Silk fibroin in ocular surface reconstruction: What is its potential as a biomaterial in ophthalmics?

Future Medicinal Chemistry

Volumn 4, Issue 17, 2012, Pages 2145-2147

  Harkin, Damien G ^a,b   Chirila, Traian V ^a,b,c  

^a QUEENSLAND UNIVERSITY OF TECHNOLOGY   (Australia)

^b QUEENSLAND EYE INSTITUTE   (Australia)

^c UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

biomaterials; corneal transplantation; eye disease; regenerative medicine; silk fibroin; tissue engineering

Indexed keywords

BIOMATERIAL; BOMBYX MORI SILK FIBROIN; COLLAGEN; ELASTIN; KERATIN; MACROGOL; MYOSIN; PROTEIN P25; SILK FIBROIN; UNCLASSIFIED DRUG;

ALPHA HELIX; AMINO ACID SEQUENCE; BINDING KINETICS; BIOCHEMICAL COMPOSITION; BIOCOMPATIBILITY; BOMBYX MORI; CELL ADHESION; CORNEA EPITHELIUM; CORNEA TRANSPLANTATION; HEAVY CHAIN; HYDROGEN BOND; HYDROPHOBICITY; MEDICAL RESEARCH; MEMBRANE PERMEABILITY; NONHUMAN; NOTE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN STABILITY; TISSUE REGENERATION;

ANIMALS; BIOCOMPATIBLE MATERIALS; BOMBYX; CORNEA; FIBROINS; HUMANS; TISSUE ENGINEERING; TISSUE SCAFFOLDS;

EID: 84870472336     PISSN: 17568919     EISSN: 17568927     Source Type: Journal    
DOI: 10.4155/fmc.12.155     Document Type: Note

References (15)

1. Minoura N, Tsukada M, Nagura M. Physico-chemical properties of silk fibroin membrane as a biomaterial. Biomaterials 11, 430-434 (1990).
2. Inoue S, Tanaka K, Arisaka F, Kimura S, Ohtomo K, Mizuno S. Silk fibroin of Bombyx mori is secreted, assembling a high molecular mass elementary unit consisting of H-chain, L-chain and P25, with a 6:6:1 molar ratio. J. Biol. Chem. 275, 40517-40528 (2000).
3. Sehnal F, Žurovec M. Construction of silk fiber core in Lepidoptera. Biomacromolecules 5, 666-674 (2004).
4. Craig CL. Evolution of arthropod silks. Annu. Rev. Entomol. 42, 231-267 (1997).
5. Altman GH, Diaz F, Jakuba C et al. Silk-based biomaterials. Biomaterials 24, 401-416 (2003).
6. Vepari C, Kaplan DL. Silk as a biomaterial. Prog. Polym. Sci. 32, 991-1007 (2007).
7. Rockwood DN, Preda RC, Yücel T, Wang X, Lovett ML, Kaplan DL. Materials fabrication from Bombyx mori silk fibroin. Nat. Protoc. 6, 1612-1630 (2011).
8. Chirila T, Barnard Z, Zainuddin, Harkin D. Silk as substratum for cell attachment and proliferation. Mater. Sci. Forum 561-565, 1549-1542 (2007).
9. Chirila TV, Barnard Z, Zainuddin, Harkin DG, Schwab IR, Hirst L. Bombyx mori silk fibroin membranes as potential substrata for epithelial constructs used in the management of ocular surface disorders. Tissue Eng. A 14, 1203-1211 (2008).
10. Lawrence BD, Marchant JK, Pindrus MA et al. Silk film biomaterials for cornea tissue engineering. Biomaterials 30, 1299-1308 (2009).
11. Bray LJ, George KA, Hutmacher DW, Chirila TV, Harkin DG. A dual-layer silk fibroin scaffold for reconstructing the human corneal limbus. Biomaterials 33, 3529-3538 (2012).
12. Madden PW, Lai JN, George KA, Giovenco T, Harkin DG, Chirila TV. Human corneal endothelial cell growth on a silk fibroin membrane. Biomaterials 32, 4076-4084 (2011).
13. Bray LJ, George KA, Ainscough SL, Hutmacher DW, Chirila TV, Harkin DG. Human corneal epithelial equivalents constructed on Bombyx mori silk fibroin membranes. Biomaterials 32, 5086-5091 (2011).
14. Higa K, Takeshima N, Moro F et al. Porous silk fibroin film as a transparent carrier for cultivated corneal epithelial sheets. J. Biomater. Sci. 22, 2261-2276 (2011).
15. Bentley E, Murphy CJ, Li F, Carlsson DJ, Griffith M. Biosynthetic corneal substitute implantation in dogs. Cornea 29, 910-916 (2010).