Cardiac conduction disturbances and differential effects on atrial and ventricular electrophysiological properties in desmin deficient mice

Journal of Interventional Cardiac Electrophysiology

Volumn 28, Issue 2, 2010, Pages 71-80

  Schrickel, Jan Wilko ^a   Stöckigt, Florian ^a   Krzyzak, Wieslaw ^b   Paulin, Denise ^b,c   Li, Zhenlin ^b,c   Lübkemeier, Indra ^a   Fleischmann, Bernd ^a   Sasse, Philipp ^a   Linhart, Markus ^a   Lewalter, Thorsten ^d   Nickenig, Georg ^a   Lickfett, Lars ^a   Schröder, Rolf ^e   Clemen, Christoph Stephan ^f  

^a UNIVERSITY OF BONN   (Germany)

^b SORBONNE UNIVERSITÉ   (France)

^c CNRS   (France)

^d ST MARIEN HOSPITAL   (Germany)

^e UNIVERSITY HOSPITAL ERLANGEN   (Germany)

^f UNIVERSITY OF COLOGNE   (Germany)

Author keywords

Arrhythmias; Conduction; Connexin; Desmin; Desmin knockout mouse; Desmin related cardiomyopathies; Desminopathy; Myofibrillar myopathy

Indexed keywords

DESMIN;

ANIMAL; ARTICLE; C57BL MOUSE; ELECTROCARDIOGRAPHY; GENOTYPE; HEART ATRIUM FIBRILLATION; HEART FUNCTION TEST; HEART MUSCLE CONDUCTION SYSTEM; HEART RATE; MOUSE; PATHOPHYSIOLOGY; PHYSIOLOGY;

ANIMALS; ATRIAL FIBRILLATION; DESMIN; ELECTROCARDIOGRAPHY; ELECTROPHYSIOLOGIC TECHNIQUES, CARDIAC; GENOTYPE; HEART CONDUCTION SYSTEM; HEART RATE; MICE; MICE, INBRED C57BL;

EID: 79952057655     PISSN: 1383875X     EISSN: 15728595     Source Type: Journal    
DOI: 10.1007/s10840-010-9482-8     Document Type: Article

References (26)

