Altered hemodynamics, endothelial function, and protein expression occur with aortic coarctation and persist after repair

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 303, Issue 11, 2012, Pages

  Menon, Arjun ^a   Eddinger, Thomas J ^b   Wang, Hongfeng ^a   Wendell, David C ^c   Toth, Jeffrey M ^a,d   LaDisa, John F ^a,d  

^a Marquette University   (United States)

^b Marquette University   (United States)

^c DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

Contractile protein; Endothelial dysfunction; Hemodynamics; Nonmuscle myosin; Vascular remodeling

Indexed keywords

ALPHA ACTIN; FIBRONECTIN; MYOSIN HEAVY CHAIN; TALIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA COARCTATION; ARTICLE; COMPUTATIONAL FLUID DYNAMICS; CONTROLLED STUDY; ENDOTHELIAL DYSFUNCTION; HEART HEMODYNAMICS; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RABBIT; SYSTOLIC BLOOD PRESSURE; THORACIC AORTA;

EID: 84870510439     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00420.2012     Document Type: Article

References (76)

1. Ainslie K, Shi ZD, Garanich JS, Tarbell JM. Rat aortic smooth muscle cells contract in response to serum and its components in a calcium independent manner. Ann Biomed Eng 32: 1667-1675, 2004.
2. Ainslie KM, Garanich JS, Dull RO, Tarbell JM. Vascular smooth muscle cell glycocalyx influences shear stress-mediated contractile response. J Appl Physiol 98: 242-249, 2005.
3. Angus JA, Campbell GR, Cocks TM, Manderson JA. Vasodilatation by acetylcholine is endothelium-dependent: a study by sonomicrometry in canine femoral artery in vivo. J Physiol 344: 209-222, 1983.
4. Angus JA, Cocks TM. Role of endothelium in vascular responses to norepinephrine, serotonin and acetylcholine. Bibl Cardiol: 43-52, 1984.
5. Barton CH, Ni Z, Vaziri ND. Enhanced nitric oxide inactivation in aortic coarctation-induced hypertension. Kidney Int 60: 1083-1087, 2001.
6. Beningo KA, Dembo M, Kaverina I, Small JV, Wang YL. Nascent focal adhesions are responsible for the generation of strong propulsive forces in migrating fibroblasts. J Cell Biol 153: 881-888, 2001.
7. Beningo KA, Hamao K, Dembo M, Wang YL, Hosoya H. Traction forces of fibroblasts are regulated by the Rho-dependent kinase but not by the myosin light chain kinase. Arch Biochem Biophys 456: 224-231, 2006.
8. Berk BC. Vascular smooth muscle growth: autocrine growth mechanisms. Physiol Rev 81: 999-1030, 2001.
9. Bobby JJ, Emami JM, Farmer RD, Newman CG. Operative survival and 40 year follow up of surgical repair of aortic coarctation. Br Heart J 65: 271-276, 1991.
10. Bohlen HG, Lash JM. Active and passive arteriolar regulation in spontaneously hypertensive rats. Hypertension 23: 757-764, 1994.
11. Brili S, Tousoulis D, Antoniades C, Aggeli C, Roubelakis A, Papathanasiu S, Stefanadis C. Evidence of vascular dysfunction in young patients with successfully repaired coarctation of aorta. Atherosclerosis 182: 97-103, 2005.
12. Brili S, Tousoulis D, Antoniades C, Vasiliadou C, Karali M, Papageorgiou N, Ioakeimidis N, Marinou K, Stefanadi E, Stefanadis C. Effects of ramipril on endothelial function and the expression of proinflammatory cytokines and adhesion molecules in young normotensive subjects with successfully repaired coarctation of aorta: a randomized cross-over study. J Am Coll Cardiol 51: 742-749, 2008.
13. Chiang HY, Korshunov VA, Serour A, Shi F, Sottile J. Fibronectin is an important regulator of flow-induced vascular remodeling. Arterioscler Thromb Vasc Biol 29: 1074-1079, 2009.
14. 2-independent signaling mechanism. J Appl Physiol 93: 1907-1917, 2002.
15. Conti MA, Adelstein RS. Nonmuscle myosin II moves in new directions. J Cell Sci 121: 11-18, 2008.
16. Denniss SG, Rush JW. Impaired hemodynamics and endothelial vasomotor function via endoperoxide-mediated vasoconstriction in the carotid artery of spontaneously hypertensive rats. Am J Physiol Heart Circ Physiol 296: H1038-H1047, 2009.
