LPS-induced c-Fos activation in NTS neurons and plasmatic cortisol increases in septic rats are suppressed by bilateral carotid chemodenervation

Advances in Experimental Medicine and Biology

Volumn 758, Issue , 2012, Pages 185-190

  Reyes, Edison Pablo ^a   Abarzúa, Sebastián ^b   Martin, Aldo ^b   Rodríguez, Jorge ^b   Cortés, Paula P ^b   Fernández, Ricardo ^b  

^a UNIVERSIDAD DEL DESARROLLO   (Chile)

^b UNIVERSIDAD ANDRÉS BELLO   (Chile)

Author keywords

c Fos; Carotid sinus nerve; Inflammation; LPS; NTS

Indexed keywords

ESCHERICHIA COLI LIPOPOLYSACCHARIDE; HYDROCORTISONE; PROTEIN C FOS;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA POSTREMA; CAROTID BODY CHEMORECEPTOR; CENTRAL NERVOUS SYSTEM; CONFERENCE PAPER; CONTROLLED STUDY; DENERVATION; HORMONAL REGULATION; HYDROCORTISONE BLOOD LEVEL; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; IMMUNOMODULATION; MALE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SEPSIS; SOLITARY TRACT NUCLEUS NEURON;

EID: 84870421033     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-94-007-4584-1_26     Document Type: Conference Paper

References (21)

1. Berthoud HR, Kressel M, Neuhuber WL (1995) Vagal afferent innervation of rat abdominal paraganglia as revealed by anterograde DiI-tracing and confocal microscopy. Acta Anat (Basel) 152:127-132
2. Bluthe RM, Walter V, Parnet P, Laye S, Lestage J, Verrier D, Poole S, Stenning BE, Kelley KW, Dantzer R (1994 Lipopolysaccharide induces sickness behaviour in rats by a vagal mediated mechanism. C R Acad Sci III 499-503
3. Dantzer R, Konsman JP, Bluthe RM, Kelley KW (2000) Neural and humoral pathways of communication from the immune system to the brain: Parallel or convergent? Auton Neurosci 85:60-65
4. De Laurentis A, Pisera D, Caruso C, Candol fi M, Mohn C, Rettori V, Seilicovich A (2002) Lipopolysaccharide- and tumor necrosis factor-induced changes in prolactin secretion and dopaminergic activity in the hypothalamic-pituitary axis. Neuroimmunomodulation 10:30-39
5. Del Río R, Moya EA, Iturriaga R (2011) Differential expression of pro-in fl ammatory cytokines, endothelin-1 and nitric oxide synthases in the rat carotid body exposed to intermittent hypoxia. Brain Res 1395:74-85
6. Emch GS, Hermann GE, Rogers RC (2000) TNF-alpha activates solitary nucleus neurons responsive to gastric distension. Am J Physiol Gastrointest Liver Physiol 279:G582-G586
7. Fernandez R, Gonzalez S, Rey S, Cortes PP, Maisey KR, Reyes EP, Larrain C, Zapata P (2008) Lipopolysaccharideinduced carotid body in fl ammation in cats: Functional manifestations, histopathology and involvement of tumour necrosis factor-alpha. Exp Physiol 93:892-907
8. Fernandez R, Nardocci G, Simon F, Martin A, Becerra A, Rodriguez-Tirado C, Maisey KR, Cuna-Castillo C, Cortes PP (2011) Lipopolysaccharide signaling in the carotid chemoreceptor pathway of rats with sepsis syndrome. Respir Physiol Neurobiol 175:336-348
9. Hermann GE, Rogers RC (2009) TNF activates astrocytes and catecholaminergic neurons in the solitary nucleus: Implications for autonomic control. Brain Res 1273:72-82
10. Hermann GE, Emch GS, Tovar CA, Rogers RC (2001) c-Fos generation in the dorsal vagal complex after systemic endotoxin is not dependent on the vagus nerve. Am J Physiol Regul Integr Comp Physiol 280:R289-R299
11. Hoffman GE, Smith MS, Verbalis JG (1993) c-Fos and related immediate early gene products as markers of activity in neuroendocrine systems. Front Neuroendocrinol 14:173-213
12. Hosoi T, Okuma Y, Matsuda T, Nomura Y (2005) Novel pathway for LPS-induced afferent vagus nerve activation: Possible role of nodose ganglion. Auton Neurosci 120:104-107
13. Lam SY, Tipoe GL, Liong EC, Fung ML (2008) Chronic hypoxia upregulates the expression and function of proin fl ammatory cytokines in the rat carotid body. Histochem Cell Biol 130:549-559
14. Liu X, He L, Stensaas L, Dinger B, Fidone S (2009) Adaptation to chronic hypoxia involves immune cell invasion and increased expression of in fl ammatory cytokines in rat carotid body. Am J Physiol Lung Cell Mol Physiol L158-L166
15. Mac Grory B, O'Connor ET, O'Halloran KD, Jones JF (2010) The effect of pro-in fl ammatory cytokines on the discharge rate of vagal nerve paraganglia in the rat. Respir Physiol Neurobiol 171:122-127
16. Mascorro JA, Yates RD (1980) Paraneurons and paraganglia: Histological and ultrastructural comparisons between intraganglionic paraneurons and extra-adrenal paraganglion cells. Adv Biochem Psychopharmacol 25:201-213
17. Pavlov VA, Wang H, Czura CJ, Friedman SG, Tracey KJ (2003) The cholinergic anti-in fl ammatory pathway: A missing link in neuroimmunomodulation. Mol Med 9:125-134
18. Paxinos G, Watson CR (2007) The rat brain in stereotaxic coordinates, 6th edn. Academic Press, Burlington, p 456
19. Steinman L (2004) Elaborate interactions between the immune and nervous systems. Nat Immunol 5:575-581
20. Wan W, Wetmore L, Sorensen CM, Greenberg AH, Nance DM (1994) Neural and biochemical mediators of endotoxin and stress-induced c-fos expression in the rat brain. Brain Res Bull 34:7-14
21. Zapata P, Larrain C, Reyes P, Fernandez R (2011) Immunosensory signalling by carotid body chemoreceptors. Respir Physiol Neurobiol 178:370-374