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Volumn 17, Issue 4, 2012, Pages 511-518

Emerging therapies for gout

Author keywords

Canakinumab; Emerging therapies; Gout; Hyperuricemia; Lesinurad; Rilonacept

Indexed keywords

ALLOPURINOL; BENZBROMARONE; C REACTIVE PROTEIN; CANAKINUMAB; COLCHICINE; FEBUXOSTAT; GLUCOCORTICOID; INDOMETACIN; INTERLEUKIN 1; LESINURAD; NONSTEROID ANTIINFLAMMATORY AGENT; PEGLOTICASE; PROBENECID; RILONACEPT; SULFINPYRAZONE; TRANILAST; TRIAMCINOLONE; ULODESINE; URATE; URIC ACID;

EID: 84870453022     PISSN: 14728214     EISSN: None     Source Type: Journal    
DOI: 10.1517/14728214.2012.736488     Document Type: Review
Times cited : (11)

References (37)
  • 1
    • 80053497428 scopus 로고    scopus 로고
    • Prevalence of gout and hyperuricemia in the us general population: The national health and nutrition examination survey 2007-2008
    • Zhu Y, Pandya BJ, Choi HK. Prevalence of gout and hyperuricemia in the US general population: the National Health and Nutrition Examination Survey 2007-2008. Arthritis Rheum 2011;63(10):3136-41
    • (2011) Arthritis Rheum , vol.63 , Issue.10 , pp. 3136-3141
    • Zhu, Y.1    Pandya, B.J.2    Choi, H.K.3
  • 2
    • 50349101970 scopus 로고    scopus 로고
    • Gout is associated with more comorbidities, poorer health related quality of life and higher health care utilization in US veterans
    • Singh JA, Strand V. Gout is associated with more comorbidities, poorer health related quality of life and higher health care utilization in US veterans. Ann Rheum Dis 2008;67(9):1310-16
    • (2008) Ann Rheum Dis , vol.67 , Issue.9 , pp. 1310-1316
    • Singh, J.A.1    Strand, V.2
  • 3
    • 34548265240 scopus 로고    scopus 로고
    • Is gout associated with reduced quality of life? A case-control study
    • Roddy E, Zhang W, Doherty M. Is gout associated with reduced quality of life? A case-control study. Rheumatology (Oxford) 2007;46(9):1441-4
    • (2007) Rheumatology (Oxford) , vol.46 , Issue.9 , pp. 1441-1444
    • Roddy, E.1    Zhang, W.2    Doherty, M.3
  • 4
    • 33748608331 scopus 로고    scopus 로고
    • EULAR evidence based recommendations for gout. Part II: Management. Report of a task force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT)
    • Zhang W, Doherty M, Bardin T, et al. EULAR evidence based recommendations for gout. Part II: management. Report of a task force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT). Ann Rheum Dis 2006;65(10):1312-24
    • (2006) Ann Rheum Dis , vol.65 , Issue.10 , pp. 1312-1324
    • Zhang, W.1    Doherty, M.2    Bardin, T.3
  • 5
    • 33750374233 scopus 로고    scopus 로고
    • EULAR evidence based recommendations for gout. Part I: Diagnosis. Report of a task force of the Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT)
    • Zhang W, Doherty M, Pascual E, et al. EULAR evidence based recommendations for gout. Part I: diagnosis. Report of a task force of the Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT). Ann Rheum Dis 2006;65(10):1301-11
    • (2006) Ann Rheum Dis , vol.65 , Issue.10 , pp. 1301-1311
    • Zhang, W.1    Doherty, M.2    Pascual, E.3
  • 6
    • 84869180170 scopus 로고    scopus 로고
    • American College of Rheumatology guidelines for management of gout. Part 2: Therapy and antiinflammatory prophylaxis of acute gouty arthritis
    • Khanna D, Khanna PP, Fitzgerald JD, et al. American College of Rheumatology guidelines for management of gout. Part 2: Therapy and antiinflammatory prophylaxis of acute gouty arthritis. Arthritis Care Res (Hoboken) 2012;64(10):1447-61
    • (2012) Arthritis Care Res (Hoboken) , vol.64 , Issue.10 , pp. 1447-1461
    • Khanna, D.1    Khanna, P.P.2    Fitzgerald, J.D.3
  • 7
    • 84869186940 scopus 로고    scopus 로고
    • American College of Rheumatology guidelines for management of gout. Part 1: Systematic nonpharmacologic and pharmacologic therapeutic approaches to hyperuricemia
