-
1
-
-
63449109698
-
Myeloma cell growth inhibition is augmented by synchronous inhibition of the insulin-like growth factor-1 receptor by NVP-AEW541 and inhibition of mammalian target of rapamycin by RAD001
-
Baumann P, Hagemeier H, Mandl-Weber S, et al. Myeloma cell growth inhibition is augmented by synchronous inhibition of the insulin-like growth factor-1 receptor by NVP-AEW541 and inhibition of mammalian target of rapamycin by RAD001. Anticancer Drugs, 2009, 20: 259-266.
-
(2009)
Anticancer Drugs
, vol.20
, pp. 259-266
-
-
Baumann, P.1
Hagemeier, H.2
Mandl-Weber, S.3
-
2
-
-
33846516354
-
Antiproliferative activity of RAD001 (everolimus) as a single agent and combined with other agents in mantle cell lymphoma
-
Haritunians T, Mori A, O'Kelly J, et al. Antiproliferative activity of RAD001 (everolimus) as a single agent and combined with other agents in mantle cell lymphoma Leukemia, 2007, 21: 333-339.
-
(2007)
Leukemia
, vol.21
, pp. 333-339
-
-
Haritunians, T.1
Mori, A.2
O'Kelly, J.3
-
3
-
-
65349114832
-
Potentiating effects of RAD001 (Everolimus) on vincristine therapy in childhood acute lymphoblastic leukemia
-
Crazzolara R, Cisterne A, Thien M, et al. Potentiating effects of RAD001 (Everolimus) on vincristine therapy in childhood acute lymphoblastic leukemia Blood, 2009, 113: 3297-3306.
-
(2009)
Blood
, vol.113
, pp. 3297-3306
-
-
Crazzolara, R.1
Cisterne, A.2
Thien, M.3
-
4
-
-
20844444898
-
Combination of the histone deacetylase inhibitor LBH589 and the hsp90 inhibitor 17-AAG is highly active against human CML-BC cells and AML cells with activating mutation of FLT-3
-
George P, Bali P, Annavarapu S, et al. Combination of the histone deacetylase inhibitor LBH589 and the hsp90 inhibitor 17-AAG is highly active against human CML-BC cells and AML cells with activating mutation of FLT-3. Blood, 2005, 105: 1768-1776.
-
(2005)
Blood
, vol.105
, pp. 1768-1776
-
-
George, P.1
Bali, P.2
Annavarapu, S.3
-
5
-
-
33748063974
-
A Phase I study of intravenous LBH589, a novel cinnamic hydroxamic acid analogue histone deacetylase inhibitor, in patients with refractory hematologic malignancies
-
Giles F, Fischer T, Cortes J, et al. A Phase I study of intravenous LBH589, a novel cinnamic hydroxamic acid analogue histone deacetylase inhibitor, in patients with refractory hematologic malignancies. Clin Cancer Res, 2006, 12: 4628-4635.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 4628-4635
-
-
Giles, F.1
Fischer, T.2
Cortes, J.3
-
6
-
-
34047255081
-
The novel mTOR inhibitor RAD001 (everolimus) induces antiproliferative effects in human pancreatic neuroendocrine tumor cells
-
Zitzmann K, De Toni EN, Brand S, et al. The novel mTOR inhibitor RAD001 (everolimus) induces antiproliferative effects in human pancreatic neuroendocrine tumor cells. Neuroendocrinology, 2007, 85: 54-60.
-
(2007)
Neuroendocrinology
, vol.85
, pp. 54-60
-
-
Zitzmann, K.1
de Toni, E.N.2
Brand, S.3
-
7
-
-
63849239484
-
Targeting of mTOR is associated with decreased growth and decreased VEGF expression in acute myeloid leukaemia cells
-
Bohm A, Aichberger KJ, Mayerhofer M, et al. Targeting of mTOR is associated with decreased growth and decreased VEGF expression in acute myeloid leukaemia cells. Eur J Clin Invest, 2009, 39: 395-405.
-
(2009)
Eur J Clin Invest
, vol.39
, pp. 395-405
-
-
Bohm, A.1
Aichberger, K.J.2
Mayerhofer, M.3
-
8
-
-
63749129788
-
PI3K and mTOR inhibitors - A new generation of targeted anticancer agents
-
Brachmann S, Fritsch C, Maira SM, et al. PI3K and mTOR inhibitors-a new generation of targeted anticancer agents. Cell Biology, 2009, 21: 1-5.
