Dnmt1-dependent DNA methylation is essential for photoreceptor terminal differentiation and retinal neuron survival

Cell Death and Disease

Volumn 3, Issue 11, 2012, Pages

  Rhee, K D ^a   Yu, J ^b   Zhao, C Y ^a   Fan, G ^b,c   Yang, X J ^a,c  

^a JULES STEIN EYE INSTITUTE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Development; DNA methylation; Dnmt1; Knockout; Mouse; Neuronal differentiation and survival; Retina

Indexed keywords

DNA METHYLTRANSFERASE 1; RHODOPSIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL CYCLE G1 PHASE; CELL CYCLE PROGRESSION; CELL DEATH; CELL EXPANSION; CELL FATE; CELL MATURATION; CELL STRUCTURE; CELL SURVIVAL; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DENDRITIC CELL; DNA METHYLATION; GENE DELETION; GENE MUTATION; MALE; MOUSE; NERVE CELL DIFFERENTIATION; NERVE CELL NETWORK; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PHOTORECEPTOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; RETINA; STEM CELL;

ANIMALS; CELL DIFFERENTIATION; CELL SURVIVAL; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA METHYLATION; FEMALE; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PHOTORECEPTOR CELLS; RETINA; RETINAL NEURONS;

EID: 84870485051     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2012.165     Document Type: Article

References (31)