    • Khanna D, Fitzgerald JD, Khanna PP, et al. American College of Rheumatology guidelines for management of gout. Part 1: Systematic nonpharmacologic and pharmacologic therapeutic approaches to hyperuricemia. Arthritis Care Res (Hoboken) 2012;64(10):1431-46
    • (2012) Arthritis Care Res (Hoboken) , vol.64 , Issue.10 , pp. 1431-1446
    • Khanna, D.1    Fitzgerald, J.D.2    Khanna, P.P.3
  • 8
    • 24944435549 scopus 로고    scopus 로고
    • Suboptimal physician adherence to quality indicators for the management of gout and asymptomatic hyperuricaemia: Results from the UK General Practice Research Database (GPRD)
    • Mikuls TR, Farrar JT, Bilker WB, et al. Suboptimal physician adherence to quality indicators for the management of gout and asymptomatic hyperuricaemia: results from the UK General Practice Research Database (GPRD). Rheumatology (Oxford) 2005;44(8):1038-42
    • (2005) Rheumatology (Oxford) , vol.44 , Issue.8 , pp. 1038-1042
    • Mikuls, T.R.1    Farrar, J.T.2    Bilker, W.B.3
  • 10
    • 2642527090 scopus 로고    scopus 로고
    • A retrospective study of the relationship between serum urate level and recurrent attacks of gouty arthritis: Evidence for reduction of recurrent gouty arthritis with antihyperuricemic therapy
    • Shoji A, Yamanaka H, Kamatani N. A retrospective study of the relationship between serum urate level and recurrent attacks of gouty arthritis: evidence for reduction of recurrent gouty arthritis with antihyperuricemic therapy. Arthritis Rheum 2004;51(3):321-5
    • (2004) Arthritis Rheum , vol.51 , Issue.3 , pp. 321-325
    • Shoji, A.1    Yamanaka, H.2    Kamatani, N.3
  • 11
    • 67651233985 scopus 로고    scopus 로고
    • Opportunities for improving medication use and monitoring in gout
    • Singh JA, Hodges JS, Asch SM. Opportunities for improving medication use and monitoring in gout. Ann Rheum Dis 2009;68(8):1265-70
    • (2009) Ann Rheum Dis , vol.68 , Issue.8 , pp. 1265-1270
    • Singh, J.A.1    Hodges, J.S.2    Asch, S.M.3
  • 12
    • 33745610176 scopus 로고    scopus 로고
    • Gout medication treatment patterns and adherence to standards of care from a managed care perspective
    • Sarawate CA, Brewer KK, Yang W, et al. Gout medication treatment patterns and adherence to standards of care from a managed care perspective. Mayo Clin Proc 2006;81(7):925-34
    • (2006) Mayo Clin Proc , vol.81 , Issue.7 , pp. 925-934
    • Sarawate, C.A.1    Brewer, K.K.2    Yang, W.3
  • 13
    • 0038391240 scopus 로고    scopus 로고
    • A literature review of the epidemiology and treatment of acute gout
    • Kim KY, Ralph Schumacher H, Hunsche E, et al. A literature review of the epidemiology and treatment of acute gout. Clin Ther 2003;25(6):1593-617
    • (2003) Clin Ther , vol.25 , Issue.6 , pp. 1593-1617
    • Kim, K.Y.1    Ralph Schumacher, H.2    Hunsche, E.3
  • 14
  • 15
    • 33746830642 scopus 로고    scopus 로고
    • Advances in the management of gout and hyperuricaemia
    • Hoskison TK, Wortmann RL. Advances in the management of gout and hyperuricaemia. Scand J Rheumatol 2006;35(4):251-60
    • (2006) Scand J Rheumatol , vol.35 , Issue.4 , pp. 251-260
    • Hoskison, T.K.1    Wortmann, R.L.2
  • 16
    • 79551674574 scopus 로고    scopus 로고
    • Prevalence of contraindications and prescription of pharmacologic therapies for gout
    • Keenan RT, ÓBrien WR, Lee KH, et al. Prevalence of contraindications and prescription of pharmacologic therapies for gout. Am J Med 2011;124(2):155-63
    • (2011) Am J Med , vol.124 , Issue.2 , pp. 155-163
    • Keenan, R.T.1    Óbrien, W.R.2    Lee, K.H.3
  • 17
    • 70349402166 scopus 로고    scopus 로고
    • The interleukin 1 inhibitor rilonacept in treatment of chronic gouty arthritis: Results of a placebo-controlled, monosequence crossover, non-randomised, single-blind pilot study
