Diagnosing multiple drug hypersensitivity in children

Pediatric Allergy and Immunology

Volumn 23, Issue 8, 2012, Pages 785-791

  Atanasković Marković, Marina ^a,b   Gaeta, Francesco ^c   Gavrović Jankulović, Marija ^d   Čirković Veličković, Tanja ^d   Valluzzi, Rocco Luigi ^c   Romano, Antonino ^c,e  

^a UNIVERSITY CHILDREN S HOSPITAL   (Serbia)

^b UNIVERSITY OF BELGRADE   (Serbia)

^c Allergy Unit   (Italy)

^d UNIVERSITY OF BELGRADE   (Serbia)

^e OASI RESEARCH INSTITUTE IRCCS   (Italy)

Author keywords

Challenges; Drug provocation tests; Multiple drug hypersensitivity; Patch tests; Skin tests

Indexed keywords

AMOXICILLIN; AMPICILLIN; ANTICONVULSIVE AGENT; AZITHROMYCIN; BACTOX; BETA LACTAM DERIVATIVE; CARBAMAZEPINE; CEFALEXIN; CEFPROZIL; CEFTRIAXONE; CEPHALOSPORIN DERIVATIVE; CLARITHROMYCIN; COTRIMOXAZOLE; DAP; ERYTHROMYCIN; FENTANYL; GENTAMICIN; IBUPROFEN; IMMUNOGLOBULIN E; LAMOTRIGINE; LIDOCAINE; METHYLPREDNISOLONE; NAPROXEN; PARACETAMOL; PENICILLIN DERIVATIVE; PENICILLIN G; PENICILLIN V; PENICILLOYL POLYLYSINE; PHENOBARBITAL; POVIDONE IODINE; TOBRAMYCIN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ADOLESCENT; ALLERGY TEST; ANAPHYLAXIS; ANGIONEUROTIC EDEMA; ARTICLE; CHILD; CLINICAL FEATURE; CONTROLLED STUDY; DIAGNOSTIC APPROACH ROUTE; DRUG ERUPTION; DRUG HYPERSENSITIVITY; FEMALE; HUMAN; MACULOPAPULAR RASH; MAJOR CLINICAL STUDY; MALE; MULTIPLE DRUG HYPERSENSITIVITY; PATCH TEST; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROVOCATION TEST; SKIN TEST; STEVENS JOHNSON SYNDROME; URTICARIA;

ADOLESCENT; ANTI-BACTERIAL AGENTS; ANTICONVULSANTS; BETA-LACTAMS; CEPHALOSPORINS; CHILD; CHILD, PRESCHOOL; DRUG HYPERSENSITIVITY; FEMALE; HUMANS; IBUPROFEN; IMMUNOGLOBULIN E; MALE; PATCH TESTS; PROSPECTIVE STUDIES; SKIN TESTS;

EID: 84870517016     PISSN: 09056157     EISSN: 13993038     Source Type: Journal    
DOI: 10.1111/pai.12020     Document Type: Article

References (38)

