In vivo imaging of lipid storage and regression in diet-induced obesity during nutrition manipulation

American Journal of Physiology - Endocrinology and Metabolism

Volumn 303, Issue 11, 2012, Pages

  Bidar, Abdel Wahad ^a   Ploj, Karolina ^a   Lelliott, Christopher ^a   Nelander, Karin ^a   Winzell, Maria Sörhede ^a   Böttcher, Gerhard ^a   Oscarsson, Jan ^a   Storlien, Leonard ^b   Hockings, Paul D ^a  

^a ASTRAZENECA R AND D   (Sweden)

^b UNIVERSITY OF SYDNEY   (Australia)

Author keywords

3R's; Brown adipose tissue; Insulin resistance; Intra abdominal adipose tissue; Intrahepatocellular lipids; Magnetic resonance imaging and spectroscopy; Mice; Power calculation; Subcutaneous adipose tissue; White adipose tissue

Indexed keywords

GLUCOSE; INSULIN; INTRAHEPATOCELLULAR LIPID; LIPID; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPSY; BLOOD CHEMISTRY; BODY COMPOSITION; BODY FAT; BODY FAT DISTRIBUTION; BODY WEIGHT; BROWN ADIPOSE TISSUE; CHEMICAL ANALYSIS; CONTROLLED STUDY; DIETARY INTAKE; FAT CONTENT; FEMALE; GLUCOSE BLOOD LEVEL; HISTOPATHOLOGY; INSULIN BLOOD LEVEL; INTRAABDOMINAL FAT; LIPID BLOOD LEVEL; LIPID COMPOSITION; LIPID LIVER LEVEL; LIPID STORAGE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; OBESITY; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; SAMPLE SIZE; SUBCUTANEOUS FAT; THREE DIMENSIONAL IMAGING; WHITE ADIPOSE TISSUE; WHOLE BODY IMAGING;

ADIPOSE TISSUE; ANIMAL FEED; ANIMALS; BODY COMPOSITION; BODY FAT DISTRIBUTION; CROSS-SECTIONAL STUDIES; DISEASE MODELS, ANIMAL; ENERGY METABOLISM; FEMALE; IMAGING, THREE-DIMENSIONAL; INSULIN RESISTANCE; LIVER; LONGITUDINAL STUDIES; MAGNETIC RESONANCE IMAGING; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MICE, INBRED C57BL; OBESITY; PHENOTYPE; RANDOM ALLOCATION; TRIGLYCERIDES;

EID: 84870545737     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00274.2012     Document Type: Article

References (53)

