Penumbral mismatch is underestimated using standard volumetric methods and this is exacerbated with time

Journal of Neurology, Neurosurgery and Psychiatry

Volumn 80, Issue 9, 2009, Pages 991-996

  Ma, H ^a   Zavala, J A ^a   Teoh, H ^a   Churilov, L ^a   Gunawan, M ^a   Ly, J ^a   Wright, P ^a   Phan, T ^a   Arakawa, S ^a   Davis, S M ^b   Donnan, G A ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b ROYAL MELBOURNE HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ACCURACY; ACUTE BRAIN DISEASE; ADULT; AGED; ARTICLE; BRAIN INFARCTION SIZE; BRAIN SIZE; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; DIFFUSION WEIGHTED IMAGING; FEMALE; HUMAN; INTERMETHOD COMPARISON; MAJOR CLINICAL STUDY; MALE; MEASUREMENT ERROR; PATIENT SELECTION; PERFUSION WEIGHTED IMAGING; PRIORITY JOURNAL; BRAIN ISCHEMIA; COHORT ANALYSIS; COMPARATIVE STUDY; IMAGE PROCESSING; MIDDLE AGED; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOLOGY; PROSPECTIVE STUDY; STROKE;

ADULT; AGED; AGED, 80 AND OVER; BRAIN ISCHEMIA; COHORT STUDIES; DIFFUSION MAGNETIC RESONANCE IMAGING; FEMALE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; STROKE; YOUNG ADULT;

EID: 69449106001     PISSN: 00223050     EISSN: 1468330X     Source Type: Journal    
DOI: 10.1136/jnnp.2008.164947     Document Type: Article

References (26)

1. Symon L, Pasztor E, Branston NM. The distribution and density of reduced cerebral blood flow following acute middle cerebral artery occlusion: an experimental study by the technique of hydrogen clearance in baboons. Stroke 1974;5:355-364
2. Symon L. The ischemic penumbra-the beginning. In: Donnan GA, Baron JC, Davis SM, et al, eds. The ischemic penumbra. USA: Informa Healthcare, 2007:1-6.
3. Butcher KS, Parsons M, MacGregor L, et al. Refining the perfusion-diffusion mismatch hypothesis. Stroke 2005;36:1153-1159
4. Schlaug G, Benfield A, Baird AE, et al. The ischemic penumbra: operationally defined by diffusion and perfusion MRI. Neurology 1999;53:1528-1537 (Pubitemid 29491949)
5. Lovblad KO, Baird AE, Schlaug G, et al. Ischemic lesion volumes in acute stroke by diffusion-weighted magnetic resonance imaging correlate with clinical outcome. Ann Neurol 1997;42:164-170 (Pubitemid 27340460)
6. Kidwell CS, Saver JL, Mattiello J, et al. Thrombolytic reversal of acute human cerebral ischemic injury shown by diffusion/perfusion magnetic resonance imaging. Ann Neurol 2000;47:462-469 (Pubitemid 30194602)
7. Koga M, Reutens DC, Wright P, et al. The existence and evolution of diffusion- perfusion mismatched tissue in white and gray matter after acute stroke. Stroke 2005;36:2132-2137 (Pubitemid 41429233)
8. Heiss W-D, Sobesky J, Smekal Uv, et al. Probability of cortical infarction predicted by flumazenil binding and diffusion-weighted imaging signal intensity: a comparative positron emission tomography/magnetic resonance imaging study in early ischemic stroke. Stroke 2004;35:1892-1898 (Pubitemid 38971871)
9. Ostergaard L, Sorensen AG, Kwong KK, et al. High resolution measurement of cerebral blood flow using intravascular tracer bolus passages. Part II: Experimental comparison and preliminary results. Magn Reson Med 1996;36:726-736
10. Ostergaard L, Weisskoff RM, Chesler DA, et al. High resolution measurement of cerebral blood flow using intravascular tracer bolus passages. Part I: Mathematical approach and statistical analysis. Magn Reson Med 1996;36:715-725
11. Butcher KS, Parsons M, MacGregor L, et al. Refining the perfusion-diffusion mismatch hypothesis. Stroke 2005;36:1153-1159
12. Altman DG. Practical statistics for medical research. London: Chapman and Hall/CRC, 1999.
13. Lin LI. A concordance correlation coefficient to evaluate reproducibility. Biometrics 1989;45:255-268
14. Sokal R, Rohlf F. Biometry, 2nd Edn. New York: WH Freeman, 1981.
15. Baird AE, Benfield A, Schlaug G, et al. Enlargement of human cerebral ischemic lesion volumes measured by diffusion-weighted magnetic resonance imaging. Ann Neurol 1997;41:581-589 (Pubitemid 27212651)
16. Olsen TS, Larsen B, Herning M, et al. Blood flow and vascular reactivity in collaterally perfused brain tissue. Evidence of an ischemic penumbra in patients with acute stroke. Stroke 1983;14:332-341
17. Bang OY, Saver JL, Buck BH, et al. Impact of collateral flow on tissue fate in acute ischaemic stroke. J Neurol Neurosurg Psychiatry 2008;79:625-629
18. Arakawa S, Wright PM, Koga M, et al. Ischemic thresholds for gray and white matter: a diffusion and perfusion magnetic resonance study. Stroke 2006;37:1211-1216 (Pubitemid 43731864)
19. Markus R, Donnan G, Kazui S, et al. Penumbral topography in human stroke: methodology and validation of the 'Penumbragram'. Neuroimage 2004;21: 1252-1259
20. Rivers CS, Wardlaw JM, Armitage PA, et al. Do acute diffusion- and perfusionweighted MRI lesions identify final infarct volume in ischemic stroke? Stroke 2006;37:98-104.
21. Kane I, Sandercock P, Wardlaw J. Magnetic resonance perfusion diffusion mismatch and thrombolysis in acute ischaemic stroke: a systematic review of the evidence to date. J Neurol Neurosurg Psychiatry 2007;78:485-491 (Pubitemid 46662896)
22. Hacke W, Albers G, Al-Rawi Y, et al. The Desmoteplase in Acute Ischemic Stroke Trial (DIAS): a phase II MRI-based 9-hour window acute stroke thrombolysis trial with intravenous desmoteplase. Stroke 2005;36:66-73. (Pubitemid 40054177)
23. Davis SM, Donnan GA, Parsons MW, et al. Effects of alteplase beyond 3 h after stroke in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET): a placebocontrolled randomised trial. Lancet Neurol 2008;7:299-309.
24. Kakuda W, Lansberg MG, Thijs VN, et al. Optimal definition for PWI/DWI mismatch in acute ischemic stroke patients. J Cereb Blood Flow Metab 2008;28:887-891 (Pubitemid 351589640)
25. California Acute Stroke Pilot Registry I. Prioritizing interventions to improve rates of thrombolysis for ischemic stroke. Neurology 2005;64:654-659
26. Heiss WD, Sobesky J, Smekal U, et al. Probability of cortical infarction predicted by flumazenil binding and diffusion-weighted imaging signal intensity: a comparative positron emission tomography/magnetic resonance imaging study in early ischemic stroke. Stroke 2004;35:1892-1898 (Pubitemid 38971871)