Involvement of transcription factor Ets-1 in the expression of the α3 integrin subunit gene

FEBS Journal

Volumn 279, Issue 24, 2012, Pages 4535-4546

  Kamoshida, Go ^a   Matsuda, Ayaka ^a   Katabami, Kouji ^a   Kato, Takumi ^a   Mizuno, Hiromi ^a   Sekine, Wakana ^a   Oku, Teruaki ^a   Itoh, Saotomo ^a   Tsuiji, Makoto ^a   Hattori, Yoshiyuki ^a   Maitani, Yoshie ^a   Tsuji, Tsutomu ^a  

^a HOSHI UNIVERSITY   (Japan)

Author keywords

Ets 1; integrin; promoter; transcription factor; transforming growth factor

Indexed keywords

ALPHA3 INTEGRIN; LUCIFERASE; TRANSCRIPTION FACTOR ETS 1; TRANSFORMING GROWTH FACTOR BETA1;

ALPHA3 INTEGRIN GENE; AMINO ACID SEQUENCE; ARTICLE; CONTROLLED STUDY; DNA FLANKING REGION; EMBRYO; ENZYME ACTIVITY; GENE EXPRESSION; GENE INDUCTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; TANDEM REPEAT; TRANSCRIPTION INITIATION; UPREGULATION;

CELL LINE, TUMOR; GENE EXPRESSION REGULATION; HUMANS; INTEGRIN ALPHA3; PROTO-ONCOGENE PROTEIN C-ETS-1; TRANSCRIPTIONAL ACTIVATION; TRANSFORMING GROWTH FACTOR BETA1; UP-REGULATION;

EID: 84870481704     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/febs.12040     Document Type: Article

References (55)

