Nicotinamide supplementation protects gestational diabetic rats by reducing oxidative stress and enhancing immune responses

Current Medicinal Chemistry

Volumn 19, Issue 30, 2012, Pages 5181-5186

  John, C M ^a,b   Ramasamy, R ^b   Al Naqeeb, G ^a   Al Nuaimi, A H D ^c   Adam, A ^a  

^a UNIVERSITI TEKNOLOGI MARA   (Malaysia)

^b UNIVERSITY PUTRA MALAYSIA   (Malaysia)

^c UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

Activated T helper cells (CD4+CD25+); Catalase; Gestational diabetes; Nicotinamide; Oxidative burst; Splenocyte proliferation; Superoxide dismutase

Indexed keywords

CATALASE; FORMYLMETHIONYLLEUCYLPHENYLALANINE; GLUCOSE; INSULIN; MESSENGER RNA; METFORMIN; NICOTINAMIDE; PHORBOL 13 ACETATE 12 MYRISTATE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CELL PROLIFERATION; CONTROLLED STUDY; ESCHERICHIA COLI; FEMALE; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; HELPER CELL; IMMUNE RESPONSE; IMMUNE SYSTEM; INSULIN BLOOD LEVEL; LIVER; LYMPHOCYTE; NEUTROPHIL; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PREGNANCY DIABETES MELLITUS; RAT; SPLEEN CELL; UPREGULATION; VITAMIN SUPPLEMENTATION;

ANIMALS; BLOOD GLUCOSE; CATALASE; CELL PROLIFERATION; DIABETES MELLITUS, EXPERIMENTAL; DIABETES, GESTATIONAL; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; INSULIN; LIVER; NEUTROPHILS; NIACINAMIDE; OXIDATIVE STRESS; PREGNANCY; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; SPLEEN; SUPEROXIDE DISMUTASE; T-LYMPHOCYTES, HELPER-INDUCER; VITAMIN B COMPLEX;

EID: 84870396074     PISSN: 09298673     EISSN: 1875533X     Source Type: Journal    
DOI: 10.2174/092986712803530449     Document Type: Article

References (49)

