Characterization of the failing murine heart in a desmin knock-out model using a clinical 3 T MRI scanner

International Journal of Cardiovascular Imaging

Volumn 28, Issue 7, 2012, Pages 1699-1705

  Sprinkart, A M ^a   Block, W ^a   Traber F ^a   Meyer, R ^a   Paulin, D ^b   Clemen, C S ^c   Schroder R ^d   Gieseke, J ^e   Schild, H ^a   Thomas, D ^a  

^a UNIVERSITY OF BONN   (Germany)

^b SORBONNE UNIVERSITÉ   (France)

^c UNIVERSITY OF COLOGNE   (Germany)

^d UNIVERSITY HOSPITAL ERLANGEN   (Germany)

^e PHILIPS HEALTHCARE   (United States)

Author keywords

3 T; Cardiac MRI; Cardiomyopathy; Desminopathy; Mouse heart

Indexed keywords

DESMIN;

AKINESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDIOMYOPATHY; CLINICAL PROTOCOL; CONTROLLED STUDY; DIAGNOSTIC IMAGING; DISEASE SEVERITY; FEMALE; HEART EJECTION FRACTION; HEART FAILURE; HEART HYPERTROPHY; HEART LEFT VENTRICLE ENDDIASTOLIC VOLUME; HEART LEFT VENTRICLE FUNCTION; HEART LEFT VENTRICLE MASS; HEART MUSCLE NECROSIS; HEART OUTPUT; HEART RIGHT VENTRICLE FUNCTION; HISTOPATHOLOGY; IN VIVO STUDY; KNOCKOUT MOUSE; MALE; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PHENOTYPE; PROTEIN DETERMINATION; RELIABILITY; TRANSGENIC MOUSE;

ANIMALS; CARDIOMYOPATHIES; DISEASE MODELS, ANIMAL; FEMALE; GENOTYPE; HEART FAILURE; MAGNETIC RESONANCE IMAGING, CINE; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MYOCARDIUM; NECROSIS; PHENOTYPE; PREDICTIVE VALUE OF TESTS; STROKE VOLUME; VENTRICULAR FUNCTION, LEFT; VENTRICULAR FUNCTION, RIGHT;

EID: 84870462248     PISSN: 15695794     EISSN: 15730743     Source Type: Journal    
DOI: 10.1007/s10554-011-9990-3     Document Type: Article

References (22)

