-
1
-
-
77952810921
-
Recent applications of microwave irradiation to medicinal chemistry
-
Alcazar, J.; Oehlrich, D. Recent applications of microwave irradiation to medicinal chemistry. Future Med. Chem. 2010, 2(2), 169-176.
-
(2010)
Future Med. Chem.
, vol.2
, Issue.2
, pp. 169-176
-
-
Alcazar, J.1
Oehlrich, D.2
-
2
-
-
65349102209
-
Microwave assisted synthesis: A new technology in drug discovery
-
Santagada, V.; Frecentese, F.; Perissutti, E.; Fiorino, F. Microwave assisted synthesis: a new technology in drug discovery. Mini Rev. Med. Chem., 2009, 9, 340-358.
-
(2009)
Mini Rev. Med. Chem.
, vol.9
, pp. 340-358
-
-
Santagada, V.1
Frecentese, F.2
Perissutti, E.3
Fiorino, F.4
-
3
-
-
84858705973
-
Iodine-catalyzed condensation of isatin with indoles: A facile synthesis of di(indolyl)indolin-2-ones and evaluation of their cytotoxicity
-
Subba Reddy, B.V.; Rajeswari, N.; Sarangapani, M.; Prashanthi, Y.; Roopa Jones, G.; Anothony, A. Iodine-catalyzed condensation of isatin with indoles: A facile synthesis of di(indolyl)indolin-2-ones and evaluation of their cytotoxicity. Biorg. Med. Chem. Lett., 2012, 22, 2460-2463.
-
(2012)
Biorg. Med. Chem. Lett.
, vol.22
, pp. 2460-2463
-
-
Subba Reddy, B.V.1
Rajeswari, N.2
Sarangapani, M.3
Prashanthi, Y.4
Roopa Jones, G.5
Anothony, A.6
-
4
-
-
84871410487
-
Synthesis and antidepressant activity of di substituted-5-aryl-1,2,4- triazoles
-
Radhika, C.; Venkatesham, A.; Sarangapani, M. Synthesis and antidepressant activity of di substituted-5-aryl-1,2,4-triazoles. Med. Chem. Res., 2011, 1-5.
-
(2011)
Med. Chem. Res.
, pp. 1-5
-
-
Radhika, C.1
Venkatesham, A.2
Sarangapani, M.3
-
5
-
-
28144443339
-
N-benzylisatin sulfonamide analogues as potent caspase-3 inhibitors: Synthesis, in vitro activity, and molecular modeling studies
-
DOI 10.1021/jm0506625
-
Chu, W.; Zhang, J.; Zeng, C.; Rothfuss, J.; Tu, Z.; Reichert, D.E.; Welch, M.J.; Mach, R.H. N-Benzylisatin sulfonamide analogues as potent caspase-3 inhibitors: synthesis, in vitro activity, and molecular modeling studies. J. Med. Chem., 2005, 48, 7637-7647. (Pubitemid 41698804)
-
(2005)
Journal of Medicinal Chemistry
, vol.48
, Issue.24
, pp. 7637-7647
-
-
Chu, W.1
Zhang, J.2
Zeng, C.3
Rothfuss, J.4
Tu, Z.5
Chu, Y.6
Reichert, D.E.7
Welch, M.J.8
Mach, R.H.9
-
6
-
-
65249096525
-
Synthesis and in vitro evaluation of sulfonamide isatin michael acceptors as small molecule inhibitors of caspase-6
-
Chu, W.; Rothfuss, J.; Chu, Y.; Zhou, D.; Mach, R. H. Synthesis and in vitro evaluation of sulfonamide isatin michael acceptors as small molecule inhibitors of caspase-6. J. Med. Chem., 2009, 52, 2188-2191.