1. Kinalski, M.; Kretowski, A. The changes in the humoral immune system during pregnancy with diabetes. Ginekol. Pol., 1999, 70(10), 800-806.
2. Di Mario, U.; Dotta, F.; Gargiulo, P.; Sutherland, J.; Andreani, D.; Guy, K.; Pachi, A.; Fallucca, F. Immunology in diabetic pregnancy: activated T cells in diabetic mothers and neonates. Diabetologia, 1987, 30(2), 66-71.
3. Yessoufou, A.; Moutairou, K. Maternal diabetes in pregnancy: early and long-term outcomes on the offspring and the concept of "metabolic memory". Exp. Diabetes Res., 2011, doi: 10.1155/2011/218598.
4. Rademacher, T.W.; Gumaa, K.; Scioscia, M. Preeclampsia, insulin signalling and immunological dysfunction: a fetal, maternal or placental disorder? J. Reprod. Immunol., 2007, 76(1-2), 78-84.
5. Roll, U.; Scheeser, J.; Standl, E.; Ziegler, A.G. Alterations of lymphocyte subsets in children of diabetic mothers. Diabetologia, 1994, 37(11), 1132-1141.
6. Fernandez-Twinn, D.S.; Ozanne, S.E. Mechanisms by which poor early growth programs type-2 diabetes, obesity and the metabolic syndrome. Physiol. Behav., 2006, 88(3), 234-243.
7. Bezek, S.; Ujhazy, E.; Dubovicky, M.; Mach, M. Nongenomic memory of foetal history in chronic diseases development. Neuro. Endocrinol. Lett., 2008, 29(5), 620-626.
8. Byrne, M.M.; Sturis, J.; O'Meara, N.M.; Polonsky, K.S. Insulin secretion in insulin-resistant women with a history of gestational diabetes. Metabolism, 1995, 44(8), 1067-1073.
9. Peuchant, E.; Brun, J.L.; Rigalleau, V.; Dubourg, L.; Thomas, M.J.; Daniel, J.Y.; Leng, J.J.; Gin, H. Oxidative and antioxidative status in pregnant women with either gestational or type 1 diabetes. Clin. Biochem., 2004, 37(4), 293-298.
10. Chen, X.; Scholl, T.O. Oxidative stress: changes in pregnancy and with gestational diabetes mellitus. Curr. Diab. Rep., 2005, 5(4), 282-288.
11. Yan, Y.; Xiong, Z.; Zhang, S.; Song, J.; Huang, Y.; Thornton, A.M.; Wang, H.; Yang, X.F. CD25 high T cells with a prolonged survival inhibit development of diabetes. Int. J. Immunopathol. Pharmacol., 2008, 21(4), 767-780.
12. Roca, V.; Calafat, M.; Larocca, L.; Ramhorst, R.; Farina, M.; Franchi, A.M.; Leiros, C.P. Potential immunomodulatory role of VIP in the implantation sites of prediabetic nonobese diabetic mice. Reproduction, 2009, 138(4), 733-742.
13. Wender-Ozegowska, E.; Kozlik, J.; Biczysko, R.; Ozegowski, S. Changes of oxidative stress parameters in diabetic pregnancy. Free Radic. Res., 2004, 38(8), 795-803.
14. Kyle, P. M. Drugs and the fetus. Curr. Opin. Obstet. Gynecol., 2006, 18(2), 93-99.
15. Pettitt, D.J.; Ospina, P.; Howard, C.; Zisser, H.; Jovanovic, L. Efficacy, safety and lack of immunogenicity of insulin aspart compared with regular human insulin for women with gestational diabetes mellitus. Diabet. Med., 2007, 24(10), 1129-1135.
16. Ratnasooriya, W.D.; Jayakody, J.R.; Premakumara, G.A. Adverse pregnancy outcome in rats following exposure to a Salacia reticulata (Celastraceae) root extract. Braz. J. Med. Biol. Res., 2003, 36(7), 931-935.
17. Bach, J.F. Strategies in immunotherapy of insulin-dependent diabetes mellitus. Ann. N. Y. Acad. Sci., 1993, 696, 364-376.
18. Boitard, C.; Timsit, J.; Sempe, P.; Bach, J.F. Experimental immunoprevention of type I diabetes mellitus. Diabetes Metab. Rev., 1991, 7(1), 15-33.
19. Bretzel, R.G. [Principles of immunotherapy in insulin-dependent diabetes mellitus]. Wien Klin Wochenschr. 1988, 100(13), 435-442.
20. DiPalma, J.R.; Thayer, W.S. Use of niacin as a drug. Annu. Rev. Nutr., 1991, (11), 169-187.
21. Bogan, K.L.; Brenner, C. Nicotinic acid, nicotinamide, and nicotinamide riboside: a molecular evaluation of NAD+ precursor vitamins in human nutrition. Annu. Rev. Nutr., 2008, (28), 115-130.
22. Murray, M.F. Nicotinamide: An oral antimicrobial agent with activity against both Mycobacterium tuberculosis and Human Immunodeficiency Virus. Clin. Infect. Dis., 2003, 1(36), 453-460.
23. Maiese, K.; Chong, Z.Z.; Hou, J.; Shang, Y.C. The vitamin nicotinamide: translating nutrition into clinical care. Molecules, 2009, 14(9), 3446-3485.
24. Velikii, N.N.; Obrosova, I.G.; Efimov, A.S.; Babicheva, E.I.; Sokil, O.P. Nicotinamide coenzymes in the regulation of cellular metabolism in various types of diabetes]. Vopr. Med. Khim., 1992, 38(4), 45-52.
25. Kolb, H.; Burkart, V. Nicotinamide in type 1 diabetes. Mechanism of action revisited. Diabetes Care, 1999, 22 Suppl 2, B16-20.
26. Fei, J.; Cook, C.; Blough, E.; Santanam, N. Age and sex mediated changes in epicardial fat adipokines. Atherosclerosis, 2010, 2122, 488-494.