17. Drexler H. Factors involved in the maintenance of endothelial function. Am J Cardiol 82: 3S-4S, 1998.
18. Drexler H. Nitric oxide and coronary endothelial dysfunction in humans. Cardiovasc Res 43: 572-579, 1999.
19. Eddinger TJ, Meer DP. Myosin II isoforms in smooth muscle: heterogeneity and function. Am J Physiol Cell Physiol 293: C493-C508, 2007.
20. Eddinger TJ, Schiebout JD, Swartz DR. Adherens junction-associated protein distribution differs in smooth muscle tissue and acutely isolated cells. Am J Physiol Gastrointest Liver Physiol 292: G684-G697, 2007.
21. Eddinger TJ, Schiebout JD, Swartz DR. Smooth muscle adherens junctions associated proteins are stable at the cell periphery during relaxation and activation. Am J Physiol Cell Physiol 289: C1379-C1387, 2005.
22. Figueroa CA, Taylor CA, Yeh V, Chiou AJ, Gorrepati ML, Zarins CK. Preliminary 3D computational analysis of the relationship between aortic displacement force and direction of endograft movement. J Vasc Surg 51: 1488-1497; discussion 1497, 2010.
23. Fitch RM, Rutledge JC, Wang YX, Powers AF, Tseng JL, Clary T, Rubanyi GM. Synergistic effect of angiotensin II and nitric oxide synthase inhibitor in increasing aortic stiffness in mice. Am J Physiol Heart Circ Physiol 290: H1190-H1198, 2006.
24. Frydrychowicz A, Arnold R, Hirtler D, Schlensak C, Stalder AF, Hennig J, Langer M, Markl M. Multidirectional flow analysis by cardiovascular magnetic resonance in aneurysm development following repair of aortic coarctation. J Cardiovasc Magn Reson 10: 30, 2008.
25. Frydrychowicz A, Berger A, Russe MF, Stalder AF, Harloff A, Dittrich S, Hennig J, Langer M, Markl M. Time-resolved magnetic resonance angiography and flow-sensitive 4-dimensional magnetic resonance imaging at 3 Tesla for blood flow and wall shear stress analysis. J Thorac Cardiovasc Surg 136: 400-407, 2008.
26. Gardiner HM, Celermajer DS, Sorensen KE, Georgakopoulos D, Robinson J, Thomas O, Deanfield JE. Arterial reactivity is significantly impaired in normotensive young adults after successful repair of aortic coarctation in childhood. Circulation 89: 1745-1750, 1994.
27. Gauthier KM, Chawengsub Y, Goldman DH, Conrow RE, Anjaiah S, Falck JR, Campbell WB. 11(R),12(S),15(S)-trihydroxyeicosa-5(Z),8(Z), 13(E)-trienoic acid: an endothelium-derived 15-lipoxygenase metabolite that relaxes rabbit aorta. Am J Physiol Heart Circ Physiol 294: H1467-H1472, 2008.
28. Graham DA, Rush JW. Cyclooxygenase and thromboxane/prostaglandin receptor contribute to aortic endothelium-dependent dysfunction in aging female spontaneously hypertensive rats. J Appl Physiol 107: 1059-1067, 2009.
29. Hu JJ, Ambrus A, Fossum TW, Miller MW, Humphrey JD, Wilson E. Time courses of growth and remodeling of porcine aortic media during hypertension: a quantitative immunohistochemical examination. J Histochem Cytochem 56: 359-370, 2008.
30. Jenkins NP, Ward C. Coarctation of the aorta: natural history and outcome after surgical treatment. Q J Med 92: 365-371, 1999.
31. Jimenez M, Daret D, Choussat A, Bonnet J. Immunohistological and ultrastructural analysis of the intimal thickening in coarctation of human aorta. Cardiovasc Res 41: 737-745, 1999.
32. Kilner PJ, Yang GZ, Mohiaddin RH, Firmin DN, Longmore DB. Helical and retrograde secondary flow patterns in the aortic arch studied by three-directional magnetic resonance velocity mapping. Circulation 88: 2235-2247, 1993.
33. Kovács M, Thirumurugan K, Knight PJ, Sellers JR. Load-dependent mechanism of nonmuscle myosin 2. Proc Natl Acad Sci USA 104: 9994-9999, 2007.
34. Kukongviriyapan U, Gow BS. Morphometric analyses of rabbit thoracic aorta after poststenotic dilatation. Circ Res 65: 1774-1786, 1989.
35. LaDisa JF, Alberto Figueroa C, Vignon-Clementel IE, Kim HJ, Xiao N, Ellwein LM, Chan FP, Feinstein JA, Taylor CA. Computational simulations for aortic coarctation: representative results from a sampling of patients. J Biomech Eng 133: 091008, 2011.
