메뉴 건너뛰기




Volumn 14, Issue 5, 2012, Pages 422-428

Glucagon-like peptide-1 and its cardiovascular effects

Author keywords

Cardiovascular disease; Dipeptidyl peptidase 4; Glucagon like peptide 1; Glucagon like peptide 1 receptor; Incretins; Myocardial infarction; Type 2 diabetesmellitus

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; DIPEPTIDYL PEPTIDASE IV; DIPEPTIDYL PEPTIDASE IV INHIBITOR; DULAGLUTIDE; EXENDIN 4; GLUCAGON LIKE PEPTIDE 1; GLUCAGON LIKE PEPTIDE 1 [7-36] AMIDE; GLUCAGON LIKE PEPTIDE 1 RECEPTOR; GLUCAGON LIKE PEPTIDE 1 RECEPTOR AGONIST; INCRETIN; LIPOPROTEIN; LIRAGLUTIDE; METFORMIN; N(G) NITROARGININE METHYL ESTER; PLACEBO; SAXAGLIPTIN; SITAGLIPTIN; SULFONYLUREA; VILDAGLIPTIN;

EID: 84870483619     PISSN: 15233804     EISSN: 15346242     Source Type: Journal    
DOI: 10.1007/s11883-012-0265-9     Document Type: Review
Times cited : (13)

References (61)
  • 1
    • 34547930879 scopus 로고    scopus 로고
    • Effect of glucagon-like peptide-1 (GLP-1) on glycemic control and left ventricular function in patients undergoing coronary artery bypass grafting
    • Sokos GG, Bolukoglu H, German J, Hentosz T, Magovern Jr GJ, Maher TD, et al. Effect of glucagon-like peptide-1 (GLP-1) on glycemic control and left ventricular function in patients undergoing coronary artery bypass grafting. Am J Cardiol. 2007;100:824-9.
    • (2007) Am J Cardiol , vol.100 , pp. 824-829
    • Sokos, G.G.1    Bolukoglu, H.2    German, J.3    Hentosz, T.4    Magovern Jr., G.J.5    Maher, T.D.6
  • 2
    • 33845293219 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 infusion improves left ventricular ejection fraction and functional status in patients with chronic heart failure
    • Sokos GG, Nikolaidis LA, Mankad S, Elahi D, Shannon RP. Glucagon-like peptide-1 infusion improves left ventricular ejection fraction and functional status in patients with chronic heart failure. J Card Fail. 2006;12:694-9.
    • (2006) J Card Fail , vol.12 , pp. 694-699
    • Sokos, G.G.1    Nikolaidis, L.A.2    Mankad, S.3    Elahi, D.4    Shannon, R.P.5
  • 3
    • 12144260853 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 can directly protect the heart against ischemia/reperfusion injury
    • Bose AK, Mocanu MM, Carr RD, Brand CL, Yellon DM. Glucagon-like peptide 1 can directly protect the heart against ischemia/reperfusion injury. Diabetes. 2005;54:146-51.
    • (2005) Diabetes , vol.54 , pp. 146-151
    • Bose, A.K.1    Mocanu, M.M.2    Carr, R.D.3    Brand, C.L.4    Yellon, D.M.5
  • 4
    • 77952889531 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 (GLP-1) attenuates postresuscitation myocardial microcirculatory dysfunction
    • Dokken BB, Hilwig WR, Teachey MK, Panchal RA, Hubner K, Allen D, et al. Glucagon-like peptide-1 (GLP-1) attenuates postresuscitation myocardial microcirculatory dysfunction. Resuscitation. 2010;81:755-60.
    • (2010) Resuscitation , vol.81 , pp. 755-760
    • Dokken, B.B.1    Hilwig, W.R.2    Teachey, M.K.3    Panchal, R.A.4    Hubner, K.5    Allen, D.6
  • 6
    • 11844269899 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 limits myocardial stunning following brief coronary occlusion and reperfusion in conscious canines
    • Nikolaidis LA, Doverspike A, Hentosz T, Zourelias L, Shen YT, Elahi D, et al. Glucagon-like peptide-1 limits myocardial stunning following brief coronary occlusion and reperfusion in conscious canines. J Pharmacol Exp Ther. 2005;312:303-8.
    • (2005) J Pharmacol Exp Ther , vol.312 , pp. 303-308
    • Nikolaidis, L.A.1    Doverspike, A.2    Hentosz, T.3    Zourelias, L.4    Shen, Y.T.5    Elahi, D.6
  • 7
    • 70350341465 scopus 로고    scopus 로고
    • Emerging cardiovascular actions of the incretin hormone glucagon-like peptide-1: Potential therapeutic benefits beyond glycaemic control?
