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Volumn 22, Issue 12, 2012, Pages 1007-1012

Early insulin treatment in type 2 diabetes: ORIGINal sin or valuable choice as ORIGINal treatment? An open debate on the ORIGIN study results

Author keywords

Glargine; Impaired fasting glucose; Impaired glucose tolerance; Insulin treatment; ORIGIN; Type 2 diabetes

Indexed keywords

ANTIDIABETIC AGENT; GLARGINE; INSULIN; LONG ACTING INSULIN;

EID: 84870442509     PISSN: 09394753     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.numecd.2012.10.004     Document Type: Short Survey
Times cited : (9)

References (24)
  • 1
    • 0344411591 scopus 로고    scopus 로고
    • ODCC, Oxford University Press, Oxford, F.L. Cross, E.A. Livingstone (Eds.)
    • ODCC " Original sin" The Oxford dictionary of the Christian church 2005, Oxford University Press, Oxford. 3rd rev. ed. F.L. Cross, E.A. Livingstone (Eds.)
    • (2005) " Original sin" The Oxford dictionary of the Christian church
  • 2
    • 75849130526 scopus 로고    scopus 로고
    • Saint Mary's Press, Winona, MN
    • Brodd Jefferey World religions 2003, Saint Mary's Press, Winona, MN.
    • (2003) World religions
    • Brodd, J.1
  • 4
    • 43849105857 scopus 로고    scopus 로고
    • Effect of intensive insulin therapy on beta-cell function and glycaemic control in patients with newly diagnosed type 2 diabetes: a multicenter randomised parallel-group trial
    • Weng J., Li Y., Xu W., Shi L., Zhang Q., Zhu D., et al. Effect of intensive insulin therapy on beta-cell function and glycaemic control in patients with newly diagnosed type 2 diabetes: a multicenter randomised parallel-group trial. Lancet 2008 May 24, 371(9626):1753-1760.
    • (2008) Lancet , vol.371 , Issue.9626 , pp. 1753-1760
    • Weng, J.1    Li, Y.2    Xu, W.3    Shi, L.4    Zhang, Q.5    Zhu, D.6
  • 5
    • 77953537179 scopus 로고    scopus 로고
    • Glucose-lowering agents and cancer mortality rates in type 2 diabetes: assessing effects of time-varying exposure
    • Bowker S.L., Yasui Y., Veugelers P., Johnson J.A. Glucose-lowering agents and cancer mortality rates in type 2 diabetes: assessing effects of time-varying exposure. Diabetologia 2010 Aug, 53(8):1631-1637.
    • (2010) Diabetologia , vol.53 , Issue.8 , pp. 1631-1637
    • Bowker, S.L.1    Yasui, Y.2    Veugelers, P.3    Johnson, J.A.4
  • 6
    • 84864270406 scopus 로고    scopus 로고
    • Basal insulin and cardiovascular and other outcomes in dysglycemia
    • ORIGIN Trial Investigators
    • Gerstein H.C., Bosch J., Dagenais G.R., Díaz R., Jung H., Maggioni A.P., et al. Basal insulin and cardiovascular and other outcomes in dysglycemia. N Engl J Med 2012 Jul 26, 367(4):319-328. ORIGIN Trial Investigators.
    • (2012) N Engl J Med , vol.367 , Issue.4 , pp. 319-328
    • Gerstein, H.C.1    Bosch, J.2    Dagenais, G.R.3    Díaz, R.4    Jung, H.5    Maggioni, A.P.6
  • 7
    • 84864219466 scopus 로고    scopus 로고
    • N-3 fatty acids and cardiovascular outcomes in patients with dysglycemia
    • ORIGIN Trial Investigators
    • Bosch J., Gerstein H.C., Dagenais G.R., Díaz R., Dyal L., Jung H., et al. n-3 fatty acids and cardiovascular outcomes in patients with dysglycemia. N Engl J Med 2012 Jul 26, 367(4):309-318. ORIGIN Trial Investigators.
    • (2012) N Engl J Med , vol.367 , Issue.4 , pp. 309-318
    • Bosch, J.1    Gerstein, H.C.2    Dagenais, G.R.3    Díaz, R.4    Dyal, L.5    Jung, H.6
  • 8
    • 36749121985 scopus 로고    scopus 로고
    • Rationale, design, and baseline characteristics for a large international trial of cardiovascular disease prevention in people with dysglycemia: the ORIGIN Trial (Outcome Reduction with an Initial Glargine Intervention)
    • Origin Trial Investigators
    • Origin Trial Investigators, Gerstein H., Yusuf S., Riddle M.C., Ryden L., Bosch J. Rationale, design, and baseline characteristics for a large international trial of cardiovascular disease prevention in people with dysglycemia: the ORIGIN Trial (Outcome Reduction with an Initial Glargine Intervention). Am Heart J 2008 Jan, 155(1):26-32.
