Genetic test feedback with weight control advice: Study protocol for a randomized controlled trial

Trials

Volumn 13, Issue , 2012, Pages

  Meisel, Susanne F ^a   Beeken, Rebecca J ^a   van Jaarsveld, Cornelia H M ^a   Wardle, Jane ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Behavior change; DNA test; Genetic test feedback; Obesity prevention

Indexed keywords

ARTICLE; BODY COMPOSITION; BODY FAT; BODY WEIGHT; CLINICAL PROTOCOL; CONTROLLED STUDY; FOLLOW UP; GENETIC SCREENING; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MOTIVATION; RANDOMIZED CONTROLLED TRIAL; WEIGHT CONTROL; WEIGHT GAIN;

BODY COMPOSITION; CLINICAL PROTOCOLS; GENETIC TESTING; HUMANS; OBESITY; OUTCOME ASSESSMENT (HEALTH CARE); PROTEINS; SAMPLE SIZE; WEIGHT LOSS;

EID: 84870443475     PISSN: None     EISSN: 17456215     Source Type: Journal    
DOI: 10.1186/1745-6215-13-235     Document Type: Article

References (41)

1. Collins F. Has the revolution arrived?. Nature 2010, 464:674-675. 10.1038/464674a, 20360716.
2. Chung WK. Implementation of genetics to personalize medicine. Gend Med 2007, 4:248-265. 10.1016/S1550-8579(07)80044-1, 18022591.
3. Khoury MJ, Gwinn M, Burke W, Bowen S, Zimmern R. Will genomics widen or help heal the schism between medicine and public health?. Am J Prev Med 2007, 33:310-317. 10.1016/j.amepre.2007.05.010, 17888858.
4. Rosenstock IM. Adoption and maintenance of lifestyle modifications. Am J Prev Med 1988, 4:349-352.
5. Senior V, Marteau TM, Peters TJ. Will genetic testing for predisposition for disease result in fatalism? A qualitative study of parents responses to neonatal screening for familial hypercholesterolaemia. Soc Sci Med 1999, 48:1857-1860. 10.1016/S0277-9536(99)00099-4, 10405022.
6. Haga SB, Khoury MJ, Burke W. Genomic profiling to promote a healthy lifestyle: not ready for prime time. Nat Genet 2003, 34:347-350. 10.1038/ng0803-347, 12923535.
7. Leventhal H, Benyamini Y, Brownlee S, Diefenbach MA, Leventhal EA, Patrick-Miller L, Robitaille C. Illness representations: theoretical foundations. Perception of health and illness 1997, 19-46. Amsterdam: Harwood Academic Publishers, Petrie KH, Weinman JA.
8. Sanderson SC, O'Neill SC, Bastian LA, Bepler G, McBride CM. What Can interest tell Us about uptake of genetic testing? intention and behavior amongst smokers related to patients with lung cancer. Pub Health Genomi 2010, 13:116-124.
9. Meisel SF, Walker C, Wardle J. Psychological responses to genetic testing for weight gain: a vignette study. Obesity (Silver Spring) 2011, 20:540-546.
10. Frosch DL, Mello P, Lerman C. Behavioral consequences of testing for obesity risk. Cancer Epidem Biomark 2005, 14:1485-1489.
11. Sanderson SC, O'Neill SC, White DB, Bepler G, Bastian L, Lipkus IM, McBride CM. Responses to online GSTM1 genetic test results among smokers related to patients with lung cancer: a pilot study. Cancer Epidem Biomark 2009, 18:1953-1961.
12. Audrain J, Boyd NR, Roth J, Main D, Caporaso NE, Lerman C. Genetic susceptibility testing in smoking-cessation treatment: One-year outcomes of a randomized trial. Addict Beh 1997, 22:741-751.
13. Marteau TM, French DP, Griffin SJ, Prevost AT, Sutton S, Watkinson C, Attwood S, Hollands GJ. Effects of communicating DNA-based disease risk estimates on risk-reducing behaviours. Cochrane Database Syst Rev 2010, 10:CD007275.
14. Lancaster T, Hajek P, Stead LF, West R, Jarvis MJ. Prevention of relapse after quitting smoking: a systematic review of trials. Arch Intern Med 2006, 166:828-835. 10.1001/archinte.166.8.828, 16636207.
15. Sanderson SC, Humphries SE, Hubbart C, Hughes E, Jarvis MJ, Wardle J. Psychological and behavioural impact of genetic testing smokers for lung cancer risk - A phase II exploratory trial. J Health Psychol 2008, 13:481-494. 10.1177/1359105308088519, 18420756.
16. Harvey-Berino J, Gold EC, West DS, Shuldiner AR, Walston J, Starling RD, Nolan A, Silver K, Poehlman ET. Does genetic testing for obesity influence confidence in the ability to lose weight? A pilot investigation. J Am Diet Assoc 2001, 101:1351-1353. 10.1016/S0002-8223(01)00323-6, 11716317.
17. Conradt M, Dierk JM, Schlumberger P, Albohn C, Rauh E, Hinney A, Hebebrand J, Rief W. A consultation with genetic information about obesity decreases self-blame about eating and leads to realistic weight loss goals in obese individuals. J Psychosom Res 2009, 66:287-295. 10.1016/j.jpsychores.2008.09.003, 19302885.
18. O'Brien KS, Puhl RM, Latner JD, Mir AS, Hunter JA. Reducing anti-Fat prejudice in preservice health students: a randomized trial. Obesity 2010, 18:2138-2144. 10.1038/oby.2010.79, 20395952.
