic stroke. Pediatr Neurol 2009; 40: 205-214.
2. del Zoppo GJ, Sharp FR, Heiss WD, Albers GW. Heterogeneity in the penumbra. J Cereb Blood Flow Metab 2011; 31: 1836-1851.
3. Northington FJ, Zelaya ME, O'Riordan DP, Blomgren K, Flock DL, Hagberg H et al. Failure to complete apoptosis following neonatal hypoxia-ischemia manifests as 'continuum' phenotype of cell death and occurs with multiple manifestations of mitochondrial dysfunction in rodent forebrain. Neuroscience 2007; 149: 822-833.
4. Stone BS, Zhang J, Mack DW, Mori S, Martin LJ, Northington FJ. Delayed neural network degeneration after neonatal hypoxia-ischemia. Ann Neurol 2008; 64: 535-546.
5. Dzietko M, Wendland M, Derugin N, Ferriero DM, Vexler ZS. Magnetic resonance imaging (MRI) as a translational tool for the study of neonatal stroke. J Child Neurol 2011; 26: 1145-1153.
6. Schiemanck SK, Kwakkel G, Post MW, Prevo AJ. Predictive value of ischemic lesion volume assessed with magnetic resonance imaging for neurological deficits and functional outcome poststroke: a critical review of the literature. Neurorehabil Neural Repair 2006; 20: 492-502.
7. Kranz PG, Eastwood JD. Does diffusion-weighted imaging represent the ischemic core? An evidence-based systematic review. AJNR Am J Neuroradiol 2009; 30: 1206-1212.
8. Lo EH. A new penumbra: transitioning from injury into repair after stroke. Nat Med 2008; 14: 497-500.
9. Popp A, Jaenisch N, Witte OW, Frahm C. Identification of ischemic regions in a rat model of stroke. PLoS ONE 2009; 4: e4764.
10. Zhan X, Kim C, Sharp FR. Very brief focal ischemia simulating transient ischemic attacks (TIAs) can injure brain and induce Hsp70 protein. Brain Res 2008; 1234: 183-197.
11. Schlaug G, Benfield A, Baird AE, Siewert B, Lovblad KO, Parker RA et al. The ischemic penumbra: operationally defined by diffusion and perfusion MRI. Neurology 1999; 53: 1528-1537.
12. Straka M, Albers GW, Bammer R. Real-time diffusion-perfusion mismatch analysis in acute stroke. J Magn Reson Imaging 2010; 32: 1024-1037.
13. Wardlaw JM. Neuroimaging in acute ischaemic stroke: insights into unanswered questions of pathophysiology. J Intern Med 2010; 267: 172-190.
14. Ma H, Zavala JA, Teoh H, Churilov L, Gunawan M, Ly J et al. Penumbral mismatch is underestimated using standard volumetric methods and this is exacerbated with time. J Neurol Neurosurg Psychiatry 2009; 80: 991-996.
15. Ghosh N, Recker R, Shah A, Bhanu B, Ashwal S, Obenaus A. Automated ischemic lesion detection in a neonatal model of hypoxic ischemic injury. J Magn Reson Imaging 2011; 33: 772-781.
16. Thomalla GJ, Kucinski T, Schoder V, Fiehler J, Knab R, Zeumer H et al. Prediction of malignant middle cerebral artery infarction by early perfusion-and diffusionweighted magnetic resonance imaging. Stroke 2003; 34: 1892-1899.
17. Na DG, Thijs VN, Albers GW, Moseley ME, Marks MP, Diffusion-weighted MR. imaging in acute ischemia: value of apparent diffusion coefficient and signal intensity thresholds in predicting tissue at risk and final infarct size. AJNR Am J Neuroradiol 2004; 25: 1331-1336.
18. Guadagno JV, Jones PS, Fryer TD, Barret O, Aigbirhio FI, Carpenter TA et al. Local relationships between restricted water diffusion and oxygen consumption in the ischemic human brain. Stroke 2006; 37: 1741-1748.
19. Jacobs MA, Knight RA, Soltanian-Zadeh H, Zheng ZG, Goussev AV, Peck DJ et al. Unsupervised segmentation of multiparameter MRI in experimental cerebral ischemia with comparison to T2, diffusion, and ADC MRI parameters and histopathological validation. J Magn Reson Imaging 2000; 11: 425-437.
20. Ashwal S, Tone B, Tian HR, Chong S, Obenaus A. Comparison of two neonatal ischemic injury models using magnetic resonance imaging. PediatrRes 2007; 61: 9-14.