    • Terkeltaub R, Sundy JS, Schumacher HR, et al. The interleukin 1 inhibitor rilonacept in treatment of chronic gouty arthritis: results of a placebo-controlled, monosequence crossover, non-randomised, single-blind pilot study. Ann Rheum Dis 2009;68(10):1613-17
    • (2009) Ann Rheum Dis , vol.68 , Issue.10 , pp. 1613-1617
    • Terkeltaub, R.1    Sundy, J.S.2    Schumacher, H.R.3
  • 18
    • 84857774498 scopus 로고    scopus 로고
    • Rilonacept (interleukin-1 trap) in the prevention of acute gout flares during initiation of urate-lowering therapy: Results of a phase II randomized double-blind placebo-controlled trial
    • Schumacher HR Jr, Sundy JS, Terkeltaub R, et al. Rilonacept (interleukin-1 trap) in the prevention of acute gout flares during initiation of urate-lowering therapy: results of a phase II randomized, double-blind, placebo-controlled trial. Arthritis Rheum 2012;64(3):876-84
    • (2012) Arthritis Rheum , vol.64 , Issue.3 , pp. 876-884
    • Schumacher Jr., H.R.1    Sundy, J.S.2    Terkeltaub, R.3
  • 19
    • 84864335117 scopus 로고    scopus 로고
    • Rilonacept (Interleukin-1 Trap) for prevention of gout flares during initiation of uric acid-lowering therapy: Results of the presurge-1 trial
    • Schumacher HR Jr, Evans RR, Saag KG, et al. Rilonacept (Interleukin-1 Trap) for prevention of gout flares during initiation of uric acid-lowering therapy: results of the presurge-1 trial. Arthritis Care Res (Hoboken) 2012;64(10):1462-70
    • (2012) Arthritis Care Res (Hoboken) , vol.64 , Issue.10 , pp. 1462-1470
    • Schumacher Jr., H.R.1    Evans, R.R.2    Saag, K.G.3
  • 20
    • 84870407461 scopus 로고    scopus 로고
    • Evaluation of Rilonacept for prevention of gout flares during initiation of uric acid loweing therapy: Results of a phase 3, randomized, double-blind, palcebo-controlled glocal trial
    • Mitha E, Fouche L, Wang J, et al. Evaluation of Rilonacept for prevention of gout flares during initiation of uric acid loweing therapy: results of a phase 3, randomized, double-blind, palcebo-controlled glocal trial. Ann Rheum Dis 2011;70(Suppl 3):168
    • (2011) Ann Rheum Dis , vol.70 , Issue.SUPPL. 3 , pp. 168
    • Mitha, E.1    Fouche, L.2    Wang, J.3
  • 22
    • 84870430907 scopus 로고    scopus 로고
    • Lonacept for gout flare prevention in patients on uric acid-lowering therapy: Results of a double-blind placebo-controlled phase 3 international safety study. [abstract]
    • Sundy JS, Schumacher HR, Kirstein J, et al. Rilonacept for gout flare prevention in patients on uric acid-lowering therapy: results of a double-blind, placebo-controlled, phase 3, international safety study. [abstract]. Arthritis Rheum 2011;63(Suppl 10):1013
    • (2011) Arthritis Rheum , vol.63 , Issue.SUPPL. 10 , pp. 1013
    • Sundy, J.S.1    Schumacher, H.R.2    Kirstein, J.3
  • 23
    • 84870404552 scopus 로고    scopus 로고
    • Rilonacept for gout flare prevention: Subgroup analysis of patients initiating or continuing uric acid-lowering therapy in a randomized placebo-controlled trial. [abstract]
    • Sundy JS, Schumacher HR, Kirstein J, et al. Rilonacept for gout flare prevention: subgroup analysis of patients initiating or continuing uric acid-lowering therapy in a randomized, placebo-controlled trial. [abstract]. Arthritis Rheum 2011;63(Suppl 10):1023
    • (2011) Arthritis Rheum , vol.63 , Issue.SUPPL. 10 , pp. 1023
    • Sundy, J.S.1    Schumacher, H.R.2    Kirstein, J.3
  • 24
    • 84870441321 scopus 로고    scopus 로고
    • Rilonacept for prevention of gout flares associated with uric acid-lowering therapy: Response rate across three phase 3 clinical trials. [abstract]
    • Schumacher HR, Evans RR, Birbara CA, et al. Rilonacept for prevention of gout flares associated with uric acid-lowering therapy: response rate across three phase 3 clinical trials. [abstract]. Arthritis Rheum 2011;63(Suppl 10):1024