    • (2008) Am Heart J , vol.155 , Issue.1 , pp. 26-32
    • Gerstein, H.1    Yusuf, S.2    Riddle, M.C.3    Ryden, L.4    Bosch, J.5
  • 9
    • 77955571410 scopus 로고    scopus 로고
    • Incidence of severe nocturnal hypoglycemia in patients with type 1 diabetes treated with insulin lispro or regular human insulin in addition to basal insulin glargine
    • Brunetti P., Muggeo M., Cattin L., Arcangeli A., Pozzilli P., Provenzano V., et al. Incidence of severe nocturnal hypoglycemia in patients with type 1 diabetes treated with insulin lispro or regular human insulin in addition to basal insulin glargine. Nutr Metab Cardiovasc Dis 2010 Sep, 20(7):519-526.
    • (2010) Nutr Metab Cardiovasc Dis , vol.20 , Issue.7 , pp. 519-526
    • Brunetti, P.1    Muggeo, M.2    Cattin, L.3    Arcangeli, A.4    Pozzilli, P.5    Provenzano, V.6
  • 10
    • 65749113590 scopus 로고    scopus 로고
    • Glucose toxicity: the leading actor in the pathogenesis and clinical history of type 2 diabetes - mechanisms and potentials for treatment
    • Giaccari A., Sorice G., Muscogiuri G. Glucose toxicity: the leading actor in the pathogenesis and clinical history of type 2 diabetes - mechanisms and potentials for treatment. Nutr Metab Cardiovasc Dis 2009 Jun, 19(5):365-377.
    • (2009) Nutr Metab Cardiovasc Dis , vol.19 , Issue.5 , pp. 365-377
    • Giaccari, A.1    Sorice, G.2    Muscogiuri, G.3
  • 11
    • 84866268783 scopus 로고    scopus 로고
    • Management of hyperglycemia in type 2 diabetes: a patient-centered approach: position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)
    • American Diabetes Association (ADA), European Association for the Study of Diabetes (EASD)European Association for the Study of Diabetes (EASD)
    • Inzucchi S.E., Bergenstal R.M., Buse J.B., Diamant M., Ferrannini E., Nauck M., et al. Management of hyperglycemia in type 2 diabetes: a patient-centered approach: position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetes Care 2012 Jun, 35(6):1364-1379. American Diabetes Association (ADA), European Association for the Study of Diabetes (EASD)European Association for the Study of Diabetes (EASD).
    • (2012) Diabetes Care , vol.35 , Issue.6 , pp. 1364-1379
    • Inzucchi, S.E.1    Bergenstal, R.M.2    Buse, J.B.3    Diamant, M.4    Ferrannini, E.5    Nauck, M.6
  • 12
    • 0032511583 scopus 로고    scopus 로고
    • Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group
    • UKPDS
    • UKPDS Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group. Lancet 1998 Sep 12, 352(9131):837-853.
    • (1998) Lancet , vol.352 , Issue.9131 , pp. 837-853
  • 13
    • 45149131667 scopus 로고    scopus 로고
    • Effects of intensive glucose lowering in type 2 diabetes
    • Action to Control Cardiovascular Risk in Diabetes Study Group
    • Gerstein H.C., Miller M.E., Byington R.P., Goff D.C., Bigger J.T., Buse J.B., et al. Effects of intensive glucose lowering in type 2 diabetes. N Engl J Med 2008 Jun 12, 358(24):2545-2559. Action to Control Cardiovascular Risk in Diabetes Study Group.
    • (2008) N Engl J Med , vol.358 , Issue.24 , pp. 2545-2559
    • Gerstein, H.C.1    Miller, M.E.2    Byington, R.P.3    Goff, D.C.4    Bigger, J.T.5    Buse, J.B.6
  • 14
    • 45149133036 scopus 로고    scopus 로고
    • Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes
    • ADVANCE Collaborative Group
    • Patel A., MacMahon S., Chalmers J., Neal B., Billot L., Woodward M., et al. Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes. N Engl J Med 2008 Jun 12, 358(24):2560-2572. ADVANCE Collaborative Group.
    • (2008) N Engl J Med , vol.358 , Issue.24 , pp. 2560-2572
    • Patel, A.1    MacMahon, S.2    Chalmers, J.3    Neal, B.4    Billot, L.5    Woodward, M.6
  • 15
    • 58149389215 scopus 로고    scopus 로고