1. Li E, Bestor TH, Jaenisch R. Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell 1992; 69: 915-926.
2. Jaenisch R, Bird A. Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nat Genet 2003; 33(Suppl): 245-254.
3. Okano M, Bell DW, Haber DA, Li E. DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell 1999; 99: 247-257.
4. Robertson KD, Wolffe AP. DNA methylation in health and disease. Nat Rev Genet 2000; 1: 11-19.
5. Klein CJ, Botuyan MV, Wu Y, Ward CJ, Nicholson GA, Hammans S et al. Mutations in DNMT1 cause hereditary sensory neuropathy with dementia and hearing loss. Nat Genet 2011; 43: 595-600.
6. Winkelmann J, Lin L, Schormair B, Kornum BR, Faraco J, Plazzi G et al. Mutations in DNMT1 cause autosomal dominant cerebellar ataxia, deafness and narcolepsy. Hum Mol Genet 2012; 21: 2205-2210.
7. Hunter A, Spechler PA, Cwanger A, Song Y, Zhang Z, Ying GS et al. DNA methylation is associated with altered gene expression in AMD. Invest Ophthalmol Vis Sci 2012; 53: 2089-2105.
8. Fan G, Beard C, Chen RZ, Csankovszki G, Sun Y, Siniaia Met al. DNA hypomethylation perturbs the function and survival of CNS neurons in postnatal animals. J Neurosci 2001; 21: 788-797.
9. Hutnick LK, Golshani P, Namihira M, Xue Z, Matynia A, Yang XW et al. DNA hypomethylation restricted to the murine forebrain induces cortical degeneration and impairs postnatal neuronal maturation. Hum Mol Genet 2009; 18: 2875-2888.
10. Wu H, Coskun V, Tao J, Xie W, GeW, Yoshikawa K et al. Dnmt3a-dependent nonpromoter DNA methylation facilitates transcription of neurogenic genes. Science 2010; 329: 444-448.
11. Feng J, Zhou Y, Campbell SL, Le T, Li E, Sweatt JD et al. Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons. Nat Neurosci 2010; 13: 423-430.
12. Cepko CL, Austin CP, Yang X, Alexiades M, Ezzeddine D. Cell fate determination in the vertebrate retina. Proc Nat Acad Sci USA 1996; 93: 589-595.
13. Blackshaw S, Fraioli RE, Furukawa T, Cepko CL. Comprehensive analysis of photoreceptor gene expression and the identification of candidate retinal disease genes. Cell 2001; 107: 579-589.
14. Livesey FJ, Furukawa T, Steffen MA, Church GM, Cepko CL. Microarray analysis of the transcriptional network controlled by the photoreceptor homeobox gene Crx. Curr Biol 2000; 10: 301-310.
15. Yoshida S, Mears AJ, Friedman JS, Carter T, He S, Oh E et al. Expression profiling of the developing and mature Nrl-/- mouse retina: identification of retinal disease candidates and transcriptional regulatory targets of Nrl. Hum Mol Genet 2004; 13: 1487-1503.
16. Solovei I, Kreysing M, Lanctôt C, Kösem S, Peichl L, Cremer T et al. Nuclear architecture of rod photoreceptor cells adapts to vision in mammalian evolution. Cell 2009; 137: 356-368.
17. Merbs SL, Khan MA, Hackler Jr L, Oliver VF, Wan J, Qian J et al. Cell-specific DNA methylation patterns of retina-specific genes. PloS One 2012; 7: e32602.
18. Rai K, Nadauld LD, Chidester S, Manos EJ, James SR, Karpf AR et al. Zebra fish Dnmt1 and Suv39h1 regulate organ-specific terminal differentiation during development. Mol Cell Biol 2006; 26: 7077-7085.
19. Rai K, Jafri IF, Chidester S, James SR, Karpf AR, Cairns BR et al. Dnmt3 and G9a cooperate for tissue-specific development in zebrafish. J Biol Chem 2010; 285: 4110-4121.
20. Powell C, Elsaeidi F, Goldman D. Injury-dependent Muller glia and ganglion cell reprogramming during tissue regeneration requires Apobec2a and Apobec2b. J Neurosci 2012; 32: 1096-1109.
21. Rowan S, Cepko CL. Genetic analysis of the homeodomain transcription factor Chx10 in the retina using a novel multifunctional BAC transgenic mouse reporter. Dev Biol 2004; 271: 388-402.
22. Jackson-Grusby L, Beard C, Possemato R, Tudor M, Fambrough D, Csankovszki G et al. Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation. Nat Genet 2001; 27: 31-39.
23. Sakagami K, Gan L, Yang XJ. Distinct effects of Hedgehog signaling on neuronal fate specification and cell cycle progression in the embryonic mouse retina. J Neurosci 2009; 29: 6932-6944.
24. Nishida A, Furukawa A, Koike C, Tano Y, Aizawa S, Matsuo I et al. Otx2 homeobox gene controls retinal photoreceptor cell fate and pineal gland development. Nat Neurosci 2003; 6: 1255-1263.
25. Furukawa T, Morrow EM, Cepko CL. Crx, a novel otx-like homeobox gene, shows photoreceptor-specific expression and regulates photoreceptor differentiation. Cell 1997; 91: 531-541.
26. Chen S, Wang QL, Nie Z, Sun H, Lennon G, Copeland NG et al. Crx, a novel Otx-like paired-homeodomain protein, binds to and transactivates photoreceptor cell-specific genes. Neuron 1997; 19: 1017-1030.
27. Rhee KD, Goureau O, Chen S, Yang XJ. Cytokine-induced activation of signal transducer and activator of transcription in photoreceptor precursors regulates rod differentiation in the developing mouse retina. J Neurosci 2004; 24: 9779-9788.
28. Nasonkin IO, Lazo K, Hambright D, Brooks M, Fariss R, Swaroop A. Distinct nuclear localization patterns of DNA methyltransferases in developing and mature mammalian retina. J Comp Neurol 2011; 519: 1914-1930.
29. Peng GH, Chen S. Crx activates opsin transcription by recruiting HAT-containing coactivators and promoting histone acetylation. Hum Mol Genet 2007; 16: 2433-2452.
30. Oh EC, Khan N, Novelli E, Khanna H, Strettoi E, Swaroop A. Transformation of cone precursors to functional rod photoreceptors by bZIP transcription factor NRL. Proc Natl Acad Sci USA 2007; 104: 1679-1684.
31. Omori Y, Katoh K, Sato S, Muranishi Y, Chaya T, Onishi A et al. Analysis of transcriptional regulatory pathways of photoreceptor genes by expression profiling of the Otx2-deficient retina. PloS One 2011; 6: e19685.