Lymphangiogenesis and podoplanin expression in oral squamous cell carcinoma and the associated lymph nodes

Applied Immunohistochemistry and Molecular Morphology

Volumn 20, Issue 6, 2012, Pages 588-594

  De Sousa, Sílvia Ferreira ^a   Gleber Netto, Frederico Omar ^a   De Oliveira Neto, Helenisa Helena ^a   Batista, Aline Carvalho ^a   Nogueira Guimarães Abreu, Mauro Henrique ^b   De Aguiar, Maria Cássia Ferreira ^a  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^b FEDERAL UNIVERSITY OF GOIÁS   (Brazil)

Author keywords

immunohistochemistry; lymph nodes; lymphangiogenesis; oral squamous cell carcinoma; podoplanin expression

Indexed keywords

ENDOGLIN; MONOCLONAL ANTIBODY D2-40; PODOPLANIN; VASCULOTROPIN C; VASCULOTROPIN RECEPTOR 3;

ADULT; ARTICLE; CANCER LOCALIZATION; CLINICAL ARTICLE; CONTROLLED STUDY; DENSITY; DISEASE ASSOCIATION; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE; LYMPH NODE METASTASIS; LYMPHANGIOGENESIS; MALE; MICROVASCULATURE; MOUTH SQUAMOUS CELL CARCINOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR CELL; TUMOR DIFFERENTIATION; TUMOR MICROENVIRONMENT; TUMOR VOLUME;

ADULT; CARCINOMA, SQUAMOUS CELL; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; LYMPH NODES; LYMPHANGIOGENESIS; LYMPHATIC METASTASIS; MALE; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; MOUTH NEOPLASMS;

EID: 84870449820     PISSN: 15412016     EISSN: 15334058     Source Type: Journal    
DOI: 10.1097/PAI.0b013e31824bb3ea     Document Type: Article

References (30)

