Altered expression of endogenous transforming growth factor β1 and early calcification related genes in rat endplate

National Medical Journal of China

Volumn 91, Issue 31, 2011, Pages 2181-2185

  Xu, Hong Guang ^a   Zhang, Xiao Ling ^b   Zhang, Xiao Hai ^a   Wang, Hong ^a   Jia, Rui Ping ^a   Tong, Wen Xue ^b   Tong, Hai Jun ^b  

^a WANNAN MEDICAL COLLEGE   (China)

^b SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Ankyrins; Chondrocytes; Transforming growth factor beta

Indexed keywords

ALIZARIN; ALKALINE PHOSPHATASE; ANKYRIN; COLLAGEN TYPE 2; COLLAGENASE 3; DISINTEGRIN; INORGANIC PYROPHOSPHATASE; METALLOPROTEINASE; PROTEOGLYCAN; THROMBOSPONDIN; TRANSCRIPTION FACTOR SOX9; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIFICATION; CARTILAGE CELL; CELL STRUCTURE; CONTROLLED STUDY; DEGENERATION; DOWN REGULATION; ENZYME METABOLISM; IN VITRO STUDY; INTERVERTEBRAL DISK; L CELL; LUMBAR VERTEBRA; MARKER GENE; NERVE ENDING; NONHUMAN; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; SPINDLE CELL; ANIMAL; CELL CULTURE; GENETICS; METABOLISM; SPRAGUE DAWLEY RAT;

ANIMALS; ANKYRINS; CELLS, CULTURED; CHONDROCYTES; COLLAGEN TYPE II; PROTEOGLYCANS; RATS; RATS, SPRAGUE-DAWLEY; SOX9 TRANSCRIPTION FACTOR; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84870444720     PISSN: 03762491     EISSN: None     Source Type: Journal    
DOI: 10.3760/cma.j.issn.0376-2491.2011.31.006     Document Type: Article

References (26)

1. Gruber HE, Gordon B, Williams C, et al. Vertebral endplate and disc changes in the aging sand rat lumbar spine: cross-sectional analyses of a large male and female population. Spine, 2007, 32: 2529-2536.
2. Bernick S, Cailliet R. Vertebral end-plate changes with aging of human vertebrae. Spine, 1982, 7: 97-102.
3. Oda J, Tanaka H, Tsuzuki N. Intervertebral disc changes with aging of human cervical vertebra: from the neonate to the eighties. Spine, 1988, 13: 1205-1211.
4. Robes S, Menage J, Urball JP. Biochemical and structural properties of the cartilage end-plate and its relation to the intervertebral disc. Spine, 1989, 14: 166-174.
5. Ea HK, Nguyen C, Bazin D, et al. Articular cartilage calcification in osteoarthritis: insights into crystal-induced stress. Arthritis Rheum, 2011, 63: 10-18.
6. Kang SW, Yoo SP, Kim BS. Effect of chondrocyte passage number on histological aspects of tissue-engineered cartilage. Biomed Mater Eng, 2007, 17: 269-276.
7. 2008, 88: 2609-2613.
8. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2 (-delta delta C (T) method. Methods, 2001, 25: 402-408.
9. Von der Mark K, Gauss V, von der Mark H, et al. Relationship between cell shape and type of collagen synthesised as chondrocytes lose their cartilage phenotype in culture. Nature, 1977, 267: 531-532.
10. Liang QQ, Cui XJ, Xi ZJ, et al. Prolonged upright posture induces degenerative changes in intervertebral discs of rat cervical spine. Spine, 2010, 36: 14-19.
11. Mori-Akiyama Y, Akiyama H, Rowitch DH, et al. Sox9 is required for determination of the chondrogenic cell lineage in the cranial neural crest. Proc Natl Acad Sci Am, 2003, 100: 9360-9365.
12. Gruber HE, Norton HJ, Ingram JA, et al. The S0X9 transcription factor in the human disc: decreased immunolocalization with age and disc degeneration. Spine, 2005, 30: 625-630.
13. Alini M, Eisenstein SM, Ito K, et al. Are animal models useful for studying human disc disorders/degeneration? Eur Spine J, 2008, 17: 2-19.
14. Ho AM, Johnson MD, Kingsley DM. Role of the mouse ank gene in control of tissue calcification and arthritis. Science, 2000, 289: 265-270.
15. Hughes AE, McGibbon D, Woodward E, et al. Localisation of a gene for chondrocalcinosis to chromosome 5p. Hum Mol Genet, 1995, 4: 1225-1228.
16. Masuda I, Hirose J. Animal models of pathologic calcification. Curr Opin Rheumatol, 2002, 14: 287-291.
17. Niirnberg P, Thiele H, Chandler D, et al. Heterozygous mutations in ANKH, the human ortholog of the mouse progressive ankylosis gene, result in craniometaphyseal dysplasia. Nat Genet, 2001, 28: 37-41.
18. Johnson K, Van Etten D, Terkeltaub R. ANK and PC-1 regulate cartilage matrix calcification by synergistically controlling extracellular ppi. Arthritis Rtheum, 2001, 44; 162.
19. Johnson KA, Hessle L, Vaingankar S, et al. Osteoblast tissue-nonspecific alkaline phosphatase antagonizes and regulates PC-1. Am J Physiol Regul Integr Comp Physiol, 2000, 279: 1365-1377.
20. Sohn P, Crowley M, Slattery E, et al. Developmental and TGF-beta-mediated regulation of Ank mRNA expression in cartilage and bone. Osteoarthritis Cartilage, 2002, 10: 482-490.
21. Derfus BA, Camacho NP, Olmez U, et al. Transforming growth factor beta-1 stimulates articular chondrocyte elaboration of matrix vesicles capable of greater calcium pyrophosphate precipitation. Osteoarthritis Cartilage, 2001, 9: 189-194.
22. Masuda I, Hirose J. Animal models of pathologic calcification. Curr Opin Rheumatol, 2002, 14: 287-291.
23. Johnson K, Terkeltaub R. Upregulated ank expression in osteoarthritis can promote both chondrocyte MMP-13 expression and calcification via chondrocyte extracellular PPi excess. Osteoarthritis Cartilage, 2004, 12: 321-335.
24. Cailotto F, Bianchi A, Sebillaud S, et al. Inorganic pyrophosphate generation by transforming growth factor-beta-1 is mainly dependent on ANK induction by Ras/Raf-1/extracellular signal-regulated kinase pathways in chondrocytes. Arthritis Res Ther, 2007, 9: 122.
25. Davidson EN, Vitters EL, van der Kraan PM, et al. Expression of transforming growth factor-beta (TGFbeta) and the TGFbeta signalling molecule SMAD-2P in spontaneous and instability-induced osteoarthritis; role in cartilage degradation, chondrogenesis and osteophyte formation. Ann Rheum Dis, 2006, 65: 1414-1421.
26. Oca P, Zaka R, Dion AS, et al. Phosphate and calcium are required for TGFbeta-mediated stimulation of ANK expression and function during chondrogenesis. J Cell Physiol, 2010, 224: 540-548.