-
(2009)
J. Med. Chem.
, vol.52
, pp. 2188-2191
-
-
Chu, W.1
Rothfuss, J.2
Chu, Y.3
Zhou, D.4
MacH, R.H.5
-
7
-
-
11044222261
-
Isatin-derived antibacterial and antifungal compounds and their transition metal complexes
-
DOI 10.1080/14756360410001710383
-
Chohan, Z.; Pervez, H.; Rauf, A.; Khan, K.M.; Supura, C.T. Isatin derived Antibacterial and Antifungal Compounds and their Transition Metal Complexes. J. Enz. Inhib. Med. Chem., 2004, 19, 417-423. (Pubitemid 40045502)
-
(2004)
Journal of Enzyme Inhibition and Medicinal Chemistry
, vol.19
, Issue.5
, pp. 417-423
-
-
Chohan, Z.H.1
Pervez, H.2
Rauf, A.3
Khan, K.M.4
Supuran, C.T.5
-
8
-
-
17444427138
-
Combinatorial optimization of isatin-β-thiosemicarbazones as anti-poxvirus agents
-
DOI 10.1021/jm049147h
-
Pirrung, M.C.; Pansare, S.V.; Das Sarma, K.; Keith, K.A.; Kern, E.R. Combinatorial Optimization of Isatin-3-thiosemicarbazones as Anti-pox virus Agents. J. Med. Chem., 2005, 48, 3045-3050. (Pubitemid 40548116)
-
(2005)
Journal of Medicinal Chemistry
, vol.48
, Issue.8
, pp. 3045-3050
-
-
Pirrung, M.C.1
Pansare, S.V.2
Das Sarma, K.3
Keith, K.A.4
Kern, E.R.5
-
9
-
-
33745660988
-
3-Arylimino-2-indolones are Potent and Selective Galanin Gal3 Receptor Antagonists
-
Konkel, M.K.; Lagu, B.; Boteju, L.W.; Jimenez, H.; Noble, S.; Walker M.W.; Chandrasena, G.; Blackburn,T.P.; Nikam, S.S.; Wright, J.L.; Korberg, B.E.; Gregory, T.; Pugsley, T.A.; Akunne, H.; Zoski, K.; Wise, L.D. 3-Arylimino-2-indolones are Potent and Selective Galanin Gal3 Receptor Antagonists. J. Med.Chem., 2006, 49, 3557-3558.
-
(2006)
J. Med.Chem.
, vol.49
, pp. 3557-3558
-
-
Konkel, M.K.1
Lagu, B.2
Boteju, L.W.3
Jimenez, H.4
Noble, S.5
Walker, M.W.6
Chandrasena, G.7
Blackburn, T.P.8
Nikam, S.S.9
Wright, J.L.10
Korberg, B.E.11
Gregory, T.12
Pugsley, T.A.13
Akunne, H.14
Zoski, K.15
Wise, L.D.16
-
10
-
-
1842450535
-
3,3-Diaryl-1,3-dihydroindol-2-ones as Antiproliferatives Mediated by Translation Initiation Inhibition
-
DOI 10.1021/jm0499716
-
Natarnath, A.; Fan, Y.H.; Chen, H.; Guo, Y.; Iyasere, J.; Harbinski, F.; Christ, W.J.; Aktas, H.; Halperin,J.A. 3,3-diaryl-1,3-dihydroindol-2-ones as antiproliferatives mediated by the translation initiation inhibition. J. Med.Chem., 2004, 47, 1882-1885. (Pubitemid 38453906)
-
(2004)
Journal of Medicinal Chemistry
, vol.47
, Issue.8
, pp. 1882-1885
-
-
Natarajan, A.1
Fan, Y.-H.2
Chen, H.3
Guo, Y.4
Iyasere, J.5
Harbinski, F.6
Christ, W.J.7
Aktas, H.8
Halperin, J.A.9
-
11
-
-
84870441565
-
Isatins inhibit cyclooxygenase-2 and inducible nitric oxide synthase in a mouse macrophage cell line
-
Matheus, M.E.; Violante, F.; Garden, S.J.; Pinto, A.C.; Fernandes, P.D. Isatins inhibit cyclooxygenase-2 and inducible nitric oxide synthase in a mouse macrophage cell line. Eur.J.Pharm., 2007, 49, 3440-3443.