21. Recker R, Adami A, Tone B, Tian HR, Lalas S, Hartman RE et al. Rodent neonatal bilateral carotid artery occlusion with hypoxia mimics human hypoxic-ischemic injury. J Cereb Blood Flow Metab 2009; 29: 1305-1316.
22. Coats JS, Freeberg A, Pajela EG, Obenaus A, Ashwal S. Meta-analysis of apparent diffusion coefficients in the newborn brain. Pediatr Neurol 2009; 41: 263-274.
23. Obenaus A, Ashwal S. Magnetic resonance imaging in cerebral ischemia: focus on neonates. Neuropharmacology 2008; 55: 271-280.
24. Wintermark P, Moessinger AC, Gudinchet F, Meuli R. Temporal evolution of MR perfusion in neonatal hypoxic-ischemic encephalopathy. J Magn Reson Imaging 2008; 27: 1229-1234.
25. Obenaus A, Dilmac N, Tone B, Tian HR, Hartman R, Digicaylioglu M et al. Longterm magnetic resonance imaging of stem cells in neonatal ischemic injury. Ann Neurol 2011; 69: 1531-8249.
26. Folkerth RD. The neuropathology of acquired pre-and perinatal brain injuries. Semin Diagn Pathol 2007; 24: 48-57.
27. Badaut J, Ashwal S, Obenaus A. Aquaporins in cerebrovascular disease: a target for treatment of brain edema? Cerebrovasc Dis 2011; 31: 521-531.
28. Farr TD, Wegener S. Use of magnetic resonance imaging to predict outcome after stroke: a review of experimental and clinical evidence. J Cereb Blood Flow Metab 2010; 30: 703-717.
29. Lefkowitz D, LaBenz M, Nudo SR, Steg RE, Bertoni JM. Hyperacute ischemic stroke missed by diffusion-weighted imaging. AJNR Am J Neuroradiol 1999; 20: 1871-1875.
30. Wang PY, Barker PB, Wityk RJ, Ulug AM, van Zijl PC, Beauchamp Jr. NJ . Diffusionnegative stroke: a report of two cases. AJNR Am J Neuroradiol 1999; 20: 1876-1880.
31. Rother J, Schellinger PD, Gass A, Siebler M, Villringer A, Fiebach JB et al. Effect of intravenous thrombolysis on MRI parameters and functional outcome in acute stroke o6 hours. Stroke 2002; 33: 2438-2445.
32. Rosso C, Hevia-Montiel N, Deltour S, Bardinet E, Dormont D, Crozier S et al. Prediction of infarct growth based on apparent diffusion coefficients: penumbral assessment without intravenous contrast material. Radiology 2009; 250: 184-192.
33. Barrett KM, Ding YH, Wagner DP, Kallmes DF, Johnston KC. Change in diffusionweighted imaging infarct volume predicts neurologic outcome at 90 days: results of the Acute Stroke Accurate Prediction (ASAP) trial serial imaging substudy. Stroke 2009; 40: 2422-2427.
34. Hand PJ, Wardlaw JM, Rivers CS, Armitage PA, Bastin ME, Lindley RI et al. MR diffusion-weighted imaging and outcome prediction after ischemic stroke. Neurology 2006; 66: 1159-1163.
35. Olivot JM, Albers GW. Diffusion-perfusion MRI for triaging transient ischemic attack and acute cerebrovascular syndromes. Curr Opin Neurol 2011; 24: 44-49.
36. Shih LC, Saver JL, Alger JR, Starkman S, Leary MC, Vinuela F et al. Perfusionweighted magnetic resonance imaging thresholds identifying core, irreversibly infarcted tissue. Stroke 2003; 34: 1425-1430.
37. Wechsler LR. Imaging evaluation of acute ischemic stroke. Stroke 2011; 42: S12-15.
38. Wintermark P, Hansen A, Gregas MC, Soul J, Labrecque M, Robertson RL et al. Brain perfusion in asphyxiated newborns treated with therapeutic hypothermia. AJNR Am J Neuroradiol 2011; 32: 2023-2029.
39. Bang OY, Liebeskind DS, Saver JL, Kim GM, Chung CS, Lee KH. Stunned brain syndrome: serial diffusion perfusion MRI of delayed recovery following revascularization for acute ischaemic stroke. J Neurol Neurosurg Psychiatry 2011; 82: 27-32.
40. Kim JH, Bang OY, Liebeskind DS, Ovbiagele B, Kim GM, Chung CS et al. Impact of baseline tissue status (diffusion-weighted imaging lesion) versus perfusion status (severity of hypoperfusion) on hemorrhagic transformation. Stroke 2010; 41: e135-142.