19. Bloss CS, Schork NJ, Topol EJ. Effect of direct-to-consumer genomewide profiling to assess disease risk. N Engl J Med 2011, 364:524-534. 10.1056/NEJMoa1011893, 21226570.
20. Frayling TM, Timpson NJ, Weedon MN, Zeggini E, Freathy RM, Lindgren CM, Perry JR, Elliott KS, Lango H, Rayner NW, Shields B, Harries LW, Barrett JC, Ellard S, Groves CJ, Knight B, Patch AM, Ness AR, Ebrahim S, Lawlor DA, Ring SM, Ben-Shlomo Y, Jarvelin MR, Sovio U, Bennett AJ, Melzer D, Ferrucci L, Loos RJ, Barroso I, Wareham NJ, et al. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 2007, 316:889-894. 10.1126/science.1141634, 2646098, 17434869.
21. Cluskey M, Grobe D. College weight gain and behavior transitions: male and female differences. J Am Diet Assoc 2009, 109:325-329. 10.1016/j.jada.2008.10.045, 19167962.
22. Steptoe A, Wardle J, Cui W, Bellisle F, Zotti AM, Baranyai R, Sanderman R. Trends in smoking, diet, physical exercise, and attitudes toward health in European university students from 13 countries, 1990-2000. Prev Med 2002, 35:97-104. 10.1006/pmed.2002.1048, 12200093.
23. Lally P, Chipperfield A, Wardle J. Healthy habits: efficacy of simple advice on weight control based on a habit-formation model. Int J Obesity 2008, 32:700-707.
24. Beeken RJ, Croker H, Morris S, Leurent B, Omar R, Nazareth I, Wardle J. Study protocol for the 10 Top Tips (10TT) Trial: Randomised controlled trial of habit-based advice for weight control in general practice. BMC Public Health 2012, 12:667. 10.1186/1471-2458-12-667, 3490723, 22898059.
25. Hardy R, Wills AK, Wong A, Elks CE, Wareham NJ, Loos RJ, Kuh D, Ong KK. Life course variations in the associations between FTO and MC4R gene variants and body size. Hum Mol Genet 2010, 19:545-552. 10.1093/hmg/ddp504, 2798720, 19880856.
26. Timko CA, Mooney K, Juarascio A. Change in eating and body related behaviors during the first year of university. Eat Weight Disord 2010, 15:E93-E97.
27. Xu L, Cheng X, Wang J, Cao Q, Sato T, Wang M, Zhao X, Liang W. Comparisons of body-composition prediction accuracy: a study of 2 bioelectric impedance consumer devices in healthy Chinese persons using DXA and MRI as criteria methods. J Clin Densitom 2011, 14:458-464. 10.1016/j.jocd.2011.04.001, 21835660.
28. Wardle J, Carnell S, Haworth CM, Farooqi IS, O'Rahilly S, Plomin R. Obesity associated genetic variation in FTO is associated with diminished satiety. J Clin Endocrinol Metab 2008, 93:3640-3643. 10.1210/jc.2008-0472, 18583465.
29. Roe L, Strong C, Whiteside C, Neil A, Mant D. Dietary intervention in primary-care - validity of the dine method for diet assessment. J Fam Practice 1994, 11:375-381.
30. Van Strien T. The Dutch Eating Behavior Questionnaire (DEBQ) for assessment of restrained, emotional, and external eating behavior. Int J Eating Dis 1986, 5:295.
31. Besson H, Harwood CA, Ekelund U, Finucane FM, McDermott CJ, Shaw PJ, Wareham NJ. Validation of the historical adulthood physical activity questionnaire (HAPAQ) against objective measurements of physical activity. Int J Behav Nutr Phys Act 2010, 7:54. 10.1186/1479-5868-7-54, 2902409, 20576086.
32. Cohen S. Perceived Stress Scale (PSS). J Health Soc Beh 1983, 24:285.
33. Cohen S. Perceived stress, quitting smoking, and smoking relapse. Health Psychol 1990, 9:466.
34. Cash TF. The development and validation of the body-image ideals questionnaire. J Pers Assess 1995, 64:466. 10.1207/s15327752jpa6403_6, 16367722.
35. Povey R, Conner M, Sparks P, James R, Shepherd R. Application of the theory of planned behaviour to two dietary behaviours: Roles of perceived control and self-efficacy. Brit J Health Psychol 2000, 5:121-139.
36. Sarkin JA, Johnson SS, Prochaska JO, Prochaska JM. Applying the transtheoretical model to regular moderate exercise in an overweight population: validation of a stages of change measure. Prev Med 2001, 33:462-469. 10.1006/pmed.2001.0916, 11676588.
37. Greene GW. Dietary applications of the stages of change model. J Am Diet Assoc 1999, 99:673-678. 10.1016/S0002-8223(99)00164-9, 10361528.
38. Prochaska JO, DiClemente C. The Transtheoretical Approach: Crossing Traditional Boundaries of Change 1984, Homewood, IL: Dow Jones/Irwin.
39. Racette SB, Deusinger SS, Strube MJ, Highstein GR, Deusinger RH. Changes in weight and health Behaviors from freshman through senior year of college. JNEB 2008, 40:39-42.
40. Vella-Zarb RA, Elgar FJ. The 'freshman 5': a meta-analysis of weight gain in the freshman year of college. J Am Coll Health 2009, 58:161-166. 10.1080/07448480903221392, 19892653.
41. Bowling A. Mode of questionnaire administration can have serious effects on data quality. J Pub Health 2005, 27:281.