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Inflammation in atherosclerosis: From pathophysiology to practice
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19942084 10.1016/j.jacc.2009.09.009 1:CAS:528:DC%2BC3cXkvFOhsg%3D%3D A concise overview of the role of inflammation and atheroslcerosis from both vascular biology and clinical perspectives
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Libby P, Ridker PM, Hansson GK. Inflammation in atherosclerosis: from pathophysiology to practice. J Am Coll Cardiol. 2009;54:2129-38. A concise overview of the role of inflammation and atheroslcerosis from both vascular biology and clinical perspectives.
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J Am Coll Cardiol
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Libby, P.1
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C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women
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DOI 10.1056/NEJM200003233421202
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Ridker PM, Hennekens CH, Buring JE, Rifai N. C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. N Engl J Med. 2000;342:836-43. (Pubitemid 30165206)
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New England Journal of Medicine
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Ridker, P.M.1
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3
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0037078969
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Comparison of C-reactive protein and low-density lipoprotein cholesterol levels in the prediction of first cardiovascular events
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DOI 10.1056/NEJMoa021993
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Ridker PM, Rifai N, Rose L, Buring JE, Cook NR. Comparison of C-reactive protein and low-density lipoprotein cholesterol levels in the prediction of first cardiovascular events. N Engl J Med. 2002;347:1557-65. (Pubitemid 35315836)
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New England Journal of Medicine
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C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: An individual participant meta-analysis
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20031199 10.1016/S0140-6736(09)61717-7 This meta-analysis of over 54 prospective cohort studies demonstrated that the magnitude of impact inflammation has on future vascular events is at least as large as that of cholesterol or blood pressure, even after adjustment for traditional risk markers
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Kaptoge S, Di Angelantonio E, Lowe G, Pepys MB, Thompson SG, Collins R, et al. C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis. Lancet. 2010;375:132-40. This meta-analysis of over 54 prospective cohort studies demonstrated that the magnitude of impact inflammation has on future vascular events is at least as large as that of cholesterol or blood pressure, even after adjustment for traditional risk markers.
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Lancet
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Kaptoge, S.1
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Development and validation of improved algorithms for the assessment of global cardiovascular risk in women: The Reynolds Risk Score
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17299196 10.1001/jama.297.6.611 1:CAS:528:DC%2BD2sXhslCqtLk%3D
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Ridker PM, Buring JE, Rifai N, Cook NR. Development and validation of improved algorithms for the assessment of global cardiovascular risk in women: the Reynolds Risk Score. JAMA. 2007;297:611-9.
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JAMA
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Ridker, P.M.1
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Comparison of the Framingham and Reynolds Risk Scores for global cardiovascular risk prediction in the multiethnic Women's Health Initiative
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22399535 10.1161/CIRCULATIONAHA.111.075929 This direct comparison indicates that the Reynolds Risk Score outperforms the more traditional Framingham Risk Score, an important paper since Reynolds includes both CRP and family history
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Cook NR, Paynter NP, Eaton CB, Manson JE, Martin LW, Robinson JG, et al. Comparison of the Framingham and Reynolds Risk Scores for global cardiovascular risk prediction in the multiethnic Women's Health Initiative. Circulation. 2012;125:1748-56. This direct comparison indicates that the Reynolds Risk Score outperforms the more traditional Framingham Risk Score, an important paper since Reynolds includes both CRP and family history.
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Cook, N.R.1
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Inflammation, pravastatin, and the risk of coronary events after myocardial infarction in patients with average cholesterol levels
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Ridker PM, Rifai N, Pfeffer MA, Sacks FM, Moye LA, Goldman S, et al. Inflammation, pravastatin, and the risk of coronary events after myocardial infarction in patients with average cholesterol levels. Cholesterol and Recurrent Events (CARE) Investigators. Circulation. 1998;98:839-44. (Pubitemid 28397432)
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Measurement of C-reactive protein for the targeting of statin therapy in the primary prevention of acute coronary events
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Ridker PM, Rifai N, Clearfield M, Downs JR, Weis SE, Miles JS, et al. Measurement of C-reactive protein for the targeting of statin therapy in the primary prevention of acute coronary events. N Engl J Med. 2001;344:1959-65. (Pubitemid 32568149)
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Clinical relevance of C-reactive protein during follow-up of patients with acute coronary syndromes in the Aggrastat-to-Zocor Trial
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Effects of statin therapy according to plasma high-sensitivity C-reactive protein concentration in the Controlled Rosuvastatin Multinational Trial in Heart Failure (CORONA): A retrospective analysis
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19917888 10.1161/CIRCULATIONAHA.109.849117 1:CAS:528:DC%2BD1MXhsVertrfK
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C-reactive protein levels and outcomes after statin therapy
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DOI 10.1056/NEJMoa042378
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Ridker PM, Cannon CP, Morrow D, Rifai N, Rose LM, McCabe CH, et al. C-reactive protein levels and outcomes after statin therapy. N Engl J Med. 2005;352:20-8. (Pubitemid 40075677)
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New England Journal of Medicine
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Ridker, P.M.1
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13
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84857153247
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Creating controversy where none exists: The important role of C-reactive protein in the CARE, AFCAPS/TexCAPS, PROVE IT, REVERSAL, A to Z, JUPITER, HEART PROTECTION, and ASCOT trials
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21896564 10.1093/eurheartj/ehr310 An excellent overview describing common misunderstadings and controversies with regard to the inflammation hypothesis of atherosclerosis
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Braunwald E. Creating controversy where none exists: the important role of C-reactive protein in the CARE, AFCAPS/TexCAPS, PROVE IT, REVERSAL, A to Z, JUPITER, HEART PROTECTION, and ASCOT trials. Eur Heart J. 2012;33:430-2. An excellent overview describing common misunderstadings and controversies with regard to the inflammation hypothesis of atherosclerosis.