36. LaDisa JF, Dholakia RJ, Figueroa CA, Vignon-Clementel IE, Chan FP, Samyn MM, Cava JR, Taylor CA, Feinstein JA. Computational simulations demonstrate altered wall shear stress in aortic coarctation patients treated by resection with end-to-end anastomosis. Congenit Heart Dis 6: 432-443, 2011.
37. Laskey WK, Parker HG, Ferrari VA, Kussmaul WG, Noordergraaf A. Estimation of total systemic arterial compliance in humans. J Appl Physiol 69: 112-119, 1990.
38. Lee SK, Kim HS, Song YJ, Joo HK, Lee JY, Lee KH, Cho EJ, Cho CH, Park JB, Jeon BH. Alteration of p66shc is associated with endothelial dysfunction in the abdominal aortic coarctation of rats. FEBS Lett 582: 2561-2566, 2008.
39. Les AS, Shadden SC, Figueroa CA, Park JM, Tedesco MM, Herfkens RJ, Dalman RL, Taylor CA. Quantification of hemodynamics in abdominal aortic aneurysms during rest and exercise using magnetic resonance imaging and computational fluid dynamics. Ann Biomed Eng 38: 1288-1313, 2010.
40. Lichtenstein O, Safar ME, Mathieu E, Poitevin P, Levy BI. Static and dynamic mechanical properties of the carotid artery from normotensive and hypertensive rats. Hypertension 32: 346-350, 1998.
41. López D, Rodríguez-Sinovas A, Agulló L, Inserte J, Cabestrero A, García-Dorado D. Acidic reoxygenation protects against endothelial dysfunction in rat aortic rings submitted to simulated ischemia. Am J Physiol Heart Circ Physiol 295: H2409-H2416, 2008.
42. Masuda H, Zhuang YJ, Singh TM, Kawamura K, Murakami M, Zarins CK, Glagov S. Adaptive remodeling of internal elastic lamina and endothelial lining during flow-induced arterial enlargement. Arterioscler Thromb Vasc Biol 19: 2298-2307, 1999.
43. Menon A, Wendell DC, Wang H, Eddinger TJ, Toth JM, Dholakia RJ, Larsen PM, Jensen ES, Ladisa JF. A coupled experimental and computational approach to quantify deleterious hemodynamics, vascular alterations, and mechanisms of long-term morbidity in response to aortic coarctation. J Pharmacol Toxicol Methods 65: 18-28, 2012.
44. Moskowitz WB, Schieken RM, Mosteller M. Altered systolic and diastolic function in children after "successful" repair of coarctation of the aorta. Am Heart J 120: 103-109, 1990.
45. Muller J, Sahni O, Li X, Jansen KE, Shephard MS, Taylor CA. Anisotropic adaptive finite element method for modelling blood flow. Comput Methods Biomech Biomed Engin 8: 295-305, 2005.
46. Nichols WW, O'Rourke MF. McDonald's Blood Flow in Arteries: Theoretical, Experimental and Clinical Principles. New York: Hodder Arnold, 2005.
47. O'Rourke MF, Cartmill TB. Influence of aortic coarctation on pulsatle hemodynamics in the proximal aorta. Circulation 44: 281-292, 1971.
48. O'Rourke MF, Safar ME. Relationship between aortic stiffening and microvascular disease in brain and kidney: cause and logic of therapy. Hypertension 46: 200-204, 2005.
49. Ojha M, Langille BL. Evidence that turbulence is not the cause of poststenotic dilatation in rabbit carotid arteries. Arterioscler Thromb 13: 977-984, 1993.
50. Ong CM, Canter CE, Gutierrez FR, Sekarski DR, Goldring DR. Increased stiffness and persistent narrowing of the aorta after successful repair of coarctation of the aorta: relationship to left ventricular mass and blood pressure at rest and with exercise. Am Heart J 123: 1594-1600, 1992.
51. Owens GK. Regulation of differentiation of vascular smooth muscle cells. Physiol Rev 75: 487-517, 1995.
52. Owens GK, Kumar MS, Wamhoff BR. Molecular regulation of vascular smooth muscle cell differentiation in development and disease. Physiol Rev 84: 767-801, 2004.
53. Potts JR, Campbell ID. Fibronectin structure and assembly. Curr Opin Cell Biol 6: 648-655, 1994.
54. Reusch P, Wagdy H, Reusch R, Wilson E, Ives HE. Mechanical strain increases smooth muscle and decreases nonmuscle myosin expression in rat vascular smooth muscle cells. Circ Res 79: 1046-1053, 1996.