    • Grieve DJ, Cassidy RS, Green BD. Emerging cardiovascular actions of the incretin hormone glucagon-like peptide-1: potential therapeutic benefits beyond glycaemic control? Br J Pharmacol. 2009;157:1340-51.
    • (2009) Br J Pharmacol , vol.157 , pp. 1340-1351
    • Grieve, D.J.1    Cassidy, R.S.2    Green, B.D.3
  • 8
    • 34248223285 scopus 로고    scopus 로고
    • Biology of incretins: GLP-1 and GIP
    • Baggio LL, Drucker DJ. Biology of incretins: GLP-1 and GIP. Gastroenterology. 2007;132:2131-57.
    • (2007) Gastroenterology , vol.132 , pp. 2131-2157
    • Baggio, L.L.1    Drucker, D.J.2
  • 10
    • 0023107555 scopus 로고
    • Insulinotropin: Glucagon-like peptide i (7-37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas
    • Mojsov S, Weir GC, Habener JF. Insulinotropin: glucagon-like peptide I (7-37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas. J Clin Invest. 1987;79:616-9.
    • (1987) J Clin Invest , Issue.79 , pp. 616-619
    • Mojsov, S.1    Weir, G.C.2    Habener, J.F.3
  • 13
    • 57149083860 scopus 로고    scopus 로고
    • The incretins: From the concept to their use in the treatment of type 2 diabetes. Part A: Incretins: Concept and physiological functions
    • Girard J. The incretins: from the concept to their use in the treatment of type 2 diabetes. Part A: incretins: concept and physiological functions. Diabetes Metab. 2008;34:550-9.
    • (2008) Diabetes Metab , vol.34 , pp. 550-559
    • Girard, J.1
  • 14
    • 77956945357 scopus 로고    scopus 로고
    • GIP: No longer the neglected incretin twin?
    • Kulkarni RN. GIP: no longer the neglected incretin twin? Sci Transl Med. 2010;2:49ps47.
    • (2010) Sci Transl Med , vol.2
    • Kulkarni, R.N.1
  • 15
    • 0027136670 scopus 로고
    • Gastric inhibitory polypeptide receptor, a member of the secretinvasoactive intestinal peptide receptor family, is widely distributed in peripheral organs and the brain
    • Usdin TB, Mezey E, Button DC, Brownstein MJ, Bonner TI. Gastric inhibitory polypeptide receptor, a member of the secretinvasoactive intestinal peptide receptor family, is widely distributed in peripheral organs and the brain. Endocrinology. 1993;133:2861-70.
    • (1993) Endocrinology , vol.133 , pp. 2861-2870
    • Usdin, T.B.1    Mezey, E.2    Button, D.C.3    Brownstein, M.J.4    Bonner, T.I.5
  • 16
    • 75749091912 scopus 로고    scopus 로고
    • Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge
    • Saxena R, Hivert MF, Langenberg C, Tanaka T, Pankow JS, Vollenweider P, et al. Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nat Genet. 2010;42:142-8.
    • (2010) Nat Genet , vol.42 , pp. 142-148
    • Saxena, R.1    Hivert, M.F.2    Langenberg, C.3    Tanaka, T.4    Pankow, J.S.5    Vollenweider, P.6
  • 17
    • 0027157849 scopus 로고
    • Biological effects and metabolic rates of glucagonlike peptide-1 7-36 amide and glucagonlike peptide-1 7-37 in healthy subjects are indistinguishable
    • Orskov C, Wettergren A, Holst JJ. Biological effects and metabolic rates of glucagonlike peptide-1 7-36 amide and glucagonlike peptide-1 7-37 in healthy subjects are indistinguishable. Diabetes. 1993;42:658-61.
    • (1993) Diabetes , vol.42 , pp. 658-661
    • Orskov, C.1    Wettergren, A.2    Holst, J.J.3
  • 18
    • 0028799007 scopus 로고
    • Differential processing of proglucagon by the subtilisin-like prohormone convertases PC2 and PC3 to generate either glucagon or glucagon-like peptide
    • Rouille Y, Martin S, Steiner DF. Differential processing of proglucagon by the subtilisin-like prohormone convertases PC2 and PC3 to generate either glucagon or glucagon-like peptide. J Biol Chem. 1995;270:26488-96.