1. Björntorp P. Obesity and adipose tissue distribution as risk factors for the development of disease. Infusionstherapie 17: 24-27, 1990.
2. Boden G, Shulman G. Free fatty acids in obesity and type 2 diabetes: defining their role in the development of insulin resistance and beta-cell dysfunction. Eur J Clin Invest 32: 14-23, 2002.
3. Bohlooly-YM, Olsson B, Bruder CEG, Lindén D, Sjögren K, Bjursell M, Egecioglu E, Svensson L, Brodin P, Waterton JC. Growth hormone overexpression in the central nervous system results in hyperphagiainduced obesity associated with insulin resistance and dyslipidemia. Diabetes 54: 51-62, 2005.
4. Buettner R, Scholmerich J, Bollheimer L. High-fat diets: modeling the metabolic disorders of human obesity in rodents. Obes Res 15: 798, 2007.
5. Carey DG, Cowin GJ, Galloway GJ, Jones NP, Richards JC, Biswas N, Doddrell DM. Effect of rosiglitazone on insulin sensitivity and body composition in type 2 diabetic patients [corrected]. [erratum appears in Obes Res 2002 Nov; 10(11): following table of contents]. Obes Res 10: 1008-1015, 2002.
6. Chan DC, Watts GF, Ng TWK, Hua J, Song S, Barrett PHR. Measurement of liver fat by magnetic resonance imaging: relationships with body fat distribution, insulin sensitivity and plasma lipids in healthy men. Diabetes Obes Metab 8: 698-702, 2006.
7. Chen YI, Cypess AM, Sass CA, Brownell A, Jokivarsi KT, Kahn CR, Kwong KK. Anatomical and functional assessment of brown adipose tissue by magnetic resonance imaging. Obesity 20: 1519-1526, 2012.
8. Chow SC, Shao J, Wang H. A note on sample size calculation for mean comparisons based on noncentral t-statistics. J Biopharm Stat 12: 441-456, 2002.
9. Cinti S. Adipocyte differentiation and transdifferentiation: plasticity of the adipose organ. J Endocrinol Invest 25: 823-835, 2002.
10. Cuchel M, Bloedon LAT, Szapary PO, Kolansky DM, Wolfe ML, Sarkis A, Millar JS, Ikewaki K, Siegelman ES, Gregg RE. Inhibition of microsomal triglyceride transfer protein in familial hypercholesterolemia. N Engl J Med 356: 148-156, 2007.
11. Cypess AM, Lehman S, Williams G, Tal I, Rodman D, Goldfine AB, Kuo FC, Palmer EL, Tseng YH, Doria A. Identification and importance of brown adipose tissue in adult humans. N Engl J Med 360: 1509-1517, 2009.
12. de Souza C, Eckhardt M, Gagen K, Dong M, Chen W, Laurent D, Burkey B. Effects of pioglitazone on adipose tissue remodeling within the setting of obesity and insulin resistance. Diabetes 50: 1863-1871, 2001.
13. Didier L, Yerby B, Deacon R, Gao J. Diet-induced modulation of mitochondrial activity in rat muscle. Am J Physiol Endocrinol Metab 293: E1169-E1177, 2007.
14. Festing M, Altman D. Guidelines for the design and statistical analysis of experiments using laboratory animals. ILAR J 43: 244-258, 2002.
15. Fissoune R, Pellet N, Chaabane L, Contard F, Guerrier D, Briguet A. Evaluation of adipose tissue distribution in obese fa/fa Zucker rats by in vivo MR imaging: effects of peroxisome proliferator-activated receptor agonists. MAGMA 17: 229-235, 2004.
16. Garbow JR, Lin X, Sakata N, Chen Z, Koh D, Schonfeld G. In vivo MRS measurement of liver lipid levels in mice. J Lipid Res 45: 1364-1371, 2004.
17. García M, Wernstedt I, Berndtsson A, Enge M, Bell M, Hultgren O, Horn M, Ahrén B, Enerback S, Ohlsson C. Mature-onset obesity in interleukin-1 receptor I knockout mice. Diabetes 55: 1205-1213, 2006.
18. Golan R, Shelef I, Rudich A, Gepner Y, Shemesh E, Chassidim Y, Harman-Boehm I, Henkin Y, Schwarzfuchs D, Avraham SB. Abdominal Superficial Subcutaneous Fat. Diabetes Care 35: 640-647, 2012.
