Recent advances in the imaging of frontotemporal dementia

Current Neurology and Neuroscience Reports

Volumn 12, Issue 6, 2012, Pages 715-723

  Whitwell, Jennifer L ^a   Josephs, Keith A ^a  

^a MAYO CLINIC   (United States)

Author keywords

Agrammatic; Apraxia of speech; Atrophy; Behavioral variant frontotemporal dementia; C9orf72 hexanucleotide repeat; Diffusion tensor imaging; Functional connectivity; Fused in sarcoma; Magnetic resonance imaging; Progranulin; Resting state functional magnetic resonance imaging; Semantic dementia; Tau; Transactivation response element DNA binding protein of 43 kDa; White matter tracts

Indexed keywords

ARTICLE; AUTOSOMAL DOMINANT INHERITANCE; BRAIN ATROPHY; BRAIN FUNCTION; DEGENERATIVE DISEASE; DIFFERENTIAL DIAGNOSIS; DIFFUSION TENSOR IMAGING; DISEASE CLASSIFICATION; FRONTAL VARIANT FRONTOTEMPORAL DEMENTIA; FRONTOTEMPORAL DEMENTIA; FUNCTIONAL MAGNETIC RESONANCE IMAGING; GENE MUTATION; GENETIC ASSOCIATION; HUMAN; IMAGE ANALYSIS; MOLECULAR PATHOLOGY; NERVE CELL NETWORK; NEUROANATOMY; NEUROIMAGING; POSITRON EMISSION TOMOGRAPHY; PROGRESSIVE NONFLUENT APHASIA; SEMANTIC DEMENTIA;

BRAIN; FRONTOTEMPORAL DEMENTIA; HUMANS; NEUROIMAGING;

EID: 84870535861     PISSN: 15284042     EISSN: 15346293     Source Type: Journal    
DOI: 10.1007/s11910-012-0317-0     Document Type: Article

References (101)