    • (1995) J Biol Chem , vol.270 , pp. 26488-26496
    • Rouille, Y.1    Martin, S.2    Steiner, D.F.3
  • 19
    • 67651173077 scopus 로고    scopus 로고
    • Incretin-based therapies for type 2 diabetes mellitus
    • Lovshin JA, Drucker DJ. Incretin-based therapies for type 2 diabetes mellitus. Nat Rev Endocrinol. 2009;5:262-9.
    • (2009) Nat Rev Endocrinol , vol.5 , pp. 262-269
    • Lovshin, J.A.1    Drucker, D.J.2
  • 20
    • 0028325376 scopus 로고
    • Divergent tissue-specific and developmental expression of receptors for glucagon and glucagonlike peptide-1 in the mouse
    • Campos RV, Lee YC, Drucker DJ. Divergent tissue-specific and developmental expression of receptors for glucagon and glucagonlike peptide-1 in the mouse. Endocrinology. 1994;134:2156-64.
    • (1994) Endocrinology , vol.134 , pp. 2156-2164
    • Campos, R.V.1    Lee, Y.C.2    Drucker, D.J.3
  • 21
    • 0033304603 scopus 로고    scopus 로고
    • The glucagon-like peptides
    • Kieffer TJ, Habener JF. The glucagon-like peptides. Endocr Rev. 1999;20:876-913.
    • (1999) Endocr Rev , vol.20 , pp. 876-913
    • Kieffer, T.J.1    Habener, J.F.2
  • 22
    • 77949273334 scopus 로고    scopus 로고
    • The glucagon-like peptide 1 receptor is essential for postprandial lipoprotein synthesis and secretion in hamsters and mice
    • Hsieh J, Longuet C, Baker CL, Qin B, Federico LM, Drucker DJ, et al. The glucagon-like peptide 1 receptor is essential for postprandial lipoprotein synthesis and secretion in hamsters and mice. Diabetologia. 2010;53:552-61.
    • (2010) Diabetologia , vol.53 , pp. 552-561
    • Hsieh, J.1    Longuet, C.2    Baker, C.L.3    Qin, B.4    Federico, L.M.5    Drucker, D.J.6
  • 23
    • 33244481977 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 abolishes the postprandial rise in triglyceride concentrations and lowers levels of non-esterified fatty acids in humans
    • Meier JJ, Gethmann A, Gotze O, Gallwitz B, Holst JJ, Schmidt WE, et al. Glucagon-like peptide 1 abolishes the postprandial rise in triglyceride concentrations and lowers levels of non-esterified fatty acids in humans. Diabetologia. 2006;49:452-8.
    • (2006) Diabetologia , vol.49 , pp. 452-458
    • Meier, J.J.1    Gethmann, A.2    Gotze, O.3    Gallwitz, B.4    Holst, J.J.5    Schmidt, W.E.6
  • 24
    • 0034857141 scopus 로고    scopus 로고
    • Development of glucagon-like peptide-1-based pharmaceuticals as therapeutic agents for the treatment of diabetes
    • Drucker DJ. Development of glucagon-like peptide-1-based pharmaceuticals as therapeutic agents for the treatment of diabetes. Curr Pharm Des. 2001;7:1399-412.
    • (2001) Curr Pharm des , vol.7 , pp. 1399-1412
    • Drucker, D.J.1
  • 25
    • 77956230708 scopus 로고    scopus 로고
    • Exenatide suppresses postprandial elevations in lipids and lipoproteins in individuals with impaired glucose tolerance and recent onset type 2 diabetes mellitus
    • Schwartz EA, Koska J, Mullin MP, Syoufi I, Schwenke DC, Reaven PD. Exenatide suppresses postprandial elevations in lipids and lipoproteins in individuals with impaired glucose tolerance and recent onset type 2 diabetes mellitus. Atherosclerosis. 2010;212:217-22.
    • (2010) Atherosclerosis , vol.212 , pp. 217-222
    • Schwartz, E.A.1    Koska, J.2    Mullin, M.P.3    Syoufi, I.4    Schwenke, D.C.5    Reaven, P.D.6
  • 26
    • 33746690405 scopus 로고    scopus 로고
    • Vildagliptin therapy reduces postprandial intestinal triglyceride-rich lipoprotein particles in patients with type 2 diabetes
    • Matikainen N, Manttari S, Schweizer A, Ulvestad A, Mills D, Dunning BE, et al. Vildagliptin therapy reduces postprandial intestinal triglyceride-rich lipoprotein particles in patients with type 2 diabetes. Diabetologia. 2006;49:2049-57.
