Brain development and cognitive, psychosocial, and psychiatric functioning in classical 21-hydroxylase deficiency

Endocrine Development

Volumn 20, Issue , 2010, Pages 88-95

  Meyer Bahlburg, Heino F L ^a  

^a NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

STEROID 21 MONOOXYGENASE;

ARTICLE; BEHAVIOR; BODY IMAGE; COGNITION; COGNITIVE DEVELOPMENT; CONGENITAL ADRENAL HYPERPLASIA; DISEASE ASSOCIATION; KARYOTYPE 46,XX; MENTAL DISEASE; NEWBORN SCREENING; PHYSICAL DEVELOPMENT; PRIORITY JOURNAL; PSYCHOSEXUAL DEVELOPMENT; PSYCHOSOCIAL DEVELOPMENT; PUBERTY; SEXUAL DEVELOPMENT; SEXUALITY; SOCIAL PSYCHIATRY; STEROID 21 MONOOXYGENASE DEFICIENCY; UROLOGIC SURGERY; VIRILIZATION;

ADRENAL HYPERPLASIA, CONGENITAL; BRAIN; COGNITION; FEMALE; HUMANS; INFANT, NEWBORN; MALE; MENTAL DISORDERS; MENTAL HEALTH; PREGNANCY; STEROID 21-HYDROXYLASE;

EID: 84870530673     PISSN: 14217082     EISSN: 16622979     Source Type: Book Series    
DOI: 10.1159/000321225     Document Type: Article

References (26)