1. Neary D, Snowden JS, Gustafson L, et al. Frontotemporal lobar degeneration: a consensus on clinical diagnostic criteria. Neurology. 1998;51:1546-54.
2. Rosen HJ, Gorno-Tempini ML, Goldman WP, et al. Patterns of brain atrophy in frontotemporal dementia and semantic dementia. Neurology. 2002;58:198-208.
3. Frings L, Mader I, Landwehrmeyer BG, Weiller C, Hull M, Huppertz HJ. Quantifying change in individual subjects affected by frontotemporal lobar degeneration using automated longitudinal MRI volumetry. Hum Brain Mapp. 2012;33:1526-35.
4. Krueger CE, Dean DL, Rosen HJ, et al. Longitudinal rates of lobar atrophy in frontotemporal dementia, semantic dementia, and Alzheimer's disease. Alzheimer Dis Assoc Disord. 2010;24:43-8.
5. Brambati SM, Renda NC, Rankin KP, et al. A tensor based morphometry study of longitudinal gray matter contraction in FTD. NeuroImage. 2007;35:998-1003.
6. Agosta F, Scola E, Canu E, et al. White matter damage in frontotemporal lobar degeneration Spectrum. Cereb Cortex. 2011.
7. Whitwell JL, Avula R, Senjem ML, et al. Gray and white matter water diffusion in the syndromic variants of frontotemporal dementia. Neurology. 2010;74:1279-87.
8. Zhang Y, Schuff N, Du AT, et al. White matter damage in frontotemporal dementia and Alzheimer's disease measured by diffusion MRI. Brain. 2009;132:2579-92.
9. Whitwell JL, Josephs KA, Avula R, et al. Altered functional connectivity in asymptomatic MAPT subjects: a comparison to bvFTD. Neurology. 2011;77:866-74.
10. Zhou J, Greicius MD, Gennatas ED, et al. Divergent network connectivity changes in behavioural variant frontotemporal dementia and Alzheimer's disease. Brain. 2010;133:1352-67.
11. Whitwell JL, Przybelski SA, Weigand SD, et al. Distinct anatomical subtypes of the behavioural variant of frontotemporal dementia: a cluster analysis study. Brain. 2009;132:2932-46.
12. Josephs Jr KA, Whitwell JL, Weigand SD, et al. Predicting functional decline in behavioural variant frontotemporal dementia. Brain. 2011;134:432-48.
13. Josephs KA, Whitwell JL, Knopman DS, et al. Two distinct subtypes of right temporal variant frontotemporal dementia. Neurology. 2009;73:1443-50.
14. Whitwell JL, Xu J, Mandrekar J, et al. Frontal asymmetry in behavioral variant frontotemporal dementia: clinicoimaging and pathogenetic correlates. Neurobiol Aging. 2012.
15. Boccardi M, Laakso MP, Bresciani L, Geroldi C, Beltramello A, Frisoni GB. Clinical characteristics of frontotemporal patients with symmetric brain atrophy. Eur Arch Psychiatry Clin Neurosci. 2002;252:235-9.
16. Davies RR, Kipps CM, Mitchell J, Kril JJ, Halliday GM, Hodges Jr. Progression in frontotemporal dementia: identifying a benign behavioral variant by magnetic resonance imaging. Arch Neurol. 2006;63:1627-31.
17. Kipps CM, Davies RR, Mitchell J, Kril JJ, Halliday GM, Hodges Jr. Clinical significance of lobar atrophy in frontotemporal dementia: application of an MRI visual rating scale. Dement Geriatr Cogn Disord. 2007;23:334-42.
18. Kipps CM, Hodges JR, Fryer TD, Nestor PJ. Combined magnetic resonance imaging and positron emission tomography brain imaging in behavioural variant frontotemporal degeneration: refining the clinical phenotype. Brain. 2009;132:2566-78.
19. Josephs KA, Whitwell JL, Jack CR, Parisi JE, Dickson DW. Frontotemporal lobar degeneration without lobar atrophy. Arch Neurol. 2006;63:1632-8.
20. Rosen HJ, Allison SC, Schauer GF, Gorno-Tempini ML, Weiner MW, Miller BL. Neuroanatomical correlates of behavioural disorders in dementia. Brain. 2005;128:2612-25.
21. Peters F, Perani D, Herholz K, et al. Orbitofrontal dysfunction related to both apathy and disinhibition in frontotemporal dementia. Dement Geriatr Cogn Disord. 2006;21:373-9.
22. Hornberger M, Geng J, Hodges Jr. Convergent grey and white matter evidence of orbitofrontal cortex changes related to disinhibition in behavioural variant frontotemporal dementia. Brain. 2011;134:2502-12.
23. Krueger CE, Laluz V, Rosen HJ, Neuhaus JM, Miller BL, Kramer JH. Double dissociation in the anatomy of socioemotional disinhibition and executive functioning in dementia. Neuropsychology. 2011;25:249-59.
24. Massimo L, Powers C, Moore P, et al. Neuroanatomy of apathy and disinhibition in frontotemporal lobar degeneration. Dement Geriatr Cogn Disord. 2009;27:96-104.