1. Carter WG, Ryan MC, &, Gahr PJ, (1991) Epiligrin, a new cell adhesion ligand for integrin alpha 3 beta 1 in epithelial basement membranes. Cell 65, 599-610.
2. Kikkawa Y, Sanzen N, &, Sekiguchi K, (1998) Isolation and characterization of laminin-10/11 secreted by human lung carcinoma cells. laminin-10/11 mediates cell adhesion through integrin alpha3 beta1. J Biol Chem 273, 15854-15859.
3. Tsuji T, (2004) Physiological and pathological roles of alpha3beta1 integrin. J Membr Biol 200, 115-132.
4. Guo N, Templeton NS, Al-Barazi H, Cashel JA, Sipes JM, Krutzsch HC, &, Roberts DD, (2000) Thrombospondin-1 promotes alpha3beta1 integrin-mediated adhesion and neurite-like outgrowth and inhibits proliferation of small cell lung carcinoma cells. Cancer Res 60, 457-466.
5. Kreidberg JA, Donovan MJ, Goldstein SL, Rennke H, Shepherd K, Jones RC, &, Jaenisch R, (1996) Alpha 3 beta 1 integrin has a crucial role in kidney and lung organogenesis. Development 122, 3537-3547.
6. Takada Y, Murphy E, Pil P, Chen C, Ginsberg MH, &, Hemler ME, (1991) Molecular cloning and expression of the cDNA for alpha 3 subunit of human alpha 3 beta 1 (VLA-3), an integrin receptor for fibronectin, laminin, and collagen. J Cell Biol 115, 257-266.
7. Tsuji T, Yamamoto F, Miura Y, Takio K, Titani K, Pawar S, Osawa T, &, Hakomori S, (1990) Characterization through cDNA cloning of galactoprotein b3 (Gap b3), a cell surface membrane glycoprotein showing enhanced expression on oncogenic transformation. Identification of Gap b3 as a member of the integrin superfamily. J Biol Chem 265, 7016-7021.
8. Tsuji T, Hakomori S, &, Osawa T, (1991) Identification of human galactoprotein b3, an oncogenic transformation-induced membrane glycoprotein, as VLA-3 alpha subunit: the primary structure of human integrin alpha 3. J Biochem 109, 659-665.
9. Takeuchi K, Hirano K, Tsuji T, Osawa T, &, Irimura T, (1995) cDNA cloning of mouse VLA-3 alpha subunit. J Cell Biochem 57, 371-377.
10. Fukushima Y, Ohnishi T, Arita N, Hayakawa T, &, Sekiguchi K, (1998) Integrin alpha3beta1-mediated interaction with laminin-5 stimulates adhesion, migration and invasion of malignant glioma cells. Int J Cancer 76, 63-72.
11. Nishimura S, Chung YS, Yashiro M, Inoue T, &, Sowa M, (1996) Role of alpha 2 beta 1- and alpha 3 beta 1-integrin in the peritoneal implantation of scirrhous gastric carcinoma. Br J Cancer 74, 1406-1412.
12. Kishima H, Shimizu K, Tamura K, Miyao Y, Mabuchi E, Tominaga E, Matsuzaki J, &, Hayakawa T, (1999) Monoclonal antibody ONS-M21 recognizes integrin alpha3 in gliomas and medulloblastomas. Br J Cancer 79, 333-339.
13. Bergamini C, Sgarra C, Trerotoli P, Lupo L, Azzariti A, Antonaci S, &, Giannelli G, (2007) Laminin-5 stimulates hepatocellular carcinoma growth through a different function of alpha6beta4 and alpha3beta1 integrins. Hepatology 46, 1801-1809.
14. Van Waes C, Surh DM, Chen Z, Kirby M, Rhim JS, Brager R, Sessions RB, Poore J, Wolf GT, &, Carey TE, (1995) Increase in suprabasilar integrin adhesion molecule expression in human epidermal neoplasms accompanies increased proliferation occurring with immortalization and tumor progression. Cancer Res 55, 5434-5444.
15. Adachi M, Taki T, Huang C, Higashiyama M, Doi O, Tsuji T, &, Miyake M, (1998) Reduced integrin alpha3 expression as a factor of poor prognosis of patients with adenocarcinoma of the lung. J Clin Oncol 16, 1060-1067.
16. Ura H, Denno R, Hirata K, Yamaguchi K, &, Yasoshima T, (1998) Separate functions of alpha2beta1 and alpha3beta1 integrins in the metastatic process of human gastric carcinoma. Surg Today 28, 1001-1006.
17. Takatsuki H, Komatsu S, Sano R, Takada Y, &, Tsuji T, (2004) Adhesion of gastric carcinoma cells to peritoneum mediated by alpha3beta1 integrin (VLA-3). Cancer Res 64, 6065-6070.