    • (2006) Diabetologia , vol.49 , pp. 2049-2057
    • Matikainen, N.1    Manttari, S.2    Schweizer, A.3    Ulvestad, A.4    Mills, D.5    Dunning, B.E.6
  • 27
    • 43249089631 scopus 로고    scopus 로고
    • Cardioprotective and vasodilatory actions of glucagon-like peptide 1 receptor are mediated through both glucagon-like peptide 1 receptor-dependent and -independent pathways
    • Ban K, Noyan-Ashraf MH, Hoefer J, Bolz SS, Drucker DJ, Husain M. Cardioprotective and vasodilatory actions of glucagon-like peptide 1 receptor are mediated through both glucagon-like peptide 1 receptor-dependent and -independent pathways. Circulation. 2008;117:2340-50.
    • (2008) Circulation , vol.117 , pp. 2340-2350
    • Ban, K.1    Noyan-Ashraf, M.H.2    Hoefer, J.3    Bolz, S.S.4    Drucker, D.J.5    Husain, M.6
  • 28
    • 0030013475 scopus 로고    scopus 로고
    • Tissue distribution of messenger ribonucleic acid encoding the rat glucagon-like peptide-1 receptor
    • Bullock BP, Heller RS, Habener JF. Tissue distribution of messenger ribonucleic acid encoding the rat glucagon-like peptide-1 receptor. Endocrinology. 1996;137:2968-78.
    • (1996) Endocrinology , vol.137 , pp. 2968-2978
    • Bullock, B.P.1    Heller, R.S.2    Habener, J.F.3
  • 29
    • 0035980166 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 increases cAMP but fails to augment contraction in adult rat cardiac myocytes
    • Vila Petroff MG, Egan JM, Wang X, Sollott SJ. Glucagon-like peptide-1 increases cAMP but fails to augment contraction in adult rat cardiac myocytes. Circ Res. 2001;89:445-52.
    • (2001) Circ Res , vol.89 , pp. 445-452
    • Vila Petroff, M.G.1    Egan, J.M.2    Wang, X.3    Sollott, S.J.4
  • 30
    • 0036307872 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 receptor stimulation increases blood pressure and heart rate and activates autonomic regulatory neurons
    • Yamamoto H, Lee CE, Marcus JN, Williams TD, Overton JM, Lopez ME, et al. Glucagon-like peptide-1 receptor stimulation increases blood pressure and heart rate and activates autonomic regulatory neurons. J Clin Invest. 2002;110:43-52.
    • (2002) J Clin Invest , vol.110 , pp. 43-52
    • Yamamoto, H.1    Lee, C.E.2    Marcus, J.N.3    Williams, T.D.4    Overton, J.M.5    Lopez, M.E.6
  • 31
    • 52049093652 scopus 로고    scopus 로고
    • GLP-1 and related peptides cause concentration-dependent relaxation of rat aorta through a pathway involving KATP and cAMP
    • Green BD, Hand KV, Dougan JE, McDonnell BM, Cassidy RS, Grieve DJ. GLP-1 and related peptides cause concentration-dependent relaxation of rat aorta through a pathway involving KATP and cAMP. Arch Biochem Biophys. 2008;478:136-42.
    • (2008) Arch Biochem Biophys , vol.478 , pp. 136-142
    • Green, B.D.1    Hand, K.V.2    Dougan, J.E.3    McDonnell, B.M.4    Cassidy, R.S.5    Grieve, D.J.6
  • 32
    • 28144441354 scopus 로고    scopus 로고
    • Active metabolite of GLP-1 mediates myocardial glucose uptake and improves left ventricular performance in conscious dogs with dilated cardiomyopathy
    • Nikolaidis LA, Elahi D, Shen YT, Shannon RP. Active metabolite of GLP-1 mediates myocardial glucose uptake and improves left ventricular performance in conscious dogs with dilated cardiomyopathy. Am J Physiol Heart Circ Physiol. 2005;289:H2401-2408.
    • (2005) Am J Physiol Heart Circ Physiol , vol.289
    • Nikolaidis, L.A.1    Elahi, D.2    Shen, Y.T.3    Shannon, R.P.4
  • 33
    • 22144437777 scopus 로고    scopus 로고
    • Effect of glucagon-like peptide-1(7-36) and exendin-4 on the vascular reactivity in streptozotocin/nicotinamide-induced diabetic rats
    • Ozyazgan S, Kutluata N, Afsar S, Ozdas SB, Akkan AG. Effect of glucagon-like peptide-1(7-36) and exendin-4 on the vascular reactivity in streptozotocin/nicotinamide-induced diabetic rats. Pharmacology. 2005;74:119-26.
