Increased expression of renal TRPM6 compensates for Mg2 wasting during furosemide treatment

Clinical Kidney Journal

Volumn 5, Issue 6, 2012, Pages 535-544

  Van Angelen, Annelies A ^a   Van Der Kemp, Annemiete W ^a   Hoenderop, Joost G ^a   Bindels, René J ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

DCT; furosemide; mouse; polyuria; TRPM6

Indexed keywords

CALBINDIN; CHLORIDE ION; CLAUDIN 7; CLAUDIN 8; DRUG VEHICLE; ELECTROLYTE; EPITHELIAL SODIUM CHANNEL; FUROSEMIDE; MAGNESIUM ION; MESSENGER RNA; PARVALBUMIN; SODIUM CHLORIDE COTRANSPORTER; SODIUM ION; SODIUM PROTON EXCHANGE PROTEIN 3; TRANSIENT RECEPTOR POTENTIAL CHANNEL M6; VANILLOID RECEPTOR 5;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALCIUM EXCRETION; CONTROLLED STUDY; DRUG EFFECT; ELECTROLYTE BLOOD LEVEL; ELECTROLYTE URINE LEVEL; HENLE LOOP; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MAGNESIUM EXCRETION; MALE; MOUSE; NONHUMAN; OSMOTIC MINIPUMP; POLYURIA; POTASSIUM EXCRETION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTON SODIUM EXCHANGE; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SODIUM EXCRETION; UPREGULATION; URINARY EXCRETION;

EID: 84870499550     PISSN: 20488505     EISSN: 20488513     Source Type: Journal    
DOI: 10.1093/ckj/sfs140     Document Type: Article

References (52)