55. Rosenthal E. Stent implantation for aortic coarctation: the treatment of choice in adults? J Am Coll of Cardiol 38: 1524-1527, 2001.
56. Sharma R, Yellowley CE, Civelek M, Ainslie K, Hodgson L, Tarbell JM, Donahue HJ. Intracellular calcium changes in rat aortic smooth muscle cells in response to fluid flow. Ann Biomed Eng 30: 371-378, 2002.
57. Small JV. Structure-function relationships in smooth muscle: the missing links. Bioessays 17: 785-792, 1995.
58. Smolensky AV, Ford LE. The extensive length-force relationship of porcine airway smooth muscle. J Appl Physiol 102: 1906-1911, 2007.
59. Speich JE, Dosier C, Borgsmiller L, Quintero K, Koo HP, Ratz PH. Adjustable passive length-tension curve in rabbit detrusor smooth muscle. J Appl Physiol 102: 1746-1755, 2007.
60. Steelman SM, Humphrey JD. Differential remodeling responses of cerebral and skeletal muscle arterioles in a novel organ culture system. Med Biol Eng Comput 49: 1015-1023, 2011.
61. Stefanadis C, Stratos C, Boudoulas H, Kourouklis C, Toutouzas P. Distensibility of the ascending aorta: comparison of invasive and noninvasive techniques in healthy men and in men with coronary artery disease. Eur Heart J 11: 990-996, 1990.
62. Stergiopulos N, Segers P, Westerhof N. Use of pulse pressure method for estimating total arterial compliance in vivo. Am J Physiol Heart Circ Physiol 276: H424-H428, 1999.
63. Strauss BH, Rabinovitch M. Adventitial fibroblasts: defining a role in vessel wall remodeling. Am J Respir Cell Mol Biol 22: 1-3, 2000.
64. Tang BT, Cheng CP, Draney MT, Wilson NM, Tsao PS, Herfkens RJ, Taylor CA. Abdominal aortic hemodynamics in young healthy adults at rest and during lower limb exercise: quantification using image-based computer modeling. Am J Physiol Heart Circ Physiol 291: H668-H676, 2006.
65. Thompson JA, Gros R, Richardson BS, Piorkowska K, Regnault TR. Central stiffening in adulthood linked to aberrant aortic remodeling under suboptimal intrauterine conditions. Am J Physiol Regul Integr Comp Physiol 301: R1731-R1737, 2011.
66. Toutouzas PC, Tousoulis D, Davies GJ. Nitric oxide synthesis in atherosclerosis. Eur Heart J 19: 1504-1511, 1998.
67. phoxin the aorta segments above and below coarctation. Biochim Biophys Acta 1723: 321-327, 2005.
68. Vicente-Manzanares M, Ma X, Adelstein RS, Horwitz AR. Nonmuscle myosin II takes centre stage in cell adhesion and migration. Nat Rev Mol Cell Biol 10: 778-790, 2009.
69. Vignon-Clementel IE, Figueroa CA, Jansen KE, Taylor CA. Outflow boundary conditions for three-dimensional finite element modeling of blood flow and pressure in arteries. Comput Methods Appl Mech Eng 195: 3776-3796, 2006.
70. Vogel V, Baneyx G. The tissue engineeting puzzle: a molecular perspective. Annu Rev Biomed Eng 5: 441-463, 2003.
71. Vriend JW, de Groot E, Bouma BJ, Hrudova J, Kastelein JJ, Tijssen JG, Mulder BJ. Carotid intima-media thickness in postcoarctectomy patients with exercise induced hypertension. Heart 91: 962-963, 2005.
72. Vriend JW, de Groot E, de Waal TT, Zijta FM, Kastelein JJ, Mulder BJ. Increased carotid and femoral intima-media thickness in patients after repair of aortic coarctation: influence of early repair. Am Heart J 151: 242-247, 2006.
73. Wentzel JJ, Corti R, Fayad ZA, Wisdom P, Macaluso F, Winkelman MO, Fuster V, Badimon JJ. Does shear stress modulate both plaque progression and regression in the thoracic aorta? Human study using serial magnetic resonance imaging. J Am Coll Cardiol 45: 846-854, 2005.
74. Windberger U, Bartholovitsch A, Plasenzotti R, Korak KJ, Heinze G. Whole blood viscosity, plasma viscosity and erythrocyte aggregation in nine mammalian species: reference values and comparison of data. Exp Physiol 88: 431-440, 2003.
75. Wolinsky H, Glagov S. Structural basis for the static mechanical properties of the aortic media. Circ Res 14: 400-413, 1964.
76. Xu C, Zarins CK, Glagov S. Biphasic response of tropoelastin at the poststenotic dilation segment of the rabbit aorta. J Vasc Surg 36: 605-612, 2002.