Multicenter epidemiological and clinical study on imported Chagas diseases in Alicante, Spain

Pathogens and Global Health

Volumn 106, Issue 6, 2012, Pages 340-345

  Ramos, José M ^a,b   Torrús, Diego ^a   Amador, Concepción ^c   Jover, Francisco ^d   Pérez Chacón, Fabiola ^a,d   Ponce, Yamileth ^b   Arjon, Francisco J ^c   Caro, Elena ^a   Martínez Peinado, Concepción ^c   Gallegos, Ingrid ^b   Cuadrado, José M ^d   Tello, Antonio ^a   Gutiérrez, Felix ^b  

^a HOSPITAL GENERAL UNIVERSITARIO DE ALICANTE   (Spain)

^b HOSPITAL GENERAL UNIVERSITARIO DE ELCHE   (Spain)

^c HOSPITAL MARINA BAIXA   (Spain)

^d HOSPITAL UNIVERSITARIO DE SAN JUAN   (Spain)

Author keywords

American trypanosomiasis; Bolivia; Chagas disease; Immigrant; Spain; Trypanosoma cruzi infection

Indexed keywords

BENZNIDAZOLE;

ADOLESCENT; ADULT; AGED; ANOREXIA; ARTICLE; CENTRAL NERVOUS SYSTEM; CHAGAS DISEASE; CHILD; CONFIDENCE INTERVAL; DRUG WITHDRAWAL; DYSESTHESIA; FAINTNESS; FEMALE; GASTROINTESTINAL TRACT; GENERAL HOSPITAL; HUMAN; HYPERTRANSAMINASEMIA; IMMIGRANT; INFANT; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; NAUSEA AND VOMITING; NEWBORN; PARESTHESIA; POLYMERASE CHAIN REACTION; PRESCHOOL CHILD; PREVALENCE; PRURITUS; RASH; RISK; SCHOOL CHILD; SPAIN; STOMACH PAIN; TRYPANOSOMA CRUZI;

ADOLESCENT; ADULT; AGED; ANTIPROTOZOAL AGENTS; BOLIVIA; CHAGAS DISEASE; CHILD; CHILD, PRESCHOOL; EMIGRATION AND IMMIGRATION; FEMALE; HOSPITALS, GENERAL; HUMANS; INFANT; MALE; MIDDLE AGED; NITROIMIDAZOLES; PREGNANCY; SPAIN; TREATMENT OUTCOME; TRYPANOSOMA CRUZI; YOUNG ADULT;

EID: 84870378288     PISSN: 20477724     EISSN: 20477732     Source Type: Journal    
DOI: 10.1179/2047773212Y.0000000039     Document Type: Article

References (27)