25. Schroeter ML, Vogt B, Frisch S, et al. Dissociating behavioral disorders in early dementia-An FDG-PET study. Psychiatry Res. 2011;194:235-44.
26. Zamboni G, Huey ED, Krueger F, Nichelli PF, Grafman J. Apathy and disinhibition in frontotemporal dementia: Insights into their neural correlates. Neurology. 2008;71:736-42.
27. Eslinger PJ, Moore P, Antani S, Anderson C, Grossman M. Apathy in frontotemporal dementia: behavioral and neuroimaging correlates. Behav Neurol. 2012;25:127-36.
28. Whitwell JL, Sampson EL, Loy CT, et al. VBM signatures of abnormal eating behaviours in frontotemporal lobar degeneration. NeuroImage. 2007;35:207-13.
29. Woolley JD, Gorno-Tempini ML, Seeley WW, et al. Binge eating is associated with right orbitofrontal-insular-striatal atrophy in frontotemporal dementia. Neurology. 2007;69:1424-33.
30. Piguet O, Petersen A, Yin Ka Lam B, et al. Eating and hypothalamus changes in behavioral-variant frontotemporal dementia. Ann Neurol. 2011;69:312-9.
31. Perry DC, Whitwell JL, Boeve BF, et al. Voxel-based morphometry in patients with obsessive-compulsive behaviors in behavioral variant frontotemporal dementia. Eur J Neurol. 2012;19:911-7.
32. Strenziok M, Pulaski S, Krueger F, Zamboni G, Clawson D, Grafman J. Regional brain atrophy and impaired decision making on the balloon analog risk task in behavioral variant frontotemporal dementia. Cogn Behav Neurol. 2011;24:59-67.
33. Eslinger PJ, Moore P, Anderson C, Grossman M. Social cognition, executive functioning, and neuroimaging correlates of empathic deficits in frontotemporal dementia. J Neuropsychiatry Clin Neurosci. 2011;23:74-82.
34. Pennington C, Hodges JR, Hornberger M. Neural correlates of episodic memory in behavioral variant frontotemporal dementia. J Alzheimers Dis. 2011;24:261-8.
35. Josephs KA, Whitwell JL, Jack Jr CR. Anatomic correlates of stereotypies in frontotemporal lobar degeneration. Neurobiol Aging. 2008;29:1859-63.
36. Gorno-Tempini ML, Hillis AE, Weintraub S, et al. Classification of primary progressive aphasia and its variants. Neurology. 2011;76:1006-14.
37. Gorno-Tempini ML, Dronkers NF, Rankin KP, et al. Cognition and anatomy in three variants of primary progressive aphasia. Ann Neurol. 2004;55:335-46.
38. Rabinovici GD, Jagust WJ, Furst AJ, et al. Abeta amyloid and glucose metabolism in three variants of primary progressive aphasia. Ann Neurol. 2008;64:388-401.
39. Chan D, Fox NC, Scahill RI, et al. Patterns of temporal lobe atrophy in semantic dementia and Alzheimer's disease. Ann Neurol. 2001;49:433-42.
40. Diehl J, Grimmer T, Drzezga A, Riemenschneider M, Forstl H, Kurz A. Cerebral metabolic patterns at early stages of frontotemporal dementia and semantic dementia. A PET study. Neurobiol Aging. 2004;25:1051-6.
41. Galton CJ, Patterson K, Graham K, et al. Differing patterns of temporal atrophy in Alzheimer's disease and semantic dementia. Neurology. 2001;57:216-25.
42. Mummery CJ, Patterson K, Price CJ, Ashburner J, Frackowiak RS, Hodges Jr. A voxel-based morphometry study of semantic dementia: relationship between temporal lobe atrophy and semantic memory. Ann Neurol. 2000;47:36-45.
43. Rohrer JD, Clarkson MJ, Kittus R, et al. Rates of hemispheric and lobar atrophy in the language variants of frontotemporal lobar degeneration. J Alzheimers Dis. 2012;30:407-11.
44. Whitwell JL, Anderson VM, Scahill RI, Rossor MN, Fox NC. Longitudinal patterns of regional change on volumetric MRI in frontotemporal lobar degeneration. Dement Geriatr Cogn Disord. 2004;17:307-10.
45. Brambati SM, Rankin KP, Narvid J, et al. Atrophy progression in semantic dementia with asymmetric temporal involvement: a tensor-based morphometry study. Neurobiol Aging. 2009;30:103-11.
46. Rohrer JD, McNaught E, Foster J, et al. Tracking progression in frontotemporal lobar degeneration: serial MRI in semantic dementia. Neurology. 2008;71:1445-51.
47. Chan D, Anderson V, Pijnenburg Y, et al. The clinical profile of right temporal lobe atrophy. Brain. 2009;132:1287-98.
48. Thompson SA, Patterson K, Hodges Jr. Left/right asymmetry of atrophy in semantic dementia: behavioral-cognitive implications. Neurology. 2003;61:1196-203.
49. Edwards-Lee T, Miller BL, Benson DF, et al. The temporal variant of frontotemporal dementia. Brain. 1997;120(Pt 6):1027-40.
50. Mion M, Patterson K, Acosta-Cabronero J, et al. What the left and right anterior fusiform gyri tell us about semantic memory. Brain. 2010;133:3256-68.