    • (2011) Arthritis Rheum , vol.63 , Issue.SUPPL. 10 , pp. 1024
    • Schumacher, H.R.1    Evans, R.R.2    Birbara, C.A.3
  • 26
    • 46149100545 scopus 로고    scopus 로고
    • The human anti-IL-1 beta monoclonal antibody ACZ885 is effective in joint inflammation models in mice and in a proof-of-concept study in patients with rheumatoid arthritis
    • Alten R, Gram H, Joosten LA, et al. The human anti-IL-1 beta monoclonal antibody ACZ885 is effective in joint inflammation models in mice and in a proof-of-concept study in patients with rheumatoid arthritis. Arthritis Res Ther 2008;10(3):R67
    • (2008) Arthritis Res Ther , vol.10 , Issue.3
    • Alten, R.1    Gram, H.2    Joosten, L.A.3
  • 27
    • 77957688721 scopus 로고    scopus 로고
    • Canakinumab for the treatment of acute flares in difficult-to-treat gouty arthritis: Results of a multicenter phase II dose-ranging study
    • So A, De Meulemeester M, Pikhlak A, et al. Canakinumab for the treatment of acute flares in difficult-to-treat gouty arthritis: results of a multicenter, phase II, dose-ranging study. Arthritis Rheum 2010;62(10):3064-76
    • (2010) Arthritis Rheum , vol.62 , Issue.10 , pp. 3064-3076
    • So, A.1    De Meulemeester, M.2    Pikhlak, A.3
  • 28
    • 79953094557 scopus 로고    scopus 로고
    • Canakinumab relieves symptoms of acute flares and improves health-related quality of life in patients with difficult-to-treat gouty arthritis by suppressing inflammation: Results of a randomized dose-ranging study
    • Schlesinger N, De Meulemeester M, Pikhlak A, et al. Canakinumab relieves symptoms of acute flares and improves health-related quality of life in patients with difficult-to-treat gouty arthritis by suppressing inflammation: results of a randomized, dose-ranging study. Arthritis Res Ther 2011;13(2):R53
    • (2011) Arthritis Res Ther , vol.13 , Issue.2
    • Schlesinger, N.1    De Meulemeester, M.2    Pikhlak, A.3
  • 29
    • 84867405545 scopus 로고    scopus 로고
    • Canakinumab for acute gouty arthritis in patients with limited treatment options: Results from two randomised multicentre active-controlled double-blind trials and their initial extensions
    • Epub ahead of print
    • Schlesinger N, Alten RE, Bardin T, et al. Canakinumab for acute gouty arthritis in patients with limited treatment options: results from two randomised, multicentre, active-controlled, double-blind trials and their initial extensions. Ann Rheum Dis 2012; Epub ahead of print
    • (2012) Ann Rheum Dis
    • Schlesinger, N.1    Alten, R.E.2    Bardin, T.3
  • 30
    • 84870448268 scopus 로고    scopus 로고
    • June 21, FDA Briefing Document. Supplemental BLA 125319: Ilaris (canakinumab) For The Following Proposed Indication: "ILARIS is indicated for the treatment of gouty arthritis attacks. ILARIS has also been shown to extend the time to the next attack and reduce the frequency of subsequent attacks"
    • Arthritis Advisory Committee Meeting, June 21, 2011. FDA Briefing Document. Supplemental BLA 125319: Ilaris (canakinumab) for the following proposed indication: "ILARIS is indicated for the treatment of gouty arthritis attacks. ILARIS has also been shown to extend the time to the next attack and reduce the frequency of subsequent attacks". Available from: http://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/ Drugs/ArthritisAdvisoryCommittee/UCM259596.pdf
    • (2011) Arthritis Advisory Committee Meeting
  • 31
    • 84870439385 scopus 로고    scopus 로고
    • RDEA594, a novel uricosuric agent, significantly reduced serum urate levels and was well tolerated in a phase 2a pilot study in hyperuricemic gout patients [abstract]
    • Lasko B, Sheedy B, Hingorani V, et al. RDEA594, a novel uricosuric agent, significantly reduced serum urate levels and was well tolerated in a phase 2a pilot study in hyperuricemic gout patients [abstract]. Arthritis Rheum 2009;60(Suppl):1105