18. Saito Y, Sekine W, Sano R, Komatsu S, Mizuno H, Katabami K, Shimada K, Oku T, &, Tsuji T, (2010) Potentiation of cell invasion and matrix metalloproteinase production by alpha3beta1 integrin-mediated adhesion of gastric carcinoma cells to laminin-5. Clin Exp Metastasis 27, 197-205.
19. Ito H, Seyama Y, &, Kubota S, (2001) Calreticulin is directly involved in anti-alpha3 integrin antibody-mediated secretion and activation of matrix metalloprotease-2. Biochem Biophys Res Commun 283, 297-302.
20. Tsuji T, Kawada Y, Kai-Murozono M, Komatsu S, Han SA, Takeuchi K, Mizushima H, Miyazaki K, &, Irimura T, (2002) Regulation of melanoma cell migration and invasion by laminin-5 and alpha3beta1 integrin (VLA-3). Clin Exp Metastasis 19, 127-134.
21. Kato T, Katabami K, Takatsuki H, Han SA, Takeuchi K, Irimura T, &, Tsuji T, (2002) Characterization of the promoter for the mouse alpha 3 integrin gene. Eur J Biochem 269, 4524-4532.
22. Katabami K, Kato T, Sano R, Ogura M, Mizuno H, Itoh S, &, Tsuji T, (2006) Characterization of the promoter for the alpha3 integrin gene in various tumor cell lines: roles of the Ets- and Sp-family of transcription factors. J Cell Biochem 97, 530-543.
23. Giannelli G, Fransvea E, Marinosci F, Bergamini C, Colucci S, Schiraldi O, &, Antonaci S, (2002) Transforming growth factor-beta1 triggers hepatocellular carcinoma invasiveness via alpha3beta1 integrin. Am J Pathol 161, 183-193.
24. Katabami K, Mizuno H, Sano R, Saito Y, Ogura M, Itoh S, &, Tsuji T, (2005) Transforming growth factor-beta1 upregulates transcription of alpha3 integrin gene in hepatocellular carcinoma cells via Ets-transcription factor-binding motif in the promoter region. Clin Exp Metastasis 22, 539-548.
25. Oikawa T, &, Yamada T, (2003) Molecular biology of the Ets family of transcription factors. Gene 303, 11-34.
26. Oettgen P, (2006) Regulation of vascular inflammation and remodeling by ETS factors. Circ Res 99, 1159-1166.
27. Dittmer J, (2003) The biology of the Ets1 proto-oncogene. Mol Cancer 2, 29. doi: 10.1186/1476-4598-2-29.
28. Sementchenko VI, &, Watson DK, (2000) Ets target genes: past, present and future. Oncogene 19, 6533-6548.
29. Furlan A, Vercamer C, Desbiens X, &, Pourtier A, (2008) Ets-1 triggers and orchestrates the malignant phenotype of mammary cancer cells within their matrix environment. J Cell Physiol 215, 782-793.
30. Behrens P, Rothe M, Wellmann A, Krischler J, &, Wernert N, (2001) The Ets-1 transcription factor is up-regulated together with MMP 1 and MMP 9 in the stroma of pre-invasive breast cancer. J Pathol 194, 43-50.
31. Nakayama T, Ito M, Ohtsuru A, Naito S, &, Sekine I, (2001) Expression of the ets-1 proto-oncogene in human colorectal carcinoma. Mod Pathol 14, 415-422.
32. Chang XZ, Li DQ, Hou YF, Wu J, Lu JS, Di GH, Jin W, Ou ZL, Shen ZZ, &, Shao ZM, (2008) Identification of the functional role of AF1Q in the progression of breast cancer. Breast Cancer Res Treat 111, 65-78.
33. Chang XZ, Yu J, Zhang XH, Yin J, Wang T, &, Cao XC, (2009) Enhanced expression of trophinin promotes invasive and metastatic potential of human gallbladder cancer cells. J Cancer Res Clin Oncol 135, 581-590.
34. Rosen GD, Barks JL, Iademarco MF, Fisher RJ, &, Dean DC, (1994) An intricate arrangement of binding sites for the Ets family of transcription factors regulates activity of the alpha 4 integrin gene promoter. J Biol Chem 269, 15652-15660.
35. Birkenmeier TM, McQuillan JJ, Boedeker ED, Argraves WS, Ruoslahti E, &, Dean DC, (1991) The alpha 5 beta 1 fibronectin receptor. Characterization of the alpha 5 gene promoter. J Biol Chem 266, 20544-20549.
36. Hickstein DD, Baker DM, Gollahon KA, &, Back AL, (1992) Identification of the promoter of the myelomonocytic leukocyte integrin CD11b. Proc Natl Acad Sci USA 89, 2105-2109.
37. Lemarchandel V, Ghysdael J, Mignotte V, Rahuel C, &, Romeo PH, (1993) GATA and Ets cis-acting sequences mediate megakaryocyte-specific expression. Mol Cell Biol 13, 668-676.