27. Carrasco-Legleu, C.E.; Sanchez-Perez, Y.; Marquez-Rosado, L.; Fattel-Fazenda, S.; Arce-Popoca, E.; Hernandez-Garcia, S.; Villa-Trevino, S. A single dose of caffeic acid phenethyl ester prevents initiation in a mediumterm rat hepatocarcinogenesis model. World J. Gastroenterol., 2006, 12(42), 6779-6785.
28. John, C.M.; Sandrasaigaran, P.; Tong, C.K.; Adam, A.; Ramasamy, R., Immunomodulatory activity of polyphenols derived from Cassia auriculata flowers in aged rats. Cell. Immunol., 2011, 271(2), 474-479.
29. Polo, V.; Saibene, A.; Pontiroli, A.E. Nicotinamide improves insulin secretion and metabolic control in lean type 2 diabetic patients with secondary failure to sulphonylureas. Acta Diabetol., 1998, 35(1),61-64.
30. Grisouard, J.; Timper, K.; Radimerski, T.M.; Frey, D.M.; Peterli, R.; Kola, B.; Korbonits, M.; Herrmann, P.; Krahenbuhl, S.; Zulewski, H.; Keller, U.; Muller, B.; Christ-Crain, M. Biochem. Pharmacol., 2010, 80(11), 1736-1745.
31. Novelli, M.; Fabregat, M.E.; Fernandez-Alvarez, J.; Gomis, R.; Masiello, P. Metabolic and functional studies on isolated islets in a new rat model of type 2 diabetes. Mol. Cell. Endocrinol., 2001, 175(1-2), 57-66.
32. Husain, G.M.; Chatterjee, S.S.; Singh, P.N.; Kumar, V. Beneficial effect of Hypericum perforatum on depression and anxiety in a type 2 diabetic rat model. Acta Pol. Pharm., 2011, 68(6), 913-918.
33. Shymans'kyi, I.O.; Kuchmerov'ska, T.M.; Donchenko, H.V.; Velykyi, M.M.; Klymenko, A.P.; Palyvoda, O.M.; Kuchmerovs'kyi, M.O. [Oxidative stress correction by nicotinamide and nicotynol-GABA in diabetic neuropathy]. Ukr. Biokhim. Zh., 2002, 74(5).
34. Lappas, M.; Permezel, M. The anti-inflammatory and antioxidative effects of nicotinamide, a vitamin B3 derivative, are elicited by FoxO3 in human gestational tissues: implications for preterm birth. J. Nutr. Biochem., 2011, 22(12), 1195-1201.
35. Chakrabarti, R.; Jung, C.Y.; Lee, T.P.; Liu, H.; Mookerjee, B.K. Changes in glucose transport and transporter isoforms during the activation of human peripheral blood lymphocytes by phytohemagglutinin. J. Immunol., 1994, 152(6), 2660-2668.
36. The European Nicotinamide Diabetes Intervention Trial (ENDIT) group. Intervening before the onset of Type 1 diabetes: baseline data from the European Nicotinamide Diabetes Intervention Trial (ENDIT). Diabetologia, 2003, 46(3), 339-346.
37. Mandrup-Poulsen, T.; Reimers, J.I.; Andersen, H.U.; Pociot, F.; Karlsen, A.E.; Bjerre, U.; Nerup, J., Nicotinamide treatment in the prevention of insulin-dependent diabetes mellitus. Diabetes Metab. Rev., 1993, 9(4), 295-309.
38. Shen Y.C.; Chen C.F.; Chiou, W.F. Andrograholide prevents oxygen radical production by human neutrophils: possible mechanism(s) involved in its antiinflammatory effect. Brit. J. Pharmacol., 2002, 135(2), 399-406.
39. Noh, H.; Ha, H. Reactive oxygen species and oxidative stress. Contrib. Nephrol., 2011, 170, 102-112.
40. McIntyre, H.D.; Zeck, W.; Russell, A. Placental growth hormone, fetal growth and the IGF axis in normal and diabetic pregnancy. Curr. Diabetes Rev., 2009, 5(3), 185-189.
41. Carpenter, M.W. Gestational diabetes, pregnancy hypertension, and late vascular disease. Diabetes Care, 2007, 30 Suppl 2, S246-250.
42. Richardson, A.C.; Carpenter, M.W. Inflammatory mediators in gestational diabetes mellitus. Obstet. Gynecol. Clin. North Am., 2007, 34 (2), 213-224.
43. Karasuyama, H.; Takatsu, K. B Lymphocyte activation. Encyclopedia of Immunology (Second Edition), 1998, 349-352.
44. Rawlings, D.J.; Schwartz, M.A.; Jackson, S.W.; Meyer-Bahlburg, A. Integration of B cell responses through Toll-like receptors and antigen receptors. Nat. Rev. Immunol., 2012, (4) 282-294.
45. Raghupathy, R. Th 1-type immunity is incompatible with successful pregnancy. Immunol. Today, 1997, (18) 10, 478-482
46. Hippen, K.L.; Riley, J.L.; June, C.H.; Blazar, B.R. Clinical perspectives for regulatory T cells in transplantation tolerance. Semin. Immunol., 2011, 23(6), 462-468.
47. Goh, J.E.; Sadler, L.; Rowan, J. Metformin for gestational diabetes in routine clinical practice. Diabet. Med., 2011, 28(9), 1082-1087.
48. Paglia, M.; Coustan, D.R. The use of oral antidiabetic medications in gestational diabetes mellitus. Curr. Diab. Rep., 2009, 9(4), 287-290.
49. Gale, E.A.; Bingley, P.J.; Emmett, C.L.; Collier, T., European Nicotinamide Diabetes Intervention Trial (ENDIT): a randomised controlled trial of intervention before the onset of type 1 diabetes. Lancet, 2004, 363(9413), 925-931.