1. Hendry BM, Ellory JC. Molecular sites for diuretic action. Trends Pharmacol Sci 1988; 9: 416-421 (Pubitemid 18265594)
2. Rose BD. Diuretics. Kidney Int 1991; 39: 336-352
3. Quamme GA. Renal handling of magnesium: drug and hormone interactions. Magnesium 1986; 5: 248-272
4. Dimke H, Hoenderop JG, Bindels RJ. Hereditary tubular transport disorders: implications for renal handling of Ca2+ and Mg2+. Clin Sci (Lond) 2009; 118: 1-18
5. Ellison DH. Diuretic drugs and the treatment of edema: from clinic to bench and back again. Am J Kidney Dis 1994; 23: 623-643 (Pubitemid 24138415)
6. Di Stefano A, Roinel N, de Rouffignac C et al. Transepithelial Ca2+ and Mg2+ transport in the cortical thick ascending limb of Henle's loop of the mouse is a voltage-dependent process. Ren Physiol Biochem 1993; 16: 157-166 (Pubitemid 23212564)
7. Quamme GA. Effect of furosemide on calcium and magnesium transport in the rat nephron. Am J Physiol 1981; 241: F340-F347
8. Lee AJ, Chen YH, Chu ML et al. [Effect of furosemide on renal magnesium and calcium excretion of different ages (II)]. Zhonghua Min Guo Xiao Er Ke Yi Xue Hui Za Zhi 1994; 35: 215-220
9. Caddell JL. Protection by magnesium of renal calcinosis in furosemide-treated weanling rats with moderate magnesium deficiency. Biol Neonate 1985; 48: 49-58 (Pubitemid 16239487)
10. Lee CT, Chen HC, Lai LW et al. Effects of furosemide on renal calcium handling. Am J Physiol Renal Physiol 2007; 293: F1231-7
11. Cohen N, Almoznino-Sarafian D, Zaidenstein R et al. Serum magnesium aberrations in furosemide (frusemide) treated patients with congestive heart failure: pathophysiological correlates and prognostic evaluation. Heart 2003; 89: 411-416 (Pubitemid 36379414)
12. Davies DL, Fraser R. Do diuretics cause magnesium deficiency? Br J Clin Pharmacol 1993; 36: 1-10
13. Jentzer JC, DeWald TA, Hernandez AF. Combination of loop diuretics with thiazide-type diuretics in heart failure. J Am Coll Cardiol 2010; 56: 1527-1534
14. Ellison DH. The physiologic basis of diuretic synergism: its role in treating diuretic resistance. Ann Intern Med 1991; 114: 886-894
15. Loon NR, Wilcox CS, Unwin RJ. Mechanism of impaired natriuretic response to furosemide during prolonged therapy. Kidney Int 1989; 36: 682-689 (Pubitemid 19239561)
16. Ellison DH, Velazquez H, Wright FS. Adaptation of the distal convoluted tubule of the rat. Structural and functional effects of dietary salt intake and chronic diuretic infusion. J Clin Invest 1989; 83: 113-126 (Pubitemid 19048413)
17. Kaissling B, Bachmann S, Kriz W. Structural adaptation of the distal convoluted tubule to prolonged furosemide treatment. Am J Physiol 1985; 248: F374-F381 (Pubitemid 15142307)
18. Branch RA, Homeida M, Levine D et al. Pharmacokinetics of frusemide related to diuretic response [proceedings]. Br J Pharmacol 1976; 57: 442P-443P
19. Andreasen F, Lauridsen IN, Hansen FA et al. Dose dependency of furosemide-induced sodium excretion. J Pharmacol Exp Ther 1989; 248: 1182-1188 (Pubitemid 19100771)
20. Schlingmann KP, Konrad M, Seyberth HW. Genetics of hereditary disorders of magnesium homeostasis. Pediatr Nephrol 2004; 19: 13-25 (Pubitemid 38088245)
21. Simon DB, Karet FE, Hamdan JM et al. Bartter's syndrome, hypokalaemic alkalosis with hypercalciuria, is caused by mutations in the Na-K-2Cl cotransporter NKCC2. Nat Genet 1996; 13: 183-188
22. Voets T, Nilius B, Hoefs S et al. TRPM6 forms the Mg2+ influx channel involved in intestinal and renal Mg2+ absorption. J Biol Chem 2004; 279: 19-25 (Pubitemid 38044794)
23. Bachmann S, Velazquez H, Obermuller N et al. Expression of the thiazide-sensitive Na-Cl cotransporter by rabbit distal convoluted tubule cells. J Clin Invest 1995; 96: 2510-2514
24. Hoenderop JG, Muller D, Van Der Kemp AW et al. Calcitriol controls the epithelial calcium channel in kidney. J Am Soc Nephrol 2001; 12: 1342-1349 (Pubitemid 32666317)
25. Hoenderop JG, Hartog A, Stuiver M et al. Localization of the epithelial Ca2+ channel in rabbit kidney and intestine. J Am Soc Nephrol 2000; 11: 1171-1178 (Pubitemid 30416212)
26. Nijenhuis T, Hoenderop JG, Loffing J et al. Thiazide-induced hypocalciuria is accompanied by a decreased expression of Ca2+ transport proteins in kidney. Kidney Int 2003; 64: 555-564 (Pubitemid 36871926)
27. Hoenderop JG, van Leeuwen JP, van der Eerden BC et al. Renal Ca2+ wasting, hyperabsorption, and reduced bone thickness in mice lacking TRPV5. J Clin Invest 2003; 112: 1906-1914 (Pubitemid 38063714)
28. Nijenhuis T, Hoenderop JG, Bindels RJ. Downregulation of Ca (2+) and Mg(2+) transport proteins in the kidney explains tacrolimus (FK506)-induced hypercalciuria and hypomagnesaemia. J Am Soc Nephrol 2004; 15: 549-557 (Pubitemid 38294784)