51. Binney RJ, Embleton KV, Jefferies E, Parker GJ, Ralph MA. The ventral and inferolateral aspects of the anterior temporal lobe are crucial in semantic memory: evidence from a novel direct comparison of distortion-corrected fMRI, rTMS, and semantic dementia. Cereb Cortex. 2010;20:2728-38.
52. Josephs KA, Whitwell JL, Vemuri P, et al. The anatomic correlate of prosopagnosia in semantic dementia. Neurology. 2008;71:1628-33.
53. Omar R, Rohrer JD, Hailstone JC, Warren JD. Structural neuroanatomy of face processing in frontotemporal lobar degeneration. J Neurol Neurosurg Psychiatry. 2011;82:1341-3.
54. Hsieh S, Hornberger M, Piguet O, Hodges Jr. Neural basis of music knowledge: evidence from the dementias. Brain. 2011;134:2523-34.
55. Johnson JK, Chang CC, Brambati SM, et al. Music recognition in frontotemporal lobar degeneration and Alzheimer disease. Cogn Behav Neurol. 2011;24:74-84.
56. Acosta-Cabronero J, Patterson K, Fryer TD, et al. Atrophy, hypometabolism and white matter abnormalities in semantic dementia tell a coherent story. Brain. 2012;134:2025-35.
57. Agosta F, Henry RG, Migliaccio R, et al. Language networks in semantic dementia. Brain. 2010;133:286-99.
58. Schwindt GC, Graham NL, Rochon E, et al. Whole-brain white matter disruption in semantic and nonfluent variants of primary progressive aphasia. Hum Brain Mapp. 2011.
59. Galantucci S, Tartaglia MC, Wilson SM, et al. White matter damage in primary progressive aphasias: a diffusion tensor tractography study. Brain. 2011;134:3011-29.
60. Josephs KA, Duffy JR, Fossett TR, et al. Fluorodeoxyglucose F18 positron emission tomography in progressive apraxia of speech and primary progressive aphasia variants. Arch Neurol. 2010;67:596-605.
61. Josephs KA, Duffy JR, Strand EA, et al. Clinicopathological and imaging correlates of progressive aphasia and apraxia of speech. Brain. 2006;129:1385-98.
62. Nestor PJ, Graham NL, Fryer TD, Williams GB, Patterson K, Hodges Jr. Progressive non-fluent aphasia is associated with hypometabolism centred on the left anterior insula. Brain. 2003;126:2406-18.
63. Grossman M, McMillan C, Moore P, et al. What's in a name: voxel-based morphometric analyses of MRI and naming difficulty in Alzheimer's disease, frontotemporal dementia and corticobasal degeneration. Brain. 2004;127:628-49.
64. Rohrer JD, Warren JD, Modat M, et al. Patterns of cortical thinning in the language variants of frontotemporal lobar degeneration. Neurology. 2009;72:1562-9.
65. Garibotto V, Borroni B, Agosti C, et al. Subcortical and deep cortical atrophy in Frontotemporal Lobar Degeneration. Neurobiol Aging. 2011;32:875-84.
66. Rohrer JD, Rossor MN, Warren JD. Syndromes of nonfluent primary progressive aphasia: a clinical and neurolinguistic analysis. Neurology. 2010;75:603-10.
67. Josephs KA, Duffy JR, Strand EA, et al. Characterizing a neurodegenerative syndrome: primary progressive apraxia of speech. Brain. 2012;135:1522-36.
68. Amici S, Ogar J, Brambati SM, et al. Performance in specific language tasks correlates with regional volume changes in progressive aphasia. Cogn Behav Neurol. 2007;20:203-11.
69. DeJesus-Hernandez M, Mackenzie IR, Boeve BF, et al. Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS. Neuron. 2011;72:245-56.
70. Renton AE, Majounie E, Waite A, et al. A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD. Neuron. 2011;72:257-68.
71. Boeve BF, Boylan KB, Graff-Radford NR, et al. Characterization of frontotemporal dementia and/or amyotrophic lateral sclerosis associated with the GGGGCC repeat expansion in C9ORF72. Brain. 2012;135:765-83.
72. Kelley BJ, Haidar W, Boeve BF, et al. Prominent phenotypic variability associated with mutations in progranulin. Neurobiol Aging. 2009;30:739-51.
73. Whitwell JL, Jack Jr CR, Boeve BF, et al. Voxel-based morphometry patterns of atrophy in FTLD with mutations in MAPT or PGRN. Neurology. 2009;72:813-20.
74. Rohrer JD, Ridgway GR, Modat M, et al. Distinct profiles of brain atrophy in frontotemporal lobar degeneration caused by progranulin and tau mutations. NeuroImage. 2010;53:1070-6.
75. Spina S, Farlow MR, Unverzagt FW, et al. The tauopathy associated with mutation +3 in intron 10 of Tau: characterization of the MSTD family. Brain. 2008;131:72-89.
76. Whitwell JL, Jack Jr CR, Boeve BF, et al. Atrophy patterns in IVS10+16, IVS10+3, N279K, S305N, P301L, and V337M MAPT mutations. Neurology. 2009;73:1058-65.