    • (2005) Pharmacology , vol.74 , pp. 119-126
    • Ozyazgan, S.1    Kutluata, N.2    Afsar, S.3    Ozdas, S.B.4    Akkan, A.G.5
  • 34
    • 0035892681 scopus 로고    scopus 로고
    • Vasorelaxant effect of glucagon-like peptide-(7-36)amide and amylin on the pulmonary circulation of the rat
    • Golpon HA, Puechner A, Welte T, Wichert PV, Feddersen CO. Vasorelaxant effect of glucagon-like peptide-(7-36)amide and amylin on the pulmonary circulation of the rat. Regul Pept. 2001;102:81-6.
    • (2001) Regul Pept , vol.102 , pp. 81-86
    • Golpon, H.A.1    Puechner, A.2    Welte, T.3    Wichert, P.V.4    Feddersen, C.O.5
  • 35
    • 33646795007 scopus 로고    scopus 로고
    • Direct effects of glucagon-like peptide-1 on myocardial contractility and glucose uptake in normal and postischemic isolated rat hearts
    • Zhao T, Parikh P, Bhashyam S, Bolukoglu H, Poornima I, Shen YT, et al. Direct effects of glucagon-like peptide-1 on myocardial contractility and glucose uptake in normal and postischemic isolated rat hearts. J Pharmacol Exp Ther. 2006;317:1106-13.
    • (2006) J Pharmacol Exp Ther , vol.317 , pp. 1106-1113
    • Zhao, T.1    Parikh, P.2    Bhashyam, S.3    Bolukoglu, H.4    Poornima, I.5    Shen, Y.T.6
  • 36
    • 58949102483 scopus 로고    scopus 로고
    • Chronic glucagon-like peptide-1 infusion sustains left ventricular systolic function and prolongs survival in the spontaneously hypertensive, heart failure-prone rat
    • Poornima I, Brown SB, Bhashyam S, Parikh P, Bolukoglu H, Shannon RP. Chronic glucagon-like peptide-1 infusion sustains left ventricular systolic function and prolongs survival in the spontaneously hypertensive, heart failure-prone rat. Circ Heart Fail. 2008;1:153-60.
    • (2008) Circ Heart Fail , vol.1 , pp. 153-160
    • Poornima, I.1    Brown, S.B.2    Bhashyam, S.3    Parikh, P.4    Bolukoglu, H.5    Shannon, R.P.6
  • 37
    • 0038202937 scopus 로고    scopus 로고
    • Antihypertensive effect of glucagon-like peptide 1 in Dahl salt-sensitive rats
    • Yu M, Moreno C, Hoagland KM, Dahly A, Ditter K, Mistry M, et al. Antihypertensive effect of glucagon-like peptide 1 in Dahl salt-sensitive rats. J Hypertens. 2003;21:1125-35.
    • (2003) J Hypertens , vol.21 , pp. 1125-1135
    • Yu, M.1    Moreno, C.2    Hoagland, K.M.3    Dahly, A.4    Ditter, K.5    Mistry, M.6
  • 38
    • 9944251347 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 relaxes rat conduit arteries via an endothelium-independent mechanism
    • Nystrom T, Gonon AT, Sjoholm A, Pernow J. Glucagon-like peptide-1 relaxes rat conduit arteries via an endothelium-independent mechanism. Regul Pept. 2005;125:173-7.
    • (2005) Regul Pept , vol.125 , pp. 173-177
    • Nystrom, T.1    Gonon, A.T.2    Sjoholm, A.3    Pernow, J.4
  • 39
    • 77955828386 scopus 로고    scopus 로고
    • Possible involvement of GLP-1(9-36) in the regional haemodynamic effects of GLP-1(7-36) in conscious rats
    • Gardiner SM, March JE, Kemp PA, Bennett T, Baker DJ. Possible involvement of GLP-1(9-36) in the regional haemodynamic effects of GLP-1(7-36) in conscious rats. Br J Pharmacol. 2010;161:92-102.