-
(2007)
Eur.J.Pharm.
, vol.49
, pp. 3440-3443
-
-
Matheus, M.E.1
Violante, F.2
Garden, S.J.3
Pinto, A.C.4
Fernandes, P.D.5
-
12
-
-
33745176602
-
Isatin compounds as noncovalent SARS coronavirus 3C-like protease inhibitors
-
DOI 10.1021/jm0602357
-
Zhou, L.; Liu, Y.; Zhang, W.; Wei, P.; Huang, C.; Pei, J.; Yaun, Y.; Lai, L. Isatin compounds as noncovalant SARS coronavirus 3Clike protease inhibitors. J. Med. Chem., 2006, 49, 3440-3443. (Pubitemid 43902449)
-
(2006)
Journal of Medicinal Chemistry
, vol.49
, Issue.12
, pp. 3440-3443
-
-
Zhou, L.1
Liu, Y.2
Zhang, W.3
Wei, P.4
Huang, C.5
Pei, J.6
Yuan, Y.7
Lai, L.8
-
13
-
-
34548401633
-
Synthesis, antibacterial, antifungal and antiviral activity evaluation of some new bis-schiff bases of isatin and their derivatives
-
Jarrahpour, A.; Khalili, D.; De Clercq, E.; Salmi, S.; Brunel, J.M. Synthesis, antibacterial, antifungal and antiviral activity evaluation of some new bis-schiff bases of isatin and their derivatives. Molecules., 2007, 12, 1720-1730.
-
(2007)
Molecules.
, vol.12
, pp. 1720-1730
-
-
Jarrahpour, A.1
Khalili, D.2
De Clercq, E.3
Salmi, S.4
Brunel, J.M.5
-
14
-
-
0347084611
-
Some pharmacological activities of new substituted pyrolloindoles, indolothiazepine and azole derivatives
-
Sharaf, O.A. Some pharmacological activities of new substituted pyrolloindoles, indolothiazepine and azole derivatives. Bull. Fac. Pharm., 1997, 35, 79-82.
-
(1997)
Bull. Fac. Pharm.
, vol.35
, pp. 79-82
-
-
Sharaf, O.A.1
-
15
-
-
1942488330
-
Anticonvulsant activity of Schiff bases of isatin derivatives
-
Verma, M.; Pandey, S.N.; Singh, K.N.; Stables, J.P. Anticonvulsant activity of Schiff bases of isatin derivatives. Acta Pharm., 2004, 54, 49-56. (Pubitemid 38524314)
-
(2004)
Acta Pharmaceutica
, vol.54
, Issue.1
, pp. 49-56
-
-
Verma, M.1
Pandeya, S.N.2
Singh, K.N.3
Stables, J.P.4
-
16
-
-
0003827997
-
-
4th ed.; Waverly Publishers: New York
-
Foye, W.M.; Lamke, T.L.; Williams, D.A.; Priniciples of medicinal chemistry, 4th ed.; Waverly Publishers: New York, 1995, pp. 855-856.
-
(1995)
Priniciples of Medicinal Chemistry
, pp. 855-856
-
-
Foye, W.M.1
Lamke, T.L.2
Williams, D.A.3
-
17
-
-
0028001561
-
Inhibition of human immunodeficiency virus by N-methylisatinbeta 4′:4′-diethylthiosemicarbazone and N-allylisatin-beta-4′: 4′-dially thiosemicarbazone
-
Teitz, Y.; Ronen, D.; Vansover, A.; Stematsky, T.; Riggs, J. L. Inhibition of human immunodeficiency virus by N-methylisatinbeta 4′:4′-diethylthiosemicarbazone and N-allylisatin-beta-4′: 4′-dially thiosemicarbazone. Antiviral Res., 1994, 24, 305-314.
-
(1994)
Antiviral Res.