1. White PC, Speiser PW: Congenital adrenal hyperplasia due to 21-hydroxylase deficiency. Endocr Rev 2000;21;245-291.
2. Arnold AP: The organizational-activational hypothesis as the foundation for a unified theory of sexual differentiation of all mammalian tissues. Horm Behav 2009;55:570-578.
3. Schulz KM, Molenda-Figueira HA, Sisk CL: Back to the future: the organizational-activational hypothesis adapted to puberty and adolescence. Horm Behav 2009;55:597-604.
4. Ciumas C, Linden Hirschberg A, Savic I: High fetal testosterone and sexually dimorphic cerebral networks in females. Cereb Cortex 2009;19:1167-1174.
5. Meyer-Bahlburg HFL, Dolezal C, Baker SW, Ehrhardt AA, New MI: Gender development in women with congenital adrenal hyperplasia as a function of disorder severity. Arch Sex Behav 2006; 35:667-684.
6. Meyer-Bahlburg HFL, Dolezal C, Baker SW, New MI: Sexual orientation in women with classical or non-classical congenital adrenal hyperplasia as function of degree of prenatal androgen excess. Arch Sex Behav 2008;37:85-99.
7. Meyer-Bahlburg HFL, Dolezal C, Baker SW, Carlson AD, Obeid JS, New MI: Prenatal androgenization affects gender-related behavior but not gender identity in 5-to 12-year-old girls with congenital adrenal hyperplasia. Arch Sex Behav 2004;33:97-104.
8. Dessens AB, Slijper FM, Drop SL: Gender dysphoria and gender change in chromosomal females with congenital adrenal hyperplasia. Arch Sex Behav 2005;34:389-397.
9. Meyer-Bahlburg HFL, Gruen RS, New MI, Bell JJ, Morishima A, Shimshi M, Bueno Y, Vargas I, Baker SW: Gender change from female to male in classical CAH. Horm Behav 1996;20:319-332.
10. Speiser PW, Azziz R, Baskin LS, Ghizzoni L, Hensle TW, Merke DP, Meyer-Bahlburg, HFL, Miller WL, Montori VM, Oberfield SE, Ritzen M, White PC: Congenital adrenal hyperplasia due to steroid 21-hydroxylase deficiency: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab 2010;95:4133-4160.
11. Khuri J, Meyer-Bahlburg HFL, Baker SW, New MI: Stigma and psychosocial trauma in women with classical congenital adrenal hyperplasia. Int J Transgender 2008;10:193.
12. Meyer-Bahlburg HFL: Gender assignment and reassignment in intersexuality: controversies, data, and guidelines for research. Adv Exp Med Biol 2002;511: 199-223.
13. Nordenskjold A, Holmdahl G, Frisen L, Falhammar H, Filipsson H, Thoren M, Janson PO, Hagenfeldt K: Type of mutation and surgical procedure affect long-term quality of life for women with congenital adrenal hyperplasia. J Clin Endocrinol Metab 2008; 93:380-386.
14. Wisniewski AB, Migeon CJ, Malouf MA, Gearhart JP: Psychosexual outcome in women affected by congenital adrenal hyperplasia due to 21-hydroxylase deficiency. J Urol 2004;171:2497-2501.
15. Crouch NS, Liao LM, Woodhouse CRJ, Conway GS, Creighton SM: Sexual function and genital sensitivity following feminizing genitoplasty for congenital adrenal hyperplasia. J Urol 2008;179:634-638.
16. Meyer-Bahlburg HFL, Baker SW, Dolezal C, Carlson AD, Obeid JS, New MI: Long-term outcome in congenital adrenal hyperplasia: gender and sexuality. Endocrinologist 2003;13:227-233.
17. Gastaud F, Bouvattier C, Duranteau L, Brauner R, Thibaud E, Kutten F, Bougneres P: Impaired sexual and reproductive outcomes in women with classical forms of congenital adrenal hyperplasia. J Clin Endocrinol Metab 2007;92:1391-1396.
18. Frisen L, Nordenstrom A, Falhammar H, Filipsson H, Holmdahl G, Janson PO, Thoren M, Hagenfeldt K, Moller A, Nordenskjold A: Gender role behavior, sexuality, and psychosocial adaptation in women with congenital adrenal hyperplasia due to CYP21A2 deficiency. J Clin Endocrinol Metab 2009;94:3432-3439.
19. Johannsen TH, Ripa CPL, Reinisch JM, Schwartz M, Mortensen EL, Main KM: Impaired cognitive function in women with congenital adrenal hyperplasia. J Clin Endocrinol Metab 2006;91:1376-1381.
20. Baker SKW: An exploratory family study of IQ and specific cognitive abilities in classical congenital adrenal hyperplasia: examined by family, genetic, and salt wasting subgroups. Doctoral dissertation. New York, Graduate School of Arts and Sciences, Columbia University, 1990.
21. Bergamaschi R, Livieri C, Uggetti C, Candeloro E, Egitto MG, Pichiecchio A, Cosi V, Bastianello S: Brain white matter impairment in congenital adrenal hyperplasia. Arch Neurol 2006;63:413-416.
22. Mueller SC, Temple V, Oh E, VanRyzin C, Williams A, Cornwell B, Grillon C, Pine DS, Ernst M, Merke DP: Early androgen exposure modulates spatial cognition in congenital adrenal hyperplasia. Psychoneuroendocrinology 2008;33:973-980.
23. Mueller SC, Ng P, Sinaii N, Leschek EW, Green-Golan L, VanRyzin C, Ernst M, Merke DP: Psychiatric characterization of children with genetic causes of hyperandrogenism. Eur J Endocrinol (in press).
24. Meyer-Bahlburg HFL, Gruen R, Baker SW, New MI: Lifetime psychiatric diagnoses in women with congenital adrenal hyperplasia. Int J Transgender 2008; 10:200.
25. Ernst M, Maheu FS, Schroth E, Hardin J, Golan LG, Cameron J, Allen R, Holzer S, Nelson E, Pine DS, Merke DP: Amygdala function in adolescents with congenital adrenal hyperplasia: a model for the study of early steroid abnormalities. Neuropsychologia 2007;45:2104-2113.
26. Meyer-Bahlburg HFL: Treatment guidelines for children with disorders of sex development. Neuropsychiatr Enfance Adolesc 2008;56:345-349.