    • (2010) Br J Pharmacol , vol.161 , pp. 92-102
    • Gardiner, S.M.1    March, J.E.2    Kemp, P.A.3    Bennett, T.4    Baker, D.J.5
  • 40
    • 77951901715 scopus 로고    scopus 로고
    • Cell death in the pathogenesis of heart disease: Mechanisms and significance
    • Whelan RS, Kaplinskiy V, Kitsis RN. Cell death in the pathogenesis of heart disease: mechanisms and significance. Annu Rev Physiol. 2010;72:19-44.
    • (2010) Annu Rev Physiol , vol.72 , pp. 19-44
    • Whelan, R.S.1    Kaplinskiy, V.2    Kitsis, R.N.3
  • 42
    • 1142309743 scopus 로고    scopus 로고
    • New directions for protecting the heart against ischaemia-reperfusion injury: Targeting the Reperfusion Injury Salvage Kinase (RISK)-pathway
    • Hausenloy DJ, Yellon DM. New directions for protecting the heart against ischaemia-reperfusion injury: targeting the Reperfusion Injury Salvage Kinase (RISK)-pathway. Cardiovasc Res. 2004;61:448-60.
    • (2004) Cardiovasc Res , vol.61 , pp. 448-460
    • Hausenloy, D.J.1    Yellon, D.M.2
  • 43
    • 34548746306 scopus 로고    scopus 로고
    • Myocardial reperfusion injury
    • Yellon DM, Hausenloy DJ. Myocardial reperfusion injury. N Engl J Med. 2007;357:1121-35.
    • (2007) N Engl J Med , vol.357 , pp. 1121-1135
    • Yellon, D.M.1    Hausenloy, D.J.2
  • 44
    • 77955480007 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 increases myocardial glucose uptake via p38alpha MAP kinase-mediated, nitric oxide-dependent mechanisms in conscious dogs with dilated cardiomyopathy
    • Bhashyam S, Fields AV, Patterson B, Testani JM, Chen L, Shen YT, et al. Glucagon-like peptide-1 increases myocardial glucose uptake via p38alpha MAP kinase-mediated, nitric oxide-dependent mechanisms in conscious dogs with dilated cardiomyopathy. Circ Heart Fail. 2010;3:512-21.
    • (2010) Circ Heart Fail , vol.3 , pp. 512-521
    • Bhashyam, S.1    Fields, A.V.2    Patterson, B.3    Testani, J.M.4    Chen, L.5    Shen, Y.T.6
  • 45
    • 77951168113 scopus 로고    scopus 로고
    • Genetic deletion or pharmacological inhibition of dipeptidyl peptidase-4 improves cardiovascular outcomes after myocardial infarction in mice
    • Sauve M, Ban K, Momen MA, Zhou YQ, Henkelman RM, Husain M, et al. Genetic deletion or pharmacological inhibition of dipeptidyl peptidase-4 improves cardiovascular outcomes after myocardial infarction in mice. Diabetes. 2010;59:1063-73.
    • (2010) Diabetes , vol.59 , pp. 1063-1073
    • Sauve, M.1    Ban, K.2    Momen, M.A.3    Zhou, Y.Q.4    Henkelman, R.M.5    Husain, M.6
  • 46
    • 84855492576 scopus 로고    scopus 로고
    • Granulocyte colony-stimulating factor treatment plus dipeptidylpeptidase- IV inhibition augments myocardial regeneration in mice expressing cyclin D2 in adult cardiomyocytes
    • Zaruba MM, Zhu W, Soonpaa MH, Reuter S, Franz WM, Field LJ. Granulocyte colony-stimulating factor treatment plus dipeptidylpeptidase-IV inhibition augments myocardial regeneration in mice expressing cyclin D2 in adult cardiomyocytes. Eur Heart J. 2012;33:129-37.
    • (2012) Eur Heart J , vol.33 , pp. 129-137
    • Zaruba, M.M.1    Zhu, W.2    Soonpaa, M.H.3    Reuter, S.4    Franz, W.M.5    Field, L.J.6
  • 47
    • 1442311383 scopus 로고    scopus 로고
    • Effects of glucagon-like peptide-1 in patients with acute myocardial infarction and left ventricular dysfunction after successful reperfusion
    • Nikolaidis LA, Mankad S, Sokos GG, Miske G, Shah A, Elahi D, et al. Effects of glucagon-like peptide-1 in patients with acute myocardial infarction and left ventricular dysfunction after successful reperfusion. Circulation. 2004;109:962-5.