19. Hu HH, Smith DL Jr, Nayak KS, Goran MI, Nagy TR. Identification of brown adipose tissue in mice with fat-water IDEAL-MRI. J Magn Reson Imaging 31: 1195-1202, 2010.
20. Hudson M. The welfare and scientific advantages of non-invasive imaging of animals used in biomedical research. Anim Welfare 14: 303-317, 2005.
21. Hwang JH, Stein DT, Barzilai N, Cui MH, Tonelli J, Kishore P, Hawkins M. Increased intrahepatic triglyceride is associated with peripheral insulin resistance: in vivo MR imaging and spectroscopy studies. Am J Physiol Endocrinol Metab 293: E1663-E1669, 2007.
22. Kelley DE. Skeletal muscle triglycerides: an aspect of regional adiposity and insulin resistance. Ann NY Acad Sci 967: 135-145, 2002.
23. Kelley DE, Goodpaster BH, Storlien L. Muscle triglyceride and insulin resistance. Annu Rev Nutr 22: 325-346, 2002.
24. Kershaw EE, Flier JS. Adipose tissue as an endocrine organ. J Clin Endocrinol Metab 89: 2548-2556, 2004.
25. Khanna A, Branca RT. Detecting brown adipose tissue activity with BOLD MRI in mice. Magn Reson Med (Jan 9, 2012). doi:10.1002/ mrm.24118.
26. Kolak M, Westerbacka J, Velagapudi VR, Wågsäter D, Yetukuri L, Makkonen J, Rissanen A, Häkkinen AM, Lindell M, Bergholm R, Hamsten A, Eriksson P, Fisher RM, Orešic M, Yki-Järvinen H. Adipose tissue inflammation and increased ceramide content characterize subjects with high liver fat content independent of obesity. Diabetes 56: 8: 1960-1968, 2007.
27. Korach-André M, Gao J, Gounarides JS, Deacon R, Islam A, Laurent D. Relationship between visceral adiposity and intramyocellular lipid content in two rat models of insulin resistance. Am J Physiol Endocrinol Metab 288: E106-E116, 2005.
28. Kotronen A, Vehkavaara S, Seppälä-Lindroos A, Bergholm R, Yki-Järvinen H. Effect of liver fat on insulin clearance. Am J Physiol Endocrinol Metab 293: E1709-E1715, 2007.
29. Larsson B, Svärdsudd K, Welin L, Wilhelmsen L, Björntorp P, Tibblin G. Abdominal adipose tissue distribution, obesity, and risk of cardiovascular disease and death: 13 year follow up of participants in the study of men born in 1913. Br Med J (Clin Res Ed) 288: 1401-1404, 1984.
30. Li H, Lelliott C, Håkansson P, Ploj K, Tuneld A, Verolin-Johansson M, Benthem L, Carlsson B, Storlien L, Michaëlsson E. Intestinal, adipose, and liver inflammation in diet-induced obese mice. Metabolism 57: 1704-1710, 2008.
31. Linder K, Arner P, Flores-Morales A, Tollet-Egnell P, Norstedt G. Differentially expressed genes in visceral or subcutaneous adipose tissue of obese men and women. J Lipid Res 45: 148-154, 2004.
32. Lumeng CN, Bodzin JL, Saltiel AR. Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest 117: 175-184, 2007.
33. Lunati E, Marzola P, Nicolato E, Fedrigo M, Villa M, Sbarbati A. In vivo quantitative lipidic map of brown adipose tissue by chemical shift imaging at 4.7 tesla J Lipid Res 40: 1395-1400, 1999.
34. Lunati E, Marzola P, Nicolato E, Sbarbati A. In-vivo quantitative hydrolipidic map of perirenal adipose tissue by chemical shift imaging at 4.7 Tesla. Int J Obes Relat Metab Disord 25: 457-461, 2001.
35. Machann J, Thamer C, Schnoedt B, Haap M, Haring HU, Claussen CD, Stumvoll M, Fritsche A, Schick F. Standardized assessment of whole body adipose tissue topography by MRI. J Magn Reson Imaging 21: 455-462, 2005.
36. Mather K. Surrogate measures of insulin resistance: of rats, mice, and men. Am J Physiol Endocrinol Metab 296: E398-E399, 2009.
37. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28: 412-419, 1985.