    • (2009) Arthritis Rheum , vol.60 , Issue.SUPPL. , pp. 1105
    • Lasko, B.1    Sheedy, B.2    Hingorani, V.3
  • 32
    • 80054098279 scopus 로고    scopus 로고
    • Efficacy and safety of lesinurad (RDEA594) a novel uricosuric agent given in combination with allopurinol in allopurinol-refractory gout patients: Randomized doubl-blind placebo-controlled phase 2b study. [abstract]
    • Perez-Ruiz F, Sundy JS, Krishnan E, et al. Efficacy and safety of lesinurad (RDEA594), a novel uricosuric agent, given in combination with allopurinol in allopurinol-refractory gout patients: randomized, doubl-blind, placebo-controlled, phase 2b study. [abstract]. Ann Rheum Dis 2011;70(Suppl 3):104
    • (2011) Ann Rheum Dis , vol.70 , Issue.SUPPL. 3 , pp. 104
    • Perez-Ruiz, F.1    Sundy, J.S.2    Krishnan, E.3
  • 33
    • 84979290199 scopus 로고    scopus 로고
    • Efficacy and safety of lesinurad (RDEA594) a novel uricosuric agent in combination with allopurinol in gout patients with an inadequate response to allopurinol: Results from the randomized blinded placebo-controlled phase 2b extension study. [abstract]
    • Perez-Ruiz F, Sundy JS, Krishnan E, et al. Efficacy and safety of lesinurad (RDEA594), a novel uricosuric agent, in combination with allopurinol in gout patients with an inadequate response to allopurinol: results from the randomized, blinded, placebo-controlled, phase 2B extension study. [abstract]. Ann Rheum Dis 2012;71(Suppl 3):439
    • (2012) Ann Rheum Dis , vol.71 , Issue.SUPPL. 3 , pp. 439
    • Perez-Ruiz, F.1    Sundy, J.S.2    Krishnan, E.3
  • 34
    • 84870448812 scopus 로고    scopus 로고
    • Pharmacokinetics, efficacy and safety of lesinurad, a novel URAT1 inhibitor, in individuals with mild to moderate renal impairment [abstract]
    • Hagerty D, Kerr B, Shen Z, et al. Pharmacokinetics, efficacy and safety of lesinurad, a novel URAT1 inhibitor, in individuals with mild to moderate renal impairment [abstract]. Arthritis Rheum 2011;63(Suppl 10):1030
    • (2011) Arthritis Rheum , vol.63 , Issue.SUPPL. 10 , pp. 1030
    • Hagerty, D.1    Kerr, B.2    Shen, Z.3
  • 35
    • 80054098279 scopus 로고    scopus 로고
    • Lesinurad (RDEA594) a novel uricosuric agent in combination with with febuxostat shows significant additive urate lowering effects in gout patients with 100% response achieved for all combination dose regimens. [abstract]
    • Fleischman RM, Shen Z, Yeh LT, et al. Lesinurad (RDEA594), a novel uricosuric agent, in combination with with febuxostat shows significant additive urate lowering effects in gout patients with 100% response achieved for all combination dose regimens. [abstract]. Ann Rheum Dis 2011;70(Suppl 3):188
    • (2011) Ann Rheum Dis , vol.70 , Issue.SUPPL. 3 , pp. 188
    • Fleischman, R.M.1    Shen, Z.2    Yeh, L.T.3
  • 36
    • 84978278678 scopus 로고    scopus 로고
    • Effects of a purine nucleoside phosphorylase inhibitor, bcx4208, on the serum uric acid concentrations in patients with gout [abstract]
    • Fitz-Patrick D, Drummond W, Pappas J, Hollister AS. Effects of a purine nucleoside phosphorylase inhibitor, bcx4208, on the serum uric acid concentrations in patients with gout [abstract]. Arthritis & Rheumatism 2010;62(Suppl 10):150
    • (2010) Arthritis & Rheumatism , vol.62 , Issue.SUPPL. 10 , pp. 150
    • Fitz-Patrick, D.1    Drummond, W.2    Pappas, J.3    Hollister, A.S.4
  • 37
    • 52449117951 scopus 로고    scopus 로고
    • Uricosuric action of losartan via the inhibition of urate transporter 1 (URAT 1) in hypertensive patients
    • Hamada T, Ichida K, Hosoyamada M, et al. Uricosuric action of losartan via the inhibition of urate transporter 1 (URAT 1) in hypertensive patients. Am J Hypertens 2008;21(10):1157-62
    • (2008) Am J Hypertens , vol.21 , Issue.10 , pp. 1157-1162
    • Hamada, T.1    Ichida, K.2    Hosoyamada, M.3


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