    • (2004) Circulation , vol.109 , pp. 962-965
    • Nikolaidis, L.A.1    Mankad, S.2    Sokos, G.G.3    Miske, G.4    Shah, A.5    Elahi, D.6
  • 49
    • 38549162147 scopus 로고    scopus 로고
    • Exenatide effects on diabetes, obesity, cardiovascular risk factors and hepatic biomarkers in patients with type 2 diabetes treated for at least 3 years
    • Klonoff DC, Buse JB, Nielsen LL, Guan X, Bowlus CL, Holcombe JH, et al. Exenatide effects on diabetes, obesity, cardiovascular risk factors and hepatic biomarkers in patients with type 2 diabetes treated for at least 3 years. Curr Med Res Opin. 2008;24:275-86.
    • (2008) Curr Med Res Opin , vol.24 , pp. 275-286
    • Klonoff, D.C.1    Buse, J.B.2    Nielsen, L.L.3    Guan, X.4    Bowlus, C.L.5    Holcombe, J.H.6
  • 50
    • 0026648961 scopus 로고
    • Isolation and characterization of exendin-4, an exendin-3 analogue, from Heloderma suspectum venom. Further evidence for an exendin receptor on dispersed acini from guinea pig pancreas
    • Eng J, Kleinman WA, Singh L, Singh G, Raufman JP. Isolation and characterization of exendin-4, an exendin-3 analogue, from Heloderma suspectum venom. Further evidence for an exendin receptor on dispersed acini from guinea pig pancreas. J Biol Chem. 1992;267:7402-5.
    • (1992) J Biol Chem , vol.267 , pp. 7402-7405
    • Eng, J.1    Kleinman, W.A.2    Singh, L.3    Singh, G.4    Raufman, J.P.5
  • 51
    • 77958030736 scopus 로고    scopus 로고
    • Efficacy and safety of saxagliptin in combination with metformin compared with sitagliptin in combination with metformin in adult patients with type 2 diabetes mellitus
    • Scheen AJ, Charpentier G, Ostgren CJ, Hellqvist A, Gause-Nilsson I. Efficacy and safety of saxagliptin in combination with metformin compared with sitagliptin in combination with metformin in adult patients with type 2 diabetes mellitus. Diabetes Metab Res Rev. 2010;26:540-9.
    • (2010) Diabetes Metab Res Rev , vol.26 , pp. 540-549
    • Scheen, A.J.1    Charpentier, G.2    Ostgren, C.J.3    Hellqvist, A.4    Gause-Nilsson, I.5
  • 52
    • 84859721063 scopus 로고    scopus 로고
    • DPP-4 inhibitors in the management of type 2 diabetes: A critical review of head-to-head trials
    • Scheen AJ. DPP-4 inhibitors in the management of type 2 diabetes: a critical review of head-to-head trials. Diabetes Metab. 2012;38:89-101.
    • (2012) Diabetes Metab , vol.38 , pp. 89-101
    • Scheen, A.J.1
  • 53
    • 33845476757 scopus 로고    scopus 로고
    • Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing metformin therapy in patients with type 2 diabetes inadequately controlled with metformin alone
    • Charbonnel B, Karasik A, Liu J, Wu M, Meininger G. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing metformin therapy in patients with type 2 diabetes inadequately controlled with metformin alone. Diabetes Care. 2006;29:2638-43.
    • (2006) Diabetes Care , vol.29 , pp. 2638-2643
    • Charbonnel, B.1    Karasik, A.2    Liu, J.3    Wu, M.4    Meininger, G.5
  • 54
    • 67649666737 scopus 로고    scopus 로고
    • Liraglutide once a day versus exenatide twice a day for type 2 diabetes: A 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6)
    • Buse JB, Rosenstock J, Sesti G, Schmidt WE, Montanya E, Brett JH, et al. Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6). Lancet. 2009;374:39-47.
    • (2009) Lancet , vol.374 , pp. 39-47
    • Buse, J.B.1    Rosenstock, J.2    Sesti, G.3    Schmidt, W.E.4    Montanya, E.5    Brett, J.H.6
  • 55
    • 51549095571 scopus 로고    scopus 로고
    • Efficacy and tolerability of exenatide monotherapy over 24 weeks in antidiabetic drug-naive patients with type 2 diabetes: A randomized, double-blind, placebo-controlled, parallelgroup study
    • Moretto TJ, Milton DR, Ridge TD, Macconell LA, Okerson T, Wolka AM, et al. Efficacy and tolerability of exenatide monotherapy over 24 weeks in antidiabetic drug-naive patients with type 2 diabetes: a randomized, double-blind, placebo-controlled, parallelgroup study. Clin Ther. 2008;30:1448-60.