-
(2009)
Cell Biology
, vol.21
, pp. 1-5
-
-
Brachmann, S.1
Fritsch, C.2
Maira, S.M.3
-
9
-
-
38049187096
-
Mammalian target of rapamycin (mTOR) inhibition activates phosphatidylinositol 3-kinase/Akt by up-regulating insulin-like growth factor-1 receptor signaling in acute myeloid leukemia: Rationale for therapeutic inhibition of both pathways
-
Tamburini J, Chapuis N, Bardet V, et al. Mammalian target of rapamycin (mTOR) inhibition activates phosphatidylinositol 3-kinase/Akt by up-regulating insulin-like growth factor-1 receptor signaling in acute myeloid leukemia: rationale for therapeutic inhibition of both pathways. Blood, 2008, 111: 379-382.
-
(2008)
Blood
, vol.111
, pp. 379-382
-
-
Tamburini, J.1
Chapuis, N.2
Bardet, V.3
-
10
-
-
57849141586
-
Blockade of mTOR signaling potentiates the ability of histone deacetylase inhibitor to induce growth arrest and differentiation of acute myelogenous leukemia cells
-
Nishioka C, Ikezoe T, Yang J, et al. Blockade of mTOR signaling potentiates the ability of histone deacetylase inhibitor to induce growth arrest and differentiation of acute myelogenous leukemia cells. Leukemia, 2008, 22: 2159-2168.
-
(2008)
Leukemia
, vol.22
, pp. 2159-2168
-
-
Nishioka, C.1
Ikezoe, T.2
Yang, J.3
-
11
-
-
34147146014
-
Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML
-
Zeng Z, Sarbassov dos D, Samudio U, et al. Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML Blood, 2007, 109: 3509-3512.
-
(2007)
Blood
, vol.109
, pp. 3509-3512
-
-
Zeng, Z.1
dos Sarbassov, D.2
Samudio, U.3
-
12
-
-
33847225602
-
Multidrug resistance-associated protein 1 expression is under the control of the phosphoinositide 3 kinase/Akt signal ransduction network in human acute myelogenous leukemia blast
-
Tazzari PL, Cappellini A, Ricci F, et al. Multidrug resistance-associated protein 1 expression is under the control of the phosphoinositide 3 kinase/Akt signal ransduction network in human acute myelogenous leukemia blast. Leukemia, 2007, 21: 427-438.
-
(2007)
Leukemia
, vol.21
, pp. 427-438
-
-
Tazzari, P.L.1
Cappellini, A.2
Ricci, F.3
-
13
-
-
56249140759
-
Involvement of p53 and Raf/MEK/ERK pathways in hematopoietic drug resistance
-
McCubrey JA, Abrams SL, Ligresti G, et al. Involvement of p53 and Raf/MEK/ERK pathways in hematopoietic drug resistance. Leukemia, 2008, 22: 2080-2090.
-
(2008)
Leukemia
, vol.22
, pp. 2080-2090
-
-
McCubrey, J.A.1
Abrams, S.L.2
Ligresti, G.3
-
14
-
-
33749002279
-
Phase I/II study of the mammalian target of rapamycin inhibitor everolimus (RAD001) in patients with relapsed or refractory hematologic malignancies
-
Yee KW, Zeng Z, Konopleva M, et al. Phase I/II study of the mammalian target of rapamycin inhibitor everolimus (RAD001) in patients with relapsed or refractory hematologic malignancies. Clin Cancer Res, 2006, 12: 5165-5173.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 5165-5173
-
-
Yee, K.W.1
Zeng, Z.2
Konopleva, M.3
-
15
-
-
77950069222
-
mTOR inhibitor RAD001 (Everolimus) enhances the effects of imatinib in chronic myeloid leykemia by raising the nuclear expression of c-ABL protein
-
Mancini M, Corradi V, Petta S, et al. mTOR inhibitor RAD001 (Everolimus) enhances the effects of imatinib in chronic myeloid leykemia by raising the nuclear expression of c-ABL protein. Leuk Res, 2010, 34: 641-648.
-
(2010)
Leuk Res
, vol.34
, pp. 641-648
-
-
Mancini, M.1
Corradi, V.2
Petta, S.3
|