1. Sahai E. Illuminating the metastatic process. Nat Rev Cancer. 2007;7:737-749.
2. Bolenz C, FernándezMI, Trojan L, et al. Lymphangiogenesis occurs in upper tract urothelial carcinoma and correlates with lymphatic tumour dissemination and poor prognosis. BJU Int. 2009;103:1040-1046.
3. Zhang Z, Helman JI, LJ Li. Lymphangiogenesis lymphatic endothelial cells and lymphatic metastasis in head and neck cancer - a review of mechanisms. Int J Oral Sci. 2010;2:5-14.
4. Shayan R, Achen MG, Stacker SA. Lymphatic vessels in cancer metastasis: bridging the gaps. Carcinogenesis. 2006;27: 1729-1738.
5. Ran S, Volk L, Hall K, et al. Lymphangiogenesis and lymphatic metastasis in breast cancer. Pathophysiology. 2010;17:229-251.
6. Margaritescu C, Pirici D, Simionescu C, et al. VEGF and VEGFRs expression in oral squamous cell carcinoma. Rom J Morphol Embryol. 2009;50:527-548.
7. Hirakawa S, Brown LF, Kodama S, et al. VEGF-C induced lymphangiogenesis in sentinel lymph nodes promotes tumor metastasis to distant sites. Blood. 2007;109:1010-1017.
8. Hirakawa S. From tumor lymphangiogenesis to lymphvascular niche. Cancer Sci. 2009;100:983-989.
9. Ishii H, Chikamatsu K, Sakakura K, et al. Primary tumor induces sentinel lymph node lymphangiogenesis in oral squamous cell carcinoma. Oral Oncol. 2010;46:373-378.
10. Myahara M, Tanuma J, Sugihara K, et al. Tumor lymphangiogenesis correlates with lymph node metastasis and clinicopathologic parameters in oral squamous cell carcinoma. Cancer. 2007; 110:1287-1294.
11. Longatto-Filho A, Oliveira TG, Pinheiro C, et al. How useful is the assessment of lymphatic vascular density in oral carcinoma prognosis? World J Surg Oncol. 2007;11:140-148.
12. Kadota K, Huang CL, Liu D, et al. The clinical significance of the tumor cell D2-40 immunoreactivity in non-small cell lung cancer. Lung Cancer. 2010;70:88-93.
13. Kreppel M, Scheer M, Drebber U, et al. Impact of podoplanin expression in oral squamous cell carcinoma: clinical and histopathologic correlations. Virchows Arch. 2010;456:473-482.
14. Yuan P, Temam S, El-Naggar S, et al. Overexpression of podoplanin in oral cancer and its association with poor clinical outcome. Cancer. 2006;107:563-569.
15. Bryne M, Koppang HS, Lilleng R, et al. Malignancy grading of the deep invasive margins of oral squamous cell carcinoma has high prognostic value. J Pathol. 1992;166:375-381.
16. Kyzas PA, Geleff S, Batistatou A, et al. Evidence for lymphangiogenesis and its prognostic implications in head and neck squamous cell carcinoma. J Pathol. 2005;206:170-177.
17. Zhao D, Pan J, Li XQ, et al. Intratumoral lymphangiogenesis in oral squamous cell carcinoma and its clinicopathological significance. J Oral Pathol Med. 2008;37:616-625.
18. Cooper JS, Pajak TF, Forastiere AA, et al. Postoperative concurrent radiotherapy and chemotherapy for high-risk squamous-cell carcinoma of the head and neck. N Eng J Med. 2004;350:1937-1944.
19. Nico B, Benagiano V, Mangieri D, et al. Evaluation of microvascular density in tumors: pro and contra. Histol Histopathol. 2008;23:601-607.
20. Martone T, Rosso P, Albera R, et al. Prognostic relevance of CD105+ microvessel density in HNSCC patient outcome. Oral Oncol. 2005;41:147-155.
21. Chung HC, Su CH, Huang HY, et al. High expression of CD105 as a prognostic predictor of early tongue cancer. Laryngoscope. 2006;116:1175-1179.
22. Schimming R, Marmè D. Endoglin (CD105) expression in squamous cell carcinoma of the oral cavity. Head Neck. 2002;24:151-156.
23. Kyzas PA, Agnantis NJ, Stefanou D. Endoglin (CD105) as a prognostic factor in head and neck squamous cell carcinoma. Virchows Arch. 2006;448:768-775.
24. Sedivy R, Beck-Mannagetta J, Haverkampf C, et al. Expression of vascular endothelial growth factor-C correlates with the lymphatic microvessel density and the nodal status in oral squamous cell cancer. J Oral Pathol Med. 2003;32:455-460.
25. Warburton G, Nikitakis NG, Roberson P, et al. Histopathological and lymphangiogenic parameters in relation to lymph node metastasis in early stage oral squamous cell carcinoma. J Oral Maxillofac Surg. 2007;65:475-484.
26. Chen F, Takenaka K, Ogawa E, et al. Flt-4-positive endothelial cell density and its clinical significance in non-small cell lung cancer. Clin Cancer Res. 2004;10:8548-8553.
27. Raica M, Cimpean A, Ribatti D. The role of podoplanin in tumor progression and metastasis. Anticancer Res. 2008;28:2997-3006.
28. Martín-Villar E, Megiás D, Castel S, et al. Podoplanin binds ERM proteins to activate RhoA and promote epithelial-mesenchymal transition. J Cell Sci. 2006;119:4541-4553.
29. Schacht V, Dadras SS, Johnson LA, et al. Up-regulation of the lymphatic marker podoplanin, a mucin-type transmembrane glycoprotein, in human squamous cell carcinomas and germ cell tumors. Am J Pathol. 2005;166:913-921.
30. Qian CN, Berghuis B, Tsarfaty G, et al. Preparing the "soil": the primary tumor induces vasculature reorganization in the sentinel lymph node before the arrival of metastatic cancer cells. Cancer Res. 2006;66:10365-10376.