38. Osculati F, Leclercq F, Sbarbati A, Zancanaro C, Cinti S, Antonakis K. Morphological identification of brown adipose tissue by magnetic resonance imaging in the rat. Eur J Radiol 9: 112-114, 1989.
39. Pietilainen KH, Rissanen A, Kaprio J, Makimattila S, Hakkinen AM, Westerbacka J, Sutinen J, Vehkavaara S, Yki-Järvinen H. Acquired obesity is associated with increased liver fat, intra-abdominal fat, and insulin resistance in young adult monozygotic twins. Am J Physiol Endocrinol Metab 288: E768-E774, 2005.
40. Ranefall P, Bidar AW, Hockings PD. Automatic segmentation of intraabdominal and subcutaneous adipose tissue in 3D whole mouse MRI. J Magn Reson Imaging 30: 554-560, 2009.
41. Ravinet Trillou C, Arnone M, Delgorge C, Gonalons N, Keane P, Maffrand JP, Soubrié P. Anti-obesity effect of SR141716, a CB1 receptor antagonist, in diet-induced obese mice. Am J Physiol Regul Integr Comp Physiol 284: R345-R353, 2003.
42. Ruder TD, Hatch GM, Siegenthaler L, Ampanozi G, Mathier S, Thali MJ, Weber OM. The influence of body temperature on image contrast in post mortem MRI. Eur. J Radiol 81: 1366-1370, 2012.
43. Russell WMS, Burch RL. The Principles of Humane Experimental Technique. London: Methuen, 1959, p. 238.
44. Ryysy L, Hakkinen AM, Goto T, Vehkavaara S, Westerbacka J, Halavaara J, Yki-Jarvinen H. Hepatic fat content and insulin action on free fatty acids and glucose metabolism rather than insulin absorption are associated with insulin requirements during insulin therapy in type 2 diabetic patients. Diabetes 49: 749-758, 2000.
45. Seppala-Lindroos A, Vehkavaara S, Hakkinen AM, Goto T, Westerbacka J, Sovijarvi A, Halavaara J, Yki-Jarvinen H. Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men. J Clin Endocrinol Metab 87: 3023-3028, 2002.
46. Shen W, Wang Z, Punyanita M, Lei J, Sinav A, Kral JG, Imielinska C, Ross R, Heymsfield SB. Adipose tissue quantification by imaging methods: a proposed classification. Obes Res 11: 5-16, 2003.
47. Slocum N, Durrant JR, Bailey D, Yoon L, Jordan H, Barton J, Brown RH, Clifton L, Milliken T, Harrington W, Kimbrough C, Faber CA, Cariello N, Elangbam CS. Responses of brown adipose tissue to dietinduced obesity, exercise, dietary restriction and ephedrine treatment. Exp Toxicol Pathol (2012). doi:10.1016/j.etp.2012.04.001.
48. Szczepaniak LS, Babcock EE, Schick F, Dobbins RL, Garg A, Burns DK, McGarry JD, Stein DT. Measurement of intracellular triglyceride stores by H spectroscopy: validation in vivo. Am J Physiol Endocrinol Metab 276: E977-E989, 1999.
49. Trouard TP, Altbach MI, Hunter GC, Eskelson CD, Gmitro AF. MRI and NMR spectroscopy of the lipids of atherosclerotic plaque in rabbits and humans. Magn Reson Med 38: 19-26, 1997.
50. van Marken Lichtenbelt WD, Vanhommerig JW, Smulders NM, Drossaerts JM, Kemerink GJ, Bouvy ND, Schrauwen P, Teule GJ. Cold-activated brown adipose tissue in healthy men. N Engl J Med 360: 1500-1508, 2009.
51. Verty ANA, Lockie SH, Stefanidis A, Oldfield BJ. Anti-obesity effects of the combined administration of CB1 receptor antagonist rimonabant and melanin-concentrating hormone antagonist SNAP-94847 in diet-inudced obese mice. Int J Obes (April 3, 2012). doi:10.1038/ijo.2012.35.
52. Virtanen KA, Lidell ME, Orava J, Heglind M, Westergren R, Niemi T, Taittonen M, Laine J, Savisto NJ, Enerbäck S, Nuutila P. Functional brown adipose tissue in healthy adults. N Engl J Med 360: 1518-1525, 2009.
53. Zancanaro C, Nano R, Marchioro C, Sbarbati A, Boicelli A, Osculati F. Magnetic resonance spectroscopy investigations of brown adipose tissue and isolated brown adipocytes. J Lipid Res 35: 2191-2199, 1994.