1. Johansson SG, Hourihane JO, Bousquet J, et al. A revised nomenclature for allergy. An EAACI position statement from the EAACI nomenclature task force. Allergy 2001: 56: 813-24.
2. Romano A, Torres MJ, Castells M, Sanz ML, Blanca M. Diagnosis and management of drug hypersensitivity reactions. J Allergy Clin Immunol 2011: 127 (Suppl. 3): S67-73.
3. Seitz CS, Bröcker EB, Trautmann A. Diagnosis of drug hypersensitivity in children and adolescents: discrepancy between physician-based assessment and results of testing. Pediatr Allergy Immunol 2011: 22: 405-10.
4. Atanasković-Marković M. Educational case series: β-lactam allergy and cross-reactivity. Pediatr Allergy Immunol 2011: 22: 770-5.
5. Caubet JC, Pichler WJ, Eigenmann PA. Educational case series: mechanisms of drug allergy. Pediatr Allergy Immunol 2011: 22: 559-67.
6. Sullivan TJ, Remedios C, Ong MD, Gilliam LK. Studies of the multiple drug allergy syndromes. J Allergy Clin Immunol 1989: 83: 270.
7. Gex-Collet C, Helbling A, Pichler WJ. Multiple drug hypersensitivity - proof of multiple drug hypersensitivity by patch and lymphocyte transformation tests. J Investig Allergol Clin Immunol 2005: 15: 293-6.
8. Kamada MM, Twarog F, Leung DY. Multiple antibiotic sensitivity in a pediatric population. Allergy Proc 1991: 12: 347-50.
9. Asero R. Detection of patients with multiple drug allergy syndrome by elective tolerance tests. Ann Allergy Asthma Immunol 1998: 80: 185-8.
10. Park J, Matsui D, Rieder MJ. Multiple antibiotic sensitivity syndrome in children. Can J Clin Pharmacol 2000: 7: 38-41.
11. Neukomm CB, Yawalkar N, Helbling A, Pichler WJ. T-cell reactions to drugs in distinct clinical manifestations of drug allergy. J Investig Allergol Clin Immunol 2001: 11: 275-84.
12. Nettis E, Colanardi MC, Paola RD, Ferrannini A, Tursi A. Tolerance test in patients with multiple drug allergy syndrome. Immunopharmacol Immunotoxicol 2001: 23: 617-26.
13. Asero R, Tedeschi A, Lorini M, Caldironi G, Barocci F. Sera from patients with multiple drug allergy syndrome contain circulating histamine-releasing factors. Int Arch Allergy Immunol 2003: 131: 195-200.
14. Halevy S, Grossman N. Multiple drug allergy in patients with cutaneous adverse drug reactions diagnosed by in vitro drug-induced interferon-gamma release. Isr Med Assoc J 2008: 10: 865-8.
15. Asero R, Tedeschi A, Riboldi P, Griffini S, Bonanni E, Cugno M. Coagulation cascade and fibrinolysis in patients with multiple-drug allergy syndrome. Ann Allergy Asthma Immunol 2008: 100: 44-8.
16. Buonomo A, Altomonte G, De Pasquale T, et al. Allergic and non-allergic drug hypersensitivity reactions in children. Int J Immunopathol Pharmacol 2010: 23: 881-90.
17. Daubner B, Groux-Keller M, Hausmann OV, et al. Multiple drug hypersensitivity: normal Treg cell function but enhanced in vivo activation of drug-specific T cells. Allergy 2012: 67: 58-66.
18. Macy E, Ho NJ. Multiple drug intolerance syndrome: prevalence, clinical characteristics, and management. Ann Allergy Asthma Immunol 2012: 108: 88-93.
19. Pichler WJ, Daubner B, Kawabata T. Drug hypersensitivity: flare-up reactions, cross-reactivity and multiple drug hypersensitivity. J Dermatol 2011: 38: 216-21.
20. Torres MJ, Blanca M, Fernandez J, et al. Diagnosis of immediate allergic reactions to beta-lactam antibiotics. Allergy 2003: 58: 961-72.
21. Romano A, Blanca M, Torres MJ, et al. Diagnosis of nonimmediate reactions to beta-lactam antibiotics. Allergy 2004: 59: 1153-60.
22. Brockow K, Romano A, Blanca M, Ring J, Pichler W, Demoly P. General considerations for skin test procedures in the diagnosis of drug hypersensitivity. Allergy 2002: 57: 45-51.
23. Empedrad R, Darter AL, Earl HS, Gruchalla RS. Nonirritating intradermal skin test concentrations for commonly prescribed antibiotics. J Allergy Clin Immunol 2003: 112: 629-30.
24. Romano A, Guéant-Rodriguez RM, Viola M, et al. Diagnosing immediate reactions to cephalosporins. Clin Exp Allergy 2005: 35: 1234-42.
25. Barbaud A, Reichert-Penetrat S, Tréchot P, et al. The use of skin testing in the investigation of cutaneous adverse drug reactions. Br J Dermatol 1998: 139: 49-58.
26. Aberer W, Bircher A, Romano A, et al. Drug provocation testing in the diagnosis of drug hypersensitivity reactions: general considerations. Allergy 2003: 58: 854-63.
27. Viola M, Rumi G, Valluzzi RL, Gaeta F, Caruso C, Romano A. Assessing potential determinants of positive provocation tests in subjects with NSAID hypersensitivity. Clin Exp Allergy 2011: 41: 96-103.
28. Castrejon JL, Berry N, El-Ghaiesh S, et al. Stimulation of human T cells with sulfonamides and sulfonamide metabolites. J Allergy Clin Immunol 2010: 125: 411-8.
29. Torres MJ, Mayorga C, Blanca M. Nonimmediate allergic reactions induced by drugs: pathogenesis and diagnostic tests. J Investig Allergol Clin Immunol 2009: 19: 80-90.
30. Cherry JD. Cutaneous manifestations of systemic infections. In: Feigin RD, Cherry JD, Demmler-Harrison GI, Kaplan SL, eds. Textbook of Pediatric Infectious Diseases, 6th edn. Philadelphia: Saunders Elsevier, 2009: 755-80.
31. Caubet JC, Kaiser L, Lemaître B, Fellay B, Gervaix A, Eigenmann PA. The role of penicillin in benign skin rashes in childhood: a prospective study based on drug rechallenge. J Allergy Clin Immunol 2011: 127: 218-22.
32. Blanca-López N, Zapatero L, Alonso E, et al. Skin testing and drug provocation in the diagnosis of nonimmediate reactions to aminopenicillins in children. Allergy 2009: 64: 229-33.
33. Mori F, Barni S, Pucci N, et al. Sensitivity and specificity of skin tests in the diagnosis of clarithromycin allergy. Ann Allergy Asthma Immunol 2010: 104: 417-9.
34. Ponvert C, Perrin Y, Bados-Albiero A, et al. Allergy to betalactam antibiotics in children: results of a 20-year study based on clinical history, skin and challenge tests. Pediatr Allergy Immunol 2011: 22: 411-8.
35. Niżankowska-Mogilnicka E, Bochenek G, Mastalerz L, et al. EAACI/GA2LEN guideline: aspirin provocation tests for diagnosis of aspirin hypersensitivity. Allergy 2007: 62: 1111-8.
36. Hassani A, Ponvert C, Karila C, Le Bourgeois M, De Blic J, Scheinmann P. Hypersensitivity to cyclooxygenase inhibitory drugs in children: a study of 164 cases. Eur J Dermatol 2008: 18: 561-5.
37. Doña I, Blanca-López N, Cornejo-García JA, et al. Characteristics of subjects experiencing hypersensitivity to non-steroidal anti-inflammatory drugs: patterns of response. Clin Exp Allergy 2011: 41: 86-95.
38. Blanca M, Romano A, Torres MJ, et al. Update on the evaluation of hypersensitivity reactions to betalactams. Allergy 2009: 64: 183-93.