38. Block KL, Shou Y, &, Poncz M, (1996) An Ets/Sp1 interaction in the 5'-flanking region of the megakaryocyte-specific alpha IIb gene appears to stabilize Sp1 binding and is essential for expression of this TATA-less gene. Blood 88, 2071-2080.
39. Donahue JP, Sugg N, &, Hawiger J, (1994) The integrin alpha v gene: identification and characterization of the promoter region. Biochim Biophys Acta 1219, 228-232.
40. Bottinger EP, Shelley CS, Farokhzad OC, &, Arnaout MA, (1994) The human beta 2 integrin CD18 promoter consists of two inverted Ets cis elements. Mol Cell Biol 14, 2604-2615.
41. Oda N, Abe M, &, Sato Y, (1999) ETS-1 converts endothelial cells to the angiogenic phenotype by inducing the expression of matrix metalloproteinases and integrin beta3. J Cell Physiol 178, 121-132.
42. Wenke AK, Rothhammer T, Moser M, &, Bosserhoff AK, (2006) Regulation of integrin alpha10 expression in chondrocytes by the transcription factors AP-2epsilon and Ets-1. Biochem Biophys Res Commun 345, 495-501.
43. Tajima A, Miyamoto Y, Kadowaki H, &, Hayashi M, (2000) Mouse integrin alphav promoter is regulated by transcriptional factors Ets and Sp1 in melanoma cells. Biochim Biophys Acta 1492, 377-384.
44. Kita D, Takino T, Nakada M, Takahashi T, Yamashita J, &, Sato H, (2001) Expression of dominant-negative form of Ets-1 suppresses fibronectin-stimulated cell adhesion and migration through down-regulation of integrin alpha5 expression in U251 glioma cell line. Cancer Res 61, 7985-7991.
45. Margadant C, &, Sonnenberg A, (2010) Integrin-TGF-beta crosstalk in fibrosis, cancer and wound healing. EMBO Rep 11, 97-105.
46. Jinnin M, Ihn H, Asano Y, Yamane K, Trojanowska M, &, Tamaki K, (2004) Tenascin-C upregulation by transforming growth factor-beta in human dermal fibroblasts involves Smad3, Sp1, and Ets1. Oncogene 23, 1656-1667.
47. Lindemann RK, Ballschmieter P, Nordheim A, &, Dittmer J, (2001) Transforming growth factor beta regulates parathyroid hormone-related protein expression in MDA-MB-231 breast cancer cells through a novel Smad/Ets synergism. J Biol Chem 276, 46661-46670.
48. Liu S, Liang Y, Huang H, Wang L, Li Y, Li J, Li X, &, Wang H, (2005) ERK-dependent signaling pathway and transcriptional factor Ets-1 regulate matrix metalloproteinase-9 production in transforming growth factor-beta1 stimulated glomerular podocytes. Cell Physiol Biochem 16, 207-216.
49. Taki M, Verschueren K, Yokoyama K, Nagayama M, &, Kamata N, (2006) Involvement of Ets-1 transcription factor in inducing matrix metalloproteinase-2 expression by epithelial-mesenchymal transition in human squamous carcinoma cells. Int J Oncol 28, 487-496.
50. Hattori Y, Ding WX, &, Maitani Y, (2007) Highly efficient cationic hydroxyethylated cholesterol-based nanoparticle-mediated gene transfer in vivo and in vitro in prostate carcinoma PC-3 cells. J Control Release 120, 122-130.
51. Takeuchi K, Tsuji T, Hakomori S, &, Irimura T, (1994) Intercellular adhesion induced by anti-alpha 3 integrin (VLA-3) antibodies. Exp Cell Res 211, 133-141.
52. Kadonaga JT, &, Tjian R, (1986) Affinity purification of sequence-specific DNA binding proteins. Proc Natl Acad Sci USA 83, 5889-5893.
53. Ko JH, Miyoshi E, Noda K, Ekuni A, Kang R, Ikeda Y, &, Taniguchi N, (1999) Regulation of the GnT-V promoter by transcription factor Ets-1 in various cancer cell lines. J Biol Chem 274, 22941-22948.
54. Kamoshida G, Matsuda A, Sekine W, Mizuno H, Oku T, Itoh S, Irimura T, &, Tsuji T, (2012) Monocyte differentiation induced by co-culture with tumor cells involves RGD-dependent cell adhesion to extracellular matrix. Cancer Lett 315, 145-152.
55. Sato T, &, Furukawa K, (2007) Sequential action of Ets-1 and Sp1 in the activation of the human beta-1,4-galactosyltransferase V gene involved in abnormal glycosylation characteristic of cancer cells. J Biol Chem 282, 27702-27712.