77. Beck J, Rohrer JD, Campbell T, et al. A distinct clinical, neuropsychological and radiological phenotype is associated with progranulin gene mutations in a large UK series. Brain. 2008;131:706-20.
78. Boxer AL, Mackenzie IR, Boeve BF, et al. Clinical, neuroimaging and neuropathological features of a new chromosome 9p-linked FTD-ALS family. J Neurol Neurosurg Psychiatry. 2011;82:196-203.
79. Mahoney CJ, Beck J, Rohrer JD, et al. Frontotemporal dementia with the C9ORF72 hexanucleotide repeat expansion: clinical, neuroanatomical and neuropathological features. Brain. 2012;135:736-50.
80. Whitwell JL, Weigand SD, Boeve BF, et al. Neuroimaging signatures of frontotemporal dementia genetics: C9ORF72, tau, progranulin and sporadics. Brain. 2012;135:794-806.
81. Murray ME, DeJesus-Hernandez M, Rutherford NJ, et al. Clinical and neuropathologic heterogeneity of c9FTD/ALS associated with hexanucleotide repeat expansion in C9ORF72. Acta Neuropathol. 2011;122:673-90.
82. Whitwell JL, Weigand SD, Gunter JL, et al. Trajectories of brain and hippocampal atrophy in FTD with mutations in MAPT or GRN. Neurology. 2011;77:393-8.
83. Borroni B, Alberici A, Premi E, et al. Brain magnetic resonance imaging structural changes in a pedigree of asymptomatic progranulin mutation carriers. Rejuvenation Res. 2008;11:585-95.
84. Kantarci K, Boeve BF, Wszolek ZK, et al. MRS in presymptomatic MAPT mutation carriers: a potential biomarker for taumediated pathology. Neurology. 2010;75:771-8.
85. Miyoshi M, Shinotoh H, Wszolek ZK, et al. In vivo detection of neuropathologic changes in presymptomatic MAPT mutation carriers: a PET and MRI study. Parkinsonism Relat Disord. 2010;16:404-8.
86. Josephs KA, Hodges JR, Snowden JS, et al. Neuropathological background of phenotypical variability in frontotemporal dementia. Acta Neuropathol. 2011;122:137-53.
87. Whitwell JL, Josephs KA. Neuroimaging in frontotemporal lobar degeneration-predicting molecular pathology. Nat Rev Neurol. 2012;8:131-42.
88. Whitwell JL, Josephs KA, Rossor MN, et al. Magnetic resonance imaging signatures of tissue pathology in frontotemporal dementia. Arch Neurol. 2005;62:1402-8.
89. Whitwell JL, Jack Jr CR, Parisi JE, et al. Imaging signatures of molecular pathology in behavioral variant frontotemporal dementia. J Mol Neurosci. 2011;45:372-8.
90. Rankin KP, Mayo MC, Seeley WW, et al. Behavioral variant frontotemporal dementia with corticobasal degeneration pathology: phenotypic comparison to bvFTD with Pick's disease. J Mol Neurosci. 2011;45:594-608.
91. Josephs KA, Whitwell JL, Dickson DW, et al. Voxel-based morphometry in autopsy proven PSP and CBD. Neurobiol Aging. 2008;29:280-9.
92. Whitwell JL, Jack Jr CR, Boeve BF, et al. Imaging correlates of pathology in corticobasal syndrome. Neurology. 2010;75:1879-87.
93. Rohrer JD, Lashley T, Schott JM, et al. Clinical and neuroanatomical signatures of tissue pathology in frontotemporal lobar degeneration. Brain. 2011;134:2565-81.
94. Mackenzie IR, Neumann M, Baborie A, et al. A harmonized classification system for FTLD-TDP pathology. Acta Neuropathol. 2011;122:111-3.
95. Rohrer JD, Geser F, Zhou J, et al. TDP-43 subtypes are associated with distinct atrophy patterns in frontotemporal dementia. Neurology. 2010;75:2204-11.
96. Whitwell JL, Jack Jr CR, Parisi JE, et al. Does TDP-43 type confer a distinct pattern of atrophy in frontotemporal lobar degeneration? Neurology. 2010;75:2212-20.
97. Whitwell JL, Jack Jr CR, Senjem ML, Josephs KA. Patterns of atrophy in pathologically confirmed FTLD with and without motor neuron degeneration. Neurology. 2006;66:102-4.
98. Josephs KA, Whitwell JL, Parisi JE, et al. Caudate atrophy on MRI is a characteristic feature of FTLD-FUS. Eur J Neurol. 2010;17:969-75.
99. Seelaar H, Klijnsma KY, de Koning I, et al. Frequency of ubiquitin and FUS-positive, TDP-43-negative frontotemporal lobar degeneration. J Neurol. 2010;257:747-53.
100. Whitwell JL, Jack Jr CR, Senjem ML, et al. MRI correlates of protein deposition and disease severity in postmortem frontotemporal lobar degeneration. Neurodegener Dis. 2009;6:106-17.
101. Pereira JM, Williams GB, Acosta-Cabronero J, et al. Atrophy patterns in histologic vs clinical groupings of frontotemporal lobar degeneration. Neurology. 2009;72:1653-60.