1. Goldfarb, L. G., Vicart, P., Goebel, H. H., & Dalakas, M. C. (2004). Desmin myopathy. Brain, 127, 723-734. (Pubitemid 38478517)
2. Schroder, R., Goudeau, B., Simon, M. C., et al. (2003). On noxious desmin: functional effects of a novel heterozygous desmin insertion mutation on the extrasarcomeric desmin cytoskeleton and mitochondria. Human Molecular Genetics, 12, 657-669. (Pubitemid 36372492)
3. Schroder, R., Vrabie, A., & Goebel, H. H. (2007). Primary desminopathies. Journal of Cellular and Molecular Medicine, 11, 416-426. (Pubitemid 47153455)
4. Selcen, D., Ohno, K., & Engel, A. G. (2004). Myofibrillar myopathy: clinical, morphological and genetic studies in 63 patients. Brain, 127, 439-451. (Pubitemid 38160328)
5. Bar, H., Strelkov, S. V., Sjoberg, G., Aebi, U., & Herrmann, H. (2004). The biology of desmin filaments: how do mutations affect their structure, assembly, and organisation? Journal of Structural Biology, 148, 137-152. (Pubitemid 39346004)
6. Price, M. G. (1984). Molecular analysis of intermediate filament cytoskeleton -a putative load-bearing structure. American Journal of Physiology, 246, H566-572.
7. Eriksson, A., & Thornell, L. E. (1979). Intermediate (skeletin) filaments in heart Purkinje fibers. A correlative morphological and biochemical identification with evidence of a cytoskeletal function. Journal of Cell Biology, 80, 231-247. (Pubitemid 9091501)
8. Li, Z., Colucci-Guyon, E., Pincon-Raymond, M., et al. (1996). Cardiovascular lesions and skeletal myopathy in mice lacking desmin. Developmental Biology, 175, 362-366. (Pubitemid 26160764)
9. Milner, D. J., Weitzer, G., Tran, D., Bradley, A., & Capetanaki, Y. (1996). Disruption of muscle architecture and myocardial degeneration in mice lacking desmin. Journal of Cell Biology, 134, 1255-1270. (Pubitemid 26300170)
10. Kreuzberg, M. M., Schrickel, J. W., Ghanem, A., et al. (2006). Connexin30.2 containing gap junction channels decelerate impulse propagation through the atrioventricular node. Proceedings of the National Academy of Sciences of the United States of America, 103, 5959-5964.
11. Schrickel, J. W., Brixius, K., Herr, C., et al. (2007). Enhanced heterogeneity of myocardial conduction and severe cardiac electrical instability in annexin A7-deficient mice. Cardiovascular Research, 76, 257-268. (Pubitemid 350198597)
12. Schrickel, J. W., Bielik, H., Yang, A., et al. (2002). Induction of atrial fibrillation in mice by rapid transesophageal atrial pacing. Basic Research in Cardiology, 97, 452 -460.
13. Coronel, R., Wilms-Schopman, F. J., de Groot, J. R., et al. (2000). Laplacian electrograms and the interpretation of complex ventricular activation patterns during ventricular fibrillation. Journal of Cardiovascular Electrophysiology, 11, 1119-1128.
14. van Rijen, H. V., Eckardt, D., Degen, J., et al. (2004). Slow conduction and enhanced anisotropy increase the propensity for ventricular tachyarrhythmias in adult mice with induced deletion of connexin43. Circulation, 109, 1048-1055. (Pubitemid 38282860)
15. Lammers, W. J., Schalij, M. J., Kirchhof, C. J., & Allessie, M. A. (1990). Quantification of spatial inhomogeneity in conduction and initiation of reentrant atrial arrhythmias. American Journal of Physiology, 259, H1254-1263. (Pubitemid 20352329)
16. Li, D., Fareh, S., Leung, T. K., & Nattel, S. (1999). Promotion of atrial fibrillation by heart failure in dogs: atrial remodeling of a different sort. Circulation, 100, 87-95. (Pubitemid 29297945)
17. Traub, O., Eckert, R., Lichtenberg-Frate, H., et al. (1994). Immunochemical and electrophysiological characterization of murine connexin40 and -43 in mouse tissues and transfected human cells. European Journal of Cell Biology, 64, 101-112. (Pubitemid 24205989)
18. Schroder, R., & Schoser, B. (2009). Myofibrillar myopathies: a clinical and myopathological guide. Brain Pathology, 19, 483-492.
19. Baker, L. C., London, B., Choi, B. R., Koren, G., & Salama, G. (2000). Enhanced dispersion of repolarization and refractoriness in transgenic mouse hearts promotes reentrant ventricular tachycardia. Circulation Research, 86, 396-407. (Pubitemid 30141758)
20. Sabir, I. N., Fraser, J. A., Killeen, M. J., Grace, A. A., & Huang, C. L. (2007). The contribution of refractoriness to arrhythmic substrate in hypokalemic Langendorff-perfused murine hearts. Pflugers Archiv. European Journal of Physiology, 454, 209-222. (Pubitemid 46525465)
21. Galou, M., Gao, J., Humbert, J., et al. (1997). The importance of intermediate filaments in the adaptation of tissues to mechanical stress: evidence from gene knockout studies. Biology of the Cell, 89, 85-97. (Pubitemid 27453890)
22. Li, J., Patel, V. V., & Radice, G. L. (2006). Dysregulation of cell adhesion proteins and cardiac arrhythmogenesis. Clin Med Res, 4, 42-52.
23. Sohl, G., & Willecke, K. (2004). Gap junctions and the connexin protein family. Cardiovascular Research, 62, 228-232. (Pubitemid 38496536)
24. Taylor, M. R., Slavov, D., Ku, L., et al. (2007). Prevalence of desmin mutations in dilated cardiomyopathy. Circulation, 115, 1244-1251. (Pubitemid 46594768)
25. Gard, J. J., Yamada, K., Green, K. G., et al. (2005). Remodeling of gap junctions and slow conduction in a mouse model of desmin-related cardiomyopathy. Cardiovascular Research, 67, 539-547. (Pubitemid 41019561)
26. Danik, S. B., Liu, F., Zhang, J., et al. (2004). Modulation of cardiac gap junction expression and arrhythmic susceptibility. Circulation Research, 95, 1035-1041. (Pubitemid 39532334)