, vol.24
, pp. 305-314
-
-
Teitz, Y.1
Ronen, D.2
Vansover, A.3
Stematsky, T.4
Riggs, J.L.5
-
18
-
-
0014734997
-
Chemistry of carbohydrazide and thiocarbohydrazide
-
Kurzer, F; Wilkinson, M. Chemistry of carbohydrazide and thiocarbohydrazide Chem. Rev., 1970, 70(1), 111-149.
-
(1970)
Chem. Rev.
, vol.70
, Issue.1
, pp. 111-149
-
-
Kurzer, F.1
Wilkinson, M.2
-
19
-
-
80052810801
-
Synthesis, properties and biological activity of thiophene: A review
-
Raghav, M.; Jha, K.K.; Sachin. K.; Isha Tomer. Synthesis, properties and biological activity of thiophene: A review. Der Pharma Chemica., 2011, 3(4), 38-54.
-
(2011)
Der Pharma Chemica.
, vol.3
, Issue.4
, pp. 38-54
-
-
Raghav, M.1
Jha, K.K.2
Sachin, K.3
Tomer, I.4
-
20
-
-
84870446918
-
-
John Wiley & Sons, Inc:Hoboken, NJ, USA
-
Blicke, F. F. Biological and pharmacological activity of thiophene and its derivatives, in chemistry of heterocyclic Compounds: Thiophene and its Derivatives, John Wiley & Sons, Inc:Hoboken, NJ, USA. 2008.
-
(2008)
Biological and Pharmacological Activity of Thiophene and Its Derivatives, in Chemistry of Heterocyclic Compounds: Thiophene and Its Derivatives
-
-
Blicke, F.F.1
-
21
-
-
84965812126
-
The mechanism of carcinogenesis. A study of the significance of cocarcinogenic action and related phenomena
-
Berenblum, I. The mechanism of carcinogenesis. A study of the significance of cocarcinogenic action and related phenomena. Cancer Res., 1941, 1, 807-814.
-
(1941)
Cancer Res.
, vol.1
, pp. 807-814
-
-
Berenblum, I.1
-
23
-
-
11444267327
-
Rexinoids may be ready for prime time in prevention, but challenges remain
-
Hede, K.; Rexinoids may be ready for prime time in prevention, but challenges remain. J. Natl. Cancer.Inst., 2004, 96(24), 1807-1808. (Pubitemid 40081311)
-
(2004)
Journal of the National Cancer Institute
, vol.96
, Issue.24
, pp. 1807-1808
-
-
Hede, K.1
-
25
-
-
43049134090
-
Simple and efficient microwave assisted Nalkylation of isatin
-
Shmidt, M.S.; Reverdito, A.M.; Kremenchuzky, L.; Perillo, I.A.; Blanco, M.M. Simple and efficient microwave assisted Nalkylation of isatin. Molecules., 2008, 13, 831-840.
-
(2008)
Molecules.
, vol.13
, pp. 831-840
-
-
Shmidt, M.S.1
Reverdito, A.M.2
Kremenchuzky, L.3
Perillo, I.A.4
Blanco, M.M.5
-
26
-
-
77956691146
-
Optimization of the production of thiocarbohydrazide using the Taguchi method
-
Zhou, J.; Wu, D.; Gou, D. J. Optimization of the production of thiocarbohydrazide using the Taguchi method. Chem Technol Biotechnol., 2010, 85(10), 1402-1406.
-
(2010)
Chem Technol Biotechnol.
, vol.85
, Issue.10
, pp. 1402-1406
-
-
Zhou, J.1
Wu, D.2
Gou, D.J.3
-
27
-
-
0025869827
-
Abdel-Hady. Reactions of isatin with thiocarbohydrazide
-
Mohamed, Badawy A.; Sayed A, Abdel-Hady. Reactions of isatin with thiocarbohydrazide. Arch. Pharm.(Weinheim), 1991,324, 349-352.