1. Instituto Nacional de Estadística. Avance del Padrón Municipal a 1 de enero 2011. Madrid: INE; 2011 [Internet]. [cited 2011 Dec 12].Available from: http://www.ine.es/prensa/np648.pdf
2. Gascon J, Bern C, Pinazo MJ. Chagas disease in Spain, the United States and other non-endemic countries. Acta Trop. 2010;115:22-7.
3. Schmunis GA. Yadon ZE. Chagas disease, a Latin American health problem becoming a world health problem. Acta Trop. 2010;115:14-21.
4. Jackson Y, Angheben A, Carrilero Fernandez B, Jansa i Lopez del Vallado JM, Jannin JG, Albajar-Viñas P. Management of Chagas disease in Europe. Experiences and challenges in Spain, Switzerland and Italy. Bull Soc Pathol Exot. 2009;102:326-9.
5. Muñoz J, Gómez i Prat J, Gállego M, Gimeno F, Treviño B, López-Chejade P, et al. Clinical profile of Trypanosoma cruzi infection in a non-endemic setting: immigration and Chagas disease in Barcelona (Spain). Acta Trop. 2009;111:51-5.
6. Jackson Y, Alirol E, Getaz L, Wolff H, Combescure C, Chappuis F. Tolerance and safety of nifurtimox in patients with chronic chagas disease. Clin Infect Dis. 2010;5:e69-75.
7. Murcia L, Carrilero B, Muñoz MJ, Iborra MA, Segovia M. Usefulness of PCR for monitoring benznidazole response in patients with chronic Chagas' disease: a prospective study in a non-diseaseendemic country. J Antimicrob Chemother. 2010;65:1759-64.
8. Pérez-Ayala A, Pérez-Molina JA, Norman F, Navarro M, Monge-Maillo B, Díaz-Menéndez M, et al. Chagas disease in Latin American migrants: a Spanish challenge. Clin Microbiol Infect. 2011;17:1108-13.
9. Instituto Nacional de Estadística. Revisión del padrón municipal 2010. Datos por municipios. 03-Alicante/Alacant. Población nacida en el extranjero por sexo, municipios y lugar de nacimiento. Madrid: INE; 2010 cited 2011 Dec 29. Available from: http://www.ine.es/jaxi/tabla.dopath5/t20/e245/p05/a2010/ l0/&file=00003004.px&type=pcaxis&L=0
10. Organización Panamericana de la Salud. Estimación cuantitativa de la enfermedad de Chagas en las Américas. Montevideo, Uruguay, Organización Panamericana de la Salud. Washington DC: PAHO Publishing; 2006. 1-28 [OPS/HDM/CD/425-06]
11. WHO - World Health Organization. Control of Chagas Disease, WHO Technical Report Series 811. Geneva: WHO; 2002. cited 2010 May 01. Available from: http://whqlibdoc.who.int/trs/WHO-TRS-905.pdf
12. Flores-Chávez M, Fernández B, Puente S, Torres P, Rodríguez M, Monedero C, et al. Transfusional chagas disease: parasitological and serological monitoring of an infected recipient and blood donor. Clin Infect Dis. 2008;46:e44-7.
13. Gascón J, Albajar P, Cañas E, Flores M, Gómez i Prat J, Herrera RN, et al. Diagnosis, management and treatment of chronic Chagas' heart disease in areas where Trypanosoma cruzi infection is not endemic. Rev Esp Cardiol. 2007;60:285-93.
14. Sosa-Estani S, Viotti R, Segura EL. Therapy, diagnosis and prognosis of chronic Chagas disease: insight gained in Argentina. Mem Inst Oswaldo Cruz. 2009;104 Suppl 1:167-80.
15. de Oliveira RB, Troncon LE, Dantas R, Menghelli UG. Gastrointestinal manifestations of Chagas' disease. Am J Gastroenterol. 1998;93:884-9.
16. Muñoz J, Coll O, Juncosa T, Vergés M, Vergés M, del Pino M, Fumado V, et al. Prevalence and vertical transmission of Trypanosoma cruzi infection among pregnant Latin American women attending 2 maternity clinics in Barcelona, Spain. Clin Infect Dis. 2009;48:1736-40.
17. Ramos JM, Milla A, Sánchez V, Vergés M, Toro C, Gutiérrez F. Prenatal screening for Trypanosoma cruzi and human T lymphotropic virus types 1 and 2 in pregnant Latin American women. Enferm Infecc Microbiol Clin. 1999;27:165-7.
18. Ramos JM, Ponce Y, Gallegos I, Flores-Chávez M, Cañavate C, Gutiérrez F. Trypanosoma cruzi infection in Elche (Spain): comparison of the seroprevalence in immigrants from Paraguay and Bolivia. Pathog Glob Health. 2012;106:102-6.
19. Garcia-Alvarez A, Sitges M, Pinazo MJ, Regueiro-Cueva A, Posada E, Poyatos S et al. Chagas cardiomyopathy: the potential of diastolic dysfunction and brain natriuretic peptide in the early identification of cardiac damage. PLoS Negl Trop Dis. 2010;21;4 pii:e826
20. Pérez-Ayala A, Pérez-Molina JA, Norman F, Monge-Maillo B, Faro MV, López-Vélez R. Gastro-intestinal Chagas disease in migrants to Spain: prevalence and methods for early diagnosis. Ann Trop Med Parasitol. 2011;105:25-9.
21. Marin-Neto JA, Rassi A Jr, Morillo CA, Avezum A, Connolly SJ, Sosa-Estani S, et al. BENEFIT Investigators. Rationale and design of a randomized placebo-controlled trial assessing the effects of etiologic treatment in Chagas' cardiomyopathy: the BENznidazole Evaluation For Interrupting Trypanosomiasis (BENEFIT). Am Heart J. 2008;156:37-43.
22. Pérez-Molina JA, Pérez-Ayala A, Moreno S, Fernández-González MC, Zamora J, López-Velez R. Use of benznidazole to treat chronic Chagas' disease: a systematic review with a meta-analysis. J Antimicrob Chemother. 2009;64:1139-47.
23. Viotti R, Vigliano C, Lococo B, Bertocchi G, Petti M, Alvarez MG, et al. Long-term cardiac outcomes of treating chronic Chagas disease with benznidazole versus no treatment: a nonrandomized trial. Ann Intern Med. 2006;144: 724-34.
24. Pinazo MJ, Muñoz J, Posada E, López-Chejade P, Gállego M, Ayala E, et al. Tolerance of benznidazole in treatment of Chagas' disease in adults. Antimicrob Agents Chemother. 2010;54:4896-9.
25. Gomes YM, Lorena VM, Luquetti AO. Diagnosis of Chagas disease: what has been achieved? What remains to be done with regard to diagnosis and follow up studies? Mem Inst Oswaldo Cruz. 2009;104 (Suppl 1):115-21.
26. Carrilero B, Murcia L, Martínez-Lage L, Segovia M. Side effects of benznidazole treatment in a cohort of patients with Chagas disease in non-endemic country. Rev Esp Quimioter. 2011;24:123-6.
27. Viotti R, Vigliano C, Lococo B, Alvarez MG, Petti M, Bertocchi G, et al. Side effects of benznidazole as treatment in chronic Chagas disease: fears and realities. Expert Rev Anti Infect Ther. 2009;7:157-63.