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Braunwald, E.1
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Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein
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18997196 10.1056/NEJMoa0807646 1:CAS:528:DC%2BD1cXhtl2gurnL
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Ridker PM, Danielson E, Fonseca FA, Genest J, Gotto Jr AM, Kastelein JJ, et al. Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein. N Engl J Med. 2008;359:2195-207.
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N Engl J Med
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Ridker, P.M.1
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Gotto, Jr.A.M.5
Kastelein, J.J.6
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Statins for the primary prevention of cardiovascular events in women with elevated high-sensitivity C-reactive protein or dyslipidemia. Results from the Justification for the Use of Statins in Prevention: An intervention trial evaluating rosuvastatin (JUPITER) and meta-analysis of women from primary prevention trials
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Mora S, Glynn RJ, Hsia J, Macfadyen JG, Genest J, Ridker PM. Statins for the primary prevention of cardiovascular events in women with elevated high-sensitivity C-reactive protein or dyslipidemia. Results from the Justification for the Use of Statins in Prevention: An intervention trial evaluating rosuvastatin (JUPITER) and meta-analysis of women from primary prevention trials. Circulation. 2010;121:1069-77.
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Mora, S.1
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Rosuvastatin for primary prevention in older persons with elevated C-reactive protein and low to average low-density lipoprotein cholesterol levels: Exploratory analysis of a randomized trial
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Glynn RJ, Koenig W, Nordestgaard BG, Shepherd J, Ridker PM. Rosuvastatin for primary prevention in older persons with elevated C-reactive protein and low to average low-density lipoprotein cholesterol levels: exploratory analysis of a randomized trial. Ann Intern Med. 2010;152:488-96.
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Ann Intern Med
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Glynn, R.J.1
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Number needed to treat with rosuvastatin to prevent first cardiovascular events and death among men and women with low low-density lipoprotein cholesterol and elevated high-sensitivity C-reactive protein: Justification for the use of statins in prevention: An intervention trial evaluating rosuvastatin (JUPITER)
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20031900 10.1161/CIRCOUTCOMES.109.848473
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Ridker PM, MacFadyen JG, Fonseca FA, Genest J, Gotto AM, Kastelein JJ, et al. Number needed to treat with rosuvastatin to prevent first cardiovascular events and death among men and women with low low-density lipoprotein cholesterol and elevated high-sensitivity C-reactive protein: justification for the use of statins in prevention: an intervention trial evaluating rosuvastatin (JUPITER). Circ Cardiovasc Qual Outcomes. 2009;2:616-23.
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18
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70350360003
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2009 Canadian Cardiovascular Society/Canadian guidelines for the diagnosis and treatment of dyslipidemia and prevention of cardiovascular disease in the adult - 2009 recommendations
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19812802 10.1016/S0828-282X(09)70715-9 1:CAS:528:DC%2BD1MXhtlynsLvF
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Genest J, McPherson R, Frohlich J, et al. 2009 Canadian Cardiovascular Society/Canadian guidelines for the diagnosis and treatment of dyslipidemia and prevention of cardiovascular disease in the adult - 2009 recommendations. Can J Cardiol. 2009;25:567-79.
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Genest, J.1
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A randomized trial of rosuvastatin in the prevention of venous thromboembolism
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Glynn RJ, Danielson E, Fonseca FA, Genest J, Gotto Jr AM, Kastelein JJ, et al. A randomized trial of rosuvastatin in the prevention of venous thromboembolism. N Engl J Med. 2009;360:1851-61.
