The effect of pro-inflammatory cytokines on the discharge rate of vagal nerve paraganglia in the rat

Respiratory Physiology and Neurobiology

Volumn 171, Issue 2, 2010, Pages 122-127

  Mac Grory, Brian ^a   O'Connor, Edward T ^a   O'Halloran, Ken D ^a   Jones, James F X ^a  

^a UNIVERSITY COLLEGE DUBLIN   (Ireland)

Author keywords

Carotid body; Cytokine; Hypoxia; IL 1 ; Inflammation; Paraganglia; Superior laryngeal nerve; TNF ; Vagus nerve

Indexed keywords

INTERLEUKIN 1BETA; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; INTERLEUKIN 1;

ANIMAL TISSUE; ARTICLE; CAROTID BODY; CELL NUCLEUS; CONTROLLED STUDY; CYTOPLASM; FEMALE; GENE TRANSLOCATION; HELA CELL; HUMAN; HUMAN CELL; NERVE FIBER; NERVE POTENTIAL; NONHUMAN; PARAGANGLION; PRIORITY JOURNAL; RAT; SUPERIOR LARYNGEAL NERVE; VAGUS NERVE; ACTION POTENTIAL; ANALYSIS OF VARIANCE; ANIMAL; AORTA CHEMORECEPTOR; CELL CULTURE; DOSE RESPONSE; DRUG EFFECTS; HELA CELL LINE; LARYNGEAL NERVE; METABOLISM; PHYSIOLOGY; WISTAR RAT;

ACTION POTENTIALS; ANALYSIS OF VARIANCE; ANIMALS; AORTIC BODIES; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HELA CELLS; HUMANS; INTERLEUKIN-1; LARYNGEAL NERVES; RATS; RATS, WISTAR; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR-ALPHA;

EID: 77950917112     PISSN: 15699048     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.resp.2010.03.001     Document Type: Article

References (16)

1. Alam I., Lewis K., Stephens J.W., and Baxter J.N. Obesity, metabolic syndrome and sleep apnoea: all pro-inflammatory states. Obes. Rev. 8 2 (2007) 119-127
2. Brophy S., Ford T.W., Carey M., and Jones J.F. Activity of aortic chemoreceptors in the anaesthetized rat. J. Physiol. (Lond.) 514 3 (1999) 821-828
3. Coleridge H.M., Coleridge J.C., and Howe A. Thoracic chemoreceptors in the dog. A histological and electrophysiological study of the location, innervation and blood supply of the aortic bodies. Circ. Res. 26 2 (1970) 235-247
4. Dahlqvist A., Hellström S., Carlsöö B., and Pequignot J.M. Paraganglia of the rat recurrent laryngeal nerve after long-term hypoxia: a morphometric and biochemical study. J. Neurocyt. 16 3 (1987) 289-297
5. Daly M.d.B. Peripheral Arterial Chemoreception and Respiratory-Cardiovascular Integration. Monograph for the Physiological Society (1997), Oxford University Press
6. Fernandez R., Gonzalez S., Rey S., Cortes P.P., Maisey K.R., Reyes E.P., Larrain C., and Zapata P. Lipopolysaccharide-induced carotid body inflammation in cats: functional manifestations, histopathology and involvement of tumour necrosis factor-α. Exp. Physiol. 93 7 (2008) 892-907
7. Goehler L.E., Gaykema R.P., Nguyen K.T., Lee J.E., Tilders F.J., Maier S.F., and Watkins L.R. Interleukin-1beta in immune cells of the abdominal vagus nerve: a link between the immune and nervous systems?. J. Neurosci. 19 7 (1999) 2799-2806
8. Hargreaves I.P., Duncan A.J., Wu L., Agrawal A., Land J.M., and Heales S.J. Inhibition of mitochondrial complex IV leads to secondary loss complex II-III activity: implications for the pathogenesis and treatment of mitochondrial encephalomyopathies. Mitochondrion 7 4 (2007) 284-287
9. Howe A., Pack R.J., and Wise J.C. Arterial chemoreceptor-like activity in the abdominal vagus of the rat. J. Physiol. (Lond.) 320 (1981) 309-318
10. Jones J.F.X., and Daly M.d.B. Reflex cardiac dromotropic responses to stimulation of the carotid and aortic chemoreceptors in the anaesthetized cat. J. Physiol. (Lond.) 502 Pt 2 (1997) 461-467
11. Lam S.Y., Tipoe G.L., Liong E.C., and Fung M.L. Chronic hypoxia upregulates the expression and function of pro-inflammatory cytokines in the rat carotid body. Histochem. Cell Biol. 130 3 (2008) 549-559
12. Liu X., He L., Stensaas L., Dinger B., and Fidone S. Adaptation to chronic hypoxia involves immune cell invasion and increased expression of inflammatory cytokines in rat carotid body. Am. J. Physiol. 296 (2009) L158-L166
13. O'Leary D.M., Murphy A., Pickering M., and Jones J.F. Arterial chemoreceptors in the superior laryngeal nerve of the rat. Respir. Physiol. Neurobiol. 141 2 (2004) 137-144
14. 2+]i in the carotid body glomus cells and increases carotid sinus nerve firings in the rat. Eur. J. Neurosci. 25 12 (2007) 3638-3647
15. Tracey K.J. The inflammatory reflex. Nature 420 6917 (2002) 853-859
16. Yu J., Lin S., Zhang J., Otmishi P., and Guardiola J.J. Airway nociceptors activated by pro-inflammatory cytokines. Respir. Physiol. Neurobiol. 156 2 (2007) 116-119