    • Glucose control and vascular complications in veterans with type 2 diabetes
    • VADT Investigators
    • Duckworth W., Abraira C., Moritz T., Reda D., Emanuele N., Reaven P.D., et al. Glucose control and vascular complications in veterans with type 2 diabetes. N Engl J Med 2009 Jan 8, 360(2):129-139. VADT Investigators.
    • (2009) N Engl J Med , vol.360 , Issue.2 , pp. 129-139
    • Duckworth, W.1    Abraira, C.2    Moritz, T.3    Reda, D.4    Emanuele, N.5    Reaven, P.D.6
  • 16
    • 53749096863 scopus 로고    scopus 로고
    • 10-year follow-up of intensive glucose control in type 2 diabetes
    • Holman R.R., Paul S.K., Bethel M.A., Matthews D.R., Neil H.A. 10-year follow-up of intensive glucose control in type 2 diabetes. N Engl J Med 2008 Oct 9, 359(15):1577-1589.
    • (2008) N Engl J Med , vol.359 , Issue.15 , pp. 1577-1589
    • Holman, R.R.1    Paul, S.K.2    Bethel, M.A.3    Matthews, D.R.4    Neil, H.A.5
  • 17
    • 83655161341 scopus 로고    scopus 로고
    • The safety profile of exogenous insulin in people with type 2 diabetes: justification for concern
    • Currie C.J., Johnson J.A. The safety profile of exogenous insulin in people with type 2 diabetes: justification for concern. Diabetes Obes Metab 2012 Jan, 14(1):1-4.
    • (2012) Diabetes Obes Metab , vol.14 , Issue.1 , pp. 1-4
    • Currie, C.J.1    Johnson, J.A.2
  • 18
    • 38949210220 scopus 로고    scopus 로고
    • Effect of a multifactorial intervention on mortality in type 2 diabetes
    • Gaede P., Lund-Andersen H., Parving H.H., Pedersen O. Effect of a multifactorial intervention on mortality in type 2 diabetes. N Engl J Med 2008 Feb 7, 358(6):580-591.
    • (2008) N Engl J Med , vol.358 , Issue.6 , pp. 580-591
    • Gaede, P.1    Lund-Andersen, H.2    Parving, H.H.3    Pedersen, O.4
  • 19
    • 68349150576 scopus 로고    scopus 로고
    • Insulin glargine and cancer: another side to the story?
    • Gale E.A. Insulin glargine and cancer: another side to the story?. Lancet 2009 Aug 15, 374(9689):521.
    • (2009) Lancet , vol.374 , Issue.9689 , pp. 521
    • Gale, E.A.1
  • 21
    • 84869780310 scopus 로고    scopus 로고
    • Plasma exposure to insulin glargine and its metabolites M1 and M2 after subcutaneous injection of therapeutic and supra-therapeutic doses of glargine in subjects with Type 1 diabetes mellitus
    • Bolli G.B., Hahn A., Schmidt R., Eisenblatter T., Dahmen R., Heise T., et al. Plasma exposure to insulin glargine and its metabolites M1 and M2 after subcutaneous injection of therapeutic and supra-therapeutic doses of glargine in subjects with Type 1 diabetes mellitus. Diabetes Care 2012 Dec, 35(12):2626-2630.
    • (2012) Diabetes Care , vol.35 , Issue.12 , pp. 2626-2630
    • Bolli, G.B.1    Hahn, A.2    Schmidt, R.3    Eisenblatter, T.4    Dahmen, R.5    Heise, T.6
  • 22
    • 84869824367 scopus 로고    scopus 로고
    • Metabolism of insulin glargine after repeated daily subcutaneous injections in subjects with Type 2 diabetes mellitus
    • Lucidi P., Porcellati F., Rossetti P., Candeloro P., Marinelli Andreoli A., Cioli P., et al. Metabolism of insulin glargine after repeated daily subcutaneous injections in subjects with Type 2 diabetes mellitus. Diabetes Care 2012 Dec, 35(12):2647-2649.
    • (2012) Diabetes Care , vol.35 , Issue.12 , pp. 2647-2649
    • Lucidi, P.1    Porcellati, F.2    Rossetti, P.3    Candeloro, P.4    Marinelli Andreoli, A.5    Cioli, P.6
  • 24
    • 33846931618 scopus 로고    scopus 로고
    • Proinflammatory effects of glucose and anti-inflammatory effect of insulin: relevance to cardiovascular disease
    • Dandona P., Chaudhuri A., Ghanim H., Mohanty P. Proinflammatory effects of glucose and anti-inflammatory effect of insulin: relevance to cardiovascular disease. Am J Cardiol 2007 Feb 19, 99(4A):15B-26B.
    • (2007) Am J Cardiol , vol.99 , Issue.4 A
    • Dandona, P.1    Chaudhuri, A.2    Ghanim, H.3    Mohanty, P.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.