Preliminary evaluation of the safety and efficacy of standard intravenous immunoglobulins in pregnant women with primary cytomegalovirus infection

Clinical and Vaccine Immunology

Volumn 19, Issue 12, 2012, Pages 1991-1993

  Polilli, Ennio ^a   Parruti, Giustino ^a   D'Arcangelo, Francesca ^a   Tracanna, Elisa ^a   Clerico, Luigi ^a   Savini, Vincenzo ^a   D'Antonio, Francesco ^a   Rosati, Maurizio ^a   Manzoli, Lamberto ^b   D'Antonio, Domenico ^a   Nigroe, Giovanni ^c  

^a Pescara General Hospital   (Italy)

^b UNIVERSITY OF CHIETI   (Italy)

^c University of L Aquila   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

HUMAN IMMUNOGLOBULIN; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN M ANTIBODY; VIRUS ANTIBODY; VIRUS DNA;

ADULT; AMNIOCENTESIS; ANTIBODY TITER; ARTICLE; ASYMPTOMATIC INFECTION; BLOOD SAMPLING; CONGENITAL INFECTION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CYTOMEGALOVIRUS INFECTION; DRUG EFFICACY; DRUG INFUSION; DRUG SAFETY; FEMALE; FIRST TRIMESTER PREGNANCY; GENE AMPLIFICATION; GROWTH RETARDATION; HUMAN; HUMORAL IMMUNITY; INTRAUTERINE INFECTION; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; NAUSEA; NEWBORN; PLACENTAL TRANSFER; PREDICTION; PREGNANCY OUTCOME; PRIMARY INFECTION; PRIORITY JOURNAL; RATING SCALE; RECURRENT INFECTION; UNSPECIFIED SIDE EFFECT; URINALYSIS; VIRUS TRANSMISSION; VOMITING;

ADULT; CYTOMEGALOVIRUS INFECTIONS; FEMALE; HUMANS; IMMUNOGLOBULINS, INTRAVENOUS; IMMUNOTHERAPY; INFUSIONS, INTRAVENOUS; PREGNANCY; PREGNANCY COMPLICATIONS, INFECTIOUS; PREGNANT WOMEN;

EID: 84870443364     PISSN: 15566811     EISSN: 1556679X     Source Type: Journal    
DOI: 10.1128/CVI.00509-12     Document Type: Article

References (19)

1. Adler SP, Chandrika T, Lawrence L, Baggett J. 1983. Cytomegalovirus infections in neonates acquired by blood transfusions. Pediatr. Infect. Dis. 2:114-118. (Pubitemid 13098162)
2. Adler SP, Nigro G. 2009. Findings and conclusions from CMV hyperimmune globulin treatment trials. J. Clin. Virol. 46(Suppl 4):S54-S57.
3. Baccard-Longere M, Freymuth F, Cointe D, Seigneurin JM, Grangeot-Keros L. 2001. Multicenter evaluation of a rapid and convenient method for determination of cytomegalovirus immunoglobulin G avidity. Clin. Diagn. Lab. Immunol. 8:429-431. (Pubitemid 32217078)
4. Bayry J, et al. 2003. Mechanisms of action of intravenous immunoglobulin in autoimmune and inflammatory diseases. Neurol. Sci. 24(Suppl 4):S217-S221. (Pubitemid 37304326)
5. Bodéus M, Beulné D, Goubau P. 2001. Ability of three IgG-avidity assays to exclude recent cytomegalovirus infection. Eur. J. Clin. Microbiol. Infect. Dis. 20:248-252. (Pubitemid 32477242)
6. Bravo D, et al. 2011. Comparative evaluation of three automated systems for DNA extraction in conjunction with three commercially available real-time PCR assays for quantitation of plasma cytomegalovirus DNAemia in allogeneic stem cell transplant recipients. J. Clin. Microbiol. 49:2899-2904.
7. Buxmann H, et al. 2012. Use of cytomegalovirus hyperimmunoglobulin for prevention of congenital cytomegalovirus disease: a retrospective analysis. J. Perinat. Med. 40:439-446.
8. Chakravarti A, Kashyap B, Wadhwa A. 2007. Relationship of IgG avidity index and IgM levels for the differential diagnosis of primary from recurrent cytomegalovirus infections. Iran J. Allergy Asthma Immunol. 6:197-201.
9. Grangeot-Keros L, et al. 1997. Value of cytomegalovirus (CMV) IgG avidity index for the diagnosis of primary CMV infection in pregnant women. J. Infect. Dis. 175:944-946. (Pubitemid 27142973)
10. Jauniaux E, et al. 1995. Materno-fetal immunoglobulin transfer and passive immunity during the first trimester of human pregnancy. Hum. Reprod. 10:3297-3300. (Pubitemid 26027278)
11. Kaveri SV, Maddur MS, Hegde P, Lacroix-Desmazes S, Bayry J. 2011. Intravenous immunoglobulins in immunodeficiencies: more than mere replacement therapy. Clin. Exp. Immunol. 64(Suppl 2):2-5.
12. Krampe K, Briem-Richter A, Fischer L, Nashan B, Ganschow R. 2010. The value of immunoprophylaxis for cytomegalovirus infection with intravenous immunoglobulin in pediatric liver transplant recipients receiving a low-dose immunosupressive regimen. Pediatr. Transplant. 14:67-71.
13. La Torre R, Nigro G, Mazzocco M, Best AM, Adler SP. 2006. Placental enlargement in women with primary maternal cytomegalovirus infection is associated with fetal and neonatal disease. Clin. Infect. Dis. 43:994-1000. (Pubitemid 44631098)
14. Nigro G, Adler SP, La Torre R, Best AM. 2005. Passive immunization during pregnancy for congenital cytomegalovirus infection. N. Engl. J. Med. 353:1350-1362. (Pubitemid 41362703)
15. Nigro G, et al. 2012. Immunoglobulin therapy of fetal cytomegalovirus infection occurring in the first half of pregnancy - a case-control study of the outcome in children. J. Infect. Dis. 205:215-227.
16. Planitzer CB, Saemann MD, Gajek H, Farcet MR, Kreil TR. 2011. Cytomegalovirus neutralization by hyperimmune and standard intravenous immunoglobulin preparations. Transplantation 92:267-270.
17. Shah SR. 2008. A newer immunoglobulin intravenous (IGIV)-Gammagard liquid 10%: evaluation of efficacy, safety, tolerability and impact on patient care. Expert Opin. Biol. Ther. 8:799-804. (Pubitemid 351860209)
18. Visentin S, et al. 2012. Early primary cytomegalovirus infection in pregnancy: maternal hyperimmunoglobulin therapy improves outcomes among infants at 1 year of age. Clin. Infect. Dis. 55:497-503.
19. Yeager AS, et al. 1981. Prevention of transfusion-acquired cytomegalovirus infections in newborn infants. J. Pediatr. 98:281-287. (Pubitemid 11191091)