1. Epstein FH (2007) MR in mouse models of cardiac disease. NMR Biomed 20:238-255. (Pubitemid 46830265)
2. Bunck AC, Engelen MA, Schnackenburg B, Furkert J, Bremer C, Heindel W et al (2009) Feasibility of functional cardiac MR imaging in mice using a clinical 3Tesla whole body scanner. Invest Radiol 44:749-756.
3. Agbulut O, Li Z, Mouly V, Butler-Browne GS (1996) Analysis of skeletal and cardiac muscle from desmin knockout and normal mice by high resolution separation of myosin heavy-chain isoforms. Biol Cell 88:131-135. (Pubitemid 126820243)
4. Balogh J, Merisckay M, Li Z, Paulin D, Arner A (2002) Hearts from mice lacking desmin have a myopathy with impaired active force generation and unaltered wall compliance. Cardiovasc Res 53:439-450. (Pubitemid 34117695)
5. Li Z, Colucci-Guyon E, Pincon-Raymond M, Mericskay M, Pournin S, Paulin D et al (1996) Cardiovascular lesions and skeletal myopathy in mice lacking desmin. Dev Biol 175: 362-366. (Pubitemid 26160764)
6. Milner DJ, Taffet GE, Wang X, Pham T, Tamura T, Hartley C et al (1999) The absence of desmin leads to cardiomyocyte hypertrophy and cardiac dilation with compromised systolic function. J Mol Cell Cardiol 31:2063-2076. (Pubitemid 29537605)
7. Milner DJ, Weitzer G, Tran D, Bradley A, Capetanaki Y (1996) Disruption of muscle architecture and myocardial degeneration in mice lacking desmin. J Cell Biol 134: 1255-1270. (Pubitemid 26300170)
8. Thornell L, Carlsson L, Li Z, Mericskay M, Paulin D (1997) Null mutation in the desmin gene gives rise to a cardiomyopathy. J Mol Cell Cardiol 29:2107-2124. (Pubitemid 27348522)
9. Schrickel JW, Stockigt F, Krzyzak W, Paulin D, Li Z, Lubkemeier I et al (2010) Cardiac conduction disturbances and differential effects on atrial and ventricular electrophysiological properties in desmin deficient mice. J Interv Card Electrophysiol 28:71-80.
10. Roth DM, Swaney JS, Dalton ND, Gilpin EA, Ross J Jr (2002) Impact of anesthesia on cardiac function during echocardiography in mice. Am J Physiol Heart Circ Physiol 282:H2134-H2140. (Pubitemid 34663023)
11. Nahrendorf M, Wiesmann F, Hiller KH, Han H, Hu K, Waller C et al (2000) In vivo assessment of cardiac remodeling after myocardial infarction in rats by cinemagnetic resonance imaging. J Cardiovasc Magn Reson 2:171-180.
12. Cerqueira MD, Weissman NJ, Dilsizian V, Jacobs AK, Kaul S, Laskey WK et al (2002) Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart a statement for healthcare professionals from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association. Int J Cardiovasc Imaging 18:539-542. (Pubitemid 34262671)
13. Manning WJ, Wei JY, Katz SE, Litwin SE, Douglas PS (1994) In vivo assessment of LV mass in mice using highfrequency cardiac ultrasound: necropsy validation. Am J Physiol 266:H1672-H1675. (Pubitemid 24150800)
14. Franco F, Thomas GD, Giroir B, Bryant D, Bullock MC, Chwialkowski MC et al (1999) Magnetic resonance imaging and invasive evaluation of development of heart failure in transgenic mice with myocardial expression of tumor necrosis factor-alpha. Circulation 99:448-454. (Pubitemid 29051273)
15. Daire JL, Jacob JP, Hyacinthe JN, Croisille P, Montet-Abou K, Richter S et al (2008) Cine and tagged cardiovascular magnetic resonance imaging in normal rat at 1.5 T: a rest and stress study. J Cardiovasc Magn Reson 10.
16. Schneider JE, Wiesmann F, Lygate CA, Neubauer S (2006) How to perform an accurate assessment of cardiac function in mice using high-resolution magnetic resonance imaging. J Cardiovasc Magn Reson 8:693-701. (Pubitemid 44195990)
17. Zhou R, Pickup S, Glickson JD, Scott CH, Ferrari VA (2003) Assessment of global and regional myocardial function in the mouse using cine and tagged MRI. Magn Reson Med 49:760-764. (Pubitemid 36389987)
18. Wiesmann F, Ruff J, Hiller KH, Rommel E, Haase A, Neubauer S (2000) Developmental changes of cardiac function and mass assessed with MRI in neonatal, juvenile, and adult mice. Am J Physiol Heart Circ Physiol 278:H652- H657. (Pubitemid 30131267)
19. Wiesmann F, Frydrychowicz A, Rautenberg J, Illinger R, Rommel E, Haase A et al (2002) Analysis of right ventricular function in healthy mice and a murine model of heart failure by in vivo MRI. Am J Physiol Heart Circ Physiol 283:H1065-H1071.
20. Liu G, Iden JB, Kovithavongs K, Gulamhusein R, Duff HJ, Kavanagh KM (2004) In vivo temporal and spatial distribution of depolarization and repolarization and the illusive murine T wave. J Physiol-Lond 555:267-279. (Pubitemid 38313076)
21. Strach K, Sommer T, Grohe C, Meyer C, Fischer D, Walter MC et al (2008) Clinical, genetic, and cardiac magnetic resonance imaging findings in primary desminopathies. Neuromuscul Disord 18:475-482.
22. He Y, Zhang Z, Hong D, Dai Q, Jiang T (2010) Myocardial fibrosis in desmin-related hypertrophic cardiomyopathy. J Cardiovasc Magn Reson 12:68.