-
(1991)
Arch. Pharm.(Weinheim)
, vol.324
, pp. 349-352
-
-
Mohamed Badawy, A.1
Sayed, A.2
-
28
-
-
0020454904
-
5-Substituted 2'-deoxyuridines: Correlation between inhibition of tumor cell growth and inhibition of thymidine kinase and thymidylate synthetase
-
DOI 10.1016/0006-2952(82)90594-9
-
Balzarini, J.; De Clercq, E.; Mertes, M.P.; Shugar, D.; Torrence, P.F. 5-Substituted 2'-deoxy uridines: correlation between inhibition of tumor cell growth and inhibition of thymidine kinase and thymidylate synthetase. Biochem. Pharmacol., 1982, 31, 3673- 3682. (Pubitemid 13244137)
-
(1982)
Biochemical Pharmacology
, vol.31
, Issue.22
, pp. 3673-3682
-
-
Balzarini, J.1
De Clercq, E.2
Mertes, M.P.3
-
29
-
-
0035976047
-
Cancer chemopreventive agents, serratane-type triterpenoids from Picea jezoensis
-
DOI 10.1016/S0304-3835(01)00650-4, PII S0304383501006504
-
Tanaka, T.; Minami, T.; Tsujimoto, K.; Matsunaga, S.; Tokuda, H.; Nishino, H.; Terada, Y.; Yoshitake, A. Cancer chemopreventive agents, serratane-type triterpenoids from Picea jezoensis Cancer Lett. 2001, 172(2), 119-126. (Pubitemid 32889705)
-
(2001)
Cancer Letters
, vol.172
, Issue.2
, pp. 119-126
-
-
Tanaka, R.1
Minami, T.2
Tsujimoto, K.3
Matsunaga, S.4
Tokuda, H.5
Nishino, H.6
Terada, Y.7
Yoshitake, A.8
-
30
-
-
0013891274
-
Immunofluorescence in cells derived from Burkitt's Lymphoma
-
Henle, G.; Henle, W. Immunofluorescence in cells derived from Burkitt's Lymphoma. J. Bacteriol., 1966, 91, 1248-1256.
-
(1966)
J. Bacteriol.
, vol.91
, pp. 1248-1256
-
-
Henle, G.1
Henle, W.2
-
31
-
-
0002175935
-
-
De Vita, V.T.; Busch H; Ed., Academic Press: New York
-
Suffness, M.; Dourus, J In: De Vita, V.T.; Busch H; Ed. Methods in Cancer Research. Part A, Academic Press: New York, 1979, Vol 16, pp 84-96.
-
(1979)
Methods in Cancer Research. Part A
, vol.16
, pp. 84-96
-
-
Suffness, M.1
Dourus, J.2
-
32
-
-
0029008108
-
Retinoid chemoprevention of aerodigestive cancer: From basic research to the clinic
-
Hong, W.K.; Lippman, S.M.; Hittleman, W.N.; Lotan, R. Retinoid chemoprevention of aerodigestive cancer: from basic research to the clinic. Clin. Cancer Res., 1995, 1,677-686.
-
(1995)
Clin. Cancer Res.
, vol.1
, pp. 677-686
-
-
Hong, W.K.1
Lippman, S.M.2
Hittleman, W.N.3
Lotan, R.4
-
33
-
-
80955178343
-
-
Tanaka, R.; Tsujii, H.; Yamada, T.; Kajimoto, T.; Tokuda, H.; Arai, T.; Suzuki, N.; Hasegawa, J.; Hamashima, Y.; Node, M. Eur. J.Med. Chem., 2011, 46, 3368-3375.
-
(2011)
Eur. J.Med. Chem.
, vol.46
, pp. 3368-3375
-
-
Tanaka, R.1
Tsujii, H.2
Yamada, T.3
Kajimoto, T.4
Tokuda, H.5
Arai, T.6
Suzuki, N.7
Hasegawa, J.8
Hamashima, Y.9
Node, M.10
|