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Glynn, R.J.1
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20
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Reduction in C-reactive protein and LDL cholesterol and cardiovascular event rates after initiation of rosuvastatin: A prospective study of the JUPITER trial
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19329177 10.1016/S0140-6736(09)60447-5 1:CAS:528:DC%2BD1MXktV2gsL8%3D This paper from the JUPITER trial demonstrates that lowering CRP was as important as lowering LDL-C in terms of preventing first ever vascular events
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Ridker PM, Danielson E, Fonseca FA, Genest J, Gotto Jr AM, Kastelein JJ, et al. Reduction in C-reactive protein and LDL cholesterol and cardiovascular event rates after initiation of rosuvastatin: a prospective study of the JUPITER trial. Lancet. 2009;373:1175-82. This paper from the JUPITER trial demonstrates that lowering CRP was as important as lowering LDL-C in terms of preventing first ever vascular events.
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Lancet
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Ridker, P.M.1
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21
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Relation of baseline high-sensitivity C-reactive protein level to cardiovascular outcomes with rosuvastatin in the Justification for Use of statins in Prevention: An Intervention Trial Evaluating Rosuvastatin (JUPITER)
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20599004 10.1016/j.amjcard.2010.03.018 1:CAS:528:DC%2BC3cXosVWnsro%3D
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Ridker PM, MacFadyen J, Libby P, Glynn RJ. Relation of baseline high-sensitivity C-reactive protein level to cardiovascular outcomes with rosuvastatin in the Justification for Use of statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER). Am J Cardiol. 2010;106:204-9.
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Am J Cardiol
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Pharmacogenetic determinants of statin-induced reduction in C-reactive protein
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22230323 10.1161/CIRCGENETICS.111.961847 1:CAS:528:DC%2BC38XltFOjtL0%3D
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Chu AY, Guilianini F, Barratt BJ, Nyberg F, Chasman DI, Ridker PM. Pharmacogenetic determinants of statin-induced reduction in C-reactive protein. Circ Cardiovasc Genet. 2012;5:58-65.
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Circ Cardiovasc Genet
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Chu, A.Y.1
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23
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Genetic determinants of statini-induced low-density lipoprotein cholesterol reduction. The Justificaton for the Use of statins in Prevention: An Intervention Trial Evalauting Rosuvastatin (JUPITER) Trial
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22331829 10.1161/CIRCGENETICS.111.961144 1:CAS:528:DC%2BC38Xos1Wguro%3D
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Chasman DI, Guilianini F, MacFadyen J, Barratt BJ, Nyberg F, Ridker PM. Genetic determinants of statini-induced low-density lipoprotein cholesterol reduction. The Justificaton for the Use of statins in Prevention: an Intervention Trial Evalauting Rosuvastatin (JUPITER) Trial. Circ Cardiovasc Genet. 2012;5:257-64.
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Circ Cardiovasc Genet
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Chasman, D.I.1
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24
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67949124665
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Testing the inflammatory hypothesis of atherothrombosis: Scientific rationale for the cardiovascular inflammation reduction trial (CIRT)
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19630828 10.1111/j.1538-7836.2009.03404.x 1:CAS:528:DC%2BD1MXpvV2itr4%3D
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Ridker PM. Testing the inflammatory hypothesis of atherothrombosis: scientific rationale for the cardiovascular inflammation reduction trial (CIRT). J Thromb Haemost. 2009;7 Suppl 1:332-9.
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J Thromb Haemost
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Ridker, P.M.1
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25
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80053644777
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Interleukin-1beta inhibition and the prevention of recurrent cardiovascular events: Rationale and design of the Canakinumab Anti-inflammatory Thrombosis Outcomes Study (CANTOS)
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21982649 10.1016/j.ahj.2011.06.012 1:CAS:528:DC%2BC3MXht1OhsLzJ This is the formal rationale and design paper for the CANTOS trial and contains full details of the protocol
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Ridker PM, Thuren T, Zalewski A, Libby P. Interleukin-1beta inhibition and the prevention of recurrent cardiovascular events: rationale and design of the Canakinumab Anti-inflammatory Thrombosis Outcomes Study (CANTOS). Am Heart J. 2011;162:597-605. This is the formal rationale and design paper for the CANTOS trial and contains full details of the protocol.
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Am Heart J
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Ridker, P.M.1
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Zalewski, A.3
Libby, P.4
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26
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77951800951
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NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
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20428172 10.1038/nature08938 1:CAS:528:DC%2BC3cXltl2mu7w%3D An important biologic paper describing the role played by cholesterol crystals in activating the inflammasome and thus leading to increased interleukin-1 production
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Nature
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Duewell, P.1
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Cholesterol crystals activate the NLRP3 inflammasome in human macrophages: A novel link between cholesterol metabolism and inflammation
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PLoS One
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Autophagy links inflammasomes to atherosclerotic progression
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The role of the interleukin-1-receptor antagonist in blocking inflammation mediated by interleukin-1
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