29. Bindels RJ, Timmermans JA, Hartog A et al. Calbindin-D9k and parvalbumin are exclusively located along basolateral membranes in rat distal nephron. J Am Soc Nephrol 1991; 2: 1122-1129
30. Li WY, Huey CL, Yu AS. Expression of claudin-7 and -8 along the mouse nephron. Am J Physiol Renal Physiol 2004; 286: F1063-F1071 (Pubitemid 38656361)
31. Amemiya M, Loffing J, Lotscher M et al. Expression of NHE-3 in the apical membrane of rat renal proximal tubule and thick ascending limb. Kidney Int 1995; 48: 1206-1215
32. Nishinaga H, Komatsu R, Doi M et al. Circadian expression of the Na+/H+ exchanger NHE3 in the mouse renal medulla. Biomed Res 2009; 30: 87-93
33. Suki WN, Eknoyan G, Martinez-Maldonado M. Tubular sites and mechanisms of diuretic action. Annu Rev Pharmacol 1973; 13: 91-106
34. Bartter FC, Pronove P, Gill JR Jr. et al. Hyperplasia of the juxtaglomerular complex with hyperaldosteronism and hypokalemic alkalosis. A new syndrome. Am J Med 1962; 33: 811-828
35. Takahashi N, Chernavvsky DR, Gomez RA et al. Uncompensated polyuria in a mouse model of Bartter's syndrome. Proc Natl Acad Sci USA 2000; 97: 5434-5439 (Pubitemid 30313736)
36. Schultheis PJ, Lorenz JN, Meneton P et al. Phenotype resembling Gitelman's syndrome in mice lacking the apical Na+-Clcotransporter of the distal convoluted tubule. J Biol Chem 1998; 273: 29150-5 (Pubitemid 28507614)
37. Groenestege WM, Hoenderop JG, van den Heuvel L et al. The epithelial Mg2+ channel transient receptor potential melastatin 6 is regulated by dietary Mg2+ content and estrogens. J Am Soc Nephrol 2006; 17: 1035-1043
38. Wong NL, Sutton RA, Dirks JH. Is lymphocyte magnesium concentration a reflection of intracellular magnesium concentration? J Lab Clin Med 1988; 112: 721-726 (Pubitemid 19022457)
39. Gozzi T, Durler S, Truttman AC et al. Free circulating magnesium and loop diuretics in humans. Eur J Clin Pharmacol 1997; 53: 275-276 (Pubitemid 28018304)
40. Simon DB, Nelson-Williams C, Bia MJ et al. Gitelman's variant of Bartter's syndrome, inherited hypokalaemic alkalosis, is caused by mutations in the thiazide-sensitive Na-Cl cotransporter. Nat Genet 1996; 12: 24-30 (Pubitemid 26011315)
41. Gitelman HJ, Graham JB, Welt LG. A new familial disorder characterized by hypokalemia and hypomagnesaemia. Trans Assoc Am Physicians 1966; 79: 221-235
42. Hoenderop JG, van der Kemp AW, Hartog A et al. Molecular identification of the apical Ca2+ channel in 1,25-dihydroxyvitamin D3-responsive epithelia. J Biol Chem 1999; 274: 8375-8378 (Pubitemid 29164624)
43. Dussol B, Moussi-Frances J, Morange S et al. A randomized trial of furosemide vs hydrochlorothiazide in patients with chronic renal failure and hypertension. Nephrol Dial Transplant 2005; 20: 349-353 (Pubitemid 40276891)
44. Na KY, Oh YK, Han JS et al. Upregulation of Na+ transporter abundances in response to chronic thiazide or loop diuretic treatment in rats. Am J Physiol Renal Physiol 2003; 284: F133-F143 (Pubitemid 35471293)
45. Stanton BA, Kaissling B. Adaptation of distal tubule and collecting duct to increased Na delivery. II. Na+ and K+ transport. Am J Physiol 1988; 255: F1269-F1275
46. Abdallah JG, Schrier RW, Edelstein C et al. Loop diuretic infusion increases thiazide-sensitive Na(+)/Cl(-)-cotransporter abundance: role of aldosterone. J Am Soc Nephrol 2001; 12: 1335-1341 (Pubitemid 32666316)
47. van der Lubbe N, Lim CH, Fenton RA et al. Angiotensin II induces phosphorylation of the thiazide-sensitive sodium chloride cotransporter independent of aldosterone. Kidney Int 2011; 79: 66-76
48. San-Cristobal P, Pacheco-Alvarez D, Richardson C et al. Angiotensin II signaling increases activity of the renal Na-Cl cotransporter through a WNK4-SPAK-dependent pathway. Proc Natl Acad Sci USA 2009; 106: 4384-4389
49. Mutig K, Saritas T, Uchida S et al. Short-term stimulation of the thiazide-sensitive Na+-Cl- cotransporter by vasopressin involves phosphorylation and membrane translocation. Am J Physiol Renal Physiol 2010; 298: F502-F509
50. Pedersen NB, Hofmeister MV, Rosenbaek LL et al. Vasopressin induces phosphorylation of the thiazide-sensitive sodium chloride cotransporter in the distal convoluted tubule. Kidney Int 2010; 78: 160-169
51. Simon DB, Lu Y, Choate KA et al. Paracellin-1, a renal tight junction protein required for paracellular Mg2+ resorption. Science 1999; 285: 103-106 (Pubitemid 29307575)
52. Konrad M, Schaller A, Seelow D et al. Mutations in the tightjunction gene claudin 19 (CLDN19) are associated with renal magnesium wasting, renal failure, and severe ocular involvement. Am J Hum Genet 2006; 79: 949-957 (Pubitemid 44763409)