    • (2008) Clin Ther , vol.30 , pp. 1448-1460
    • Moretto, T.J.1    Milton, D.R.2    Ridge, T.D.3    MacConell, L.A.4    Okerson, T.5    Wolka, A.M.6
  • 56
    • 59449101432 scopus 로고    scopus 로고
    • Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD-3Mono): A randomised, 52-week, phase III, double-blind, parallel-treatment trial
    • Garber A, Henry R, Ratner R, Garcia-Hernandez PA, Rodriguez-Pattzi H, Olvera-Alvarez I, et al. Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD-3Mono): a randomised, 52-week, phase III, double-blind, parallel-treatment trial. Lancet. 2009;373:473-81.
    • (2009) Lancet , vol.373 , pp. 473-481
    • Garber, A.1    Henry, R.2    Ratner, R.3    Garcia-Hernandez, P.A.4    Rodriguez-Pattzi, H.5    Olvera-Alvarez, I.6
  • 57
    • 34347219401 scopus 로고    scopus 로고
    • Once-daily sitagliptin, a dipeptidyl peptidase-4 inhibitor, for the treatment of patients with type 2 diabetes
    • Hanefeld M, Herman GA, Wu M, Mickel C, Sanchez M, Stein PP. Once-daily sitagliptin, a dipeptidyl peptidase-4 inhibitor, for the treatment of patients with type 2 diabetes. Curr Med Res Opin. 2007;23:1329-39.
    • (2007) Curr Med Res Opin , vol.23 , pp. 1329-1339
    • Hanefeld, M.1    Herman, G.A.2    Wu, M.3    Mickel, C.4    Sanchez, M.5    Stein, P.P.6
  • 58
    • 33847024333 scopus 로고    scopus 로고
    • Efficacy and tolerability of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy over 12 weeks in patients with type 2 diabetes
    • Scott R, Wu M, Sanchez M, Stein P. Efficacy and tolerability of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy over 12 weeks in patients with type 2 diabetes. Int J Clin Pract. 2007;61:171-80.
    • (2007) Int J Clin Pract , vol.61 , pp. 171-180
    • Scott, R.1    Wu, M.2    Sanchez, M.3    Stein, P.4
  • 59
    • 77952309372 scopus 로고    scopus 로고
    • Liraglutide versus sitagliptin for patients with type 2 diabetes who did not have adequate glycaemic control with metformin: A 26-week, randomised, parallel-group, open-label trial
    • Pratley RE, Nauck M, Bailey T, Montanya E, Cuddihy R, Filetti S, et al. Liraglutide versus sitagliptin for patients with type 2 diabetes who did not have adequate glycaemic control with metformin: a 26-week, randomised, parallel-group, open-label trial. Lancet. 2010;375:1447-56.
    • (2010) Lancet , vol.375 , pp. 1447-1456
    • Pratley, R.E.1    Nauck, M.2    Bailey, T.3    Montanya, E.4    Cuddihy, R.5    Filetti, S.6
  • 60
    • 55549136417 scopus 로고    scopus 로고
    • Effects of exenatide versus sitagliptin on postprandial glucose, insulin and glucagon secretion, gastric emptying, and caloric intake: A randomized, cross-over study
    • DeFronzo RA, Okerson T, Viswanathan P, Guan X, Holcombe JH, MacConell L. Effects of exenatide versus sitagliptin on postprandial glucose, insulin and glucagon secretion, gastric emptying, and caloric intake: a randomized, cross-over study. Curr Med Res Opin. 2008;24:2943-52.
    • (2008) Curr Med Res Opin , vol.24 , pp. 2943-2952
    • Defronzo, R.A.1    Okerson, T.2    Viswanathan, P.3    Guan, X.4    Holcombe, J.H.5    MacConell, L.6
  • 61
    • 77953182696 scopus 로고    scopus 로고
    • Assessing the cardio-cerebrovascular safety of vildagliptin: Meta-analysis of adjudicated events from a large Phase III type 2 diabetes population
    • Schweizer A, Dejager S, Foley JE, Couturier A, Ligueros-Saylan M, Kothny W. Assessing the cardio-cerebrovascular safety of vildagliptin: meta-analysis of adjudicated events from a large Phase III type 2 diabetes population. Diabetes Obes Metab. 2010;12:485-94.
    • (2010) Diabetes Obes Metab , vol.12 , pp. 485-494
    • Schweizer, A.1    Dejager, S.2    Foley, J.E.3    Couturier, A.4    Ligueros-Saylan, M.5    Kothny, W.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.