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This interesting study documents the presence of cognitive changes before other symptoms occur among people with incidental findings of brain lesions typical of MS
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Lebrun C, Blanc F, Brassat D, et al. Cognitive function in radiologically isolated syndrome. Mult Scler. 2010;16:919-25. This interesting study documents the presence of cognitive changes before other symptoms occur among people with incidental findings of brain lesions typical of MS.
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Another recent interesting study documenting CI in patients with RIS
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This study clarifies the long-standing paradox of why lesion burden does not correlate with CI
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Mesaros S, Rocca MA, Kacar K, et al. Diffusion tensor MRI tractography and cognitive impairment in multiple sclerosis. Neurology. 2012;78:969-75. This study clarifies the long-standing paradox of why lesion burden does not correlate with CI.
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This study documents changes in the default and control networks in patients with MS and correlates these changes with CI
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Hawellek DJ, Hipp JF, Lewis CM, et al. Increased functional connectivity indicates the severity of cognitive impairment in multiple sclerosis. Proc Natl Acad Sci U S A. 2011;108:19066-71. This study documents changes in the default and control networks in patients with MS and correlates these changes with CI.
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This is an important randomized placebo-controlled trial that, unfortunately, showed no benefit with donepezil
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Krupp LB, Christodoulou C, Melville P, et al. Multicenter randomized clinical trial of donepezil for memory impairment in multiple sclerosis. Neurology. 2011;76:1500-7. This is an important randomized placebo-controlled trial that, unfortunately, showed no benefit with donepezil.
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Lovera JF, Frohman E, Brown TR, et al. Memantine for cognitive impairment in multiple sclerosis: a randomized placebo-controlled trial. Mult Scler. 2010;16:715-23. Our randomized multicenter trial with memantine also failed to show any beneficial effect.
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